老年高血压合并冠心病患者的心率变异性分析

目的了解老年高血压(EH)病合并冠心病(CHD)患者心率变异性的特点及其临床意义。方法选择EH患者34例及EH合并CHD患者32例,老年健康对照组38例,青年健康对照组51例,进行24h动态血压和动态心电图检查,对两组患者心率变异性(HRV)参数及室性心律失常发生率进行对照分析。结果与对照组比较,EH组和EH合并CHD组HRV均降低(P<0.05),其中EH合并CHD组HRV降低更为显著(P<0.01);与对照组比较,EH组和EH合并CHD组室性心律失常的发生率增加(P<0.05),其中EH合并CHD组室性心律失常的发生率增加更为显著(P<0.01)。结论反映自主神经活性变化的HRV可作为高血压患者预后的重要指标之一。尤其对EH合并CHD的患者,临床上除降压治疗外,还应根据HRV的改变情况给予积极改善自主神经功能的治疗。     

氧化CaMKII人类心室细胞模型的建立与电生理的仿真研究

钙/钙调蛋白依赖性蛋白激酶II(Calcium/Calmodulin-dependent protein kinase II,CaMKII)是一种主要表达于心脏中的细胞信号分子,氧化激活的CaMKII与多种致心律失常心脏疾病密切相关.为了分析氧化CaMKII对于细胞电生理的影响,结合CaMKII激活的生物化学动力学特征,开发了氧化CaMKII人类心室细胞模型,模拟仿真研究活性氧(Reactive oxygen species,ROS)增强情况下,离子电流、细胞内钙循环和细胞膜动作电位的变化.仿真结果发现,当ROS的浓度升高时,CaMKII的激活量增加,细胞质和肌浆网钙离子浓度升高,动作电位缩短.本模型为研究CaMKII致心律失常提供了量化分析手段,构建了微观分子功能改变与宏观细胞动作电位变化之间的定量关系,具有重要的理论和应用价值.     

浦氏纤维对心室电传导系统影响的仿真研究

浦肯野氏纤维在保证心室肌同步有序列的收缩中起着重要作用,在许多情况下被认为是严重室性心律失常发生的源头。为了探索性地研究浦肯野氏纤维的宽度对心室电传导系统的影响,建立了人的包含浦肯野氏纤维的心室电传导系统计算模型来模拟不同宽度下电兴奋在心室组织中的传导过程。仿真结果发现,当浦肯野氏纤维的宽度增加时,其传导电兴奋的驱动能力增大,进而引起心室肌组织中电兴奋的传导速率的增大。本模型对心律失常诱发机制研究提供了新的研究手段,还可以用来更加深入地研究浦肯野氏纤维一心室肌耦合连接机制,具有重大的理论和实践意义。     

激光生物平衡技术治疗冠心病临床研究

对303例冠心病患者随机分为激光生物平衡治疗组和对照组，结果接受激光生物平衡技术治疗的病人，其心绞痛缓解，心电图、血液流变学及血脂、血糖的改善与对照组相比有显著性差异。     

比较不同性别的健康者和冠心病患者的血液流变学差异

目的：比较不同性别的健康者和冠心病患者的血液流变学差异。方法：检测健康者与冠心病患者的血液流变学各项指标,并分析形成差异的原因。结果：对照组与冠心病组红细胞降集性女性高于男性,而血液浓度,粘度男性大于女性,差异均非常显著（Ｐ〈０．０１）,结论：对照组不同性别的红细胞聚集性差异可能与红细胞表面电荷量有关,全血粘度差异可能与红细胞压积有关;冠心病组不同性别的红细胞聚集性差异可能与红细胞变形能力下降有关     

老年肺癌手术患者围手术期处理

目的：探讨老年肺癌患者围手术期的治疗经验。方法：对68例60岁以上老年肺癌患者的外科治疗进行分析。结果：68例老年肺癌患者合并高血压病19例,糖尿病11例,冠心病4例,慢性支气管炎、肺气肿10例。均行手术治疗,术后并发症19例,并发症发生率28．0％,其中心肺并发症占89．5％（17／19）。无围手术期死亡。结论：老年肺癌患者术前合并心肺血管疾病增加了手术的风险性,术前全面了解病情,加强围手术期管理,是提高手术疗效的关键;采取适当的治疗措施,老年肺癌患者也可以取得满意的治疗效果。     

老年男性阻塞性睡眠呼吸暂停程度与代谢综合征的相关性研究

目的：研究老年男性阻塞性睡眠呼吸暂停综合征（obstructive sleep apnea syndrome ,OSAS）严重程度与代谢综合征的相关性。方法：随机选择我院收治的663例老年患者,根据呼吸暂停及低通气指数,将其分为非OSAS 组和轻、中、重度OSAS 组。比较各组患者颈围、体质指数（BMI）、腰臀比、血压、血脂、空腹血糖等,分析OSAS严重程度与代谢综合征及其组分发病率之间的相关性。结果 OSAS患者的颈围、BMI、腰臀比、收缩压、舒张压、空腹血糖等显著高于非OSAS组患者。OSAS严重程度与颈围、BMI、甘油三酯等存在显著正相关,且随着OSAS严重程度的增加,代谢综合征及其组分的发生率呈逐渐递增趋势。结论：老年男性阻塞性睡眠呼吸暂停程度与代谢综合征发病率密切相关,这可能是阻塞性睡眠呼吸暂停综合征增加心血管疾病发生率和死亡率的主要原因。     

乳头状胶质神经元肿瘤的MRI及病理表现

目的分析2例乳头状胶质神经元肿瘤（PGNT）同时复习文献,归纳总结其影像表现。方法使用GE公司3．0T磁共振扫描仪对1名12岁女性及1名27岁男性PGNT患者进行MR平扫及增强扫描,分析2例患者的临床表现、MRI特点及病理特征,并对文献资料进行归纳总结。结果2例患者临床表现为失神发作和癫痫。MRI表现为囊实性病变及囊性病变伴壁结节,增强扫描后实性部分及壁结节明显强化。2例均位于颞叶,其中1例与侧脑室关系密切。病理镜下可见特征性的假乳头结构和双相分化的神经胶质细胞及神经元。结论PGNT的MRI表现以囊性肿块伴壁结节多见,病灶位置多靠近脑室且与脑室关系密切,脑室旁型和脑室外型的分类有助于诊断。     

弱激光对冠心病患者循环系统的影响

目的 :研究氦氖激光内关穴照射对老年冠心病患者循环系统的影响。方法 :老年冠心病患者 4 0例 ,采用氦氖激光照射内关穴 ,激光波长为 6 32 .8nm ,功率为 5mW ,15min/穴 ,1次 /d ,2 0次为 1疗程。治疗前 (Ⅰ )、首次治疗后即刻 (Ⅱ )和第一疗程结束后 (Ⅲ )检测血流动力学。结果 :Ⅰ与Ⅱ比较心脏总功率 (CWT)、左心排指数 (LCI)、心肌耗氧量 (CMO)、冠脉缺血阈值 (CMR)参数改善差异非常显著 (P <0 .0 1) ,左室有效功率 (LWE)改善差异有显著性 (P <0 .0 5 ) ;Ⅰ与Ⅲ比较 :CMO、CMR改善差异非常显著 (P <0 .0 1) ,CWT改善差异有显著性 (P <0 .0 5 )。结论 :氦氖激光照射内关穴治疗老年冠心病可改善患者心脏功能、冠脉循环和心肌耗氧量 ,是老年冠心病二级预防和治疗、控制病情发展的方便有效方法     

基于LK光流和网格运动统计的图像匹配改进算法

针对AKAZE算法在玻璃封装电连接器图像匹配中准确率低及耗时长的问题,文中提出了基于LK光流和网格运动统计的图像匹配改进算法。首先采用AKAZE算法提取玻璃封装电连接器特征点,运用M-LDB描述子进行特征描述。然后利用LK光流法计算匹配区域进行条件约束,从而得到匹配点,并通过FLANN算法进行特征匹配。最后将玻璃封装电连接器图像划分为多个网格,计算FLANN匹配好的特征点邻域的正确匹配个数和阈值并剔除误匹配点。文中实验采用公开数据集和玻璃封装电连接器数据,从实时性和准确性两方面对算法性能进行验证分析。结果表明,改进的算法在处理模糊、亮度及旋转变化的玻璃封装电连接器图像对时,其匹配准确率均达到93%以上,耗时为0.4 s内,证明了算法的有效性。     

Resolution Enhancement Technology:Integrated Process Solutions using OPC

DUV lithography, using the 248 nm wavelength, is a viable manufacturing option for devices with features at 130 nm and less. Given the low kl value of the lithography, integrated process development is a necessary method for achieving acceptable process latitude. The application of assist features for rule based OPC requires the simultaneous optimization of the mask, illumination optics and the resist.Described in this paper are the details involved in optimizing each of these aspects for line and space imaging.A reference pitch is first chosen to determine how the optics will be set. The ideal sigma setting is determined by a simple geometrically derived expression. The inner and outer machine settings are determined, in turn,with the simulation of a figure of merit. The maximum value of the response surface of this FOM occurs at the optimal sigma settings. Experimental confirmation of this is shown in the paper.Assist features are used to modify the aerial image of the more isolated images on the mask. The effect that the diffraction of the scattering bars (SBs) has on the image intensity distribution is explained. Rules for determining the size and placement of SBs are also given.Resist is optimized for use with off-axis illumination and assist features. A general explanation of the material' s effect is discussed along with the affect on the through-pitch bias. The paper culminates with the showing of the lithographic results from the fully optimized system.     

Cost-effective test solutions for smart card and other integrated flash applications

From its emergence in the late 1980s as a lower cost alternative to early EEPROM technologies, flash memory has evolved to higher densities and speedsand rapidly growing acceptance in mobile applications.In the process, flash memory devices have placed increased test requirements on manufacturers. Today, as flash device test grows in importance in China, manufacturers face growing pressure for reduced cost-oftest, increased throughput and greater return on investment for test equipment. At the same time, the move to integrated flash packages for contactless smart card applications adds a significant further challenge to manufacturers seeking rapid, low-cost test.     

Theoretical analysis of the relationship between the Brillouin gain coefficient and the strain in the optical-fiber sensors

The relation between the power of the Brillouin signal and the strain is one of the bases of the distributed fiber sensors of temperature and strain. The coefficient of the Bfillouin gain can be changed by the temperature and the strain that will affect the power of the Brillouin scattering. The relation between the change of the Brillouin gain coefficient and the strain is thought to be linear by many researchers. However, it is not always linear based on the theoretical analysis and numerical simulation. Therefore, errors will be caused if the relation between the change of the Brillouin gain coefficient and the strain is regarded as to be linear approximately for measuring the temperature and the strain. For this reason, the influence of the parameters on the Brillouin gain coefficient is proposed through theoretical analysis and numerical simulation.     

An improved parallel thinning algorithm with two subiterations

The parallel thinning algorithm with two subiterations is improved in this paper. By analyzing the notions of connected components and passes, a conclusion is drawn that the number of passes and the number of eight-connected components are equal. Then the expression of the number of eight-connected components is obtained which replaces the old one in the algorithm. And a reserving condition is proposed by experiments, which alleviates the excess deletion where a diagonal line and a beeline intersect. The experimental results demonstrate that the thinned curve is almost located in the middle of the original curve connectivelv with single pixel width and the processing speed is high.     

Novel fiber-optical interferometer with miniaturized probe for in-hole measurements

Today, micro-system technology and the development of new MEMS （Micro-Electro-Mechanical Systems） are emerging rapidly. In order for this development to become a success in the long run, measurement systems have to ensure product quality. Most often, MEMS have to be tested by means of functionality or destructive tests. One reason for this is that there are no suitable systems or sensing probes available which can be used for the measurement of quasi inaccessible features like small holes or cavities. We present a measurement system that could be used for these kinds of measurements. The system combines a fiber optical, miniaturized sensing probe with low-coherence interferometry, so that absolute distance measurements with nanometer accuracy are possible.     

Development of the readout system for waveguide multilayer optical card

Waveguide multilayer optical card （WMOC） is a novel storage device of three-dimensional optical information. An advanced readout system fitting for the WMOC is introduced in this paper. The hardware mainly consists of the light source for reading, WMOC, motorized stages addressing unit, microscope imaging unit, CCD detecting unit and PC controlling ＆ processing unit. The movement of the precision motorized stage is controlled by the computer through Visual Basic （VB） language in software. A control panel is also designed to get the layer address and the page address through which the position of the motorized stages can be changed. The WMOC readout system is easy to manage and the readout result is directly displayed on computer monitor.     

Study of waveguide coupling efficiency in hybrid silicon lasers

This paper presents a new method to increase the waveguide coupling efficiency in hybrid silicon lasers. We find that the propagation constant of the InGaAsP emitting layer can be equal to that of the Si resonant layer through improving the design size of the InP waveguide. The coupling power achieves 42% of the total power in the hybrid lasers when the thickness of the bonding layer is 100 nm. Our result is very close to 50% of the total power reported by Intel when the thickness of the thin bonding layer is less than 5 nm. Therefore, our invariable coupling power technique is simpler than Intel＇s.     

Collinear phase-matching study of terahertz-wave generation via difference frequency mixed in GaAs and Inp

The collinearly phase-matching condition of terahertz-wave generation via difference frequency mixed in GaAs and InP is theoretically studied. In collinear phase-matching, the optimum phase-matching wave hands of these two crystals are calculated. The optimum phase-matching wave bands in GaAs and lnP are 0.95-1.38μm and 0.7-0.96μm respectively. The influence of the wavelength choice of the pump wave on the coherent length in THz-wave tuning is also discussed. The influence of the temperature alteration on the phase-matching and the temperature tuning properties in GaAs crystal are calculated and analyzed. It can serve for the following experiments as a theoretical evidence and a reference as well.     

Effects of the alloy compositions on the phonon-polaritons in ternary mixed crystals

Composition dependence of bulk and surface phonon-polaritons in ternary mixed crystals are studied in the framework of the modified random-element-isodisplacement model and the Bom-Huang approximation. The numerical results for Several Ⅱ - Ⅵ and Ⅲ- Ⅴ compound systems are performed, and the polariton frequencies as functions of the compositions for ternary mixed crystals AlxGa1-xAs, GaPxAS1-x, ZnSxSe1-x, GaAsxSb1-x, GaxIn1-xP, and ZnxCd1-xS as examples are given and discussed. The results show that the dependence of the energies of two branches of bulk phonon-polaritons which have phonon-like characteristics, and surface phonon-polaritons on the compositions of ternary mixed crystals are nonlinear and different from those of the corresponding binary systems.