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Christer Nystr m G
Ran Alderborn Margareta Duberg Per-Gunnar Karehill 《Drug development and industrial pharmacy》1993,19(17):2143-2196
Two factors could be regarded as primary factors for the compactability of powders: the dominating bond mechanism and the surface area over which these bonds are active. Owing to considerable experimental difficulties, these factors have not been evaluated in any detail for pharmaceutical materials. Instead, more indirect, secondary factors are normally studied and used for correlations with tablet strength. Such secondary factors are particle size, shape and surface texture. Also the importance of volume reduction mechanisms, i.e. elastic deformation, plastic deformation and particle fragmentation have been studied in detail.
For the investigation of dominating bond mechanisms and estimation of the magnitude of the surface area of the solids involved in interparticulate attraction in compacts several pharmaceutical excipients representing both plastically deforming materials (sodium chloride, Avicel® PH 101, Sta-Rx 1500®, and sodium bicarbonate) and fragmenting materials (lactose, sucrose, paracetamol and Emcompress®) have been used in a series of publications from our laboratory.
The bonding mechanisms discussed have been solid bridges, representing continous solid bridges between tablet particles, intermolecular forces, representing weaker attraction forces active over distances and mechanical interlocking, representing a bond type dependent on hooking and twisting of irregularly shaped particles. To characterize the dominating bond mechanisms, measurements of compact strength has been performed in media known to reduce bonding with intermolecular forces. The media used were liquids with different dielectric constants and films of magnesium stearate. The results establish that the intermolecular forces constitute the dominating bond mechanism for pharmaceutical materials. Bonding with solid bridges contribute to the compact strength only for coarse plastically deforming materials that can melt during compaction. Only for sodium chloride, of the materials tested, is there substantial evidence for the existence of solid bridges. Bonding with mechanical interlocking is a bonding mechanism of minor importance for most of the investigated materials with the possible exception of Avicel® PH 101.
The results indicate that the surface area utilized for bonding with solid bridges for sodium chloride as measured with gas adsorption is small in relation to the total surface area of the compact. For all the materials bonding with intermolecular forces, only a proportional relation between compact surface area and bonding surface area could be possible. By using permeametry surface area data, the surface specific compact strength was characterized and found similar for all materials bonding primarily with intermolecular forces. For such materials a large bonding surface area will thus be obtained if the surface area of the particles in the tablet is large. This could either be achieved by the use of materials that undergo extensive fragmentation or by the use of very fine paniculate materials or qualities with pronounced surface roughness. It is suggested that most of the so called plastically deforming pharmaceutical materials often possess inadequate plasticity for the development of large zones that could take part in the interparticulate attraction by intermolecular forces. 相似文献
For the investigation of dominating bond mechanisms and estimation of the magnitude of the surface area of the solids involved in interparticulate attraction in compacts several pharmaceutical excipients representing both plastically deforming materials (sodium chloride, Avicel® PH 101, Sta-Rx 1500®, and sodium bicarbonate) and fragmenting materials (lactose, sucrose, paracetamol and Emcompress®) have been used in a series of publications from our laboratory.
The bonding mechanisms discussed have been solid bridges, representing continous solid bridges between tablet particles, intermolecular forces, representing weaker attraction forces active over distances and mechanical interlocking, representing a bond type dependent on hooking and twisting of irregularly shaped particles. To characterize the dominating bond mechanisms, measurements of compact strength has been performed in media known to reduce bonding with intermolecular forces. The media used were liquids with different dielectric constants and films of magnesium stearate. The results establish that the intermolecular forces constitute the dominating bond mechanism for pharmaceutical materials. Bonding with solid bridges contribute to the compact strength only for coarse plastically deforming materials that can melt during compaction. Only for sodium chloride, of the materials tested, is there substantial evidence for the existence of solid bridges. Bonding with mechanical interlocking is a bonding mechanism of minor importance for most of the investigated materials with the possible exception of Avicel® PH 101.
The results indicate that the surface area utilized for bonding with solid bridges for sodium chloride as measured with gas adsorption is small in relation to the total surface area of the compact. For all the materials bonding with intermolecular forces, only a proportional relation between compact surface area and bonding surface area could be possible. By using permeametry surface area data, the surface specific compact strength was characterized and found similar for all materials bonding primarily with intermolecular forces. For such materials a large bonding surface area will thus be obtained if the surface area of the particles in the tablet is large. This could either be achieved by the use of materials that undergo extensive fragmentation or by the use of very fine paniculate materials or qualities with pronounced surface roughness. It is suggested that most of the so called plastically deforming pharmaceutical materials often possess inadequate plasticity for the development of large zones that could take part in the interparticulate attraction by intermolecular forces. 相似文献
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The objective of this study is to evaluate surface quality of compressed Douglas fir (Pseudotsuga menziesii) veneer sheets in the form of its roughness. Veneer samples were compressed using pressure levels of 1.0 N/mm2, 2.0 N/mm2, and 2.5 N/mm2 at two temperatures of 180 °C and 210 °C for 3 min. A fine stylus profilometer was used to evaluate surface roughness of the veneer samples. Three roughness parameters, namely average roughness (Ra), mean peak-to-valley height (Rz), and maximum roughness (Rmax) values were determined. The results obtained in this study showed that the surface roughness parameters of the thermally compressed veneers decreased with increasing press temperature and pressure level. It appears that initial data found in this work would provide some benefit to more efficient use of adhesive to manufacture plywood and laminated veneer lumber (LVL) panels with enhanced properties. 相似文献
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钛表面的氧化对钛瓷结合强度的影响 总被引:1,自引:0,他引:1
研究了钛表面氧化对钛/瓷结合强度的影响, 并采用溶胶凝胶技术在钛表面制备SnOx中间层, 研究SnOx层对钛/瓷结合强度的影响. 结果表明:空气炉中800℃氧化3min后, 钛/瓷结合强度明显下降; 烤瓷炉中预氧化3min, 钛/瓷结合强度无明显变化. 热处理使钛表面生成一层金红石型氧化层, 钛/瓷剥脱主要发生在金红石氧化层与钛之间. 采用溶胶-凝胶法经300℃处理后在钛表面制得的SnOx涂层, 可有效隔绝氧向Ti表面的扩散, 防止钛表面的过度氧化, 提高了钛/瓷结合强度. 经SnOx涂层处理后, 钛/瓷剥脱主要发生在SnOx涂层内. 相似文献
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聚丙烯粉料表面的紫外光和射线辐照接枝 总被引:4,自引:0,他引:4
以马来酸酐(MAH)、丙烯酸(AA)、丙烯酸乙酯(EA)、丙烯酰胺(AA)为单体,对预氧化和未处理的聚丙烯(PP)粉进行固相光接枝、溶液光接枝,固相γ射线接枝以及γ射线预辐照溶液接枝,用FT-IR、ESCA和化学滴定法对接枝聚丙烯进行了定性和定量表征。结果表明,各单位均在聚丙烯表面发生了不同程度的接枝共聚。 相似文献
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双金属热轧复合的界面结合影响因素及结合机理 总被引:5,自引:1,他引:4
在综合了不同材料热轧复合的实验基础上,分析了双金属热轧复合过程中不同工艺条件对结合质量的影响.结果表明:轧制前清除材料表面的覆盖膜有助于轧制过程中形成结合点;轧制过程中适当的轧制温度和轧制压下量能大量消除轧制过程中在金属表面形成的氧化膜,从而使组元材料能形成机械结合;在热烧结过程中,原子通过界面扩散可以消除轧制过程中由于界面微观不平整形成的空洞,同时通过原子间的相互作用使组元材料间形成冶金结合.依据固相结合理论分析得出,双金属热轧复合的界面结合过程包括:金属间物理接触形成机械结合阶段,原子通过化学作用形成化学键及通过界面扩散消除空洞的冶金结合阶段,以及互扩散阶段. 相似文献
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Yingwei Li Tatsuya Higaki Xiangsha Du Rongchao Jin 《Advanced materials (Deerfield Beach, Fla.)》2020,32(41):1905488
Chirality is ubiquitous in nature and occurs at all length scales. The development of applications for chiral nanostructures is rising rapidly. With the recent achievements of atomically precise nanochemistry, total structures of ligand-protected Au and other metal nanoclusters (NCs) are successfully obtained, and the origins of chirality are discovered to be associated with different parts of the cluster, including the surface ligands (e.g., swirl patterns), the organic–inorganic interface (e.g., helical stripes), and the kernel. Herein, a unified picture of metal–ligand surface bonding-induced chirality for the nanoclusters is proposed. The different bonding modes of M–X (where M = metal and X = the binding atom of ligand) lead to different surface structures on nanoclusters, which in turn give rise to various characteristic features of chirality. A comparison of Au–thiolate NCs with Au–phosphine ones further reveals the important roles of surface bonding. Compared to the Au–thiolate NCs, the Ag/Cu/Cd–thiolate systems exhibit different coordination modes between the metal and the thiolate. Other than thiolate and phosphine ligands, alkynyls are also briefly discussed. Several methods of obtaining chiroptically active nanoclusters are introduced, such as enantioseparation by high-performance liquid chromatography and enantioselective synthesis. Future perspectives on chiral NCs are also proposed. 相似文献
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Diffusion bonding studies were performed on Laser Surface Melted (LSM) Ni-Cr-Fe material. LSM generates metastable microstructures with extended solid solution. The rapid quenching associated with LSM generates a zone that is void of intragranular precipitates, consists of well-defined grain boundaries via intergranular carbides, and contains fine-grained material. Grain growth across the bondlineand precipitate morphology were studied as a function of laser beam power (energy density) and bonding temperature. LSM at low energy density produced excellent grain growth across the bondline even when bonding at low temperature. 相似文献
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通过反相气相色谱法(IGC),采用非极性和极性探针分子研究了新型热塑性聚氨酯弹性体(DTPU)的色散表面自由能和表面Lewis酸碱性质,并与传统的推进剂用热塑性聚氨酯粘合剂(BTPU)做了对比。结果表明,DTPU与BTPU的色散表面自由能较为接近,并且随着温度的升高而线性降低;DTPU的酸常数Ka和碱常数Kb分别为0.09和0.48,而BTPU的酸常数Ka和碱常数Kb分别为0.06和0.37,DTPU的酸性和表面总的酸碱作用能力较大,与推进剂中高能固体填料具有更好的相互作用。 相似文献
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焊前处理方式对LF6铝合金扩散焊的影响 总被引:4,自引:0,他引:4
利用Gleeble-1500热/力模拟试验机,研究了LF6铝合金的扩散焊工艺,通过对焊接温度、压力、时间的调整和选用不同的料前处理方法,确定了最佳的扩散规范,研究结果表明:在一定的温度和时间范围内,LF65铝合金扩散焊接头的剪切哟度随焊接温度和时间的增加而提高;化学浸蚀法比机械打磨法能更有效的去除铝合金表面的氧化膜;在现有试验条件下,得到LF6铝合金扩散焊的最佳规范参数,搭接试扩散焊接头的剪切强度 相似文献
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纳米级二氧化钛的表面包覆技术 总被引:9,自引:0,他引:9
表面包覆技术是继成功制备出纳米TiO2 后,为获得特异性能及适应多种应用场合而发展起来的新研究项目。本文综述了近年来纳米级TiO2 表面包覆技术的研究成果及进展,并提出当前和今后的研究方向。 相似文献
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对八钢冷轧薄板厂钢卷产生的粘结缺陷进行追踪,从热轧卷来料、冷轧轧机、罩式炉退火、平整工艺对粘结进行系统的研究,找出各机组粘结缺陷的影响因素和影响方式,并提出冷轧厂及其各机组的控制措施。 相似文献