Synthesis and Application of Hethacrylate Polyhers in the Forhulation of Hatrix Tablets

Polymers were prepared by using two types of methacrylate monomers viz. hydrophobic monomers (methymethacrylate, butylmethacrylate) and hydrophilic monomers (2-hydroxy ethyl methacrylate, 2-hydroxy propyl methacrylate) using solution polymerisation method. Characterisation of the physico-chemical properties of the polymers was studied. The polymers were then evaluated as matrix formers for drugs selected on the basis of their aqueous solubility.     

Bioadhesive Polymers - Synthesis, Evaluation and Application in Controlled Release Tablets

Synthesis of series of cross linked polymers of methacrylic acid (PMAs) and acrylic acid (PAAs) is reported. Polymers of both the types have been investigated for physiochemical properties like solubility, density, swelling index and equilibrium swelling. A suitable method was devised for study of bioadhesion. Floating tablets were prepared and coated with some of the synthesized polymers. The tablets were then evaluated for physical properties (including bioadhesion) as well as for drug content and in vitro drug release. The results were compared with those obtained with Carbopol 934P. Some polymers showed better bioadhesion and drug release pattern as compared to Carbopol 934P.     

Bioadhesive Polymers - Synthesis,Evaluation and Application in Controlled Release Tablets

Abstract

Synthesis of series of cross linked polymers of methacrylic acid (PMAs) and acrylic acid (PAAs) is reported. Polymers of both the types have been investigated for physiochemical properties like solubility, density, swelling index and equilibrium swelling. A suitable method was devised for study of bioadhesion. Floating tablets were prepared and coated with some of the synthesized polymers. The tablets were then evaluated for physical properties (including bioadhesion) as well as for drug content and in vitro drug release. The results were compared with those obtained with Carbopol 934P. Some polymers showed better bioadhesion and drug release pattern as compared to Carbopol 934P.     

Application of the Statistical Multivariate Analysis to the Release Characterization of Matrix Tablets

The introduction of new sustances that can be used as excipient in controlled release formulations constitutes a relevant step in obtaining simple, reliable and accurate methods which makes it possible to reproduce the controlled release of drugs.

Therefore, the aim of this work is to study the influence of different technological variables on the modulation of the release of the active principle compressed with a new excipient to formulate matrix tablets. A Poliamyde 12 was used as the rate-controlling polymer in controlled-release tablet formulation. Different techniques of multivariate analysis have been applied to the release characterization of matrix tablets studied.     

Application of the Statistical Multivariate Analysis to the Release Characterization of Matrix Tablets

The introduction of new sustances that can be used as excipient in controlled release formulations constitutes a relevant step in obtaining simple, reliable and accurate methods which makes it possible to reproduce the controlled release of drugs.

Therefore, the aim of this work is to study the influence of different technological variables on the modulation of the release of the active principle compressed with a new excipient to formulate matrix tablets. A Poliamyde 12 was used as the rate-controlling polymer in controlled-release tablet formulation. Different techniques of multivariate analysis have been applied to the release characterization of matrix tablets studied.     

Application of Laser Hologram Interferometry to the Distortion Determination of Sugar-Coated Tablets

Abstract

Sugar-Coated tablets of different core materials were prepared and the degree of distortion of the sugar coat was determined by the laser holographic interferometry of double exposure method. It was found that, as the degree of expansion of the tablet core material increased, the sugar coat became more distorted. By the present method, nondestructive measurement of a minute amount of distortion is possible and thus superior to conventional methods.     

Application of Laser Hologram Interferometry to the Distortion Determination of Sugar-Coated Tablets

Sugar-Coated tablets of different core materials were prepared and the degree of distortion of the sugar coat was determined by the laser holographic interferometry of double exposure method. It was found that, as the degree of expansion of the tablet core material increased, the sugar coat became more distorted. By the present method, nondestructive measurement of a minute amount of distortion is possible and thus superior to conventional methods.     

含1,3,4-噻二唑环聚合物的合成及应用研究进展

含1,3,4-噻二唑环聚合物作为一类新型功能性的芳香杂环聚合物,由于其独特的储能性能、电催化活性、富电子特性而备受关注。近20年来对于含1,3,4-噻二唑环聚合物的研究从未间断,主要集中在材料的电化学合成和结构表征及其在可充电锂电池正极材料、生物化学传感器、临床诊断和药理学等领域的应用。电化学合成的方法有利于制备厚度可控的自支撑膜和对电极进行修饰,缺陷是造成电解液污染、成本高以及不适合规模化生产。研究者们尝试使用化学氧化聚合的方法来合成含1,3,4-噻二唑环聚合物,但除了2,5-二巯基-1,3,4-噻二唑聚合物可通过此方法成功合成外,主要得到的是一些配合物或配位聚合物。采用绿色的规模化的制备工艺来合成含1,3,4-噻二唑环聚合物是大势所趋。含1,3,4-噻二唑环聚合物的结构表征由于受到溶解性的限制,表征手段主要为X射线光电子能谱和红外(拉曼)光谱。2,5-二巯基-1,3,4-噻二唑聚合物由于具有高能量密度和高比容量而在二次锂电池正极材料的应用方面受到研究者们的青睐,但存在着充放电缓慢和电容量衰减快等缺陷。基于含1,3,4-噻二唑环聚合物修饰电极构建的传感器可高灵敏且高选择性地探测许多生物相关分子,但电极的稳定性有待改善。在所有的1,3,4-噻二唑环聚合物中,聚2-氨基-1,3,4-噻二唑(PAT)、聚5-氨基-1,3,4-噻二唑-2-硫醇或5-氨基-2-巯基-1,3,4-噻二唑(PAMT)以及聚2,5-二巯基-1,3,4-噻二唑(PBT)已通过电化学方法合成;PBT也在绿色的合成条件下采用化学氧化合成法合成得到,为其他1,3,4-噻二唑环聚合物的合成提供了借鉴,本课题组也通过化学氧化聚合法制备了PAT、PAMT和聚2-巯基-1,3,4-噻二唑(PTT)三类聚合物。目前,PBT作为二次锂电池正极材料研究得最多,其理论比容量高达362mAh/g,研究者们将PBT与聚吡咯、聚苯胺或水溶性磺化石墨烯等导电聚合物制成复合电极,进一步提高比容量和电极的稳定性并且加速充放电过程。基于含1,3,4-噻二唑环聚合物修饰电极构建的传感器在探测天然产物有效成分的含量、人和哺乳动物血液和体液或药品注射液中药物或代谢产物的含量、中药材或食品中的农药残留量以及水溶液中的重金属离子含量等方面取得了丰硕的成果;而将1,3,4-噻二唑环聚合物与全氟磺酸粘合剂、多壁碳纳米管复合可减少聚合物流失,从而起到增强电极稳定性和延长使用寿命的作用。本文归纳了1,3,4-噻二唑环聚合物研究进展,分别对1,3,4-噻二唑环聚合物的合成、结构表征途径及其应用等进行了介绍,分析了1,3,4-噻二唑环聚合物的研究中面临的问题并展望了其应用前景,以期为1,3,4-噻二唑环聚合物的制备工艺和功能拓展提供参考。     

取代基苯硼酸的合成与应用进展

综述了取代基苯硼酸类化合物的合成和应用研究进展,展望了其在医药等相关领域的广阔前景.取代基苯硼酸的合成方法主要有两种:有机锂试剂法和格氏试剂法.取代基苯硼酸被广泛应用于电子、化学、医药、生物等领域,特别是在糖类传感器方面.目前其应用研究成为热点,并且随着人们对新型农药、医药的需求,大量开发利用取代基苯硼酸类新原料已成为一个引人注目的发展趋势.     

聚脲的合成与应用

聚脲主要通过二异氰酸酯和二胺或二异氰酸酯和水反应聚合得到,聚合方式主要有直接聚合、溶液聚合、乳液聚合、气相沉积聚合等。文中综述了聚脲较新的研究进展,讨论了反应注塑与喷涂聚脲弹性体、聚脲微胶囊、聚脲气相沉积聚合等应用,并展望了聚脲的研究和应用前景。     

油酸在纳米材料合成中的研究与应用

油酸作为溶剂或表面活性剂在制备单分散纳米晶材料方面有着重要的作用,通过其合成的纳米材料已日益成为研究和应用的热点.本文综述一些重要单分散纳米晶金属材料和氧化物材料的制备方法、合成原理及其应用,着重介绍了油酸在制备单分散纳米晶材料方面的作用机制.最后展望了单分散纳米晶材料的未来.     

微乳化技术在无机纳米材料制备中的应用及发展

本文介绍了微乳液的概念,微乳反应器的原理以及微乳液各组分对于化学反应的影响因素,阐述了微乳化技术在纳米材料制备领域中的应用状况.探讨了目前该领域的研究进展,并对今后的研究工作进行了展望.     

Application of Simplex and Statistical Analysis for Correction of Pitting in Aqueous Film Coated Tablets

Pitting or pin hole formation is a tablet defect that is commonly observed in aqueous film coated tablets containing highly moisture-sensitive materials. It is generally believed that pitting is due to dissolution of soluble particles on the tablet surface when the tablet is overwetted during the coating process. An experiment was conducted to study the effects of spray rate and pan speed, the two important factors contributing to this condition. The data thus obtained were analyzed by using the simplex search procedure and the appropriate statistical methods. The levels of the two factors that minimized pitting were achieved as a result of the analysis.     

原子转移自由基聚合在超支化大分子合成中的应用进展

超支化聚合物是一类具有不同于线性聚合物性质的新型高分子材料,原子转移自由基聚合(ATRP)作为一种活性可控聚合方法,在超支化聚合物合成领域发挥着重要的作用。ATRP在Cu(I)催化体系下不仅可以催化AB~*型单体生成超支化聚合物,而且还可以多官能团的大分子为引发剂,生成具有核-壳结构的两亲性共聚物或其它特殊结构大分子。文中主要介绍了近年来采用ATRP法合成的不同结构超支化聚合物,并对ATRP在超支化大分子合成中的应用前景进行了展望。     

低聚磷酸铵的合成及其在灭火剂中的应用

工业上用作阻燃剂的聚磷酸铵一般具有长链结构,其聚合度n≥20,短链的低聚磷酸铵（n≤10)由于反应条件的难以控制,以及干燥困难而没有得到应用。但低聚磷酸铵具有较低的熔点和烧结点,用来灭火时能迅速分解形成膜层覆盖于燃烧物表面使火焰熄灭。该文研究了以磷酸和尿素合成低聚磷酸铵的合成条件,测定了以低聚磷酸铵为主要成分的干粉灭火剂的主要物理性能和灭火性能。结果表明,该灭火剂的性能指标达到了相关国家标准的要求。     

PVB树脂的合成及应用

目前生产聚乙烯醇缩丁醛树脂(PVB)的方法有3种.在综合3种方法优点的基础上研究出了生产PVB的新方法.实验结果表明,此种方法生产的PVB可以有效地应用于安全玻璃的生产上.     

磁流体的制备及应用

磁流体是具有广阔应用前景的功能液体。本文阐述了磁流体的主要制备方法,讨论了表征其性能的主要参数,着重介绍了磁流体在工程领域、生物医药、物质分选以及环境治理等方面的应用,展望了今后磁流体的研究与发展方向。     

三嗪型树枝状化合物的合成及其应用

三嗪型树枝状化合物是一类新型的功能化高分子材料,具有潜在的应用价值和广阔的应用前景,是当今树枝状化学研究中最为活跃的方向之一。介绍了近年来三嗪型树枝状化合物的研究进展,介绍了部分树枝状化合物的合成及其应用,并展望了此类化合物良好的应用前景。     

磁性脂质体的制备及应用

磁性脂质体是掺入磁性载体材料的脂质体,由于其良好的载药性、磁靶向性以及生物相容性而受到广泛的研究.综述了磁性脂质体的制备方法,总结了磁性脂质体在靶向药物、热化疗、造影剂领域中的应用研究进展最后展望了磁性脂质体的发展方向.     

促漂剂的合成筛选及应用

综述了促漂剂的结构类型，并进行了合成及应用研究。