KRAS is one of the most studied oncogenes. It is well known that KRAS undergoes post-translational modifications at its C-terminal end. These modifications are essential for its membrane location and activity. Despite significant efforts made in the past three decades to target the mechanisms involved in its membrane localization, no therapies have been approved and taken into the clinic. However, many studies have recently reintroduced interest in the development of KRAS inhibitors, either by directly targeting KRAS or indirectly through the inhibition of critical steps involved in post-translational KRAS modifications. In this review, we summarize the approaches that have been applied over the years to inhibit the membrane localization of KRAS in cancer and propose a new anti-KRAS strategy that could be used in clinic. 相似文献
Suitable membranes for blood‐contacting medical applications need to be resistant in confrontation with blood proteins and cells, while possessing high blood compatibility and permeability at the same time. Herein, an overview of the recent advances and strategies that have been used to enhance the hemocompatibility of polymeric membranes is provided. The review focuses on two modification strategies: (i) physical modifications and (ii) chemical modifications. It also highlights the current progress in the design of hemocompatible‐functionalized membranes for biomedical applications. Subsequently, the commonly applied biocompatibility tests are also discussed and finally the future perspectives of the application of polymeric membranes in the biomedical field are presented.
ABSTRACT The hydrophobic polyether sulfone membranes were prepared by the sol-gel method to be applied in an air gap membrane distillation setup for desalination. The surface modifications were carried out using Trimethylsilyl chloride (TMSCl) and Methyltrimethoxysilane (MTMS) solutions. The membranes were characterized using Attenuated Total Reflection Infrared (ATR-IR) spectroscopy, Scanning Electron Microscopy (SEM), and Optical Contact Angle (OCA) methods. The effects of membrane preparation as well as operating conditions such as temperature difference, salt concentration, feed rotation speed, and cold-side temperature on membrane performance were investigated using central composite design method. It was found that feed temperature has the largest effect among the parameters on the permeation flux. The flow rate and salt rejection of the membrane in the optimum conditions were 4.47 Kg m?2 h?1 and 99.37%, respectively. 相似文献
Reactive air brazing of the ceramic oxygen transport membrane material BSCF causes microstructural modifications. The trend towards minimizing of membrane thicknesses requires a physical understanding of these modifications since they may influence both oxygen permeation and mechanical properties. To this purpose, wetting samples with variations in the Ag-xCuO braze alloy (1 < x < 25 at.-%) and the brazing time (0 < t < 120 min) were characterized by quantitative image analysis. We found that the pore size in reactive air brazed BSCF increases with increased brazing time as well as CuO-content in the braze. A local porosity minimum is always observed at the end of the reaction zone close to the unaffected bulk BSCF. Additionally, a zone with unidirectionally elongated grains at the end of which silver residues were found is observed. The observed coarsening effects are explained by liquid melt film penetration along the grain boundaries which increases the grain boundary mobility. Phase field simulations qualitatively confirmed the experimentally observed elongated grain structure. 相似文献