Design and Analysis of the 4-Anilinoquin(az)oline Kinase Inhibition Profiles of GAK/SLK/STK10 Using Quantitative Structure-Activity Relationships

The 4-anilinoquinoline and 4-anilinoquinazoline ring systems have been the focus of significant efforts in prior kinase drug discovery programs, which have led to approved medicines. Broad kinome profiles of these compounds have now been assessed with the advent of advanced screening technologies. These ring systems, while originally designed for specific targets including epidermal growth factor receptor (EGFR), but actually display a number of potent collateral kinase targets, some of which have been associated with negative clinical outcomes. We have designed and synthesized a series of 4-anilinoquin(az)olines in order to better understand the structure-activity relationships of three main collateral kinase targets of quin(az)oline-based kinase inhibitors: cyclin G associated kinase (GAK), STE20-like serine/threonine-protein kinase (SLK) and serine/threonine-protein kinase 10 (STK10). This was achieved through a series of quantitative structure-activity relationship (QSAR) analysis, water mapping of the kinase ATP binding sites and extensive small-molecule X-ray structural analysis.     

Targeting the Water Network in Cyclin G-Associated Kinase (GAK) with 4-Anilino-quin(az)oline Inhibitors

Water networks within kinase inhibitor design and more widely within drug discovery are generally poorly understood. The successful targeting of these networks prospectively has great promise for all facets of inhibitor design, including potency and selectivity for the target. Herein, we describe the design and testing of a targeted library of 4-anilinoquin(az)olines for use as inhibitors of cyclin G-associated kinase (GAK). GAK cellular target engagement assays, ATP binding-site modelling and extensive water mapping provide a clear route to access potent inhibitors for GAK and beyond.     

Targeting an EGFR Water Network with 4-Anilinoquin(az)oline Inhibitors for Chordoma

Quinoline- and quinazoline-based kinase inhibitors of the epidermal growth factor receptor (EGFR) have been used to target non-small cell lung cancer (NSCLC) and chordomas with varying amounts of success. We designed and prepared compounds to probe several key structural features including an interaction with Asp855 within the EGFR DGF motif and interactions with the active site water network. EGFR target engagement was then evaluated in a cellular assay, with the inhibitors then profiled in representative cellular models of NSCLC and chordomas. In addition, structure–activity relationship insight into EGFR inhibitor design with potent dimethoxyquin(az)olines identified compounds 1 [N-(3-ethynylphenyl)-6,7-dimethoxyquinolin-4-amine], 4 [N-(3-ethynylphenyl)-6,7-dimethoxyquinazolin-4-amine], and 7 [4-((3-ethynylphenyl)amino)-6,7-dimethoxyquinoline-3-carbonitrile]. We also identified 6,7-dimethoxy-N-(4-((4-methylbenzyl)oxy)phenyl)quinolin-4-amine (compound 18 ), which is the most potent inhibitor (IC₅₀=310 nm ) of the UCH-2 chordoma cell line to date.     

Synthesis,Crystal Structure,and Thermal Behavior of 3‐(4‐Aminofurazan‐3‐yl)‐4‐(4‐nitrofurazan‐3‐yl)furazan (ANTF)

The energetic material 3‐(4‐aminofurazan‐3‐yl)‐4‐(4‐nitrofurazan‐3‐yl)furazan (ANTF) with low melting‐point was synthesized by means of an improved oxidation reaction from 3,4‐bis(4′‐aminofurazano‐3′‐yl)furazan. The structure of ANTF was confirmed by ¹³C NMR spectroscopy, mass spectrometry, and the crystal structure was determined by X‐ray diffraction. ANTF crystallized in monoclinic system P2₁/c, with a crystal density of 1.785 g cm⁻³ and crystal parameters a=6.6226(9) Å, b=26.294(2) Å, c=6.5394(8) Å, β=119.545(17)°, V=0.9907(2) nm³, Z=4, μ=0.157 mm⁻¹, F(000)=536. The thermal stability and non‐isothermal kinetics of ANTF were studied by differential scanning calorimetry (DSC) with heating rates of 2.5, 5, 10, and 20 K min⁻¹. The apparent activation energy (E_a) of ANTF calculated by Kissinger's equation and Ozawa's equation were 115.9 kJ mol⁻¹ and 112.6 kJ mol⁻¹, respectively, with the pre‐exponential factor lnA=21.7 s⁻¹. ANTF is a potential candidate for the melt‐cast explosive with good thermal stability and detonation performance.     

Synthesis and properties of magnetic sensitive shape memory Fe3O4/poly(ε‐caprolactone)‐polyurethane nanocomposites

Fe₃O₄/poly (ε‐caprolactone)‐polyurethane (PCLU) shape memory nanocomposites were prepared by an in situ polymerization method. The thermal properties, magnetic properties, and shape memory properties of the nanocomposites were investigated systematically. The results showed that the Fe₃O₄ nanoparticles were homogeneously dispersed in the PCLU matrix, which ensured good shape memory properties of nanocomposites in both hot water and an alternating magnetic field (f = 45 kHz, H = 29.7 kA m^?1/36.7 kA m^?1). The nanocomposites started to recover near 40°C, which is slightly higher than body temperature. Thus, they would not change their deformed shape during the implanting process into the human body. Considering potential clinical applications, 45°C was chosen as shape recovery temperature which is slightly higher than 37°C, and the nanocomposites had high shape recovery rate at this temperature. With increasing content of Fe₃O₄ nanoparticles, the shape memory properties of the nanocomposites in an alternating magnetic field increased and the best recovery rate reached 97%, which proves that this kind of nanocomposites might be used as potential magnetic sensitive shape memory materials for biomedical applications. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2013     

Luminescence investigations of novel orange‐red fluorapatite KLaSr3(PO4)3F: Sm3+ phosphors with high thermal stability

Single‐phase KLaSr₃(PO₄)₃F: Sm³⁺ phosphors with fluorapatite structure were prepared via high‐temperature solid‐state method in air atmosphere for the first time. The X‐ray diffraction, scanning electron microscope, diffuse reflectance spectra, photoluminescence spectra, and temperature‐dependent emission spectra, as well as lifetimes were measured to characterize the as‐prepared phosphors. Phase results indicated that KLaSr₃(PO₄)₃F: Sm³⁺ belongs to hexagonal system with a space group of P‐6. Photoluminescence measurements showed the emission spectrum was composed of four sharp peaks at about 564, 602 (the strongest one), 646, and 702 nm, corresponding to the ⁴G_5/2‐⁶H_J (J=5/2, 7/2, 9/2, and 11/2) transitions of Sm³⁺ ions. The optimum doping concentration of Sm³⁺ ions was turned out to be 0.03 (mol), and the mechanism of energy transfer among Sm³⁺ ions was considered to be dipole‐dipole interaction by using Dexter's theory. In addition, the critical distance R_c for energy transfer among Sm³⁺ ions were calculated to be 9.97 Å according to Blasse concentration quenching method. The selected KLa_0.97Sr(PO₄)₃F: 0.03Sm³⁺ exhibited high thermal stability with an activation energy of 0.163 eV. Besides, the Commission International de l'Eclairage chromaticity coordinate of the phosphor were located in the orange‐reddish light region.     

Ab initio calculation of the evolution of [SiN4-nOn] tetrahedron during β-Si3N4(0001) surface oxidation

The easy-going oxidation of silicon nitride (Si₃N₄) at high temperature greatly hampers its potential applications. Here, we explored the reaction mechanism between β-Si₃N₄ and O₂ via density functional theory (DFT) calculation, which discloses that O atoms are preferentially adsorbed on the top of Si atoms and N₂ starts to be generated as the dominant gas product at 2/3 monolayer (ML) O coverage. The vacancies formed by N₂ removal attract the O adatoms to transfer to the site of the N vacancy, which accelerates the adsorption of O and the formation of Si–O bonds toward the growth of SiO₂ product. The surface oxidation of β-Si₃N₄ (0001) has been clarified by the unambiguous evolution of [SiN_4-nO_n] (n = 0-4) tetrahedrons going through from [SiN₄] tetrahedron to [SiO₄] tetrahedron, providing a deep insight into intrinsic oxidation process of Si₃N₄ ceramic.     

Fluorite-like LixLn5–xMo3O16.5–1.5xFx (Ln = La,Pr, Nd) compounds isostructural with Nd5Mo3O16

Li_xLn_5–xMo₃O_16.5–1.5xF_x (0.8 ≤ x ≤ 1.4 (Ln = La), 0.4 ≤ x ≤ 1 (Ln = Pr), 0.6 ≤ x ≤ 1 (Ln = Nd)) solid solutions on the Ln₅Mo₃O₁₆–LiLn₄Mo₃O₁₅F joins of the Ln₂O₃–MoO₃–LiF ternary systems, similar to the fluorite-related cubic compound Nd₅Mo₃O₁₆, have been prepared by solid-state reactions. Substitutions of lithium on the rare-earth site and fluorine on the oxygen site have been shown to lead to a reversible phase transition accompanied by an anomaly in permittivity and a jump in conductivity by one and half orders of magnitude. In a wet atmosphere, the Li_xLn_5–xMo₃O_16.5–1.5xF_x compounds may have proton conductivity.     

Radical Copolymerization of 2-(3′-Acryloxy)propoxythioxanthone and 1-Methyl-4-(3′-acryloxy)propoxythioxanthone with Methyl Methacrylate

Two new monomers based on thioxanthone, 2-(3′-acryloxy)propoxythioxanthone (M-2) and 1-methyl-4-(3′-acryloxy)propoxythioxanthone (M-4), were prepared and their radical copolymerization at 70°C with methyl methacrylate (MMA) was studied. By varying the conversion reached for a fixed feed composition, f_MMA=0·983, and using Jaacks method, the reactivity ratios were determined. Identical values of reactivity ratios were found for both systems, with values of r_MMA=2·46 and r_M-2=r_M-4=0·4. The homopolymerization of MMA in the presence of a model compound, 1-methyl-4-propoxythioxanthone, was also examined and confirmed that the thioxanthone chromophore does not have any influence on the free radical polymerization of MMA. © of SCI.     

Insight into luminescent properties,energy transfer and thermal stability of NaBa4(AlB4O9)2Cl3:Ce3+, Tb3+ phosphors

A series of Ce³⁺ and Tb³⁺ singly- and co-doped NaBa₄(AlB₄O₉)₂Cl₃ (NBAC) phosphors have been synthesized via high-temperature solid state route. The crystal structure, morphology, photoluminescent properties, thermal properties and energy transfer process between Ce³⁺ and Tb³⁺ were systematically investigated. The structure refinements indicated that the phosphors based on NBAC crystallized in P42nm polar space group in monoclinic phase. The emission color could be tuned from blue (0.1595, 0.0955) to green (0.2689, 0.4334) via changing the ratio of Ce³⁺/Tb³⁺. The energy transfer mechanism of Ce³⁺/Tb³⁺ was verified to be dipole–quadrupole interaction via the examination of decay times of Ce³⁺ based on Dexter's theory. The good thermal stability showed the intensities of Ce³⁺ at 150°C were about 66.9% and 64.88% in NBAC:0.09Ce³⁺ and NBAC:0.09Ce³⁺, 0.07Tb³⁺ of that at room temperature, and the emission intensities of Tb³⁺ remained 102.41% in NBAC:0.11Tb³⁺ and 95.22% in NBAC:0.09Ce³⁺, 0.07Tb³⁺ due to the nephelauxetic shielding effect and the highly asymmetric rigid framework structure of NBAC. The maximum external quantum efficiency (EQE) of Ce³⁺ in NBAC:0.09Ce³⁺, yTb³⁺ phosphors could reach 43.38% at y = 0.13. Overall, all the results obtained suggested that NBAC:Ce³⁺, Tb³⁺ could be a promising option for n-UV pumped phosphors.     

Tailoring the surface architecture of poly(3‐hydroxybutyrate‐co‐4‐hydroxybutyrate) scaffolds

This study was designed to determine whether the surface modifications of the various poly(3‐hydroxybutyrate‐co‐4‐hydroxybutyrate) [P(3HB‐co‐4HB)] copolymer scaffolds fabricated would enhance mouse fibroblast cells (L929) attachment and proliferation. The P(3HB‐co‐4HB) copolymer with a wide range of 4HB monomer composition (16–91 mol %) was synthesized by a local isolate Cupriavidus sp. USMAA1020 by employing the modified two‐stage cultivation and by varying the concentrations of 4HB precursors, namely γ‐butyrolactone and 1,4‐butanediol. Five different processing techniques were used in fabricating the P(3HB‐co‐4HB) copolymer scaffolds such as solvent casting, salt‐leaching, enzyme degradation, combining salt‐leaching with enzyme degradation, and electrospinning. The increase in 4HB composition lowered melting temperatures (T_m) but increased elongation to break. P(3HB‐co‐91 mol % 4HB) exhibited a melting point of 46°C and elongation to break of 380%. The atomic force analysis showed an increase in the average surface roughness as the 4HB monomer composition increased. The mouse fibroblasts (L929) cell attachment was found to increase with high 4HB monomer composition in copolymer scaffolds. These results illustrate the importance of a detailed characterization of surface architecture of scaffolds to provoke specific cellular responses. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012     

Crystal structure and microwave dielectric properties of La2(Zr1−xTix)3(MoO4)9 (0 ≤ x ≤ 0.1) ceramics

La₂(Zr_1−xTi_x)₃(MoO₄)₉ (0 ≤ x ≤ 0.1) ceramics were prepared by the traditional solid-state reaction method. XRD analysis showed that La₂(Zr_1−xTi_x)₃(MoO₄)₉ (0 ≤ x ≤ 0.1) ceramics belonged to a trigonal system. Based on the chemical bond theory, the consequences of bond energy, bond ionicity, lattice energy, and thermal expansion coefficient of ceramics on microwave dielectric properties were discussed. As Ti⁴⁺ addition was increased, the reduction in dielectric constant was ascribed to the fact that the polarizability of Ti⁴⁺ is smaller than Zr⁴⁺, and the downward trend was related to the bond ionicity. Besides, the tendency of Q·f value depended on the packing fraction and the lattice energy. The improvement in τ_f value, the increase in bond energy, and the decrease in the coefficient of thermal expansion were all correlated. The far-infrared spectra implied that the absorptions of structural phonon oscillation were the main reason for the maximum polarization contribution. La₂(Zr_0.92Ti_0.08)₃(MoO₄)₉ ceramics sintered at 750°C for 4 hours exhibited the best dielectric properties (ε_r = 10.33, Q·f = 80 658 GHz, and τ_f = 3.48 ppm/°C).     

Thermal analyses of poly(3-hydroxybutyrate), poly(3-hydroxybutyrate-co-3-hydroxyvalerate), and poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)

Thermal analyses of poly(3-hydroxybutyrate) (PHB), poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(HB–HV)], and poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) [P(HB–HHx)] were made with thermogravimetry and differential scanning calorimetry (DSC). In the thermal degradation of PHB, the onset of weight loss occurred at the temperature (°C) given by T_o = 0.75B + 311, where B represents the heating rate (°C/min). The temperature at which the weight-loss rate was at a maximum was T_p = 0.91B + 320, and the temperature at which degradation was completed was T_f = 1.00B + 325. In the thermal degradation of P(HB–HV) (70:30), T_o = 0.96B + 308, T_p = 0.99B + 320, and T_f = 1.09B + 325. In the thermal degradation of P(HB–HHx) (85:15), T_o = 1.11B + 305, T_p = 1.10B + 319, and T_f = 1.16B + 325. The derivative thermogravimetry curves of PHB, P(HB–HV), and P(HB–HHx) confirmed only one weight-loss step change. The incorporation of 30 mol % 3-hydroxyvalerate (HV) and 15 mol % 3-hydroxyhexanoate (HHx) components into the polyester increased the various thermal temperatures T_o, T_p, and T_f relative to those of PHB by 3–12°C (measured at B = 40°C/min). DSC measurements showed that the incorporation of HV and HHx decreased the melting temperature relative to that of PHB by 70°C. © 2001 John Wiley & Sons, Inc. J Appl Polym Sci 82: 90–98, 2001     

Synthesis and characterization of CeO2/Bi2O3/gC3N4 ternary Z-scheme nanocomposite

An effective and facile phytogenic method was used to prepare CeO₂/Bi₂O₃ and CeO₂/Bi₂O₃/gC₃N₄ composites using Eichhornia crassipes phytoextract. The synthesized catalysts were characterized using techniques such as XRD, FTIR, UV-DRS, PL, SEM-EDAX, XPS, zeta potential, and TGA. These catalysts showed diverse photocatalytic and optical properties due to the alteration in the bandgap. The synthesized composites exhibited good photocatalytic activity by degrading Malachite green (MG) dye. The increase in the photocatalytic activity could be attributed to the p-n heterojunction of the catalysts with efficient charge separation and strong oxidative ability. The modified photocatalysts showed excellent catalytic activity and reusability under visible light. The superior efficiency and its applications in environmental remediation make these catalysts a potential candidate for photocatalysis.     

Fe3O4-nanoparticle-functionalized 3D-printed injectable microgel

Magnetic Fe₃O₄ nanoparticles have attached attention in bone tissue engineering because of their superior magnetism and great biocompatibility. However, some disadvantages such as the potential risk of agglomeration impair their applications. Here, we proposed a hybrid magnetic nanocomposite microgel by the integration of Fe₃O₄ nanoparticles and digital lighting processing (DLP) three-dimensional (3D) printing technology. The 3D-printed microgels could be precisely customized by printing the mixture of gelatin methacryloyl (GelMA) solution and polydopamine-coated Fe₃O₄ nanoparticles, in which polydopamine decoration improved the hydrophilicity and distribution of the incorporated Fe₃O₄. The degradable microgels could be injected through a 22-G needle while retaining their original shape after injection. Interestingly, the addition of Fe₃O₄ nanoparticles into GelMA solution displayed improved printing accuracy. Moreover, these magnetic microgels were biocompatible in vitro and in vivo. After induction within osteogenic medium, addition of nanoparticles upregulated the osteogenic gene expression of rat bone mesenchymal stem cells (BMSCs). In a word, this work provides a magnetic microplatform, which shows great potential in bone tissue engineering.     

Simultaneous accommodation of Dy3+ at the lattice site of β-Ca3(PO4)2 and t-ZrO2 mixtures: Structural stability,mechanical, optical,and magnetic features

Structurally stable β-Ca₃(PO₄)₂/t-ZrO₂ composite mixtures with the aid of Dy³⁺ stabilizer were accomplished at 1500°C. The precursors comprising Ca²⁺, P⁵⁺, Zr⁴⁺, and Dy³⁺ have been varied to obtain five different combinations. The results revealed the fact that complete phase transformation of calcium-deficient apatite to β-Ca₃(PO₄)₂ occurred only at 1300°C, whereas the evidence of t-ZrO₂ crystallization is obvious at 900°C. The dual occupancy of Dy³⁺ at β-Ca₃(PO₄)₂ and t-ZrO₂ structures was evident; however, Dy³⁺ initially prefers to occupy β-Ca₃(PO₄)₂ lattice until its saturation limit and thereafter accommodates at the lattice site of ZrO₂. The typical absorption and emission behavior of Dy³⁺ were noticed in all the systems and, moreover, the surrounding symmetry of Dy³⁺ domains has been determined from the luminescence study. All the systems ensured paramagnetic response that is generally contributed by the presence of Dy³⁺. A gradual increment in the phase content of t-ZrO₂ in the composite mixtures ensured a significant improvement in the hardness and Young's modulus of the investigated compositions.     

Anthranilic acid assisted preparation of Fe3O4–poly(aniline‐co‐o‐anthranilic acid) nanoparticles

Magnetic Fe₃O₄–poly(aniline‐co‐o‐anthranilic acid) nanoparticles were prepared by a novel and simple method: anthranilic acid assisted polymerization. The synthetic strategy involved two steps. First, Fe₃O₄ nanoparticles capped by anthranilic acid were obtained by a chemical precipitation method, and then the aniline and oxidant were added to the modified Fe₃O₄ nanoparticles to prepare well‐dispersed Fe₃O₄–poly(aniline‐co‐o‐anthranilic acid) nanoparticles. Fe₃O₄–poly(aniline‐co‐o‐anthranilic acid) nanoparticles exhibited a superparamagnetic behavior (i.e., no hysteresis loop) and high‐saturated magnetization (M_s = 21.5 emu/g). The structure of the composite was characterized by Fourier‐transform infrared spectra, X‐ray powder diffraction patterns, and transmission electron microscopy, which proved that the Fe₃O₄–poly(aniline‐co‐o‐anthranilic acid) nanoparticles were about 20 nm. Moreover, the thermal properties of the composite were evaluated by thermogravimetric analysis, and it showed excellent thermal stability. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 1666–1671, 2006     

聚乙二醇/聚乙烯吡咯烷酮修饰的纳米Fe3O4粒子的制备与表征

为了获得能够在水中稳定分散,具有广泛应用前景的磁性纳米粒子,以不同分子量的聚乙烯吡咯烷酮(PVP)作为修饰剂,在聚乙二醇(PEG)中高温热分解乙酰丙酮铁(Fe(acac)₃)制备了纳米Fe₃O₄粒子。采用X射线粉末衍射仪(XRD)、透射电镜(TEM)、高分辨透射电镜(HRTEM)、超导量子干涉仪(SQUID)、热重分析仪(TGA)、傅里叶变换红外光谱仪(FT-IR)、纳米粒度与zeta电位分析仪对样品进行了表征,并对样品在生理盐水和生理缓冲液中的稳定性进行了研究,结果表明:制备的纳米Fe₃O₄粒子具有高的结晶度以及单分散性,在300 K下,具有超顺磁性和较高的饱和磁化强度;PEG和PVP共同修饰于纳米Fe₃O₄粒子表面,为纳米Fe₃O₄粒子提供了良好的水分散性;制备的纳米Fe₃O₄粒子在生理盐水和多种生理缓冲液中能够高度溶解并稳定地分散。水中的纳米Fe₃O₄粒子表面呈电中性,表面修饰层的空间位阻效应是所制备的纳米粒子在水溶液中高分散的原因。     

Superparamagnetic polyvinylpyrrolidone/chitosan/Fe3O4 electrospun nanofibers as effective U(VI) adsorbents

Magnetoactive electrospun fibrous membranes consisting of polyvinylpyrrolidone (PVP), chitosan (CS) and pre-fabricated, double-layer oleic acid-coated magnetite nanoparticles (OA.OA.Fe₃O₄) were fabricated and evaluated as new adsorbent materials for the removal and recovery of uranium (U(VI)) from aqueous solutions. The adsorption has been investigated by batch-type experiments and the solid material has been characterized by X-ray diffraction spectroscopy (XRD), Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), transmission electron microscopy/energy dispersive X-ray analysis (TEM/EDX) and vibration sample magnetometry (VSM) measurements prior and after uranium adsorption. The experimental adsorption data were found to be well fitted with the Langmuir isotherm and the pseudo-second order kinetic model. The results indicate that PVP/CS/OA.OA.Fe₃O₄ fibrous adsorbents exhibit good adsorption properties towards U(VI) in aqueous solutions, achieving a q_max value of 0.77 mol kg⁻¹ (183.3 mg g⁻¹) at pH 6.0. The experiments regarding the regeneration and reuse of the magnetoactive adsorbents were carried out using Na₂CO₃, at pH ~11. After four cycles, the percentage relative adsorption remained stable (~100%) whereas the desorption percentage decreased from 31.9% to 21.0%. Generally, the presented results demonstrate that the incorporation of the Fe₃O₄ NPs has a positive effect on the adsorption efficiency of U(VI) from aquatic environments.     

Site-selective occupation and luminescence property investigation of Ca18Na3Y(PO4)14:Eu2+ phosphor for full-spectrum LED

Cyan-emitting phosphors have attracted widespread attention as an integral part to realize full-spectrum lighting. Understanding the site occupation of luminescence centers is of great importance to design and clarify the luminescent mechanism for new cyan-emitting phosphors. Here, we report a cyan-emitting phosphor Ca₁₈Na₃Y(PO₄)₁₄:Eu²⁺ synthesized by the high-temperature solid-state method. The crystal structure is characterized by X-ray diffraction and refined by the Rietveld method. The diffuse reflectance spectra, excitation/emission spectra, fluorescence decay curves, thermal stability, and related mechanism are systematically studied. The results show that Ca₁₈Na₃Y(PO₄)₁₄:Eu²⁺ crystallizes in a trigonal crystal system with space group R3c. Under excitation at 350 nm, a broadband cyan emission can be obtained at 500 nm with a half-width of about 120 nm, which is caused by Eu²⁺ occupying five different sites in host, namely, Na2O₁₂ (450 nm), (Ca3/Na1)O₈ (485 nm), Ca2O₈ (515 nm), Ca1O₇ (565 nm), and (Ca4/Y)O₆ (640 nm), respectively. Moreover, crystal structure, room and low temperature spectroscopy, and luminescence decay time are used to skillfully verify the site-selective occupation of Eu²⁺. Finally, a full-spectrum light-emitting diode (LED) lamp is fabricated with an improved color rendering index (∼90.3), CCT (∼5492 K), and CIE coordinates (0.332, 0.318). The results show that Ca₁₈Na₃Y(PO₄)₁₄:Eu²⁺ has the potential to act as a cyan emission phosphor for full-spectrum white LEDs.