基于MDA的并行仿真可视化组件建模范式

并行仿真是提高分析仿真运行效率的有效途径.当前国内外并行仿真由于缺乏高效统一的可视化组件建模范式的指导,往往需要采用从上到下的集中式开发模式,开发门槛高、效率低、二次建模困难,且模型间的耦合度大、协调难,模型与仿真平台紧密绑定,难以实现模型的分步开发、封装、快速组装及平台间模型的重用.作者结合组件建模及MDA技术的优势...     

面向高性能工业仿真的交互可视分析引擎

针对大规模仿真数据对仿真设计分析造成的前后连贯交互力弱、可视交互力低的问题,提出一个面向高性能工业仿真的交互可视分析引擎.首先构建可高效耦合几何模型和计算网格的三维混合数据模型;然后提出面向前后连贯仿真设计的并行可视分析流程;最后通过体网格外表面提取的图元数据轻量化方法,耦合GPU真实感绘制,以支撑实时高质量的仿真设计与分析.该引擎已集成到国产航空发动机仿真软件中,结果表明,可流畅地支持大规模仿真应用的设计分析,Trent-1000发动机模型数千万非结构网格的一键导入交互性能高出ANSYS商业软件8倍以上.     

Molecular insights into evolution

The evolution of ribonucleic acid (RNA) molecules in the test tube provides a possible way to study evolutionary optimization and adaptation to the environment on time scales accessible to human observers. Diversity of genotypes, however, is prohibitive for a complete experimental recording of the process at the molecular level. The number of RNA sequences and structures is too large to be determined by means of currently available techniques. Computer simulation, on the other hand, is able to handle large numbers of individual sequences and has no major problem with data retrieval. However, it can deal only with simplified relations between genotypes and phenotypes, i.e., RNA sequences and structures, respectively. Based on a coarse-grained notion of structure, as represented by RNA secondary structures, for example, a comprehensive model of evolution has been developed that allows as to follow optimization at full molecular resolution. This model describes the course of in vitro selection experiments, and provides a straightforward explanation for the occurrence of steps observed in evolution. It initiated the development of new mathematical concepts which analyse evolution as a complex process viewed simultaneously in concentration space, sequence space, and shape space. This work was presented, in part, at the Third International Symposium on Artificial Life and Robotics, Oita, Japan, January 19–21, 1998     

基于PowerSGL视景仿真中的若干关键技术

该文探讨了基于ＰｏｗｅｒＳＧＬ视景仿真中的一些关键技术,这些技术已在多种模拟器视景仿真中得到应用,产生了良好的效果。     

地形数据格式转换及其在视景仿真中应用

该文开发了一个地形数据格式转换工具,它能将．ＤＣ格式的图形数据转换为．Ｃ格式的图形数据,界面友好,应用方便。已在多种模拟器视景仿真中得到应用。     

Wireless in Africa: insights into mobile markets

The explosive growth of mobile telephony in Africa offers insights into the differences in deploying new technologies in underdeveloped countries.     

Proteomic insights into cardiac cell death and survival

Cardiovascular disease is the leading cause of death and disability in the developed world. To design novel therapeutic strategies to treat and prevent this disease, better understanding of cardiac cell function is necessary. In addition to (and, indeed, in combination with) genetics, physiology and molecular biology, proteomics plays a critical role in our understanding of cardiovascular systems at multiple scales. The purpose of this review is to examine recent developments in the field of myocardial injury and protection, examining how proteomics has informed investigations into organelles, signaling complexes, and cardiac phenotype.     

Visual FoxPro编程技巧

笔者最近使用ＶＦＰ5 .0进行数据库开发 ,现结合自己在实际开发中对ＶＦＰ的认识和体会 ,介绍ＶＦＰ应用中使用的一些技巧和经验 ,以求抛砖引玉 ,同时希望能对用ＶｉｓｕａｌＦｏｘｐｒｏ进行编程开发的朋友有一定帮助。1　背景音乐的实现　　利用ＶｉｓｕａｌＦｏｘｐｒｏ编制应用程序时 ,如果能给应用程序添加背景音乐 ,无疑是件锦上添花的事。一般的方法是利用ＯＬＥ(对象嵌入与链接 )进行嵌套。具体方法是选择“表单控件”上的“ＯＬＥ容器控件” ,将其拖到表单上 ,再在“插入对象(ＩｎｓｅｒｔＯｂｊｅｃｔ)”窗口中选择“媒体剪辑” ,…     

Integrating multiple cues into adaptive hierarchical segmentation for high-resolution remote-sensing images

Image segmentation has been, and still is, a hot research topic in computer vision and pattern recognition. However, few existing segmentation algorithms are suitable for all objects presented in high-resolution remote-sensing (HRRS) images, because the relevant methods often implement segmentation in the same mode for the whole image rather than considering the different characteristics of various objects. Therefore, this article proposes an adaptive hierarchical segmentation framework for HRRS images by integrating multiple cues (e.g. intensity, texture and boundary). This two-stage framework first analyses the class of region presented in the study image, then according to this analysis, partitions each region class by adaptively utilizing the proper segmentation method with the most representative features. The distinctive characteristics of this framework are that the first stage simplifies the problem before using the segmentation method, and the second stage guarantees that the segmentation is carried out with the representative cues and corresponding suitable method for these cues. The performance of the proposed segmentation framework is demonstrated through a complete set of experimental results and substantiated using quantitative criteria.     

Characterization of a high-resolution solid-state micropump that can be integrated into microfluidic systems

Ni–Mn–Ga is a magnetic shape memory (MSM) alloy that can strain up to 6 % when a magnetic field is applied to it. By applying a localized magnetic field to the MSM element, the strain can be precisely controlled and manipulated. By using Ni–Mn–Ga and a local magnetic field, an MSM micropump that is capable of controlling the flow within a microfluidic system has been developed. A computational fluid dynamics analysis illustrates the flow of the liquid at the outlet of the micropump and will be used to optimize future models of the pump. The performance of the MSM micropump, such as its flow rate and pumping pressure, is measured and presented in this study. Beyond its performance, there are also several advantages intrinsic to the MSM micropump. It is controlled by a magnetic field and is therefore contact-free. Depending upon the magnetic field, the MSM micropump can act as either a valve or a reversible pump. It is self-priming and capable of pumping gases as well as viscous liquids, and it has a simple design which consists primarily of the MSM alloy itself. Coupled with its scalability, it is clear that the MSM micropump is a strong candidate for an integratable flow control solution.     

Load Runner7．8

Autodesk Civil 3D是专门为土地开发领域设计的,它可以在工程对象之间创建智能关系。其3D交互功能使用户可以轻松地建立和分析不同的设计方案，并实时更正错误,从而为用户提供了更大的设计灵活性。当用户修改了设计中的某个工程对象,与之相关的所有内容都会自动更新。用户只需输入一次数据,该软件就会根据您预先设置的设计规则和标准自动进行更改。Autodesk Civil 3D可以动态更新用户的设计变更，能够实时进行修正。     

Some insights into the impact of affective information when delivering feedback to students

ABSTRACT

The relation between affect-driven feedback and engagement on a given task has been largely investigated. This relation can be used to make personalised instructional decisions and/or modify the affect content within the feedback. However, although it is generally assumed that providing encouraging feedback to students should help them adopt a state of flow, there are instances where those messages might result counterproductive. In this paper, we present a case study with 48 secondary school students using an Intelligent Tutoring System for arithmetical word problem solving. This system, which makes some common assumptions on how to relate affective state with performance, takes into account subjective (user's affective state) and objective information (previous problem performance) to decide the upcoming difficulty levels and the type of affective feedback to be delivered. Surprisingly, results revealed that feedback was more effective when no emotional content was included, and lead to the conclusion that purely instructional and concise help messages are more important than the emotional reinforcement contained therein. This finding shows that this is still an open issue. Different settings present different constraints generating related compounding factors that affect obtained results. This research confirms that new approaches are required to determine when, how and where affect-driven feedback is needed. Affect-driven feedback, engagement and their mutual relation have been largely investigated. Student's interactions combined with their emotional state can be used to make personalised instructional decisions and/or modify the affect content within the feedback, aiming to entice engagement on the task. However, although it is generally assumed that providing encouraging feedback to the students should help them adopt a state of flow, there are instances where those encouraging messages might result counterproductive. In this paper, we analyze these issues in terms of a case study with 48 secondary school students using an Intelligent Tutoring System for arithmetical word problem solving. This system, which makes some common assumptions on how to relate affective state with performance, takes into account subjective (user's affective state) and objective (previous problem performance) information to decide the difficulty level of the next exercise and the type of affective feedback to be delivered. Surprisingly, findings revealed that feedback was more effective when no emotional content was included in the messages, and lead to the conclusion that purely instructional and concise help messages are more important than the emotional reinforcement contained therein. This finding, which coincides with related work, shows that this is still an open issue. Different settings present different constraints and there are related compounding factors that affect obtained results, such as the message's contents and their target, how to measure the effect of the message on engagement through affective variables considering other issues involved, and to what extent engagement can be manipulated solely in terms of affective feedback. The contribution here is that this research confirms that new approaches are needed to determine when, how and where affect-driven feedback is needed. In particular, based on our previous experience in developing educational recommender systems, we suggest the combination of user-centred design methodologies with data mining methods to yield a more effective feedback.     

Proteomic profiling reveals comprehensive insights into adrenergic receptor-mediated hypertrophy in neonatal rat cardiomyocytes

Myocardial adrenergic receptors (ARs) play important roles in cardiac hypertrophy. However, the detailed molecular mechanism of AR-mediated cardiac hypertrophy remains elusive to date. To gain full insight into how ARs are involved in the regulation of cardiac hypertrophy, protein expression profiling was performed with comparative proteomics approach on neonatal rat cardiomyocytes. Forty-six proteins were identified as differentially expressed in hypertrophic cardiomyocytes induced by AR stimulation. To better understand the biological significance of the obtained proteomic data, we utilized the ingenuity pathway analysis tool to construct biological networks and analyze function and pathways that might associate with AR-mediated cardiac hypertrophy. Pathway analysis strongly suggested that ROS may be involved in the development of AR-mediated cardiac hypertrophy, which was then confirmed by further experimentation. The results showed that a marked increase in ROS production was detected in AR-mediated cardiac hypertrophy and blocking of ROS production significantly inhibited AR-mediated cardiac hypertrophy. We further proved that the ROS production was through NADPH oxidase or the mitochondrial electron transport chain and this ROS accumulation resulted in activation of extracellular signal-regulated kinase 1/2 leading to AR-mediated cardiac hypertrophy. These experimental results support the hypothesis, from the ingenuity pathway analysis, that AR-mediated cardiac hypertrophy is associated with the dysregulation of a complicated oxidative stress-regulatory network. In conclusion, our results provide a basis for understanding the detailed molecular mechanisms of AR-mediated cardiac hypertrophy.     

Structural insights into a high affinity nanobody:antigen complex by homology modelling

Porphyromonas gingivalis is a major periodontitis-causing pathogens. P. gingivalis secrete a cysteine protease termed RgpB, which is specific for Arg-Xaa bonds in substrates. Recently, a nanobody-based assay was used to demonstrate that RgpB could represent a novel diagnostic target, thereby simplifying. P. gingivalis detection. The nanobody, VHH7, had a high binding affinity and was specific for RgpB, when tested towards the highly identical RgpA.In this study a homology model of VHH7 was build. The complementarity determining regions (CDR) comprising the paratope residues responsible for RgpB binding were identified and used as input to the docking. Furthermore, residues likely involved in the RgpB epitope was identified based upon RgpB:RgpA alignment and analysis of residue surface accessibility. CDR residues and putitative RgpB epitope residues were used as input to an information-driven flexible docking approach using the HADDOCK server. Analysis of the VHH7:RgpB model demonstrated that the epitope was found in the immunoglobulin-like domain and residue pairs located at the molecular paratope:epitope interface important for complex stability was identified.Collectively, the VHH7 homology model and VHH7:RgpB docking supplies knowledge of the residues involved in the high affinity interaction. This information could prove valuable in the design of an antibody-drug conjugate for specific RgpB targeting.     

Visual FoxPro6.0中数据转换成图表输出的方法

随着计算机技术的发展,用数据库来管理各类数据已经越来越普遍,本文用Visual FoxPro6.0作为工具,为数据库应用系统中的动态数据提供一种转换成图表输出的简单方法。     

Visual servo control. I. Basic approaches

This paper is the first of a two-part series on the topic of visual servo control using computer vision data in the servo loop to control the motion of a robot. In this paper, we describe the basic techniques that are by now well established in the field. We first give a general overview of the formulation of the visual servo control problem. We then describe the two archetypal visual servo control schemes: image-based and position-based visual servo control. Finally, we discuss performance and stability issues that pertain to these two schemes, motivating the second article in the series, in which we consider advanced techniques     

The State of the Art in Integrating Machine Learning into Visual Analytics

Visual analytics systems combine machine learning or other analytic techniques with interactive data visualization to promote sensemaking and analytical reasoning. It is through such techniques that people can make sense of large, complex data. While progress has been made, the tactful combination of machine learning and data visualization is still under‐explored. This state‐of‐the‐art report presents a summary of the progress that has been made by highlighting and synthesizing select research advances. Further, it presents opportunities and challenges to enhance the synergy between machine learning and visual analytics for impactful future research directions.     

视觉设计中信息量层次控制与传达效果研究

我们做视觉设计的目的是为了与受众进行沟通,把我们所要表达的信息传递给受众,让他们接受吸收。那么信息是什么?信息量又是什么?受众接受信息的方式怎样?设计师如何对所要传达的信息进行合理的安排?如何在设计中对信息划分层次?受众的接受层次怎样?设计师如何在设计中安排好自己的表达层次?设计师对信息的传递和受众对信息的接受,这行为本身并非简单的发送与接收。而是视知觉在所有层次上参与相互交流,影响的无限交换。