牛黄上清片、清火片、清凉喉片燃烧分析

选择牛黄上清片、清火片、清凉喉片作为研究对象,测定3种清热解毒药燃烧热、燃烧稳定性,建立3种清热解毒药的多指标综合评价体系,这项研究为热重分析方法研究药品燃烧稳定性评价与研究提供有力地科学依据。     

清火栀麦片、清咽片、咽炎片热重及热值分析

选择清火栀麦片、清咽片、咽炎片作为研究对象,测定3种清热解毒药燃烧热、燃烧稳定性,建立3种清热解毒药的多指标综合评价体系,为药品评价与研究提供有力地科学依据。     

金菊五花茶/小柴胡/复方板蓝根颗粒的热重及热值分析

选择金菊五花茶、小柴胡、复方板蓝根颗粒作为研究对象,测定3种清热解毒药燃烧热、燃烧稳定性,建立3种清热解毒药的多指标综合评价体系,为药品评价与研究提供有力的科学依据。     

4种清热解毒药热重及热值分析

目的:本文选择复方感冒灵,复方金银花,一清颗粒,小儿七星茶颗粒作为研究对象,从燃烧热和燃烧稳定性方面评价药品质量。方法:测定4种清热解毒药燃烧热、燃烧稳定性。结果:建立4种清热解毒药的多指标综合评价体系。结论:这项研究为热重分析方法研究食品药品燃烧稳定性评价与研究提供有力地科学依据。     

热重分析法研究麸炒苍术、盐知母、玄参三种中草药的热稳定性

选择不同产地的麸炒苍术、盐知母、玄参三种中草药作为研究对象,对三种中草药多指标测定与综合评价。从燃烧稳定评价中草药质量。结果表明：三种不同中草药燃烧热稳定性顺序为：玄参>麸炒苍术>盐知母。这项研究为热重分析方法研究中草药燃烧稳定性评价提供有力地科学依据,这项研究建立的多指标综合评价体系为中草药作用评价提供一种新思路。     

王不留行、鸡血藤、延胡索燃烧稳定性和多指标计量分析研究

选择王不留行、鸡血藤、延胡索3种中草药作为研究对象，测定3种中草药燃烧热、燃烧稳定性，脂肪、灰分、微量元素、粗纤维含量。结果表明，3种中草药燃烧热顺序为延胡索>王不留行>鸡血藤；燃烧稳定性排序为：鸡血藤>延胡索>王不留行；脂肪含量(%)大小顺序为：王不留行>延胡索>鸡血藤；灰分含量大小顺序为：王不留行>延胡索>鸡血藤；粗纤维含量大小顺序为：鸡血藤>延胡索>王不留行；燃烧热、燃烧性(中草药的燃烧稳定性)、脂肪含量、灰分、粗纤维含量、微量元素多指标的顺序为：延胡索>鸡血藤>王不留行。建立3种中草药的多指标分析及评价体系，为大规模开发中草药资源以及中草药分类研究提供有力地科学依据。     

3种阿莫西林燃烧稳定性研究

选择3种阿莫西林作为研究对象,利用氧弹量热计测定燃烧热,热重分析阿莫西林的燃烧稳定性。建立3种阿莫西林的多指标综合评价体系,为阿莫西林燃烧稳定性研究提供有力的科学依据。     

丹参、川芎、当归燃烧稳定性和多指标计量分析研究

选择不同产地的丹参、川芎、当归三种中草药作为研究对象,测定三种中草药的燃烧热、燃烧稳定性、脂肪、粗纤维、灰分、微量元素。结果表明,3种中草药燃烧热的顺序为：丹参>川芎>当归;燃烧稳定性排序为：当归>丹参>川芎;脂肪含量(%)大小顺序为：川芎>当归>丹参;灰分含量大小顺序为：丹参>川芎>当归;粗纤维含量大小顺序为：川芎>当归>丹参。燃烧热、燃烧性(中草药的燃烧稳定性)、脂肪含量、灰分、粗纤维、微量元素含量多指标的顺序为：丹参>川芎>当归。本研究建立3种中草药的多指标分析及评价体系,为大规模开发中草药资源以及中草药分类研究提供有力的科学依据。     

3种阿昔洛韦片燃烧稳定性分析

选择3种阿昔洛韦片作为研究对象,利用氧弹量热计测定燃烧热,热重分析阿昔洛韦片的燃烧稳定性。建立3种阿昔洛韦片的多指标综合评价体系,为阿昔洛韦片燃烧稳定性研究提供有力的科学依据。     

茶叶肉桂、西湖叶、花香水仙多指标计量分析

选择不同产地的肉桂、西湖叶、花香水仙三种茶叶作为研究对象，测定三种茶叶的燃烧热、燃烧稳定性、脂肪、粗纤维、灰分、微量元素。结果表明，3种茶叶燃烧热的顺序为西湖叶>肉桂>花香水仙；燃烧稳定性排序为西湖叶>花香水仙>肉桂；脂肪含量（%）大小顺序为肉桂>花香水仙>西湖叶；灰分含量大小顺序为肉桂>花香水仙>西湖叶；粗纤维含量大小顺序为肉桂>花香水仙>西湖叶。燃烧热、燃烧性（中草药的燃烧稳定性）、脂肪含量、灰分、粗纤维、微量元素含量多指标的顺序为肉桂>花香水仙>西湖叶。本研究建立3种茶叶的多指标分析及评价体系，为大规模开发茶叶资源及茶叶分类研究提供有力的科学依据。     

非明胶空心胶囊

一段时期以来,个别的空心胶囊制造厂家唯利是图,无视国家法规,置广大消费者的健康安全于不顾,将蓝矾皮明胶作为空心胶囊的原料;更有甚者个别明胶制造厂从国外进口皮革边角料等洋垃圾作为食用或药用明胶的原料.这些不法商家的行为严重扰乱了食用明胶、药用明胶及空心胶囊的市场.人们对明胶的可信性降低,转而寻找非明胶空心胶囊.     

Thermoplastic Starch and Drug Delivery Capsules

The thermoplastics processing of natural hydrophilic polymers in the presence of water is a recent development with very wide possible applications. Eventually, oil-based polymer materials could be replaced in many applications by inexpensive, natural products from renewable resources. As with conventional thermoplastics, hydrophilic polymer melts may be processed by injection-moulding and extrusion. The present contribution focuses on the injection-moulding of potato starch. The basis of the processing is described. In addition, the rheological behaviour of the starch/water melts during processing is analysed quantitatively to give apparent melt viscosities. The mechanical properties of moulded starch materials and the drug delivery behaviour of starch capsules are discussed. © 1997 SCI.     

Photophysics Applied to Cavitands and Capsules

The use of light as a stimulus to control functional materials or nano-devices is appealing, because it provides convenient control of triggering events where and when they are desired without introducing extra components to the system. Many photophysical and photochemical processes are extremely fast, giving rise to nearly instantaneous onset of events. However, these fast processes can be challenging to engineer into chemical systems. Supramolecular chemistry offers a convenient way to study and control photoprocesses. Given the reversible and self-programmed nature of modern host–guest systems, a modular approach can be considered in which different photoprocesses are coupled to obtain complex functions that emerge and are controlled solely by light inputs. In this review, we highlight recent examples of photoswitching and photophysics applied in the context of supramolecular host–guest systems, with a particular emphasis on resorcinarene-based cavitands and hydrogen-bonded capsules.     

Supramolecular Capsules Derived from Calixpyrrole Scaffolds

This review article describes recent results obtained in the self-assembly of supramolecular capsules derived from calixpyrrole components. Due to their ease of synthesis, calix[4]pyrroles are by far the most typically used units in these systems. A clear conformational and structural analogy exists between calix[4]arenes and calix[4]pyrroles. However, to date, the number of examples in the literature that use calix[4]pyrrole scaffolds instead of calix[4]arenes for the construction of supramolecular capsules is still meager. Four different approaches are considered for the use of calix[4]pyrrole derivatives in the assembly of molecular capsules. Firstly, in an analogous manner to resorcin[4]arenes and pyrogallol[4]arenes, aryl-extended calix[4]pyrroles with hydroxyl groups in their upper rim self-assemble through direct or mediated rim-to-rim interactions into capsular aggregates. Secondly, aryl-extended calix[4]pyrroles having non-complementary hydrogen-bonding groups in their upper rim form dimeric templated capsules with suitable substrates. Thirdly, the elaboration of the upper rim of the calix[4]pyrroles with urea groups affords dimeric capsules with polar functionalized interiors that closely resemble their tetraurea calix[4]arene analogs. Finally, the chemical modification of the pyrrole units of octamethyl calix[4]pyrrole into tetrathiafulvalene derivatives yields dimeric capsules induced by anion coordination that display interesting properties in the binding of electron-poor guests.     

胶囊中替普瑞酮含量的测定方法

采用高效液相色谱法测定斯维舒胶囊主要成分替普瑞酮含量,以C18柱为分析柱,乙腈-水(9:1)为流动相,检测波长为205 nm,柱温室温,外标法测定,线性范围为0.05-0.30 mg/L,线性方程为A=6.0×106C-2.9×105,r=0.999 7,回收率为99.7%,RSD为0.45%.本法简单、快速、准确,可用于批次样品的含量测定及质量控制.     

植物硬空心胶囊性能检测

对羧甲基葡甘聚糖-大豆分爵蛋白制备的植物硬空心胶囊的性能进行了检测,根据GB13731-92,检测了胶囊的崩解时限、干燥失重率等性能.结果表明,胶囊无异味,体积、长度均满足国标;性能达标,其崩解时限8.4 min、干燥失重率13.75%,灰分含量1.8%.     

软胶囊制备工艺研究

目的:优化软胶囊的最佳制备工艺条件。方法:以明胶、甘油、水、PEG400比例为指标,通过L9(34)正交试验筛选了软胶囊的制备工艺,采用压制法制得软胶囊。测定黏度和崩解时间,优化软胶囊制备工艺条件。结果:明胶、甘油、水和PEG400比例为1∶0.5∶1∶0.07,黏度为4.66。结论:该工艺简单可行,是软胶囊的最佳制备工艺流程。     

依鲁替尼胶囊处方的筛选研究

目的:对依鲁替尼胶囊的处方进行筛选,获得合适的辅料用量。方法 :采用正交设计法分别考查崩解剂、表面活性剂和润滑剂,以溶出度为主要考查指标。结果:辅料中影响胶囊溶出度的主要因素是十二烷基硫酸钠,最优处方组成为交联羧甲基纤维素钠13.2mg,十二烷基硫酸钠13.2mg,硬脂酸镁1.8mg。结论:采用本处方可生产出符合质量要求的产品。     

高效液相色谱法测定甲磺酸培氟沙星胶囊的含量

采用高效液相色谱法同时测定甲磺酸培氟沙星胶囊的含量.C18柱(Eclipse4.6mm×150mm);流动相以0.05mol/L枸橼酸-乙腈(8218);检测波长276nm;流速1ml/min.线性范围为8～48μg/r=0.996(n=6);平均回收率99.8%,RSD为030%