State and trait negative affect as predictors of objective and subjective symptoms of respiratory viral infections.

State and trait negative affect (NA) were measured in healthy people immediately before an illness was induced through exposure to a respiratory virus. State NA, disease-specific health complaints (e.g., runny nose, congestion, sneezing), and an associated objective marker of disease severity (mucus secretion weights) were assessed daily during the illness. Baseline trait and state NA were both associated with increased numbers of subsequent complaints. Although greater numbers of complaints among people high in state NA were explicable in terms of greater disease severity, the association of trait NA and symptoms was independent of objective disease. The trait NA complaint association was also independent of state NA and hence not attributable to trait-elicited state affect. Greater trait NA was associated with biases in complaining during but not before illness. This suggested failure to discriminate between symptoms rather than increased sensitivity or hypochondriacal response. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The influence of state and trait affect on HIV risk behaviors: A daily diary study of MSM.

Objective: To characterize the influence of state and trait affect on HIV risk behaviors. Design: Men who have sex with men (N = 155) completed reports of trait affect and daily reports of affect and sexual behaviors each night for up to 30 days. Main Outcome Measures: Analyses focused on the role of state and trait positive activation (PA), negative activation (NA), anxious arousal (AA), and sexual activation (SA) on sexual risk taking, operationalized as having a sex partner, a partner-related risk composite, and an HIV risk behavior composite. Results: State SA was positively associated with having a sex partner and HIV risk behaviors; trait SA was positively associated with partner-related risk. State AA was negatively associated with having a sex partner and positively associated with HIV risk behaviors. Trait AA had a negative association with partner-related risk and moderated the effects of state AA. State PA was negatively associated with HIV risk behaviors, and trait PA had a main effect on having a sex partner. NA had no significant trait or state effects. Conclusion: These data suggest a role for multiple affective states in sexual risk taking. Models of HIV risk-taking behaviors should be extended to include affective processes. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Somatic complaints in pediatric patients: A prospective study of the role of negative life events, child social and academic competence, and parental somatic symptoms.

This prospective study of 197 pediatric patients with chronic abdominal pain examined the role of negative family life events and several potential moderator variables (child social and academic competence, parental somatic symptoms, and child sex) in child somatic complaints 1 year after a clinic visit. Results indicated that (a) among children low in social competence at the time of the initial clinic visit, higher levels of subsequent negative life events predicted higher levels of somatic complaints at follow-up; (b) among boys in families with high levels of negative life events, those whose mothers were characterized by high levels of somatic symptoms had higher levels of somatic complaints at follow-up; and (c) children whose fathers were characterized by high levels of somatic symptoms showed higher levels of somatic complaints at follow-up, regardless of the level of life events. Possible mechanisms accounting for these findings are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Anhedonia, positive and negative affect, and social functioning in schizophrenia

This study examines the relationship between anhedonia and the trait dimensions of positive affect (PA) and negative affect (NA) in schizophrenia. The relationship between poor social functioning in schizophrenia and these individual differences in affectivity is also examined. Schizophrenia outpatients (n = 37) and normal controls (n = 15) were assessed at a baseline evaluation and again approximately 90 days later. Consistent with the hypothesized decrease in hedonic capacity in schizophrenia, patients reported significantly greater physical and social anhedonia and less PA than controls. However, the schizophrenia group also reported significantly greater NA and social anxiety than did controls. In support of the dispositional view of these individual differences in affectivity, trait measures demonstrated test-retest reliability, and group differences between the schizophrenia group and controls were stable over the 90-day followup period. Within the schizophrenia group, physical and social anhedonia were comparably negatively correlated with trait PA; however, social but not physical anhedonia was significantly positively correlated with NA and social anxiety. Poor social functioning in the schizophrenia group was associated with greater physical and social anhedonia and greater NA and social anxiety. Alternatively, greater trait PA was related to better social functioning. These findings indicate that schizophrenia is characterized by both low PA and elevated NA and that these affective characteristics are a stable feature of the illness. The results also suggest important links between affect and social functioning in schizophrenia.     

Do parents reinforce somatic complaints in their children?

Objective: To examine the influence of parental solicitousness on self-reported somatic complaints in school-age children. Design and Main Outcome Measures: Participants were 564 children (mean age 10 years) and their parents. Children completed self-report measures of somatic complaints, parental solicitousness, depressiveness, fear, and sense of coherence. Somatic complaints were assessed again 6 months later. Parents also completed a questionnaire about solicitousness. Results: Parental solicitousness as reported by children or parents was unrelated to the frequency of self-reported somatic complaints. Symptoms of depression, fear, and lower sense of coherence were associated with more somatic complaints, but did not interact with parental solicitousness. Conclusion: Parental solicitousness seems unrelated to more frequent somatic complaints in schoolchildren. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Negative affect and the reporting of physical symptoms among college students.

This study examined relations between negative affect and the reporting of physical symptoms for a group of college students by empirically deriving, through cluster analyses, two profiles that differed in their levels of trait anxiety, trait anger, and depressive symptoms, and then evaluating differences in symptom reporting between these two profiles. Analyses revealed that persons with an elevated profile of negative affect reported being bothered by physical complaints statistically more often than those persons with the converse profile. Additional analyses indicated that the relation between levels of negative affect and physical complaints was mediated by trait anxiety. Physical symptom reporting is discussed in the context of its being a possible correlate of neuroticism. The mediating role of anxiety and implications for counseling are also discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Diurnal mood variation in major depressive disorder.

Depression disturbs mood, but a clear picture of diurnal mood rhythms in depression has yet to emerge. This study examined variations in positive affect (PA) and negative affect (NA), two dimensions of mood that generate diurnal patterns among healthy individuals. Repeated measurements of NA and PA in daily life were obtained over 6 days from 47 depressed outpatients and 39 healthy individuals using the Experience Sampling Method. Relative to healthy individuals, depressed individuals exhibited increasing PA levels during the day with a later acrophase. In contrast, depressed persons' NA exhibited a more pronounced diurnal rhythm and was more variable from moment to moment than healthy individuals'. Ambulatory mood measurements in depression suggest distinct diurnal disturbances of positive and negative affect. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The examination of myofascial face pain and its relationship to psychological distress among women.

In this study, 110 female myofascial face pain patients were assessed monthly for 10 months on measures of pain, distress, and stressful life events. D. A. Kenny and A. J. Zautra's (1995) structural equation model for examining the separate trait, state, and error components of the variables was used to analyze the data. Both pain and distress had sizable trait variance, and the trait components were correlated. The 2 variables also showed sizable state variance, and the states of pain covaried with states of distress. A significant time-lagged relationship between the 2 variables was found: Increases in distress led to elevations in pain 1 mo later. Stressful life events arising from major social roles were also associated with greater distress, but not pain. Illness events unrelated to the pain syndrome were associated with both pain and distress. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Psychosocial Variables, External Barriers, and Stage of Mammography Adoption.

Guided by H. Triandis's (1980) theory of behavior and the transtheoretical model, the study purpose was to examine differences in psychosocial variables and external conditions by stage of mammography adoption. Sampled from a statewide population, participants (N=509) were women aged 51-80. They had been contacted by telephone, screened for eligibility (e.g., no history of cancer or recent mammogram), and interviewed 3-6 months later. Higher utility beliefs, social influences, and practitioner interactions about mammography were associated with improved stage of adoption, as were lower negative affect and external barriers regarding mammography. Higher decisional balance scores, with and without negative affect toward mammography were associated with improved stage. Controlling for variables reflecting pros and cons, negative affect toward mammography further distinguished among stages. A richer set of pros and cons measures could explain screening more fully. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A longitudinal study of negative affect and self-perceived competence in young adolescents.

In a 4-wave, 2-year longitudinal design, the authors obtained measures of negative affect (NA) and self-perceived competence from 220 boys and 216 girls who were 7th graders at the beginning of this study. NA was operationalized as the common dimension underlying self-reports of depressive symptoms, anxiety symptoms, and negative emotions. Self-perceived competence consisted of 2 higher order constructs: a well-behaved/good-student factor and an attractive/athletic/popular factor. Structural equation modeling revealed very high stability estimates for all constructs. Nevertheless, self-perceived competence in the attractive/athletic/popular domain predicted changes in NA. Conversely, NA predicted changes in self-perceived competence in the well-behaved/good-student domain. The primacy of NA versus self-cognitions depends, in part, on the type of self-cognitions being examined. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Dorsal lesions of the prefrontal cortex: effects on alcohol consumption and subcortical monoaminergic systems

Male Wistar rats were subjected to either bilateral aspiration lesions of the dorsal regions of the prefrontal cortex (PFC) or sham lesions and placed on a 6-week, modified sucrose-fading procedure. At the time of sacrifice, the size of the lesion, both in anterior-posterior and medial-lateral dimensions, was measured. Following sacrifice, levels of dopamine (DA), serotonin (5-HT), norepinephrine (NE), and their metabolites were measured in the midbrain (raphe) and nucleus accumbens (NA). Lesioned animals had reductions in 5-HT in the NA, and DA and NE in the raphe. The lesioned group drank more of a solution of 5% alcohol than controls early in the sucrose fading, and less during the later stages. In the lesioned group, the size of the left- and right-hemisphere lesions predicted 5-HIAA levels in the NA, and 5-HT and 5-HIAA levels in the raphe. A laterality effect was noted, such that the size of left-hemisphere lesions were positively associated with raphe 5-HT and 5-HIAA levels, and negatively associated with 5-HT levels in the NA, while right-hemisphere lesions showed the opposite relationships. In addition, the width of the left-hemisphere lesion predicted some measures of alcohol intake. These results suggest that, in the rat, the dorsal PFC is involved in the regulation of monoamines in subcortical regions known to be important in the regulation of reinforced behaviors, and that this regulation differs between hemispheres and shows a laterality effect. In addition, the dorsal PFC appears to have a subtle involvement in the regulation of alcohol intake.     

On babies and bathwater: Disease impact and negative affectivity in the self-reports of persons with rheumatoid arthritis.

The degree to which self-reports of health and functioning reflect negative affectivity (NA), a dispositional tendency to emphasize the negative, was examined with data from a 7-year longitudinal study of adaptation to rheumatoid arthritis. Principal component analyses performed on each of 8 waves of data consistently indicated that the dominant factor in these data was defined by measures of pain and functional impairment. In the final wave, Disease Impact, a scale derived from this component, was directly compared to NA. The 2 scales demonstrated considerable discriminant validity, and most of the significant intercorrelations among Disease Impact and the other variables examined remained statistically significant after the influence of NA was partialed out. These results suggest that reports of pain, impairment, and associated variables reflected disease-related outcomes and processes and not simply NA. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effects of stressful daily events on mood states: relationship to global perceived stress

This study used experience sampling methodology to examine the relationship between stressful daily events and mood. Eighty-five male white-collar workers completed self-reports 10 times a day for 5 days. Controlling for individual differences in mood levels, multilevel regression analyses showed that events were followed by increases in negative affect (NA) and agitation (Ag) and by decreases in positive affect (PA). More unpleasant events were associated with greater changes in all three mood dimensions; controllability mitigated the effects of events on NA and PA. Prior events had persistent effects on current mood. High perceived stress (PS) was associated with greater reactivity of NA and PA to current events, whereas trait anxiety moderated reactivity of Ag. Results indicate that PS is related not only to a higher frequency of reported events but also to more intense and prolonged mood responses to daily stress.     

Therapy processes and outcomes of psychological interventions for women diagnosed with gynecological cancers: A test of the generic process model of psychotherapy.

Objective: Little attention has been paid to the role of nonspecific therapy processes in the efficacy of psychological interventions for individuals diagnosed with cancer. The goal of the current study was to examine the three constructs from the generic model of psychotherapy (GMP): therapeutic alliance, therapeutic realizations, and therapeutic openness/involvement in the treatment outcome of women with gynecological cancers attending either a 7-session supportive counseling intervention or a coping and communication skills intervention. Method: Two hundred and three women completed measures of alliance, realizations, and openness after Intervention Sessions 2, 3, and 6, as well as measures of depressive symptoms after these sessions and 6 months after the pre-intervention assessment (posttreatment). Results: Consistent with the GMP, in early sessions, therapeutic bond predicted openness in terms of positive affect experienced during sessions, and both aspects of openness (positive and negative affect), in turn, predicted more therapeutic realizations. Therapeutic realizations predicted perceptions of greater session progress, and greater therapeutic bond predicted more therapeutic realizations. When early session GMP variables were used to predict later GMP processes and outcomes and posttreatment outcomes, early therapeutic bond predicted later session therapeutic realizations directly and indirectly via emotional arousal, emotional arousal predicted session progress, session progress predicted lower postsession depressive symptoms, and depressive symptoms as rated after Session 6 predicted depressive symptoms 3 months posttreatment. However, a number of additional associations among GMP processes were found. Conclusions: Our results suggest that therapy processes played a role in predicting both short- and long-term treatment outcomes. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Age-related changes in cerebral and peripheral monoamine contents in stroke-prone spontaneously hypertensive rats

1. We examined monoamine contents in various regions of the brain and catecholamine contents in the heart and the adrenal gland of stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar-Kyoto (WKY) rats aged 1.5, 3 and 6 months. 2. The noradrenaline (NA) content and the 5-hydroxytryptamine (5-HT) content in the brainstem were larger in 1.5 month old SHRSP than in the age-matched WKY. In addition, at age 6 months the brainstem 5-HT content was higher in SHRSP than in WKY. 3. The NA and 5-HT contents in basal ganglia, thalamus, hypothalamus, septum and anterior and lateral cerebral cortex showed no significant difference between SHRSP and WKY at any age. 4. The dopamine (DA) contents in all brain regions examined did not differ between WKY and SHRSP at any age. 5. The NA contents in left and right ventricles were larger in 3 month old SHRSP than in the age-matched WKY, but were lower in 6 month old SHRSP than in the age-matched WKY. The cardiac DA contents did not differ between the two rat strains of any age. 6. The adrenal NA and adrenaline (A) contents in 6 month old SHRSP were significantly larger than those in the corresponding WKY. 7. These findings suggest that the increased NA and 5-HT contents in the brainstem may be related to the onset of hypertension, and that the altered cardiac NA contents and adrenal NA and A contents change as a result of the onset or persistence of hypertension.     

Mood, blood pressure, and heart rate at work: An experience-sampling study.

We describe a study that examined the distinctiveness of momentary positive and negative affect (PA and NA) and their relationships with blood pressure and heart rate at work in a sample of 67 full-time employees who provided psychological and physiological measurements multiple times a day, over 10 working days. These employees recorded their subjective ratings on personal digital assistant devices programmed specifically for this study, and assessed their blood pressure and heart rate using automatic recording devices, at each measurement period. Results support the distinctiveness of PA and NA. First, within-individual factor analyses confirmed the existence of two underlying factors in the momentary affect ratings. Second, the within-individual correlations between PA and NA scores (?.14), and among the two latent constructs (?.13) were both low in magnitude. Finally, as predicted by theory, NA was significantly related to blood pressure within individuals, whereas PA and blood pressure were unrelated (both PA and NA were related to heart rate within individuals, as predicted). (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Associations between stress, trait negative affect, acute immune reactivity, and antibody response to hepatitis B injection in healthy young adults.

Eighty-four healthy graduate participants were administered the standard course of 3 hepatitis B vaccinations. Five months after the first dose (shortly after the second injection), each participant completed psychosocial measures, and a blood sample was drawn for determination of hepatitis B surface antibody titer. After completion of the vaccination series, participants performed an acute stress protocol, consisting of a 30-min adaptation period and a 5-min evaluative speech task. Blood was drawn at the end of the resting and task periods for assessment of cellular immune measures. Lower antibody response, as assessed after the second hepatitis B injection, was predicted independently by (a) high trait negative affect and (b) diminished T-cell proliferation in response to PHA. These data provide evidence that trait negative affect and the magnitude of stress-induced suppression of immune function may have clinical significance. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Predictors of suicide attempts: State and trait components.

The authors examined the state and trait components of 3 predictors of suicide attempts (depression, hopelessness, and anxiety), and their relationship to suicidal behavior. Self-report questionnaire and interview data from 180 adolescents enrolled in a prospective naturalistic study were analyzed. Between 23% and 30% of the variance in the predictors was attributable to subjects' trait levels of these variables; the trait, as well as the state, components of the predictor variables were interrelated; and trait levels of these variables were consistently related to suicide attempts. To reduce long-term risk of suicide attempts, clinicians should focus not only on reducing short-term distress but also on reducing individuals' more enduring patterns (trait levels) of negative affectivity. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The structure of depression among elderly institution residents: affective and somatic correlates of physical frailty

BACKGROUND: Confounding of depression with somatic illness and anxiety, a problem in any age group, may be especially troublesome in frail older persons. This paper examined this problem in a factor analytic study of the structure of depressive symptomatology, identifying affective and somatic symptom clusters and relating those clusters to health and functional variables cross-sectionally and prospectively over a 1-year interval. METHODS: The factor structure of a DSM-IV symptom checklist was examined among 1,245 elderly long-term care residents. Regression analyses examined the association of resulting factors with cognition, functional disability, self- and physician-rated health, and pain at baseline and a year later. One-year mortality was also examined. RESULTS: Factor analysis revealed three unique symptom clusters: depressed mood, somatic symptoms, and psychic anxiety. Depressed mood and somatic symptoms were associated cross-sectionally with all functional health variables, but psychic anxiety was associated only with pain. Longitudinally, depressed mood was the only independent predictor of decline in cognition, functional ability, physician-rated health, and mortality; the last effect, however, did not withstand control for baseline health and functioning. Somatic symptoms at baseline predicted decrement in self-rated health a year later. Effects varied as a function of cognitive status. CONCLUSIONS: These data suggest that concerns about the confounding role of somatic symptoms in the association of depression with physical health are unfounded. Although somatic symptoms of depression and anxiety were associated with health and functional status cross-sectionally, depressed mood was by far the stronger predictor of health declines over time.     

Intraindividual and interindividual analyses of positive and negative affect: Their relation to health complaints, perceived stress, and daily activities.

I examined correlates of Negative Affect (NA) and Positive Affect (PA) through both within- and between-subjects analyses. Eighty subjects completed a daily questionnaire for 6-8 weeks. Each day they rated (a) their mood, (b) the extent to which they suffered from various minor physical problems, (c) their level of stress, (d) the time they spent socializing, and (e) whether or not they had exercised. Subjects also completed several trait tests measuring their general affective level, frequency of health problems, and social tendencies. A between-subjects analysis showed the expected pattern: Level of physical complaints and perceived stress were correlated with individual differences in NA but not in PA, whereas social indicators and frequency of exercise were related only to PA. The within-subjects results generally exhibited a similar pattern: Social activity and exercise were more strongly related to PA, whereas perceived stress was highly related to NA. However, the most significant finding was that, contrary to prediction, health complaints were as strongly related to intraindividual fluctuations in PA as in NA. Possible interpretations of the observed correlates of NA and PA are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)