Leadership in these changing times

The nonenzymatic conjugation of metabolites is decreased in chronic diseases of the liver, which is caused by decreased concentration of glutathione. The activities of glutathione enzymes are increased, this indicating the development of compensatory processes of mobilization of the second phase of detoxication, that is, increased conjugation under conditions of suppression of the cytochrome P-450 system. Measurement of liver glutathione transferase is a highly informative test for assessing the activity of the pathological process, particularly important in patients with chronic active hepatitis and cirrhosis of the liver.     

Following your heart or your head: Focusing on emotions versus information differentially influences the decisions of younger and older adults.

[Correction Notice: An erratum for this article was reported in Vol 16(2) of Journal of Experimental Psychology: Applied (see record 2010-12508-005). The wrong author order was listed. The correct order is presented in the erratum.] Research on aging has indicated that whereas deliberative cognitive processes decline with age, emotional processes are relatively spared. To examine the implications of these divergent trajectories in the context of health care choices, we investigated whether instructional manipulations emphasizing a focus on feelings or details would have differential effects on decision quality among younger and older adults. We presented 60 younger and 60 older adults with health care choices that required them to hold in mind and consider multiple pieces of information. Instructional manipulations in the emotion-focus condition asked participants to focus on their emotional reactions to the options, report their feelings about the options, and then make a choice. In the information-focus condition, participants were instructed to focus on the specific attributes, report the details about the options, and then make a choice. In a control condition, no directives were given. Manipulation checks indicated that the instructions were successful in eliciting different modes of processing. Decision quality data indicate that younger adults performed better in the information-focus than in the control condition whereas older adults performed better in the emotion-focus and control conditions than in the information-focus condition. Findings support and extend extant theorizing on aging and decision making as well as suggest that interventions to improve decision-making quality should take the age of the decision maker into account. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Taking your place or matching your face: Two paths to empathic embarrassment.

Empathic responding may be elicited by different processes, depending on the available situational and affective cues. We investigated two such processes, perspective-taking and nonverbal mimicry. In Study 1, participants watched an embarrassed or unembarrassed confederate dancing to music while either remaining objective or engaging in perspective-taking. Both manipulations affected empathic embarrassment. Study 2 further examined the effects of targets' embarrassment displays and observers' prior experience with the situation upon spontaneous perspective-taking, expressive mimicry, and empathic embarrassment. Embarrassment displays increased mimicry, but also spontaneous perspective-taking and subsequent empathy. Prior experience moderated the effects of embarrassment displays on perspective-taking and empathy. Path analyses demonstrated that embarrassment displays exerted indirect effects on empathic embarrassment through both perspective-taking and mimicry. The results suggest that available affective and situational cues can activate different routes to empathy, and highlight the value of simultaneously investigating target- and observer-based sources of influence. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Strategic control in a naming task: Changing routes or changing deadlines?

S. Monsell, K. E. Patterson, A. Graham, C. H. Hughes, and R. Milroy (1992) reported that high-frequency irregular words are named faster when presented in a "pure" block than when mixed with nonwords. They attributed this effect to a de-emphasis of an assembly route in the pure block. The current authors replicated this effect in Experiment 1. In Experiments 2 and 3, similar effects resulted from mixing high- and low-frequency regular words with nonwords and from mixing high- and low-frequency irregular words together. Further, in all cases, the more slowly named stimuli were named faster in mixed blocks than in pure blocks. An alternative to the de-emphasis account, which is based on strategic control of initiation of articulation, was supported in Experiment 4 by confirming the alternative account's novel prediction of a regularity effect for high-frequency words in pure blocks. Implications for the single- versus dual-route debate and for interpretations of strategy effects in general are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Daily interpersonal experiences, context, and alcohol consumption: Crying in your beer and toasting good times.

The authors explored a multidimensional view of drinking, whereby social and solitary drinking represent distinct behaviors associated with positive and negative experiences, respectively. Using daily diary methodology and multilevel analytic strategy, the authors examined, over 30 days, the within-person association of negative and positive experiences and alcohol consumption in different contexts and focused on interpersonal experiences. On days with more negative interpersonal experiences, participants engaged in more solitary drinking (i.e., drinking at home and alone), whereas on days with more positive interpersonal experiences they drank more in social contexts. The authors also demonstrated that individuals high on neuroticism drank more in solitary contexts on days with more negative interpersonal experiences, relative to those with lower neuroticism. These findings lend support to models linking daily drinking motivation and context-dependent drinking behavior. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A comparison of cathepsin B processing and distribution during neuronal death in rats following global ischemia or decapitation necrosis

OBJECTIVE: The relationship between the left ventricular (LV) relaxation time constant and early diastolic filling is not fully defined. This study provides additional evidence that LV isovolumic pressure fall in the normal intact heart in response to certain interventions is not adequately described by a model of monoexponential decay and that its relationship to filling is complex. METHODS AND RESULTS: To gain further insight into the relationship between LV relaxation and early rapid filling we measured LV isovolumic relaxation rate, peak early filling velocity (E), LV volumes, and transmitral pressures at baseline and in the first postextrasystolic beat after a short-coupled extrasystole in 9 anesthetized dogs. Postextrasystolic isovolumic relaxation rate was slowed as measured by 3 commonly used time constants, while E was increased 32%. LV contractility and peak pressure were also increased, while LV end-systolic volume was decreased. LV minimum pressure was deceased, while the early diastolic transmitral pressure gradient was increased. Although all relaxation time constants measured over the entire isovolumic relaxation phase indicated slowed relaxation, direct measurement of isovolumic relaxation time indicated no change in relaxation rate. Calculation of the time constants and direct measurement of isovolumic relaxation time during early isovolumic pressure decay indicated slowed postextrasystolic pressure decay rate compared with baseline, while calculation of time constants and direct measurement of isovolumic relaxation time during late isovolumic relaxation indicated augmented postextrasystolic pressure decay rate versus baseline. CONCLUSIONS: This non-exponential behavior of LV isovolumic pressure decay in postextrasystolic beats after short-coupled extrasystoles provides further evidence that the relationship that exists between ventricular relaxation and early filling is not simple. The results are interpreted in terms of current theoretical formulations that attribute control of myocardial relaxation to the interaction between inactivation-dependent and load-dependent mechanisms.     

The times, they are a changing: A review of Raising children in a socially toxic environment.

Reviews the book, Raising children in a socially toxic environment by J. Gabarino (1995). In this book, Garbarino sets out to offer his views on what childhood ought to be, how children map their own worlds (thus define, themselves), what their basic needs are, the levels in which those needs are being met, as well as offer suggestions for ways in which readers can change the "toxic environment" to aid in the healthy development of children and youth. The book is challenging to read because it is true. Although the pages are not replete with "hard data," they are filled with factual accounts that paint a discouraging, in fact depressing picture of the life of children in our communities. The book is powerful because, if successful, we are forced to accept the fact that this is American society today. There is no question that the issues articulated by Garbarino in this book, such as teenage homicide, gang warfare, domestic violence, and child abuse, are real. The influences of Urie Bronfenbrenner (1977) and ecological systems theory provide the conceptual framework for this book. Accordingly, development is the result of complex interactions among child and family systems and the social environment in which they function. Related to the ecological orientation is the notion that "it takes a village" to effect change. In other words, there is an implicit message that successful, healthy childrearing is the shared responsibility of individuals, groups, communities, external forces, and broad-based sanctions and regulations. As such, readers who take this book seriously will be forced to look at it not only as a professional resource with "good information," but as a call to accept a role for working within their individual and community contexts to influence change. Although the book falls short in providing concrete directives for change, it sends a strong message that we are all responsible, and a more subtle message that change is possible. If each and every reader could make one or two changes in their own behaviors and priorities as an outcome of reading this book, it will have served an invaluable service. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Differentiating sexist from nonsexist therapists: or My analogue can beat your analogue.

Argues that G. Stricker (see record 1977-29882-001), in his article on research concerning sex bias in psychotherapy, does not have a proper appreciation of the merits of analog data. A capsule review is presented of the evolution of sex-bias hypotheses and the major analog studies that were conducted to test these hypotheses. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Why do I like thee: Is it your performance or my orders?

Examined the extent to which employee evaluations are determined by the leader's influence tactics and the assessments of followers' motives rather than by their performance. 113 business majors were randomly assigned to act as authoritarian or democratic leaders of 5-person work groups that manufactured model airplanes. Measures of leader influence tactics, leader assessments of the extent to which followers were either internally or externally motivated to work effectively, and leader evaluations of followers were gathered at the end of the work session. The number of airplane models produced was used as the performance measure. It was found that (a) the democratic leaders perceived the followers as internally motivated to work effectively, (b) the leaders' perception of the followers as internally motivated was strongly related to favorable evaluations of the followers, and (c) the leaders' employee evaluations were not related to the followers' performance. Findings are discussed in terms of previous research that has linked the use of power to evaluations of followers. (14 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A penny (or peso) for your thoughts: an unusual intermediate target

The Gaza Strip borders the southern part of Israel and Egypt. There is a remarkable difference in the prevalence of antibodies to hepatitis C virus (HCV) between Israel (0.5%) and Egypt (10%). A few thousand inhabitants cross the borders daily from the Gaza Strip to both countries. The objectives of this study were to investigate the prevalence of HCV infection in the Gaza Strip, an area that was not studied before, and to study HCV transmission in the Gaza Strip by characterizing the genotypes of HCV in Southern Israel and the Gaza Strip and comparing them with those found in Egypt. HCV prevalence in the Gaza Strip was found to be 2.2%, relatively higher than in Israel but lower than in Egypt. The most common genotypes found were type 1 b in Southern Israel and type 4 in the Gaza Strip, corresponding to the most prevalent genotype in Egypt. Similarity between type 4 isolates from the Gaza Strip and Egypt was illustrated further by sequence analysis of the HCV 5' noncoding region (NCR).     

Progesterone reduces sympathetic tone without changing blood pressure or fluid balance in men

There is scant information on the effects of progesterone on circulation. Changes in catecholamine levels, blood pressure and transcapillary fluid balance were measured in 12 men before and during administration of natural progesterone (Utrogestan). Before administration, systolic blood pressure was significantly correlated with venous adrenaline (r = 0.67, p = 0.01). There was a significant decrease (p = 0.004) in venous noradrenaline during progesterone administration, and systolic blood pressure was significantly correlated with the arteriovenous difference for noradrenaline (r = 0.66, p = 0.02). Serum progesterone, which attained levels similar to those found in women during the luteal phase, did not significantly alter blood pressure, body weight or intra- to extravascular fluid shift. It is concluded that progesterone may have a direct action by increasing the uptake of noradrenaline from the synaptic cleft or by decreasing the nerve firing rate. Interestingly, the pretreatment finding of a significant correlation between blood pressure and adrenaline was less evident during progesterone administration.     

Colonic transit times and the effect of lactulose or lactitol in hospitalized patients

OBJECTIVE: To investigate whether a small dose (10 g per day) of a laxative (liquid lactulose, crystallized lactulose, or crystallized lactitol) can prevent the slow colonic transit associated with the physical inactivity of hospitalization. DESIGN: Patients were randomly allocated to one of four groups: control, liquid lactulose, crystallized lactulose or crystallized lactitol, and the average of mean colonic transit times in these groups was compared. SETTING: Gastroenterologic Unit, Hospital dos Covoes, Coimbra, Portugal. PATIENTS: Patients with normal bowel movements, admitted to hospital for the investigation of conditions not associated with constipation or diarrhoea, were allocated to one of the four treatment groups and had their mean colonic transit times studied after hospitalization using radiopaque markers and abdominal radiographs. Each study group had 18 patients. During the study, each patient was given a normal diet and no drugs except the relevant laxative. RESULTS: The average of the mean colonic transit times in each of the four groups were: 52.16 h [95% confidence interval (CI) 39.42-64.84] for controls; 22.45 h (95% CI 13.84-31.06) in the liquid lactulose group; 24.05 (95% CI 12.13-35.97) in the crystallized lactulose group; and 35.95 (95% CI 23.82-48.08) in the crystallized lactitol group. The differences were statistically significant for the two lactulose groups. The study of the mean colonic regional transit times showed that these differences related to transit in the right colon. CONCLUSIONS: A small dose of lactulose (either liquid or crystallized) was effective in preventing slow colonic transit and constipation in hospitalized patients without causing unwanted symptoms. The slow transit affected mainly the right colon, and it was in this region that the laxative had effect.     

The art of Gestalt therapy: or What are you doing with your feet now?

Analyzes a filmed interview between F. Perls and his patient, Gloria, along the lines of J. Haley's (1958) "The Art of Psychoanalysis," noting that there are similarities between the interactional processes in Gestalt therapy and psychoanalysis.) Perls's seeming lack of interest in the interpersonal processes in the interview plus his attempt to frustrate the client are major influences on the observed patterns of communication. Many aspects of the interaction seemed puzzling to Gloria because Perls often ignored what she said and rapidly changed the topic. The influence of Perls's personal idiosyncrasies plus apparent shortcomings and blind spots in the Gestalt therapy theory are pointed out. (10 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Prostate-specific antigen doubling times are similar in patients with recurrence after radical prostatectomy or radiotherapy: a novel analysis

PURPOSE: Some investigators have analyzed the rate of growth of prostate cancer that has recurred after definitive radiotherapy or radical prostatectomy using serum prostate-specific antigen (PSA) doubling times (DT). We examined all PSA values in recurrent patients to determine the pattern and rate of increase in PSA after radiation therapy and radical prostatectomy. PATIENTS AND METHODS: Charts of 96 recurrent radical prostatectomy patients (mean age, 62.8 years; range, 47 to 76) and 42 recurrent radiation therapy patients (mean age, 67.2 years; range, 52 to 83) were reviewed. All available PSA values between the date of operation/radiation treatment and last follow-up evaluation or the initiation of second-line therapy are included. Rate of PSA DT was not assumed to be constant over time; it was instead allowed to vary. We use a piecewise linear random-coefficients model in time for log (PSA), which allowed different mean models for both treatments. RESULTS: The PSA DT in the first year after radiation therapy was--1.17 years, which reflects the continuous decline in PSA in the average patients during the first year after radiotherapy despite eventual biochemical progression. In contrast, the PSA DT in the radical prostatectomy group was 0.66 in the first year. In year 2, after radiation therapy, the PSA DT was lengthy at 1.82 years, significantly longer (P = .0025) than in the radical prostatectomy group (0.76 years). After year 2, there were no significant differences between the two groups (P > .05). CONCLUSION: A piecewise linear random-coefficients model enables interval analysis of PSA DT. While the PSA DT after radiation therapy and radical prostatectomy are different in the first 2 years, the rate of increase in PSA appears to be similar in the two groups after year 2, which suggests the rate of growth of cancers that recur after radiation therapy and radical prostatectomy is similar.     

Thorough record keeping: A good defense in a litigious era.

Psychotherapists, like other health professionals, are concerned about the increase in malpractice litigation and insurance rates. Properly kept records, made in anticipation of future litigation, may be crucial for the psychotherapist who is faced with a malpractice suit. We review cases in which records influenced the outcome of malpractice suits, and we make specific recommendations regarding the optimal maintenance of records. (PsycINFO Database Record (c) 2010 APA, all rights reserved)