A comparison of microtubule assembly in brain extracts from young and old rats

The effect of repeated doses of indomethacin on mean peak velocity (MPV) and time-averaged mean velocity in the middle cerebral artery was assessed in 10 ventilated neonates with a patent ductus arteriosus using colour/duplex Doppler technique prior to, and 10, 30, and 120 min after the first and the third dose. Velocities were significantly reduced up to 120 min after the first dose. The third dose resulted in a significant reduction in MPV at 10 and 30 min following treatment. This reduction was half of that observed after the first dose. Systemic blood pressure (BP) and heart rate did not change significantly after each separate dose. However, by the third dose, mean and diastolic BP were significantly increased from pretreatment levels. The attenuated response of cerebral blood flow (CBF) velocities to the third dose of indomethacin compared with the first dose is probably related to altered haemodynamics. Indomethacin should be used cautiously in infants with other conditions which are known to decrease CBF such as hypotension, hypocarbia and polycythaemia.     

Training for attentional control in dual task settings: A comparison of young and old adults.

The authors examined whether the learning and performance of dual tasks by young and old adults could be enhanced through training. Adults were trained with either a fixed-priority or variable-priority training strategy on a monitoring task and an alphabet-arithmetic task and then transferred to a scheduling and a paired-associates running memory task. Participants in the variable priority condition learned the monitoring and alphabet-arithmetic tasks more quickly and achieved a higher level of mastery on these tasks than did those in the fixed-priority condition. Moreover, participants trained with the variable priority technique showed evidence of the development of automatic processing and a more rapid rate of learning and higher level of mastery of the transfer tasks than did the fixed-priority participants. These results are discussed in terms of the mechanisms that underlie learning and performance of dual tasks and with respect to potential applications. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Youth suicide in Norway, 1990-1992: a comparison between children and adolescents completing suicide and age- and gender-matched controls

In Norway 1990-1992, the suicide rate was 18.6 per 100,000 individuals per year for boys 15-19 years old and 6.3 for girls, and for 10-14 year olds the rate was 2.7 for boys and 0.5 for girls. Comparison of all completed suicides (N = 129) with gender- and age-matched control subjects identified depression (OR = 19.9; CI = 11.2, 35.5), disruptive disorders (OR = 6.0; CI = 3.1, 11.4), and previous suicidal behavior (OR = 3.4, CI = 2.0, 5.6) as main risk factors. Of the suicide completers, 74% had mental disorders. Suicidal intent was previously expressed by 48%, but few (24%) had received treatment, despite well-developed health services. A history of disruptive disorders (17%) and substance abuse (10%) were less frequently found than in previous studies, but binge drinking may contribute to the adolescent suicide rate.     

Epidemiological study of youth suicide: comparison between primary suicidals and repeaters

A survey of 537 subjects, under 20 years old and hospitalized after attempted suicide, showed that 30% had attempted suicide at least once before. There were statistically significant differences between repeaters and non-repeaters in psychopathological characteristics (psychiatric diagnosis and previous school behavior problems), socio-demographic characteristics (family size, alcoholism in the family) and in family relationships. Verification and development of these findings would lead to the construction of a scale of risk of repeating attempted suicide.     

References in conversation between young and old normal adults.

Compared the way in which young and elderly adults cooperate to achieve a mutually acceptable reference. Pairs of young and elderly interlocutors performed a repeated referential communication task in which they were asked to converse about arranging complex figures in a particular order. With repetition of the task, both partners, regardless of age, needed fewer words and speaking turns to find mutually acceptable references. However, the older Ss were slower to benefit from the repetition and required more collaborative work to reach an agreement. The elderly were less likely to take previously shared information into account; they produced proportionally less requests for potential elaboration, and they were more likely to be idiosyncratic in their interpretation of the referents. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Seizure induced C-Fos mRNA in the rat brain: comparison between young and aging animals

Although there are many publications on the usefulness of magneto-therapy, discrepancies exist about the utility of electromagnetic fields in skin wound healing. The objective of this work was to study the effect of electromagnetic fields on wound healing in rats. Thirty six male Wistar rats were used; a rectangular lesion was made in the back of each animal (4.2 cm x 2.3 cm). They were divided into 3 groups: group C (control) with sham treatment; group C50, treated with continuous electromagnetic fields of 5 mT (50 Gauss) and group P200, treated with pulsed electromagnetic fields of 20 mT (200 G). The treatments were of 30 minutes a day during 21 days. The corporal weights (Table 1) and the wound longitudinal and transversal maximal axis (Figures 1, 2) were weekly recorded and the data was evaluated by analysis of variance. On day 14, the P200 group showed the maximal longitudinal axis which was smaller than that of group C (p < 0.01). On day 21 in both treated groups the maximal longitudinal axis was smaller than that of group C (p < 0.01); besides the axis was smaller in the P200 group than in the C50 group (p < 0.05). No statistical differences were observed in the remaining data. The results showed a facilitating effect of electromagnetic fields on wound healing in rats. Pulsed electromagnetic fields seem to have a precocious and larger healing effect than continuous electromagnetic fields.     

A note on old and young in helping groups.

Compared group behaviors in helping-group contexts for age-homogeneous groups of elderly and young adults. Ss were attending either 2 local senior citizen centers (mean ages 73 and 70 yrs) or adult education courses (mean age 69 yrs), or were college students in psychology courses (mean age 19 yrs). Different and similar patterns of group process frequencies were examined. The dimension of self-disclosure, which was observed more frequently among the elderly, is evaluated. Differences between the age groups on this dimension are explored in terms of identity issues across the life span and differential awareness of shared problems. Implications for group helping interventions among the elderly are considered. (9 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Encoding and memory for visible speech and gestures: A comparison between young and older adults.

Two experiments explored whether older adults have developed a strategy of compensating for slower speeds of language processing and hearing loss by relying more on the visual modality. Experiment 1 examined the influence of visual articulatory movements of the face (visible speech) in auditory–visual syllable classification in young adults and older adults. Older adults showed a significantly greater influence of visible speech. Experiment 2 examined immediate recall in three spoken-language sentence conditions: speech alone, with visible speech, or with both visible speech and iconic gestures. Sentences also varied in meaningfulness and speech rate. In the old adult group, recall was better for sentences containing visible speech compared with the speech-alone sentences in the meaningful sentence condition. Old adults' recall showed no overall benefit of the presence of gestures. Young adults' recall on meaningful sentences was not higher for the visible speech compared with the speech-alone condition, whereas recall was significantly higher with the addition of iconic gestures. In the anomalous sentence condition, both young and old adults showed an advantage in recall by the presence of visible speech.… (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Social comparison between young children in achievement situations.

Examined the development of children's motivations to socially compare in a situation in which they were free to seek or not seek information about how another child was doing. 16 males and 16 females each at the kindergarten, 1st, and 2nd grade levels were recruited through the newspaper and paid to participate. Pairs of Ss in the same grade worked on a speed task under high- and low-competition conditions. The frequency and duration with which Ss pushed a button to observe their partner's progress on a monitor was the index of the strength of motivation. Results show the expected developmental increase in comparison behavior. Only in 2nd graders did the expected positive relationship between level of competition and performance appear. At the kindergarten level, the means were in the opposite direction, while for the 1st-grade level the relation between competition and performance depended on sex. Results are discussed in terms of alternative predictions derived from theories by L. Festinger (1954) and J. Veroff (1969). (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Encoding and retrieval differences between young and old: The impact of attentional capacity usage.

An experiment was conducted to investigate (a) whether the semantic processing deficit in the aged can be attributed to age differences in capacity usage during encoding and (b) age differences in terms of the interaction between encoding and retrieval operations. Young and older adults engaged in both a primary (semantic, rhyme, and arithmetic questions) and secondary task (probe monitoring) at encoding and retrieval. The study provided no evidence for the hypothesis that the age-related semantic processing deficit is the result of age differences in capacity usage during semantic and nonsemantic encoding. However, there was evidence that reinstating the encoded semantic context with the same semantic cue at retrieval did not help older subjects as much as younger subjects at recall. These results were interpreted as suggesting that there may be an age deficit in the effective use of semantic contextual information at encoding and retrieval rather than a simple age deficit in semantic processing at encoding. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Differences in platelet alpha-granule release between normals and immune thrombocytopenic patients and between young and old platelets

We studied the effect of central line catheters on thrombus formation in the right atrium (RA), including the incidence and echocardiographic characteristics of the catheter-associated thrombus as well as possible clinical implications in patients. We prospectively studied 55 patients by transesophageal echocardiography within 1 week after Hickman catheter implantation and on a follow-up study at 6 to 8 weeks. We succeeded in imaging the catheter tip in 48 of the 55 patients (87%). In the baseline study 13 had the tip placed in the RA, eight at the superior vena cava-atrium junction, and 27 in the superior vena cava. An abnormal mass, consistent with a thrombus, was found in 12.5% of the patients, all of which were seen within the 13-patient (46%) group with the Hickman catheter tip placed in the RA. Hickman catheter insertion is associated with high incidence (12.5%) of early formation of RA thrombus. The formation of these thrombi is asymptomatic and highly associated (p < 0.001) with the catheter tip position in the RA, in contrast to their positioning in the superior vena cava or in its junction with the right atrium. On the basis of these findings, we recommend that special attention and effort be given to placing of the catheter tip in the superior vena cava and avoiding the RA during the implantation procedure.     

Show versus no show: A comparison of referral calls to a suicide prevention and crisis service.

Conducted an exploratory content analysis of 20 pairs of taped telephone calls to a suicide prevention and crisis service. Variables that might differentiate between referrals resulting in "show" and those resulting in "no show," were studied. A show and a no show call for each of 20 telephone therapists were coded. It is concluded that a scale based on 6 indexes would differentiate between the 2 groups. Motivation of the caller for getting help and the concreteness of the therapist emerged as most important factors in the 6-item scale. The relationship between this research and a crisis intervention model is discussed. (28 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Physiological and fitness comparison between young Japanese and American males

Environmental and cultural aspects are known to influence particular characteristics of an ethnic group and, as such, are partially responsible for distinguishing an ethnic group from others. This study was designed to compare non-athlete young Japanese and American males on a variety of physiological and fitness characteristics in order to locate and quantify the magnitude of any physiological and fitness differences between the two races. Aerobic capacity based upon bicycle ergometer, resting heart rate, and resting blood pressure, vertical jump, grip strength, and flexibility as measured by sit-and-reach, and trunk-and-neck extension tests were obtained for 20 Japanese and 20 American males whose ages ranged between 19 and 25 years. Cardiovascular and aerobic capacity data indicated that the Americans had higher blood pressure (both systolic and diastolic blood pressures) and higher absolute VO2max than the Japanese. However, the Japanese had a higher relative VO2max value than the Americans. The Japanese had higher values than those of the Americans in the vertical jump and for trunk-and-neck flexibility. Within the limitation of the present study, it can be concluded that the Japanese had a higher lower extremity power and better flexibility in the trunk-and-neck extension compared with the American.     

Loneliness among the oldest old, a comparison between residents living in nursing homes and residents living in the community

To ascertain whether membrane signal transduction is induced by bullous pemphigoid (BP) antibody and whether cell lysis is induced by its complement activation, we assessed the intracellular Ca2+ concentration ([Ca2+]i), intracellular pH, membrane potential and morphology of living cells by following the time course of fluorescence intensity of Fluo-3/AM, Snaff-1/AM, Dioc-5 and Luciffer yellow, respectively. A transient increase of Fluo-3 fluorescence intensity in DJM-1 cells (a squamous cell carcinoma line) was revealed when the cells were incubated with 2 of five IgG1 BP antibodies. However, no transient increase of Fluo-3 fluorescence intensity was revealed when the cells were incubated with IgG2 and IgG4 BP antibodies. A transient increase of Fluo-3 fluorescence intensity was revealed in DJM-1 cells incubated with 3 of seven IgG1 and 1 of four IgG2 BP antibodies in an EGTA-containing low-Ca2+ medium. On the other hand, the Dioc-5 fluorescence intensity did not change significantly, though the increase of Fluo-3 fluorescence intensity was observed. The increase of Snarf-1 fluorescence intensity was revealed in DJM-1 cells incubated with 2 of five IgG1 BP antibodies, but was not revealed in the cells incubated with IgG2 or IgG4 of BP antibodies. Study of complement activation by BP IgG1 showed a transient increase of Fluo-3 fluorescence intensity of with 3 of five IgG1 BP antibodies when DJM-1 cells were incubated with complement-supplemented normal-Ca2+ medium. At the same time, however, endocytosis and cell lysis were not observed with 2 IgG1 BP antibodies which did induce an increase of Fluo-3 fluorescence intensity when Lucifer-yellow-loaded DJM-1 cells were incubated with complement-supplemented normal-Ca2+ medium. We examined next whether anti-180 kD BP antigen monoclonal antibodies (mAbs R-223 and 233) induce an increase of Fluo-3 fluorescence intensity. MAb R-223 did not induce any increase of Fluo-3 fluorescence intensity in DJM-1 cells, when incubated with normal- and low-Ca2+ media However, mAb R-223 induced a transient increase of Fluo-3 fluorescence intensity in DJM-1 cells when incubated with complement-supplemented normal-Ca2+ medium. MAb 233 did not induced an increase of Fluo-3 fluorescence intensity in DJM-1 cells when incubated with normal- and low-Ca2+ media. These results suggest that the BP IgG1 induces Ca2+ release from intracellular storage sites, however, the complement activated by BP IgG1 does not induce cell lysis. It could not be confirmed that anti-180 kD BP antigen antibody induced Ca2+ release from intracellular storage sites.     

Pediatric hematology and oncology in Italy: half a century of progress, an ongoing search for improvement

Review of a series of 98 eyes removed at autopsy from 86 AIDS patients identified 12 cases (14%) showing varying degrees of microscopic calcium oxalate deposition. The oxalate crystals were birefringent using polarisation microscopy and were stained histochemically by the silver nitrate-rubeanic acid method (Yasue), a stain considered to be specific for calcium oxalate. In two cases, the deposition was extensive and involved the surface of the ciliary processes, ciliary body and pars plana of the retina, the retinal and optic nerve blood vessel wall, a few retinal pigment cells, and the anterior inner sclera. A lesser degree of intraocular involvement was observed in the remaining 10 cases. In all but two eyes, where a peripheral active area of cytomegalovirus retinitis was present, no other significant microscopical abnormality was found. Clinically, these patients were asymptomatic. At autopsy, oxalate deposits were found in the kidney and/or thyroid in seven of the patients.     

A stereological study of substantia nigra in young and old rhesus monkeys

The number of pigmented and non-pigmented neurons in the substantia nigra (SN) of 10 old and six young female Macaca mulatta monkeys and in three old alpha male monkeys were estimated using new stereological cell counting methods. No systematic right-left differences were noted, nor were old animals different from young ones with respect to SN volume (68.9 mm3 vs. 62.8 mm3) or absolute number of nerve cells (320,000 vs. 312,000). However, the total number of pigmented neurons was about eight times higher in old animals compared with young ones (166,000 vs. 21,400) while the total number of non-pigmented SN neurons was less than half in old animals compared with young ones (139,000 vs. 285,000). These differences create difficulties in generalizing experimental results from the rhesus animal model to man. It seems unlikely that a simple correlation can be made between pigmented and tyrosine hydroxylase (TH) positive neurons in SN in monkeys. Instead of estimating the total number of pigmented and non-pigmented cells, only SN neurons positive for TH using immunohistochemical techniques might be used an indicator of the total number of dopaminergic neurons in SN in monkeys.     

A comparison of community attitudes towards suicide in Windsor and Los Angeles.

Administered a Suicide Opinion Questionnaire (SOQ; G. Domino et al, 1980) to 103 community adults in Windsor, Canada, and 103 in Los Angeles, California. Samples were matched as to gender, age, and occupational status. Significant differences were obtained on 5 of the 8 SOQ scales, with Windsor Ss showing greater endorsement of agreement on the Mental Illness, Cry for Help, and Right to Die scales and lesser endorsement of agreement on the Religion and Moral Evil scales than Los Angeles Ss. (French abstract) (PsycINFO Database Record (c) 2010 APA, all rights reserved)