Multifunctional catheters combining intracardiac ultrasound imaging and electrophysiology sensing

A family of 3 multifunctional intracardiac imaging and electrophysiology (EP) mapping catheters has been in development to help guide diagnostic and therapeutic intracardiac EP procedures. The catheter tip on the first device includes a 7.5 MHz, 64-element, side-looking phased array for high resolution sector scanning. The second device is a forward-looking catheter with a 24-element 14 MHz phased array. Both of these catheters operate on a commercial imaging system with standard software. Multiple EP mapping sensors were mounted as ring electrodes near the arrays for electrocardiographic synchronization of ultrasound images and used for unique integration with EP mapping technologies. To help establish the catheters' ability for integration with EP interventional procedures, tests were performed in vivo in a porcine animal model to demonstrate both useful intracardiac echocardiographic (ICE) visualization and simultaneous 3-D positional information using integrated electroanatomical mapping techniques. The catheters also performed well in high frame rate imaging, color flow imaging, and strain rate imaging of atrial and ventricular structures. The companion paper of this work discusses the catheter design of the side-looking catheter with special attention to acoustic lens design. The third device in development is a 10 MHz forward-looking ring array that is to be mounted at the distal tip of a 9F catheter to permit use of the available catheter lumen for adjunctive therapy tools.     

Feasibility of noncontact intracardiac ultrasound ablation and imaging catheter for treatment of atrial fibrillation

Atrial fibrillation (AF) affects 1% of the population and results in a cost of 2.8 billion dollars from hospitalizations alone. Treatments that electrically isolate portions of the atria are clinically effective in curing AF. However, such minimally invasive catheter treatments face difficulties in mechanically positioning the catheter tip and visualizing the anatomy of the region. We propose a noncontact, intracardiac transducer that can ablate tissue and provide rudimentary imaging to guide therapy. Our design consists of a high-power, 20 mm by 2 mm, 128-element, transducer array placed on the side of 7-French catheter. The transducer will be used in imaging mode to locate the atrial wall; then, by focusing at that location, a lesion can be formed. Imaging of previously formed lesions could potentially guide placement of subsequent lesions. Successive rotations of the catheter will potentially enable a contiguous circular lesion to be created around the pulmonary vein. The challenge of intracardiac-sized transducers is achieving high intensities (300-5000 W/cm2) needed to raise the temperature of the tissue above 43 degrees C. In this paper, we demonstrate the feasibility of an intracardiac-sized transducer for treatment of atrial fibrillation. In simulations and proof-of-concept experiments, we show a 37 degrees C temperature rise in the lesion location and demonstrate the possibility of lesion imaging.     

Integrated catheter for 3-D intracardiac echocardiography and ultrasound ablation

A catheter device with integrated ultrasound imaging array and ultrasound ablation transducer is introduced. This device has been designed for use in interventional cardiac procedures in which the cardiac anatomy is first imaged using real-time three-dimensional (3-D) ultrasound, then ablated to treat arrhythmias. The imaging array includes 112 elements operating at 5.4 MHz arranged in a 2-D matrix. Individual elements have a bandwidth of 21% and an insertion loss of 80 dB. The array has an azimuth resolution of 12 degrees and an elevation resolution of 8.7 degrees. The ablation transducer is a concentric piezoelectric transducer PZT-4 ring (outside diameter (O.D.), 4.5 mm, inside diameter (I.D.), 3.1 mm) operating at 10 MHz that surrounds the imaging array. It can produce a spatial-peak, temporal-average intensity up to 16 W/cm2. The entire device fits into a 9 Fr lumen with a 14 Fr tip to accommodate the ablation ring. With this device we have imaged, in realtime 3-D, a variety of targets including wire phantoms, fixed sheep hearts, and fresh bovine tissue. The ablation ring has been used to heat tissue-mimicking rubber 14 degrees C, as well as create lesions in fresh bovine tissue.     

Real-time 3-D ultrasound guidance of interventional devices

We have previously developed 2-D array transducers for many real-time volumetric imaging applications. These applications include transducers operating up to 7 MHz for transthoracic imaging, up to 15 MHz for intracardiac echocardiography (ICE), 5 MHz for transesophageal echocardiography (TEE) and intracranial imaging, and 7 MHz for laparoscopic ultrasound imaging (LUS). Now we have developed a new generation of miniature ring-array transducers integrated into the catheter deployment kits of interventional devices to enable real-time 3-D ultrasound scanning for improved guidance of minimally invasive procedures. We have constructed 3 new ring transducers. The first consists of 54 elements operating at 5 MHz. Typical measured transducer element bandwidth was 25%, and the 50 Ohm round trip insertion loss was -65 dB. Average nearest neighbor cross talk was -23.8 dB. The second is a prototype 108-element transducer operating at 5 MHz. The third is a prototype 108-element ring array with a transducer center frequency of 8.9 MHz and a -6 dB bandwidth of 25%. All transducers were integrated with an 8.5 French catheter sheath of a Cook Medical, Inc. vena cava filter deployment device.     

Synthetic phased arrays for intraluminal imaging of coronaryarteries

A 64-element, high efficiency, ceramic piezoelectric array transducer operating at 20 MHz has been constructed for ultrasonic intraluminal imaging. The array is mounted on the surface of a 1.2 mm diameter catheter appropriate for coronary artery applications. Integrated into the catheter tip is a custom analog chip set permitting complete data capture from the array. That is, on each firing any combination of array elements can be selected independently as transmitter or receiver. Using data acquired in this way, a complete phased array aperture (i.e., independent transmit and receive apertures) can be synthesized. Reconstruction hardware based on a custom application specific integrated circuit (ASIC) has been designed and built to produce real-time images. Beam forming coefficients are derived using an optimal filtering approach accounting for the circular geometry of the array. Simulated and measured beam patterns for this system are compared. In addition, images of coronary anatomy acquired with the real-time system are displayed demonstrating the marked image quality improvement compared to previous synthetic aperture intraluminal systems     

Elevation performance of 1.25D and 1.5D transducer arrays

Present 1D phased array probes have outstanding lateral and axial resolution, but their elevation performance is determined by a fixed aperture focused at a fixed range. Multi-row array transducers can provide significantly improved elevation performance in return for “modest” increases in probe and system complexity. Time domain simulations of elevation beam profiles are used to compare several types of multi-row probes. The elevation aperture of a 1.25D probe increases with range, but the elevation focusing of that aperture is static and determined principally by a mechanical lens with a fixed focus (or foci). 1.25D probes can provide substantially better near- and far-field slice thickness performance than 1D probes and require no additional system beamformer channels. 1.5D, probes use additional beamformer channels to provide dynamic focusing and apodization in elevation. 1.5D probes can provide detail resolution comparable to, and contrast resolution substantially better than, 1.25D probes, particularly in the mid- and far-field. Further increases in system channel count allow the use of 1.75D and 2D arrays for adaptive acoustics and two-dimensional beam steering. Significant improvements in clinical image quality can be expected as multi-row probes become increasingly available in the marketplace     

Direct writing of microlenses in polycarbonate with excimer laser ablation

A method for fabricating microlenses in polycarbonate material is reported. Using a direct-write technique based on scanning excimer laser ablation with a circular beam, we can etch an arbitrary shape in the polymer material. The beam is obtained by imaging a circular aperture onto the polymer surface, and scanning is realized by the translation stage carrying the sample, which makes successive contours with well-chosen diameters and scan velocities. Afterward, to smooth the ablated surface and release it from debris, a large beam aperture covering the full lens area is used to ablate the lens deeper into the substrate. The fabrication process and the characterization method are described, including calculation of the contour set for a desired lens shape. The optical performance is evaluated by Mach-Zehnder interferometry, showing that aberrations below lambda/10 are possible for slow lenses.     

用于毫米波焦面阵成像系统的扩展半球介质透镜

毫米波成像是近年来毫米波领域的一个研究热点,而焦面阵成像因其具有实时成像的优点更加受到重视。中分析可用为面阵成像的扩展半球介质透镜。这种焦面阵成像结构将集成天线阵贴附在透镜背面接收透镜聚焦的功率,消除了集成天线工作在毫米波频段时存在的表面波对天线性的影响,具有尺寸紧凑、损耗小的特点。采用Stratton-Chu公式和射线追迹分析了电磁波入射到扩展半球透镜上时在其背面的场分布,即透镜的焦区场分布,以获得透镜用于焦面阵成像时的性能。为验证分析方法的正确性,对平面波垂直入射和会聚高斯束入射两种情形进行了实验验证,实验结果与理论分析吻合较好。该透镜天线还可用来消除常规集成毫米波系统中抛物面天线与集成前端之间的过渡,以降低损耗,改善系统性能,也可用于与准光系统的连接或耦合。该结果将对上述应用提供理论指导。     

Challenges and implementation of radiation-force imaging with an intracardiac ultrasound transducer

Intracardiac echocardiography (ICE) has been demonstrated to be an effective imaging modality for the guidance of several cardiac procedures, including radiofrequency ablation (RFA). However, assessing lesion size during the ablation with conventional ultrasound has been limited, as the associated changes within the B-mode images often are subtle. Acoustic radiation force impulse (ARFI) imaging is a promising modality to monitor RFAs as it is capable of visualizing variations in local stiffnesses within the myocardium. We demonstrate ARFI imaging with an intracardiac probe that creates higher quality images of the developing lesion. We evaluated the performance of an ICE probe with ARFI imaging in monitoring RFAs. The intracardiac probe was used to create high contrast, high resolution ARFI images of a tissue-mimicking phantom containing stiffer spherical inclusions. The probe also was used to examine an excised segment of an ovine right ventricle with a RFA-created surface lesion. Although the lesion was not visible in conventional B-mode images, the ARFI images were able to show the boundaries between the lesion and the surrounding tissue. ARFI imaging with an intracardiac probe then was used to monitor cardiac ablations in vivo. RFAs were performed within the right atrium of an ovine heart, and B-mode and ARFI imaging with the intracardiac probe was used to monitor the developing lesions. Although there was little indication of a developing lesion within the B-mode images, the corresponding ARFI images displayed regions around the ablation site that displaced less.     

Improvement of chromatic aberration of a plastic rod lens array. 1. Combination-color lens arrays consisting of several kinds of rod lenses with different gradient constants and different color filter functions

We propose a new type of rod lens array with improved chromatic aberration. The new rod lens array consists of several kinds of rod lenses with different gradient constants and different color filter functions. The gradient constant of each lens was prepared such that the total conjugate length was identical to the specific wavelength of the lens with a constant lens length. We call our new type of rod lens array a combination-color lens array. The characteristics of this color-type lens array are as follows: high angular aperture, short focal length, and ease of production with established procedures. The optical resolution of the rod lens array is 300 dpi in a wide wavelength range that is high enough to be applied to color scanners.     

Sound field calculations for an ultrasonic linear phased array with a spherical liquid lens

Lenses are often used to provide focusing in the elevation dimension of ultrasonic linear phased-array transducers. The use of a liquid lens in this application adds a variable geometric focusing capability, determined by the radius of curvature of the lens surface and speed of sound in the liquid, to the electronic focusing produced by the linear phased array. An efficient method to calculate the sound field radiated from the linear phased-array transducer through the liquid lens is presented. It treats the lens surface as a secondary source distribution according to Huygens's principle, and employs a modified form of the rectangular radiator method to calculate the field. The appropriate phases for the array elements to focus and steer the beam are calculated by considering the refraction on the lens surface. Comparisons of computer simulations and experimental measurements of the field intensity distribution of a prototype linear array transducer with a liquid lens demonstrate the accuracy of the proposed method.     

Graded-index fiber lens proposed for ultrasmall probes used in biomedical imaging

The quality and parameters of probing optical beams are extremely important in biomedical imaging systems both for image quality and light coupling efficiency considerations. For example, the shape, size, focal position, and focal range of such beams could have a great impact on the lateral resolution, penetration depth, and signal-to-noise ratio of the image in optical coherence tomography. We present a beam profile characterization of different variations of graded-index (GRIN) fiber lenses, which were recently proposed for biomedical imaging probes. Those GRIN lens modules are made of a single mode fiber and a GRIN fiber lens with or without a fiber spacer between them. We discuss theoretical analysis methods, fabrication techniques, and measured performance compared with theory.     

Optimization of a piezoelectric linear motor in terms of the contact parameters

The contact kinetics of piezoelectric linear motors determines the operational characteristics like speed and torque or transmitted mechanical power and efficiency. Piezoelectric linear motors are driven by tangential stress in the interface between tip of shaking beam and slider. A good contact between the tip and slider is necessary for a reliable analysis of the motor, which is needed for the optimization of its performance. The piezoelectric linear motor was fabricated and the characteristics of the motor were investigated by external conditions such as tip shape with different curvatures and contact force between the tip and the slider. It was found in this investigation that the optimal curvature of the tip and the contact force are curvature of 1 and 10, respectively, for the high actuating speed, and curvature of 1 and 40 N, respectively, for the high actuating force. Finally, tip shape has an influence on the characteristics of linear motor.     

Integration of scanning probes and ion beams

We report the integration of a scanning force microscope with ion beams. The scanning probe images surface structures non-invasively and aligns the ion beam to regions of interest. The ion beam is transported through a hole in the scanning probe tip. Piezoresistive force sensors allow placement of micromachined cantilevers close to the ion beam lens. Scanning probe imaging and alignment is demonstrated in a vacuum chamber coupled to the ion beam line. Dot arrays are formed by ion implantation in resist layers on silicon samples with dot diameters limited by the hole size in the probe tips of a few hundred nm.     

Real-time rectilinear volumetric imaging

Current real-time volumetric scanners use a 2-D array to scan a pyramidal volume consisting of many sector scans stacked in the elevation direction. This scan format is primarily useful for cardiac imaging to avoid interference from the ribs. However, a real-time rectilinear volumetric scan with a wider field of view close to the transducer could prove more useful for abdominal, breast, or vascular imaging. In previous work, computer simulations of very sparse array transducer designs in a rectilinear volumetric scanner demonstrated that a Mills cross array showed the best overall performance given current system constraints. Consequently, a 94×94 Mills cross array including 372 active channels operating at 5 MHz has been developed on a flexible circuit interconnect. In addition, the beam former delay software and scan converter display software of the Duke volumetric scanner were modified to achieve real-time rectilinear volumetric scanning consisting of a 30-mm×8-mm×60-mm scan at a rate of 47 volumes/s. Real-time rectilinear volumetric images were obtained of tissue-mimicking phantoms, showing a spatial resolution of 1 to 2 mm. Images of carotid arteries in normal subjects demonstrated tissue penetration to 6 cm     

Numerical analysis of astigmatism correction in gradient refractive index lens based optical coherence tomography catheters

Endoscopic optical coherence tomography (OCT) catheters comprise a transparent tube to separate the imaging instrument from tissues. This tube acts as a cylindrical lens, introducing astigmatism into the beam. In this report, we quantified this negative effect using optical simulations of OCT catheter devices, and discuss possible compensation strategies. For esophageal imaging, the astigmatism is aggravated by the long working distance. For intracoronary imaging, the beam quality is degraded due to the liquid imaging environment. A nearly circular beam profile can be achieved by a curved focusing optics. We also consider the method of matching refractive indices, and it is shown to successfully restore a round beam.     

Volumetric real-time imaging using a CMUT ring array

A ring array provides a very suitable geometry for forward-looking volumetric intracardiac and intravascular ultrasound imaging. We fabricated an annular 64-element capacitive micromachined ultrasonic transducer (CMUT) array featuring a 10-MHz operating frequency and a 1.27-mm outer radius. A custom software suite was developed to run on a PC-based imaging system for real-time imaging using this device. This paper presents simulated and experimental imaging results for the described CMUT ring array. Three different imaging methods--flash, classic phased array (CPA), and synthetic phased array (SPA)--were used in the study. For SPA imaging, two techniques to improve the image quality--Hadamard coding and aperture weighting--were also applied. The results show that SPA with Hadamard coding and aperture weighting is a good option for ring-array imaging. Compared with CPA, it achieves better image resolution and comparable signal-to-noise ratio at a much faster image acquisition rate. Using this method, a fast frame rate of up to 463 volumes per second is achievable if limited only by the ultrasound time of flight; with the described system we reconstructed three cross-sectional images in real-time at 10 frames per second, which was limited by the computation time in synthetic beamforming.     

密集型矩形阵列参数对激光Lamb波成像的影响分析

激光超声技术具有非接触、检测效率高等优点,在无损检测领域受到广泛关注;充分利用激光超声技术的高空间分辨率特性,结合密集型矩形阵列和激光Lamb波技术进行板中缺陷检测。采用连续小波变换对频带宽、时域分辨率低的激光Lamb波信号进行提取,得到特定频率下具有高时域分辨率的窄带信号;利用线性映射补偿技术消除所提取窄带信号中的频散,消除频散的信号用于缺陷成像;最后,结合幅值成像技术和符号相干因子成像技术对频散补偿后的信号进行处理,实现铝板中缺陷的成像和定位。在此基础上,进一步对不同的阵元数量和阵元间距对密集型矩形阵列指向性和缺陷成像质量的影响进行分析。当阵元数量为16,阵元间距为一个Lamb波波长时,主瓣宽度较窄且没有栅瓣出现,缺陷成像质量得到有效提高。     

菲涅尔型阵列光纤准直器的研究

菲涅尔透镜列阵，具有易阵列化的优点，设计中心波长相同的透镜列阵和中心波长不同的透镜列阵，并对由此列阵构成的准直器的光束耦合特征进行分析和计算，与通用的准直器的相关参数进行比较，表明菲涅尔透镜列阵在光束准直耦合中具有较高的耦合效率，可以用于制作阵列光纤准直器。     

Fabrication and characterization of probes for combined scanning electrochemical/optical microscopy experiments

A technique that combines scanning electrochemical microscopy (SECM) and optical microscopy (OM) was implemented with a new probe tip. The tip for scanning electrochemicaVoptical microscopy (SECM/OM) was constructed by insulating a typical gold-coated near-field scanning optical microscopy tip using electrophoretic anodic paint. Once fabricated, the tip was characterized by steady-state cyclic voltammetry, as well as optical and electrochemical approach experiments. This tip generated a stable steady-state current and well-defined SECM approach curves for both conductive and insulating substrates. Durable tips whose geometry was a ring with < 1 microm as outer ring radius could be consistently fabricated. Simultaneous electrochemical and optical images of an interdigitated array electrode were obtained with a resolution on the micrometer scale, demonstrating good performance of the tip as both an optical and an electrochemical probe for imaging microstructures. The SECM feedback current measurements were successfully employed to determine tip-substrate distances for imaging.