Latent structure and factorial invariance of a neuropsychological test battery for the study of preclinical Alzheimer's disease.

Objective: To examine the latent structure of a test battery currently being used in a longitudinal study of asymptomatic middle-aged adults with a parental history of Alzheimer's disease (AD) and test the invariance of the factor solution across subgroups defined by selected demographic variables and known genetic risk factors for AD. Method: An exploratory factor analysis (EFA) and a sequence of confirmatory factor analyses (CFA) were conducted on 24 neuropsychological measures selected to provide a comprehensive estimate of cognitive abilities most likely to be affected in preclinical AD. Once the underlying latent model was defined and the structural validity established through model comparisons, a multigroup confirmatory factor analysis model was used to test for factorial invariance across groups. Results: The EFA solution revealed a factor structure consisting of five constructs: verbal ability, visuospatial ability, speed & executive function, working memory, and verbal learning & memory. The CFA models provided support for the hypothesized 5-factor structure. Results indicated factorial invariance of the model across all groups examined. Conclusions: Collectively, the results suggested a relatively strong psychometric basis for using the factor structure in clinical samples that match the characteristics of this cohort. This confirmed an invariant factor structure should prove useful in research aimed to detect the earliest cognitive signature of preclinical AD in similar middle aged cohorts. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Structural constraints on process explanations in cognitive aging.

Much of the current research in the area of cognitive aging has been focused on investigating specific processes presumed to be responsible for the age differences observed in particular cognitive tasks. A central thesis of this article is that age-related effects on cognitive variables seldom occur in isolation, and hence, they are best interpreted in the context of the structural interrelations that exist among variables and the relations of age on that organizational structure. Results from analyses of 2 separate data sets suggest that large proportions of the age-related effects across a wide range of cognitive variables are shared and that independent, or unique, age-related effects often contribute relatively little to the age differences observed in many cognitive variables. These findings imply that it is important to consider the structure within which a variable occurs when attempting to investigate the processes responsible for age-related differences on that variable. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Problem behaviors associated with deletion Prader-Willi, Smith-Magenis, and cri du chat syndromes

Many studies have failed to determine a systematic dose-response relationship across different cognitive tasks between caffeine and EEG power spectra. However, a nonlinear approach to EEG analysis, which reconstructs a multi-dimensional state space from each electrode recording, can be used to compute the number of active degrees of freedom in the signal (the correlation dimension, D2), and can be interpreted as a measure of signal complexity. This study attempted to determine a consistent dose-response relationship between caffeine and EEG D2, across six oral caffeine doses (100-600 mg), with each subject acting as their own control, to create a probabilistic bias against finding any consistent linear or nonlinear dose-response relationship across different cognitive tasks. The experiment (n = 10) was conducted with three within-subjects explanatory variables, 2 (experimental, placebo) x 8 (caffeine level) x 4 (type of cognitive task performed), with EEG D2 as the response variable, measured from Fz, F3, F4 and Cz. A significant three-way interaction was found [F(21,245.3) = 3.65, P = 0.001]. Regression analyses revealed a linear trend for the response variable across trials for the placebo condition (average R2 = 0.54), whereas linear+quadratic trends explained an average 30% of the variance for the experimental condition, compared to 0.01% for the linear fit, indicating a robust quadratic dose-response relationship between caffeine and EEG D2. Three conditions had positive quadratic co-efficients, and one condition had a negative quadratic co-efficient. These results are discussed in terms of the implications for brain dynamics, and with respect to recent criticisms of the computation of D2 from EEG.     

Validity of MMPI-2 profiles in chronic back pain patients: differences in path models of coping and somatization

OBJECTIVE: To show clinical utility and empirical validity of Minnesota Multiphasic Personality Inventory-2 (MMPI-2) chronic pain patient subgroups by identification of differential multivariate relationships across groups. METHOD: This study used structural equation modeling to test cognitive coping strategies and somatization as mediator variables in path models with pain severity and depression used as exogenous (independent) variables and patient's activity level as the final endogenous (dependent) variable, across MMPI-2 profiles. RESULTS: Hierarchical cluster analysis, performed on a sample of 569 chronic low back patients, resulted in four cluster profiles identifiable as those found in previous work with the MMPI-2 (within normal limits, V-type, neurotic triad, and depressed-pathological). Somatization mediated the relationship between depression and activity level for the neurotic triad group but not the other three groups. A positive linear relationship was found between somatization and depression for the within normal limits, neurotic triad, and depressed-pathological groups, whereas their linear association was negative for the V-type group. Cognitive coping strategies mediated the relationship between depression and activity level for the within normal limits group. In addition, cognitive coping was predictive of activity level for the within normal limits, V-type, and neurotic triad groups but not for the depressed-pathological group. CONCLUSION: Consistent with previous cluster analytic studies, this study replicated four MMPI-2 cluster profile groups in chronic pain patients. These results have also shown that several multivariate relationships between variables are different across MMPI-2 groups, providing evidence for the validity for these MMPI-2 subgroups.     

Independence of age-related influences on cognitive abilities across the life span

Age-related increases in childhood and age-related decreases in adulthood have been reported for a wide variety of cognitive variables, but relatively little research has addressed the question of the independence of these influences. In this project, cross-sectional life span data (age 5 to 94 years) from the nationally representative sample used to establish the norms for the Woodcock-Johnson Psycho-Educational Battery (R. W. Woodcock & M. B. Johnson, 1989, 1990) were subjected to several types of analyses. The results indicated that the majority of age-related differences appear to be shared across different cognitive variables and are well predicted by individual differences in higher order factors. These findings suggest that the role of task-specific interpretations of developmental differences in cognition needs to be reevaluated to take into consideration the lack of independence of age-related influences on a variety of cognitive variables.     

Non-selective effects of amiloride and its analogues on ion transport systems and their cytotoxicities in cardiac myocytes

Qualitative research is now published across the family practice and medical literature. This article is designed to help busy family physicians decide which qualitative studies are worth reading and to provide them with the tools to appreciate and evaluate research design and analysis. By using clinical analogies, the qualitative research process can be better understood.     

A decade review of college teaching research: 1970–1980.

Reviews research by Canadian psychologists on college and university teaching in 1970–1980. One group of studies investigated the effectiveness of various instructional innovations, ranging from the learning cell to educational TV. A 2nd body of research focused on the evaluation of effective teaching, especially the reliability and validity of teacher rating forms. A 3rd research approach examined the characteristics of learners, teachers, and courses, including such factors as the background and attitudes of both faculty and students, student achievement, personality and cognitive variables among learners, the training of teachers, and the content and structure of courses. Three general questions are discussed in the light of the available research evidence: whether Canadian research on college teaching can be considered unique, whether it is significant, and whether it has affected psychological theory or teaching practice. (French abstract) (70 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Empirical investigation of the cognitive mediational paradigm for research on counseling.

Examined relations among counselor and client cognitions, behaviors, and ratings in 29 counseling sessions involving 10 different counselor–client pairs, using stimulated recall and content analysis. Clients were university students; there were 4 counselors with 7–25 yrs' experience and 3 who were counseling interns. The design of the study permitted assessments of the impact of counselor experience (novice vs experienced) and stage of counseling (early, middle, and end) on these variables. Consistency in various parts of the sequential chain of counselor intention (counselor behavior, client perceptions of counselor intention and behavior, client cognitive processing, and client behavior) was lower for interpersonal cognitive than for interpersonal behavioral or intrapersonal cognitive–behavioral links. Consistency across different elements in this chain was observed to account for a significant proportion of the variance in counselor ratings of session effectiveness. Consistent, interpretable patterns observed across counselor intentions, counselor behaviors, and client cognitive processing are discussed. Relatively few effects of stage of counseling or of counselor experience were observed. (32 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Physical fitness training and mental health.

Reviews theory and research that have attempted to relate fitness training to improvements on psychological variables among normals as well as selected clinical populations. Theoretical speculations in this area are critiqued, and research designs are evaluated as either experimental or quasi-experimental and therefore interpretable, or preexperimental and therefore largely uninterpretable. The research suggests that physical fitness training leads to improved mood, self-concept, and work behavior; the evidence is less clear as to its effects on cognitive functioning, although it does appear to bolster cognitive performance during and after physical stress. Except for self-concept, personality traits are not affected by improvements in physical fitness. Mentally retarded children demonstrate psychological improvement following physical fitness training, but no conclusion can be reached regarding the effects of physical fitness training with other clinical syndromes. (2? p ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Cognitive and family therapies for adolescent depression: Treatment specificity, mediation, and moderation.

The specificity of cognitive and family therapies, and potential treatment mediators and moderators, was examined in a randomized clinical trial for adolescent depression. After acute treatment, cognitive-behavioral therapy (CBT) exerted specific effects on cognitive distortions relative to either systemic-behavioral family therapy (SBFT) or nondirective supportive therapy (NST). At 2-year follow-up, SBFT was found to impact family conflict and parent–child relationship problems more than CBT; NST and CBT tended to show a greater reduction in anxiety symptoms than SBFT. Nonspecific therapist variables qualified few outcome analyses. No measures of cognitive distortion or family dysfunction mediated or moderated treatment outcome. As in adult studies, relatively few areas of treatment specificity or mediation were identified. The implications of these findings for clinical treatment and research in adolescent depression are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Nonparametric alternatives for testing main effects hypotheses: A model for combining data across independent studies.

Describes G. A. Mack and J. H. Skillings's (1980) and A. Benard and P. Van Elteren's (1953) forms of the combined Kruskal-Wallis test, 2 nonparametric tests that can be used to make comparisons across K groups in a design with B blocks or in B independent studies. It is suggested that the dependent variables across studies may be alternative measures of the same underlying construct, and an application of the models to B. G. Davis's (1972, 1974) data on the clinical skills of 3 groups of nurses is described. (12 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Psychosocial functioning and depression: Distinguishing among antecedents, concomitants, and consequences.

In this article we attempt to distinguish empirically between psychosocial variables that are concomitants of depression, and variables that may serve as antecedents or sequelae of this disorder. We review studies that investigated the relationship between depression and any of six psychosocial variables after controlling for the effects of concurrent depression. The six variables examined are attributional style, dysfunctional attitudes, personality, social support, marital distress, and coping style. The review suggests that whereas there is little evidence in adults of a cognitive vulnerability to clinical depression, disturbances in interpersonal functioning may be antecedents or sequelae of this disorder. Specifically, marital distress and low social integration appear to be involved in the etiology of depression, and introversion and interpersonal dependency are identified as enduring abnormalities in the functioning of remitted depressives. We attempt to integrate what is known about the relationships among these latter variables, suggests ways in which they may influence the development of depression, and outline specific issues to be addressed in future research. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Meta-analysis of facial identification studies.

Presents a meta-analysis of 128 eyewitness identification and facial recognition studies involving 960 experimental conditions and 16,950 Ss. The meta-analysis was designed to determine what knowledge has been accumulated on factors that influence facial identification performance and what areas of facial identification research would benefit from further research. Two techniques were used: an effect size analysis, which integrates the effect sizes of independent variables across studies, and a study-characteristics analysis, which integrates the influence of study characteristics on performance. A number of variables operating at the encoding and retrieval stages yielded large effects on performance. These variables included context reinstatement, transformations in the appearance of faces, depth of processing strategies, target distinctiveness, and elaboration at encoding. Additional variables yielding strong effects on recognition performance were exposure time, cross-racial identification, and retention interval. There was little correspondence between a variable's impact on hit rate and false-alarm rate. A list of the studies used in the meta-analysis is appended. (49 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Cognitive dissonance.

This article reviews critically the experimental evidence in support of cognitive dissonance theory as applied to complex social events. The criticisms which can be made of this literature fall into 2 main classes. 1st, the experimental manipulations are usually so complex and the crucial variables so confounded that no valid conclusions can be drawn from the data. 2nd, a number of fundamental methodological inadequacies in the analysis of results—as, e.g., rejection of cases and faulty statistical analysis of the data—vitiate the findings. As a result, one can only say that the evidence adduced for cognitive dissonance theory is inconclusive. Suggestions are offered for the methodological improvement of studies in this area. The review concludes with the thesis that the most attractive feature of cognitive dissonance theory, its simplicity, is in actual fact a self-defeating limitation. (44 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease

The relationship between progressive cognitive decline and underlying neuropathology associated with Alzheimer s disease (AD) is a key issue in defining the mechanisms responsible for functional loss. This has been a subject of much controversy, with separate studies comparing various clinical and neuropathological indices in AD. Further, it is difficult to compare studies with differences in histochemical staining protocols, brain regions examined, and data quantification criteria. There are many difficulties in designing a clinical-pathological correlative study involving AD patients. It is necessary to control for several key parameters. For example, a broad range of cognitively impaired subjects is needed, as well as short postmortem delays, brief intervals between cognitive testing and death, and the most sensitive detection and quantification techniques. In this study, we carefully controlled for each of these parameters to determine if there is a relationship between global cognitive dysfunction and multiple neuropathological indices. We selected 20 individuals representing a broad range of cognitive ability from normal to severely impaired based on the MMSE, Blessed IMC, and CDR. We counted plaque number, NFT number, dystrophic neurite number, and the relative extent of thioflavine positive plaques and neuritic involvement within plaques. We also quantified cortical area occupied by beta-amyloid immunoreactivity (A beta Load) and PHF-1 positive neuropil threads and tangles (PHF Load) using computer-based image analysis. Interestingly, we found that most pathologic measures correlated highly with the severity of dementia. However, the strongest predictor of premortem cognitive dysfunction on all three cognitive measures was the relative area of entorhinal cortex occupied by beta-amyloid deposition. In conclusion, our data show that in a carefully controlled correlative study, a variety of neuropathological variables are strongly correlated with cognitive impairment. Plaque related variables may be as strongly related to cognitive dysfunction as other established measures, including synapse loss, cell death and tau hyperphosphorylation, although no correlative study can demonstrate causality.     

Socialization and the altruistic behavior of children.

Reviews recent research into altruistic behavior by children, utilizing 4 major sections. The 1st concerns the generality of children's social altruism across behavioral situations. The 2nd concerns person variables with particular emphasis on age and the cognitive/developmental variables of moral judgment and role taking. The 3rd discusses environmental variables and involves more or less direct attempts to demonstrate socializing processes at work. Items dealt with are reinforcement, the role of models, training in role taking, and verbal socialization procedures such as preaching and induction. Finally, theory is considered with particular emphasis on social learning and cognitive development. (2 p ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Reappraisal of the A-B therapist "type" distinction in terms of the Personality Research Form.

Assessed personality dimensions involved in the A-B therapist "type" distinction which has proven predictive of therapist-patient compatibility in several clinical and analogue studies. The A-B scale scores of 223 male undergraduates were related to the 22 variables of Jackson's Personality Research Form. Multiple discriminant analyses and factor analyses strongly supported the hypothesis that A-B status is explicable in personality terms: so-called A-type Ss (predicted to be compatible with schizoid patients) were characterized by cautious self-expression, social ineptness, and a restricted cognitive scope; B-type Ss (presumably compatible with neurotic patients) appeared socially ascendant and "open" to complex experiences. Results were supported by a cross-validation study of 50 professional Ss. As in prior research, the variables differentiating A-B statuses appeared to involve a prominent "masculinity-femininity" component. (30 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Cognitive, behavioral, and family factors in the differentiation of depressive and anxiety disorders during childhood.

Contribution of cognitive, behavioral, and family environment variables to the differentiation of depressive and anxiety disorders in children was explored. 59 children from Grades 4–7 (14 diagnosed with a depressive disorder, 16 diagnosed with depressive and anxiety disorders, 11 diagnosed with an anxiety disorder, and 18 nondisturbed controls) completed measures of the depressive cognitive triad, depressive cognitions, social skills, family environment, and maladaptive family messages. Results of a stepwise discriminant function analysis indicated that 2 discriminant functions composed of 7 variables from the cognitive, behavioral, and family environment domains accounted for 91% of the between-groups variance. Results suggest that depressive disorders can be distinguished from anxiety disorders on the basis of ratings of cognition, social skills, and family environment. Implications for existing research and a model of depression during childhood are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)