Risk factors for developing asthma and allergic rhinitis. A 7-year follow-up study of college students

Nine hundred three former college freshmen were followed 7 yr after entering college by means of a detailed allergy questionnaire. Original data collected from the students as freshmen, including a history of atopy and allergy skin test results, were evaluated in relation to the frequency of developing new allergies. During the 7-yr follow-up period, new cases of hay fever occurred in 12.6%, nonseasonal allergic rhinitis in 4.8%, and new asthma in 2.5%. The risks of developing asthma and allergic rhinitis are both significantly associated with a prior positive allergy skin test. The risk of developing asthma, not hay fever, is significantly associated with a prior history of atopy. The association of positive allergy skin tests with the development of new cases of allergy remains significant throughout the 7-yr follow-up period. However, individuals who had all negative skin tests developed significantly fewer new cases of clinical allergy during the first 3 yr of follow-up; in the next 4 yr of the 7-yr follow-up, increased numbers of individuals with negative scratch tests developed new cases of allergy. Thus, negative skin tests proved of less prognostic value during the last 4-yr period of this 7-yr study, although significant differences still are apparent between the positive and negative reactor groups.     

Retention in situ and spectral analysis of fluorescent vacuole components in sections of plant tissues

This paper describes an educational programme where clinical guidelines are used in dental education and assesses the value of these guidelines as perceived by undergraduate students. It presents a comparison of students' own assessments of their performance with those of their instructors, according to such guidelines. The educational programme at the Faculty of Odontology, Lund University, is described through 3 main principles: problem-based learning, adoption of a holistic attitude to patient care and the promotion of oral health. The dental curriculum occupies 5 years comprising 10 semesters. 41, 5th semester students (16 male and 25 female) participated in the study. Students were introduced to guidelines in group discussions at the beginning of the semester. At the completion of a patient's planned course of treatment, the outcome was formally assessed both by students and clinical instructors. Performance was scored in various categories as "excellent", "acceptable" or "unacceptable" according to the standards defined. A total of 1373 scores were made by both students and instructors. 88% cent of students used the guidelines often or almost always and found them useful. Overall, no students received an "unacceptable" score and 40% of students achieved a score of "excellent". Female students tended towards a higher score, but this was not significant. Instructors' and students' scores agreed in almost 90% of instances. Students under-scored their performance more frequently than they over-scored it. It appears that the use of clinical guidelines may encourage an increased awareness of the decision-making processes involved in clinical practice, but it must be acknowledged that these guidelines are complex both in derivation and application.     

Evaluation of the allergenicity of spore and mycelia extracts of Pisolithus tinctorius

The antigenic and allergenic chemical analysis of spore and mycelia extracts of Pisolithus tinctorius was carried out. The spores were collected from basidiocarps in plantations of Eucalyptus spp and the mycelia from culture in MNM medium. With basis on the fungus growth curve, the mycelia masses were obtained after 10, 20, 30, and 40 days of incubation, which correspond, respectively, to the beginning, middle and end of the log phase, and beginning of the decline phase. The mycelia masses, together with the spores, were submitted to the action of three extractors (Coca, Tris-HCl, and ammonium bicarbonate). The contents of carbohydrates and proteins were determined. The SDS-PAGE electrophoretical analysis revealed separate fractions in these extracts, besides common fractions, in function of cultivation time and extraction methods. The selected extracts for the allergic tests were the ones with the highest number of fractions. The prick-tests were conducted in 374 patients--rural workers, eucalyptus plantation workers, and college students. The positivity to the "prick test" with the antigenic extract of P. tinctorius was, respectively, 3.78%, 28.20% and 6.40%. Most prick-test positive patients (82.75%) also presented symptoms of respiratory allergy (asthma and rhinitis). There was no reactivity difference when the spore and mycelia extracts were employed. The analysis of the positive patients' sera revealed the presence of IgE specific to the P. tinctorius antigens. Since Pisolithus tinctorius is found as mycorrhiza of Eucalyptus spp, and this plant is used in reforestation in most countries, the importance of that fungus should be regarded as a possible cause of respiratory allergies, especially in occupationally exposed workers.     

On recruiting graduate students.

"In the fall of 1955, the Committee on Undergraduate Education conducted a questionnaire survey of American colleges regarding their undergraduate psychology programs." About ? of the country's 4 year liberal arts colleges cooperated. 73% of responding institutions offer a major in psychology. About 75% of the colleges offering majors have 1 term courses in introductory psychology, the other 25% have 2 terms 10 colleges require less than 20 semester hours work for the major in psychology, 12 require 35 semester hours or more. Data are also presented in answer to the following questions: (a) How many students enter graduate school each year? (b) What proportion of seniors and senior majors continue into graduate study? (c) Are small colleges better at producing graduate students? (d) Did the survey identify any single variable associated with rate of producing graduate students? (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Expectation and reality in freshman adjustment to college.

Earlier investigations of the "freshman myth" have focused on the differences between expectations and perceptions of the college environment and have shown that entering students typically anticipate more from that environment than is subsequently realized. The present study examined differences between expectations and perceptions of self-assessed adjustment to college to determine whether students also expect more of themselves than is subsequently realized. Occurrence of the myth in this new form was found among college freshmen at 2 colleges. A college adjustment scale was completed by 185 Ss before entering school, in the 8th wk of the 1st semester, and in the 5th wk of the 1st semester at one school. At the other school, an expectations scale was completed by 172 Ss during the orientation period prior to beginning the academic year. The adjustment scale was completed by 258 Ss in the 8th wk of the 2st semester. 123 Ss completed both scales. Differences in occurrence of the myth in various aspects of the adjustment are described, and the possibility of differences in occurrence at the 2 colleges is considered. Evidence concerning the course of the myth over time is presented, and individual differences in and behavioral correlates of the myth are identified. (24 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effects of a creative studies program on structure-of-intellect factors.

Administered a 2-yr sequence of 4 semester-long courses in creative problem solving to college students in an experimental group and gave no training to control students. Each semester emphasized a different aspect of creativity, and effects were assessed at the end of each semester with tests designed to reflect J. P. Guilford's Structure-of-Intellect model. A pretest battery established the initial comparability of 145 experimental and 153 control Ss. 101 experimental and 57 control Ss completed the 4-semester course and/or testing. The training had no significant effect on memory or evaluation operations but significantly improved divergent production, convergent production, and cognition. The data support a multidimensional analysis of creativity, involving not only idea-finding (divergent production) but also knowing (cognition), judging, and implementing ideas (cognition and convergent and divergent production). (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The effect of a new tear substitute containing glycerol and hyaluronate on keratoconjunctivitis sicca

The present study of asthmatic children examined relationships among the frequencies of prior respiratory infections (i.e., those prior to the development of asthma) and recent (past year) respiratory infections, asthma severity, and the impacts of 12 common asthma triggers: air pollution, allergy problems, anger, cigarette smoke, excitement, high humidity, high or low environmental temperature, laughter, nighttime hours, physical activity, respiratory infection, and stress or worry. Data on these variables were obtained through a survey in which 325 families completed questionnaires; 121 families had asthmatic children who were 2-20 years of age. Pearson correlational analyses revealed many significant positive correlations: The frequencies of prior and recent infections were correlated. The frequency of prior infections was correlated with the impacts of all asthma triggers except allergy problems, but the frequency of recent infections was correlated only with the impacts of air pollution, cigarette smoke, respiratory infection, and nighttime hours as triggers of asthma attacks. Asthma severity was correlated with the frequencies of prior and recent respiratory infections and with the impact of respiratory infection as an asthma trigger.     

Rereading Effects Depend on Time of Test.

Previous research has shown better text learning after rereading versus 1 reading of a text. However, rereading effects have only been explored using immediate tests, whereas most students face delays between study and test. In 2 experiments, 423 college students read a text once, twice in massed fashion, or twice with 1 week between trials. Students were tested either immediately or 2 days after study. On an immediate test, performance was greater after massed versus single reading, whereas performance for distributed rereading was not significantly greater than after single reading. On a delayed test, performance was greater after distributed versus single reading, whereas performance for massed rereading and single reading no longer differed significantly. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Reciprocation ideology.

A questionnaire was used to assess college students' ideologies concerning the use of reciprocation for self-gain. Two independent dimensions were found involving beliefs that (a) returning greater help than previously received will result in generous repayments (creditor ideology) and (b) caution in returning help is required to avoid being taken advantage of (reciprocation wariness). The students subsequently took part in a bargaining situation with a partner who possessed low resources or high resources and who was programmed to give a small proportion or a large proportion of those resources. Students who possessed a strong creditor ideology returned greater resources to two kinds of partners: a partner with high resources who acted stingily and a partner with low resources who acted generously. Students with high reciprocation wariness showed reduced responsiveness to their partner's generosity, returning relatively less to a generous partner and more to a stingy partner. The results indicate that individuals differ systematically in their ideology and behavior involving the use of reciprocation for self-gain. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Inhibition of protein synthesis induced by adenine nucleotides requires their metabolism into adenosine

Adverse reactions to food may be mediated by immunological or non immunological mechanisms. The term "food allergy" describes an event in which a definite immunopathological process can be demonstrated and a cause and effect relationship must be present. Symptoms and signs of food allergy may appear in any organ system, depending in part on the age of the subject and on the allergen involved. At present it is generally agreed that the only effective therapy for food allergy is strict elimination of the offending food antigen. Institution of a food elimination diet should be considered comparable to prescribing a medication, which carries along definite risk-benefit ratio. Consequently, appropriate diagnostic measures base on history, skin test, or radioallergosorbent test (Rast) and blind food challenges, must be utilized before implementing special diets. The allergist and other health care professionals must recognize the advantages of elimination diets (improvement of symptoms) as well as disadvantages (increase of the time required to purchase food and prepare meals, impossibility to eat at restaurants, at friends' houses or at school with consequent possible social isolation, nutritional disorders) and choose the most appropriate elimination diet.     

Pluralistic ignorance and alcohol use on campus: Some consequences of misperceiving the social norm.

Four studies examined the relation between college students' own attitudes toward alcohol use and their estimates of the attitudes of their peers. All studies found widespread evidence of pluralistic ignorance: Students believed that they were more uncomfortable with campus alcohol practices than was the average student. Study 2 demonstrated this perceived self–other difference also with respect to one's friends. Study 3 tracked attitudes toward drinking over the course of a semester and found gender differences in response to perceived deviance: Male students shifted their attitudes over time in the direction of what they mistakenly believed to be the norm, whereas female students showed no such attitude changes. Study 4 found that students' perceived deviance correlated with various measures of campus alienation, even though that deviance was illusory. The implications of these results for general issues of norm estimation and responses to perceived deviance are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Preparedness of Engineering Freshman to Inquiry-Based Learning

Educational experts, past and present, urge engineering colleges nationwide to transform their pedagogical paradigm from a predominantly lecture- to an inquiry-based teaching approach. Written comments by two seniors, deploring having to read and write in a required course of an ABET accredited program, highlight a common expectation of today’s students. Presented are the disturbing results of a survey that assessed the level of learning skills exhibited by 1,020 engineering freshmen. Time management not only surfaced as needing drastic remediation but it also correlated with the level of students’ motivation to succeed in college. Problems with poor time management were listed by 25% of the freshman cohort at the end of the first semester. From monitoring the submittals of online homework it was learned that timeliness corresponded with the final grade achieved in a course. The work presented in this paper indicates that universities need not only to address the students’ learning preferences but also equip them with the skills necessary to engage actively in the knowledge-building process, a necessary sea-change in engineering education.     

Group-based motivational interviewing for alcohol use among college students: An exploratory study.

How can practicing psychologists help reduce excessive alcohol consumption among college students? Over 80% of college students consume alcohol, and a significant percentage drinks excessively with myriad problems. Brief interventions based on motivational interviewing (MI) have been identified for use with college populations. The authors randomly assigned 91 freshman students to a brief, classroom-based MI intervention or an assessment control condition. At the end of the semester, MI group participants reported fewer drinks per occasion and fewer episodes of intoxication compared to controls. A classroom-based, MI-style intervention might be an efficient, sustainable, and effective means of reducing heavy drinking among college students. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Motivational level and response to academic encouragement among low-achieving college males.

Investigated the relationship between academic achievement motivation and response to academic encouragement, using 2 different counseling letters. Ss were 150 male college freshmen who had received 1 or 2 failing grades in their 1st semester. Motivation was measured by Biggs' College Opinion Survey Questionnaire. No differences were found between the experimental letter groups and no-contact controls on either posttreatment GPA or on the number of helping sources contacted by the Ss. However, the high-motivation experimental Ss had significantly higher posttreatment GPAs and fewer "F" grades than low-motivation experimental Ss. There were no differences in posttreatment GPAs or number of "F" grades between high- and low-motivation controls. Implications for the role of the university counseling center in future attempts at helping low-achieving college students are discussed. (20 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The role of optimism in social network development, coping, and psychological adjustment during a life transition.

The authors investigated the extent to which social support and coping account for the association between greater optimism and better adjustment to stressful life events. College students of both genders completed measures of perceived stress, depression, friendship network size, and perceived social support at the beginning and end of their 1st semester of college. Coping was assessed at the end of the 1st semester. Greater optimism, assessed at the beginning of the 1st semester of college, was prospectively associated with smaller increases in stress and depression and greater increases in perceived social support (but not in friendship network size) over the course of the 1st semester of college. Mediational analyses were consistent with a model in which increases in social support and greater use of positive reinterpretation and growth contributed to the superior adjustment that optimists experienced. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Meta-analysis of DRD3 gene and schizophrenia: ethnic heterogeneity and significant association in Caucasians

BACKGROUND: Children with asthma may be at increased risk for low immunization rates given that they have recurrent illnesses that often result in acute care visits to their pediatrician, visits to the emergency room, admissions to the hospital, and visits to subspecialists, where immunizations are not routinely administered. OBJECTIVES: To assess immunization rates for routine and influenza vaccines in children with asthma and assess factors that may contribute to delay. METHODS: We conducted a cross-sectional survey of 117 children aged 6 to 48 months with onset of asthma within the first 15 months of life. Subjects were recruited from an allergy and immunology clinic at an urban, tertiary care center. Those judged to have immunization delay did not have the required 4 DTP, 3 OPV, and 1 MMR vaccine by age 24 months (4:3:1 series). Receipt of influenza vaccine was determined for eligible children with moderate to severe asthma. RESULTS: Seventy-four (80%) children had up-to-date immunizations at age 24 months. Those with delay had fewer visits to a subspecialist than those who were up-to-date (1 versus 2 visits P = .010). Twenty-two (25%) of 87 eligible subjects received influenza vaccine. Recipients were more likely to have been hospitalized than nonrecipients (77% versus 49%, P = .022). CONCLUSIONS: Though the majority of young children with asthma were up-to-date for routine immunizations, only 25% of children with moderate to severe asthma received influenza vaccine. Greater efforts must be made by pediatricians and asthma subspecialists to ensure that children with moderate to severe asthma are immunized against influenza virus.     

Drug allergies in the surgical population

Many patients claim to have drug allergies. However, the signs and symptoms of "allergic reactions" are seldom documented and the drug allergies are rarely properly assessed. The goal of this study was to determine the incidence of claimed "drug allergies" in a surgical population. After obtaining institutional approval, the study was carried out at five hospitals affiliated with Dalhousie University. Patients were interviewed by the investigators during the preoperative anaesthetic evaluation over six months and all signs and symptoms of drug reactions were recorded. The validity of the claimed allergy was based on the history. The allergies were assigned to one of three groups: (1) High probability of an allergic reaction: one or more of the signs and symptoms typical of an immunological reaction, with or without a family history, or a history of atopy; (ii) Low probability of an allergic reaction: signs and symptoms of the reaction were predictable reactions or side effects of the drug, without the occurrence of reactions mentioned above; or (iii) Unknown status: no information concerning the reaction of history was available. Of 1818 adult and paediatric patients (914 female/904 male) interviewed, 511 (28.1%) claimed to have one or more drug allergies (a total of 671 allergies). More women than men claimed to have drug allergies (60.3% vs 39.7%) and there was a positive correlation between age, number of medications and reported drug allergies. Antibiotics (50%), opioids (27%), non-steroidal anti-inflammatory agents (10%), and sedatives (5%) accounted for 92% of all claimed drug allergies. Overall, 50% of claimed allergies had a high probability of true allergic reactions.(ABSTRACT TRUNCATED AT 250 WORDS)     

Practitioner and student latex exposure and allergy

Greater application of universal precautions has increased practitioner exposure to chemicals present in personal protective equipment. Of prime concern is the latex present in examination and surgical gloves. A survey concerning latex exposure, allergies, and handwashing was administered to three advanced classes of dental students and was sent to 300 private practitioners in Central Indiana. Results indicate that adverse skin reactions to latex start while in dental school. Problems due to latex gloves were reported by 18.6 percent of the students. Student handwashing materials and methods were adequate, except for inadequate washing time. Adverse skin reactions were reported by 24.1 percent of practitioners wearing latex gloves. Two handwashing problems were noted--inadequate washing time and the common use of water instead of an antimicrobial soap after glove removal. Both students and practitioners reported relatively high levels of personal and family histories of allergy to a variety of sources.     

The diagnosis of drug allergies. Utilizing in vitro mast cell test and IgE inhibition test

With the ever-increasing use of pharmaceuticals and the relatively high risk of developing drug allergies, particularly for patients in hospitals and for ambulatory patients with a history of drug allergy, the need to develop in vitro assays for drug allergy is great. In the early 1970's a mast cell technique was developed for diagnosis of drug allergies. A PRIST inhibition assay has also recently been developed to detect IgE antibodies to drug allergens. This test has also been referred to as the Total IgE Inhibition Test by Specific Drug Allergen, and is a variant of the in vitro RAST Test. In vitro mast cell and IgE inhibition tests are applied for identification of drug and chemical allergens and for their cautious clinical trial to prevent future drug and chemical reactions. Over the last eight years, over 1,300 patients were examined utilizing the mast cell technique. Over 100 drugs were tested, with penicillin, barbiturates, "caine" derivatives and sulfonamides most frequently employed. Of 270 patients with well-defined drug reactions, 190 (70 per cent) gave a positive response to the mast cell test. Eighty-five per cent of sera tested with Type I reactions gave a mast cell response. Of these, a group of 30 patients was studied with PRIST inhibition as well. Procedures for comparative testing of necessary drugs and/or chemicals in cases of high anaphylaxis risk of reaction in the clinical setting, hospital or office are included in the study as well as individual case reports. Mast cell assay coupled with IgE inhibition has been successfully used to diagnose drug and chemical allergic reactions. The incidence of positivity is high when the offending drug causes a Type I allergic reaction. The cases reported indicate that both the Mast Cell and the PRIST inhibition assays are useful for diagnosing and setting the clinical treatment and clinical course of the patient. The mast cell assay would be potentially employed for patient use in hospitals where the incidence of drug allergy is highest and for occupational health in the chemical industry. The greatest potential would be in outpatient care applied to patients with multiple drug allergies in the selection of safe drugs (test negative by both methods, and other clinical studies) for future drug usage.