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α-松油烯为原料的单萜衍生物合成及其构造解析 总被引:6,自引:0,他引:6
把α-松油烯与马来酸酐的分子间Diels-Alder环加成反应产物1-甲基-4-(1-甲基乙基)-双环[2.2.2]-5-辛烯-2,3-二酸酐(1),在甲醇溶剂中,用Raney Ni为催化剂进行加氢,获得了加氢产物1-甲基-4-(1-甲基乙基)-双环[2.2.2]辛烷-2,3-二酸酐(2),然后,对化合物1和2分别进行加水分解反应获得了二羧酸化合物1-甲基-4-(1-甲基乙基)-双环[2.2.2]-5-辛烯-2,3-二羧酸(3)和-个新化合物1-甲基-4-(1-甲基乙基)-双环[2.2.2]辛烷-2,3-二羧酸(4)。用^1HNMR(^1H-^1H Cosy)以及^13CNMR(DEPT,HMQC,HMBC,NNE,INADEQUATE)高分解能核磁共振测定手法对化合物1~4进行了详细的解析和化学位鹈的归属. 相似文献
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2-氯-6,7-二氢喹啉培(5H)-酮是四氢喹啉是一个重要的含氮杂环化合物。文章以2-氯-5,6,7,8-四氢喹啉为原料,经氧化、酯化、水解反应后得到2.氯-5,6,7,8-四氢喹啉-8-醇,再经Anelli氧化后得到总收率为57,8%的目标产物。所得化合物的结构均经核磁和质谱确证。 相似文献
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以顺丁烯二酸酐、氯苯经 Friedle- Crafts反应合成了 1 ,2 -二 (4-氯化苯甲酰基 )乙烯。经 Diels- Alder反应 ,以环戊二烯环合成了含环己烯结构的双氯双酮化合物 :3,6 -亚甲基桥 - 4 ,5 -二 (4-氯化苯甲酰基 )环己烯。并用质谱、红外光谱、氢核磁共振谱、碳核磁共振谱及 Dept1 35谱等方法对化合物进行了表征 ,证明了化合物的结构。该化合物具有不饱和双键结构 ,是制备聚芳醚酮功能高分子材料的理想单体。 相似文献
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4,4’-(4,4’-砜基二苯氧基)二苯甲酰氯(SODBC)的合成 总被引:1,自引:0,他引:1
以对甲基苯酚、4,4’-二氯二苯砜为原料,通过亲核取代反应合成了4,4’-二(4-甲基苯氧基)二苯砜,用高锰酸钾将甲基氧化得到4,4’-(4,4’-砜基二苯氧基)二苯甲酸(SoDBA),后者在二氯亚砜和路易斯碱的催化下合成了4,4’-(4,4’-砜基二苯氧基)二苯甲酰氯(SoDBC)白色固体。用FT-IR、H—NMR、3C—NMR、DSC等对其进行了表征,实验证明该化合物具有预期的结构和较高的纯度。 相似文献
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通过1H-1H COSY、HSQC和HMBC等2D NMR技术对3-三氟甲基-4-[(4-甲基哌嗪-1-基)甲基]苯胺的1H NMR和13C NMR谱进行了全归属,给出了相应的耦合常数。 相似文献
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近年来,手性磷酸被广泛应用于催化不对称反应。通过以手性(R)-BINOL为原料,在联萘骨架的3,3’-位上通过醚化、取代、磷酸化等制备得到喹啉取代的新型含联萘骨架的手性Brnsted酸催化剂。所有化合物的结构用核磁碳谱、氢谱对进行了标征鉴定。我们并对目标化合物的刚性结构进行了讨论。 相似文献
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Assignment of signals in aliphatic region of 1H NMR spectrum for epoxidized natural rubber was carried out through NMR spectroscopy. The epoxidized natural rubber was prepared by epoxidation of purified natural rubber with peracetic acid in latex stage followed by degradation with propanal and ammonium persulfate. The resulting liquid epoxidized natural rubber was characterized through 1D- and 2D-NMR spectroscopy. The unknown signals in the aliphatic region of the 1H NMR spectrum were assigned through 13C NMR and two-dimensional heteronuclear shift correlation (HETCOR) measurement. The assignments were proved by two-dimensional inverse detected heteronuclear long-range shift correlation (HMBC) and two-dimensional homonuclear shift correlation (COSY) measurements, and they were supported with epoxidized squalene as a model compound through NMR spectroscopy. 相似文献
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Several new chiral oligomers of spiro-salenCo(III)X (spiro = 1.1′-spirobiindane-7.7′-diol) complexes have been designed, synthesized, and characterized by nuclear magnetic resonance (NMR), infrared (IR), and elemental analyses, in which, the chiral spiro moieties are first introduced into a scaffold of chiral salenCo catalysts. They were used to catalyze the asymmetric cycloaddition of epoxides with carbon dioxide. Under very mild reaction conditions, a kinetic resolution of racemic epoxides with CO2 was smoothly initiated by these chiral oligomer catalysts with good enantioselectivities, which can be attributed to the match effect between chiral backbones of salen and spiro. High stability and easy recyclability are their major advantages. 相似文献
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磷杂螺环化合物的合成及表征 总被引:4,自引:0,他引:4
合成了双(4 甲撑 2,6,7 三氧杂 1 磷杂双环[2,2,2]辛烷)磷酸三聚氰胺盐(Ⅲ)及2,6,7 三氧杂 1 磷杂双环[2,2,2]辛烷甲醇(Ⅰ)、双(4 甲撑 2,6,7 三氧杂 1 磷杂双环[2,2,2]辛烷)氯代磷酸酯(Ⅱ),三者的得率分别为727%、900%及573%;同时对化合物(Ⅰ)、(Ⅱ)及(Ⅲ)的核磁共振碳谱和红外光谱谱图进行了归属和解析,并得到元素分析的证实 相似文献
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以过量的乙二醇与三氧化二锑进行脱水水反应,用甲苯带水剂将生成的水带出,再进行真空减压除水合成了聚酯催化剂乙二醇锑,并研究了反应物摩尔配比、反应温度对产品收率的影响。采用了元素分析、FT-IR,^1HMR,^13NMR等分析手段表征了目标化合物的分子结构,并对化合物红外光谱及核磁共振谱带进行了归属分析。 相似文献
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The preparation of chiral compounds in enantiomerically pure form is a challenging goal in modern organic synthesis. The use of chiral metal complex catalysis is a powerful, economically feasible tool for the preparation of optically active organic compounds on both laboratory and industrial scales. In particular, the metals coordinated by one or more chiral phosphorus ligands exhibit amazing enantioselectivity and reactivity. Many chiral phosphorus ligands have been synthesized and used in transition-metal-catalyzed asymmetric reactions in past decades. However, a large number of reactions still lack effective chiral ligands, and the enantioselectivities in many reactions are substrate-dependent. The development of effective chiral phosphorus ligands, especially ligands having novel chiral backbones, is still an important task in the area of asymmetric catalysis. Molecules containing a spirocyclic framework are ubiquitous in nature. The synthesis of molecules with this spiro structure can be traced back to 100 years ago. However, the use of this spirocyclic framework to construct chiral phosphorus ligands is a recent event. This Account outlines the design and synthesis of a new family of chiral spiro phosphorus ligands including spiro diphosphines and spiro monodentate phosphorus ligands with 1,1'-spirobiindane and 9,9'-spirobifluorene backbone and their applications in transition-metal-catalyzed asymmetric hydrogenation and carbon-carbon bond formation reactions. The chiral spiro diphosphine lgands SDP with a 1,1'-spirobiindane backbone and SFDP with a 9,9'-spirobifluorene backbone, and the spiro monophosphorus ligands including phosphoramidites, phosphites, phosphonites, and phospholane with a 1,1'-spirobiindane backbone were synthesized in good yields from enantiomerically pure 1,1'-spirobiindane-7,7'-diol and 9,9'-spirobifluoren-1,1'-diol. The ruthenium complexes of chiral spiro diphosphine ligands proved to be very effective catalysts for asymmetric hydrogenations of ketones, alpha-arylaldehydes and alpha,beta-unsaturated acids. The rhodium complexes of chiral spiro monophosphorus ligands are highly enantioselective for the asymmetric hydrogenations of alpha- and beta-dehydroamino acid derivatives, alpha-arylethenyl acetamides and non- N-acyl enamines. The spiro monophosphorus ligands were demonstrated to be highly efficient for the Rh-catalyzed asymmetric addition of arylboronic acids to aldehydes and N-tosylarylimines, Pd-catalyzed asymmetric allylation of aldehydes with allylic alcohols, Cu-catalyzed asymmetric ring opening reactions with Grignard reagents, and Ni-catalyzed asymmetric hydrovinylation of styrene derivatives with ethylene. The chiral spiro phosphorus ligands show high enantioselectivities for a wide range of transition-metal-catalyzed asymmetric reactions. In most of these transformations, the enantioselectivities of spiro phosphorus ligands are superior to those obtained by using the corresponding phosphorus ligands with other backbones. These results arise from the intriguing chiral inducement of spiro structures of the ligands. 相似文献
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