矿山投资项目的经济可靠性分析

本文以内部收益率为评价指标,建立了矿山投资项目经济可靠性分析的Monte Carlo和偏差和法的数学模型,并通过一实例分析了矿山投资项目的经济可靠性。     

发挥工程设计在化肥建设中的主导作用

本文从工程设计角度提出了深化设计改革,优化设计技术和设计单位应在化肥工业投资建设中发挥主导作用的具体对策及措施。     

电镀工程设计

电镀工程是一种系统工程。包括工艺及设备、建筑及结构、腐蚀与防护、给水排水及废水处理、废渣处理、排风送风及过滤、采暖供热及气体动力、强电弱电照明信号及自控、总图仓库及运输等专业科研成果择优综合工程化。其中任一专业出现问题,都会牵连到其它专业,直接或间接影响到电镀产品质量和产量,影响经济效益,并涉及到环境效益和社会效益。     

基于制药工程设计竞赛培养学生工程设计能力

基于全国大学生制药工程设计竞赛平台,建立"以赛促教、以赛促学、覆盖全员"的培养学生工程设计能力。以制药工程设计为主线的模式进行培养,设计相关的理论与实践系列课程贯彻整个培养体系。全方位的工程理论与设计分阶段逐步开展,设计竞赛与理论教学、实践教学相辅相成,教学成果显著,为其他地方高校进一步完善和提高培养学生工程设计能力提供了可借鉴的方法与思路。     

矿山生态修复技术方法研究

矿山开采活动在获得最大经济利益的同时,势必给原有的生态环境带来严重破坏和影响。针对单个或小范围废弃矿山,分析露天矿山开采可能引起的地形地貌、土地占用、土壤侵蚀、地表水水质、景观格局等方面对环境的影响,同时,深入研究了露采矿山生态修复治理的工艺技术,包括露采场边坡的治理技术和采空区的生态重建工艺。     

燃气工程设计的合理性研究

燃气工程设计是项目建设的前提和基础,特别是在项目总体规划上,如何从设计的科学性与合理性上推进项目实施的经济学和安全性,显得尤为重要。本文将结合我市燃气工程项目施工实际,从工程项目设计经济性与合理性上提出有效的对策和建议。     

化工工程设计中的安全问题研究

本文首先介绍了化工工程设计中解决安全问题的重要性,接着分析了设计中存在的问题,针对这些问题,最后重点提出了一些预防和解决措施,以期为相关从业人员提供参考。     

整体法兰可靠性优化设计

对法兰进行了可靠性优化设计 ,即将概率统计和优化原理应用于法兰设计 ,以可靠度来保证法兰的安全。把δf、δ1、h、S、p作为随机变量 ,SH、SR、ST 作为约束条件 ,法兰质量作为目标函数 ,通过网格寻优 ,在满足所要求的可靠度的基础上优化法兰尺寸 ,从而减少法兰的质量 ,并用C语言编制了计算程序。将常规设计与可靠性优化设计结果进行比较 ,认为可靠性优化设计是一种有效可行的设计方法     

化工矿山预可行性研究计算机辅助设计系统

概略介绍了该系统的功能、结构、运行方式及控制逻辑结构,以及测试结果。     

露天矿半连续运输系统卸载环节生产分析与设计优化

应用排队论及可靠性等方法,结合矿山实际情况,对露天矿间断一连续运输方式的卸载环节进行了分析和设计优化,得出了一些实用结论。其方法适用于类似矿山,可为矿山的实际决策提供依据。     

The formulation of optimal mixtures with generalized disjunctive programming: A solvent design case study

Systematic approaches for the design of mixtures, based on a computer‐aided mixture/blend design (CAM^bD) framework, have the potential to deliver better products and processes. In most existing methodologies the number of mixture ingredients is fixed (usually a binary mixture) and the identity of at least one compound is chosen from a given set of candidate molecules. A novel CAM^bD methodology is presented for formulating the general mixture design problem where the number, identity and composition of mixture constituents are optimized simultaneously. To this end, generalized disjunctive programming is integrated into the CAM^bD framework to formulate the discrete choices. This generic methodology is applied to a case study to find an optimal solvent mixture that maximizes the solubility of ibuprofen. The best performance in this case study is obtained with a solvent mixture, showing the benefit of using mixtures instead of pure solvents to attain enhanced behavior. © 2016 The Authors AIChE Journal published by Wiley Periodicals, Inc. on behalf of American Institute of Chemical Engineers AIChE J, 62: 1616–1633, 2016     

Small-molecule negative modulators of adrenomedullin: design, synthesis, and 3D-QSAR study

Adrenomedullin (AM) is a peptidic hormone that was isolated in 1993, the function of which is related to several diseases such as diabetes, hypertension, and cancer. Compound 1 is one of the first nonpeptidic small-molecule negative modulators of AM, identified in a high-throughput screen carried out at the National Cancer Institute. Herein we report the synthesis of a series of analogues of 1. The ability of the synthesized compounds to disrupt the binding between AM and its monoclonal antibody has been measured, together with surface plasmon resonance (SPR)-based binding assays as implemented with Biacore technology. These data were used to derive a three-dimensional quantitative structure-activity relationship (3D-QSAR) model, with a q(2) (LOO) value of 0.8240. This study has allowed us to identify relevant features for effective binding to AM: the presence of a hydrogen-bond donor group and an aromatic ring. Evaluation of the ability of selected compounds to modify cAMP production in Rat2 cells showed that the presence of a free carboxylic acid is essential for negative AM modulation.     

The role of gamut,intuition and engagement in colour management in a design context

Colour management is ubiquitous in the digital world. However, despite the many advances in colour management over the last couple of decades, it remains an imperfect process. In the art and design community there is often a level of dissatisfaction and deep cynicism about colour management that can lead to lac of engagement with the process. This research explores colour management in a design context though three issues: the gamut issue, the intuitive issue and the engagement issue; each relates to areas where colour management could better connect with tacit design knowhow. The work focusses on the selection of colour in a digital context since for many users this is the first touch point that they have with colour management. Psychophysical studies have been carried out in both laboratory and design‐studio settings. It is shown that users can better predict the results from subtractive colour mixing than from additive colour mixing. The performance of various types of colour picker are explored and consequences for the design of user interfaces are discussed.     

The use of statistical experimental design procedures in the development and “robust” manufacture of a water-based, corrosion-inhibiting adhesive primer

Details of the statistical experimental design techniques used to prepare a robust, water-based, corrosion-inhibiting, adhesive primer of low toxicity are given and the results are used to illustrate the efficacy of the approach to both manufacture and performance of the end product.     

The use of experimental design for the study of the corrosion of bronze pretreated with AMT in artificial rainwater

Copper and copper alloys (bronze and brass) are usually employed in the manufacturing of cultural objects. When these alloys are exposed to the atmosphere, damaging corrosion products may form on their surfaces. Corrosion inhibitors are used to minimize the corrosion processes. However, the conditions that obtain the best anticorrosive performance of these inhibitors require the control of several chemical and operational parameters, which are, in practice, often chosen empirically. An experimental design was employed to determine the best values with respect to the concentration of 2-amino-5-mercapto-1,3,4-thiadiazole (AMT), the ethanol content and the immersion time of bronze in the AMT solution to achieve the most protective films on the bronze surface. Electrochemical impedance spectroscopy assays of bronze samples with and without previous immersion in the inhibitor solution and exposed to artificial rainwater were performed at the open circuit potential. The parameters and the influence of their interactions on the inhibitory effect of the film formed on the bronze surface were shown to be statistically significant. The conditions for achieving the most protective films were 0.060 M AMT, 90% v/v EtOH, and 90 min of immersion.     

正交设计在溶液浸渍法研制抗氧化石墨材料中的应用

介绍了正交设计在溶液浸渍法研制抗氧化石墨材料中的应用。通过正交设计进行实验,获得浸渍配方、浸渍工艺及热处理工艺的最优方案。实验结果和经正交设计处理的数据相符合。     

The design of experiments,training and implementation of nonlinear controllers based on neural networks

In the area of nonlinear predictive control, several control schemes using artificial neural networks have been proposed. In this work, the issues relating to the information contents of the data used to train the neural network components of these nonlinear predictive control schemes are considered. This raises questions about the design of experiments. A class of feedback-feedforward nonlinear controller based on the model predictive structure (also known as Internal Model Control, IMC, structure) is investigated. The implementation and performance of these neural network based controllers, together with comparisons to other nonlinear and linear controllers, are illustrated on two nonlinear continuous-stirred-tank-reactor simulations.