共查询到20条相似文献，搜索用时 15 毫秒
1.
Juanfeng Ou Kun Liu Jiamiao Jiang Daniela A. Wilson Lu Liu Fei Wang Shuanghu Wang Yingfeng Tu Fei Peng 《Small (Weinheim an der Bergstrasse, Germany)》2020,16(27)
Inspired by the highly versatile natural motors, artificial micro‐/nanomotors that can convert surrounding energies into mechanical motion and accomplish multiple tasks are devised. In the past few years, micro‐/nanomotors have demonstrated significant potential in biomedicine. However, the practical biomedical applications of these small‐scale devices are still at an infant stage. For successful bench‐to‐bed translation, biocompatibility of micro‐/nanomotor systems is the central issue to be considered. Herein, the recent progress in micro‐/nanomotors in biocompatibility is reviewed, with a special focus on their biomedical applications. Through close collaboration between researches in the nanoengineering, material chemistry, and biomedical fields, it is expected that a promising real‐world application platform based on micro‐/nanomotors will emerge in the near future. 相似文献
2.
3.
Dandan Xu Yong Wang Chunyan Liang Yongqiang You Samuel Sanchez Xing Ma 《Small (Weinheim an der Bergstrasse, Germany)》2020,16(27)
Micro/nanomotors (MNMs) are miniaturized machines that can perform assigned tasks at the micro/nanoscale. Over the past decade, significant progress has been made in the design, preparation, and applications of MNMs that are powered by converting different sources of energy into mechanical force, to realize active movement and fulfill on‐demand tasks. MNMs can be navigated to desired locations with precise controllability based on different guidance mechanisms. A considerable research effort has gone into demonstrating that MNMs possess the potential of biomedical cargo loading, transportation, and targeted release to achieve therapeutic functions. Herein, the recent advances of self‐propelled MNMs for on‐demand biomedical cargo transportation, including their self‐propulsion mechanisms, guidance strategies, as well as proof‐of‐concept studies for biological applications are presented. In addition, some of the major challenges and possible opportunities of MNMs are identified for future biomedical applications in the hope that it may inspire future research. 相似文献
4.
Yongfeng Zhou Wei Huang Jinyao Liu Xinyuan Zhu Deyue Yan 《Advanced materials (Deerfield Beach, Fla.)》2010,22(41):4567-4590
Hyperbranched polymers (HBPs) are highly branched macromolecules with a three‐dimensional dendritic architecture. Due to their unique topological structure and interesting physical/chemical properties, HBPs have attracted wide attention from both academia and industry. In this paper, the recent developments in HBP self‐assembly and their biomedical applications have been comprehensively reviewed. Many delicate supramolecular structures from zero‐dimension (0D) to three‐dimension (3D), such as micelles, fibers, tubes, vesicles, membranes, large compound vesicles and physical gels, have been prepared through the solution or interfacial self‐assembly of amphiphilic HBPs. In addition, these supramolecular structures have shown promising applications in the biomedical areas including drug delivery, protein purification/detection/delivery, gene transfection, antibacterial/antifouling materials and cytomimetic chemistry. Such developments promote the interdiscipline researches among surpramolecular chemistry, biomedical chemistry, nanotechnology and functional materials. 相似文献
5.
6.
Prats-Alfonso E Sisquella X Zine N Gabriel G Guimerà A del Campo FJ Villa R Eisenberg AH Mrksich M Errachid A Aguiló J Albericio F 《Small (Weinheim an der Bergstrasse, Germany)》2012,8(13):2106-2115
The identification and measurement of biomarkers is critical to a broad range of methods that diagnose and monitor many diseases. Serum auto-antibodies are rapidly becoming interesting targets because of their biological and medical relevance. This paper describes a highly sensitive, label-free approach for the detection of p53-antibodies, a prognostic indicator in ovarian cancer as well as a biomarker in the early stages of other cancers. This approach uses impedance measurements on gold microelectrodes to measure antibody concentrations at the picomolar level in undiluted serum samples. The biosensor shows high selectivity as a result of the optimization of the epitopes responsible for the detection of p53-antibodies and was validated by several techniques including microcontact printing, self-assembled-monolayer desorption ionization (SAMDI) mass spectrometry, and adhesion pull-off force by atomic force microscopy (AFM). This transduction method will lead to fast and accurate diagnostic tools for the early detection of cancer and other diseases. 相似文献
7.
8.
Patricia Y. W. Dankers Thomas M. Hermans Travis W. Baughman Yuko Kamikawa Roxanne E. Kieltyka Maartje M. C. Bastings Henk M. Janssen Nico A. J. M. Sommerdijk Antje Larsen Marja J. A. van Luyn Anton W. Bosman Eliane R. Popa George Fytas E. W. Meijer 《Advanced materials (Deerfield Beach, Fla.)》2012,24(20):2703-2709
9.
K. Jagajjanani Rao Fei Li Long Meng Hairong Zheng Feiyan Cai Wei Wang 《Small (Weinheim an der Bergstrasse, Germany)》2015,11(24):2836-2846
Synthetic microswimmers are a class of artificial nano‐ or microscale particle capable of converting external energy into motion. They are similar to natural microswimmers such as bacteria in behavior and are, therefore, of great interest to the study of active matter. Additionally, microswimmers show promise in applications ranging from bioanalytics and environmental monitoring to particle separation and drug delivery. However, since their sizes are on the nano‐/microscale and their speeds are in the μm s?1 range, they fall into a low Reynolds number regime where viscosity dominates. Therefore, new propulsion schemes are needed for these microswimmers to be able to efficiently move. Furthermore, many of the hotly pursued applications call for innovations in the next phase of development of biocompatible microswimmers. In this review, the latest developments of microswimmers powered by ultrasound are presented. Ultrasound, especially at MHz frequencies, does little harm to biological samples and provides an advantageous and well‐controlled means to efficiently power microswimmers. By critically reviewing the recent progress in this research field, an introduction of how ultrasound propels colloidal particles into autonomous motion is presented, as well as how this propulsion can be used to achieve preliminary but promising applications. 相似文献
10.
11.
Bronstein LM 《Small (Weinheim an der Bergstrasse, Germany)》2011,7(12):1609-1618
An analysis of the accumulated knowledge on virus-based nanoparticles (VNPs) consisting of virus protein capsids and inorganic cargo, such as nanoparticles (NPs), nanowires, and thin layers, is presented. Virus capsids (VCs) can serve either as templates or nanoreactors when inorganic materials are formed outside or inside VCs. The third possibility is when inorganic NPs nucleate the formation of VCs. The structural and mechanistic studies of VNP formation are paving the way to a better understating of virus structure and behavior, and these facilitate promising applications of VNPs in biomedical and materials research. 相似文献
12.
13.
14.
15.
Lee VY Havenstrite K Tjio M McNeil M Blau HM Miller RD Sly J 《Advanced materials (Deerfield Beach, Fla.)》2011,23(39):4509-4515
16.
17.
Simmchen J Baeza A Ruiz D Esplandiu MJ Vallet-Regí M 《Small (Weinheim an der Bergstrasse, Germany)》2012,8(13):2053-2059
An innovative self-propelled nanodevice able to perform motion, cargo transport, and target recognition is presented. The system is based on a mesoporous motor particle, which is asymmetrically functionalized by the attachment of single-stranded DNA onto one of its faces, while catalase is immobilized on the other face. This enzyme allows catalytic decomposition of hydrogen peroxide to oxygen and water, giving rise to the driving force for the motion of the whole system. Moreover the motor particles are able to capture and transport cargo particles functionalized with a noncomplementary single-stranded DNA molecule, only if a specific oligonucleotide sequence is present in the media. Functionalization with characteristic oligonucleotide sequences in the system implies a potential for further developments for lab-on-chip devices with applications in biomedical applications. 相似文献
18.
Tumor Therapy: NIR Light Propulsive Janus‐like Nanohybrids for Enhanced Photothermal Tumor Therapy (Small 39/2016) 
下载免费PDF全文
下载免费PDF全文 Pei‐Pei Yang Yun‐Gang Zhai Guo‐Bin Qi Yao‐Xin Lin Qiang Luo Yang Yang An‐Ping Xu Chao Yang Yong‐Sheng Li Lei Wang Hao Wang 《Small (Weinheim an der Bergstrasse, Germany)》2016,12(39):5422-5422
19.
Dhruv P. Singh Udit Choudhury Peer Fischer Andrew G. Mark 《Advanced materials (Deerfield Beach, Fla.)》2017,29(32)
The collective phenomena exhibited by artificial active matter systems present novel routes to fabricating out‐of‐equilibrium microscale assemblies. Here, the crystallization of passive silica colloids into well‐controlled 2D assemblies is shown, which is directed by a small number of self‐propelled active colloids. The active colloids are titania–silica Janus particles that are propelled when illuminated by UV light. The strength of the attractive interaction and thus the extent of the assembled clusters can be regulated by the light intensity. A remarkably small number of the active colloids is sufficient to induce the assembly of the dynamic crystals. The approach produces rationally designed colloidal clusters and crystals with controllable sizes, shapes, and symmetries. This multicomponent active matter system offers the possibility of obtaining structures and assemblies that cannot be found in equilibrium systems. 相似文献
20.
Self‐propelled micro/nanomotors have gained attention for successful application in cargo delivery, therapeutic treatments, sensing, and environmental remediation. Unique characteristics such as high speed, motion control, selectivity, and functionability promote the application of micro/nanomotors in analytical sciences. Here, the recent advancements and main challenges regarding the application of self‐propelled micro/nanomotors in sensing and environmental remediation are discussed. The current state of micro/nanomotors is reviewed, emphasizing the period of the last five years, then their developments into the future applications for enhanced sensing and efficient purification of water resources are extrapolated. 相似文献