纳米金表面修饰提高压电免疫传感器性能研究

在石英晶体微天平的金电极上通过1,6-己二硫醇交联组装纳米金颗粒修饰传感器表面,同时结合蛋白A与抗体的Fc段特异性结合的特性定向固定人IgG构建压电免疫传感器,并用于羊抗人IgG的检测.实验结果表明,与未经修饰相比,纳米金颗粒组装修饰金电极后能明显提高压电免疫传感器的检测灵敏度、重现性和再生能力等重要性能指标,修饰后的传感器也具有非常好的在线再生性能.     

HMDS改性后的纳米氧化锌的湿度响应特性研究

以石英晶体微天平传感器为平台,研究六甲基二硅胺烷(HMDS)处理前后的纳米ZnO作为敏感膜湿度敏感特性。用HMDS处理后的纳米ZnO膜表面呈厌水性,同未用HMDS处理的纳米ZnO膜相比,对湿度的响应敏感度明显降低。进一步的研究发现,用HMDS处理后的纳米ZnO膜对有机气体,如乙醇等,仍有很好的响应。该特性可被用来开发具有对水蒸汽具有抗干扰能力的气体传感器。     

基于能量传输模型的QCM负载效应研究

为准确、有效地区分引起石英晶体微天平(QCM)频偏的质量效应与阻尼效应,运用能量传输模型(ETM)的基本原理,推导出液体粘度和密度的乘积与石英晶体谐振器表面最大的振动幅度之间的显性函数关系式。可通过测试QCM的谐振频率与幅值信息将其负载效应分开,为QCM免疫传感器在医学中的诊断提供了一种理论基础。     

具有质量和电化学复合敏感效应的新型QCM生物传感器研究

石英晶体微天平(QCM)是一种传统的质量敏感型传感器,具有灵敏度高及响应时间短等优点。为拓展QCM技术在液相生物分子传感领域的应用,该文通过电化学方法在QCM表面沉积生物分子功能化的导电高分子后,成功制备了链霉亲和素敏感的QCM传感器。该传感器不仅具有对链霉亲和素的质量和电化学复合敏感效应,而且具有优异的抗其他蛋白干扰能力,有进一步应用于液相生化传感和疾病检测的潜力。     

石英晶体传感器特征阻尼理论的实验验证

本文发展了石英晶体传感器的特征阻尼理论，引入特征阻尼向量和特征阻尼角来分析石英晶体传感器在表现负载发生各种变化时的输出响应，通过研究ＮａＣｌ溶液在石英晶体电极表面的蒸发过程和沉积于电极表面的固体ＮａＣｌ在高湿环境中的潮解过程，直接观察了石英晶体传感器在质量负载和液体阻尼负载相互转变过程中的谐振频率和振荡幅值的变化情况，实验结果证明了特征阻尼理论的正确性。     

压电免疫传感器的质量灵敏度分布优化设计

从石英晶体微天平(QCM)质量灵敏度表达式出发,分析了影响其质量灵敏度分布的因素。在此基础上设计了一种新型电极配置结构的QCM,并利用9MHz的QCM仿真。仿真结果显示,在全电极区域,新型电极结构比圆形电极结构的QCM质量灵敏度分布均匀。最后,采用10 MHz的QCM免疫传感器对卵巢癌进行了实验验证,结果表明,NuTu-19抗体质量在74³70ng内,频率呈线性变化,说明改进电极结构的QCM免疫传感器具有较好的质量灵敏度分布。     

多通道石英微天平振动耦合分析

应用明德林的二维压电板理论，用有限元方法求解并分析了两圆形石英晶体微天平(MQCM)的设计参数对频率耦合的影响。通过选取合适的尺寸设计参数，可有效地使两圆形石英晶体微天平(QCM)的耦合减少到最小，指出振动耦合现象的产生是由一谐振元的基模能与另一谐振元的泛音模发生强烈耦合引起的；提出了优化设计MQCM的建议。     

QCM传感器差频信号的获取

分析研究了石英晶体微天平(QCM)传感器的工作原理.针对其敏感元件的晶片可能会受到不同因素的影响而导致输出稳定性下降的特点,介绍了利用D触发器产生差频提取频率信号的方法.降低了因环境因素对传感器造成的影响、抑制了频率漂移,提高了微天平的稳定性,使传感器的性能得到明显提高.     

真空电子技术

O462007030118用扫频测量技术研究石英晶体微天平/崔苇苇,孔涛,阴泽杰,朱大鸣(中国科学技术大学近代物理系)//核电子学与探测技术.―2006,26(2).―255～256.石英晶体微天平是一种高灵敏的质量检测仪器,已经用于液相、气相、镀膜、生物大分子等方面的研究。简单介绍了一种新的思     

石英晶体微天平研究核酸探针的杂交反应模型

核酸探针杂交是核酸研究中一项最基本的实验技术。压电基因传感检测技术可以实时动态监测电极表面核酸杂交反应。该文导出了核酸探针在石英晶体微天平电极表面上的杂交反应动力学模型,并通过实验对导出模型进行了验证、计算出相关动力学参数。相关系数为0.993。     

Resolution Enhancement Technology:Integrated Process Solutions using OPC

DUV lithography, using the 248 nm wavelength, is a viable manufacturing option for devices with features at 130 nm and less. Given the low kl value of the lithography, integrated process development is a necessary method for achieving acceptable process latitude. The application of assist features for rule based OPC requires the simultaneous optimization of the mask, illumination optics and the resist.Described in this paper are the details involved in optimizing each of these aspects for line and space imaging.A reference pitch is first chosen to determine how the optics will be set. The ideal sigma setting is determined by a simple geometrically derived expression. The inner and outer machine settings are determined, in turn,with the simulation of a figure of merit. The maximum value of the response surface of this FOM occurs at the optimal sigma settings. Experimental confirmation of this is shown in the paper.Assist features are used to modify the aerial image of the more isolated images on the mask. The effect that the diffraction of the scattering bars (SBs) has on the image intensity distribution is explained. Rules for determining the size and placement of SBs are also given.Resist is optimized for use with off-axis illumination and assist features. A general explanation of the material' s effect is discussed along with the affect on the through-pitch bias. The paper culminates with the showing of the lithographic results from the fully optimized system.     

Cost-effective test solutions for smart card and other integrated flash applications

From its emergence in the late 1980s as a lower cost alternative to early EEPROM technologies, flash memory has evolved to higher densities and speedsand rapidly growing acceptance in mobile applications.In the process, flash memory devices have placed increased test requirements on manufacturers. Today, as flash device test grows in importance in China, manufacturers face growing pressure for reduced cost-oftest, increased throughput and greater return on investment for test equipment. At the same time, the move to integrated flash packages for contactless smart card applications adds a significant further challenge to manufacturers seeking rapid, low-cost test.     

An improved parallel thinning algorithm with two subiterations

The parallel thinning algorithm with two subiterations is improved in this paper. By analyzing the notions of connected components and passes, a conclusion is drawn that the number of passes and the number of eight-connected components are equal. Then the expression of the number of eight-connected components is obtained which replaces the old one in the algorithm. And a reserving condition is proposed by experiments, which alleviates the excess deletion where a diagonal line and a beeline intersect. The experimental results demonstrate that the thinned curve is almost located in the middle of the original curve connectivelv with single pixel width and the processing speed is high.     

Theoretical analysis of the relationship between the Brillouin gain coefficient and the strain in the optical-fiber sensors

The relation between the power of the Brillouin signal and the strain is one of the bases of the distributed fiber sensors of temperature and strain. The coefficient of the Bfillouin gain can be changed by the temperature and the strain that will affect the power of the Brillouin scattering. The relation between the change of the Brillouin gain coefficient and the strain is thought to be linear by many researchers. However, it is not always linear based on the theoretical analysis and numerical simulation. Therefore, errors will be caused if the relation between the change of the Brillouin gain coefficient and the strain is regarded as to be linear approximately for measuring the temperature and the strain. For this reason, the influence of the parameters on the Brillouin gain coefficient is proposed through theoretical analysis and numerical simulation.     

Novel fiber-optical interferometer with miniaturized probe for in-hole measurements

Today, micro-system technology and the development of new MEMS （Micro-Electro-Mechanical Systems） are emerging rapidly. In order for this development to become a success in the long run, measurement systems have to ensure product quality. Most often, MEMS have to be tested by means of functionality or destructive tests. One reason for this is that there are no suitable systems or sensing probes available which can be used for the measurement of quasi inaccessible features like small holes or cavities. We present a measurement system that could be used for these kinds of measurements. The system combines a fiber optical, miniaturized sensing probe with low-coherence interferometry, so that absolute distance measurements with nanometer accuracy are possible.     

Study of waveguide coupling efficiency in hybrid silicon lasers

This paper presents a new method to increase the waveguide coupling efficiency in hybrid silicon lasers. We find that the propagation constant of the InGaAsP emitting layer can be equal to that of the Si resonant layer through improving the design size of the InP waveguide. The coupling power achieves 42% of the total power in the hybrid lasers when the thickness of the bonding layer is 100 nm. Our result is very close to 50% of the total power reported by Intel when the thickness of the thin bonding layer is less than 5 nm. Therefore, our invariable coupling power technique is simpler than Intel＇s.     

Curved crystal spectrometer for the measurement of X-ray lines from laser-produced plasmas

In order to diagnose the laser-produced plasmas, a focusing curved crystal spectrometer has been developed for measuring the X-ray lines radiated from a laser-produced plasmas. The design is based on the fact that the ray emitted from a source located at one focus of an ellipse will converge on the other focus by the reflection of the elliptical surface. The focal length and the eccentricity of the ellipse are 1350 mm and 0.9586, respectively. The spectrometer can be used to measure the X- ray lines in the wavelength range of 0.2-0.37 nm, and a LiF crystal （200） （2d = 0.4027 nm） is used as dispersive element covering Bragg angle from 30° to 67.5°. The spectrometer was tested on Shengnang- Ⅱ which can deliver laser energy of 60-80 J/pulse and the laser wavelength is 0.35 μm. Photographs of spectra including the 1 s2p ^1P1-1s^2 ^1S0 resonance line（w）, the 1s2p ^3P2-1s^2 1S0 magnetic quadrupole line（x）, the 1s2p ^3P1-1 s^2 ^1S0 intercombination lines（y）, the 1 s2p ^3S~1-1 s^2 ^1S0 forbidden line（z） in helium-like Ti Ⅹ Ⅺ and the 1 s2s2p ^2P3/2-1 s622s ^2S1/2 line（q） in lithium-like Ti Ⅹ Ⅹhave been recorded with a X-ray CCD camera. The experimental result shows that the wavelength resolution（λ/△ 2） is above 1000 and the elliptical crystal spectrometer is suitable for X-ray spectroscopy.     

Preparation and Characterization of TaN ALD Precursors

High purity organic-tantalum precursors for thin film ALD TaN were synthesized and characterized.Vapor pressure and thermal stability of these precursors were studied.From the vapor pressure analysis,it was found that TBTEMT has a higher vapor pressure than any other published liquid TaN precursor,including TBTDET,TAITMATA,and IPTDET.Thermal stability of the alkyl groups on the precursors was investigated using a 1H NMR technique.The results indicated that the tertbutylimino group is the most stable group on TBTDET and TBTEMT as compared to the dialkylamido groups.Thermal stability of TaN precursors decreased in the following order:TBTDET ＞ PDMAT ＞ TBTEMT.In conclusion,precursor vapor pressure and thermal stability were tuned by making slight variations in the ligand sphere around the metal center.     

Electronic Structure of Semiconductor Nanocrystals

This paper reviews our recent development of the use of the large-scale pseudopotential method to calculate the electronic structure of semiconductor nanocrystals, such as quantum dots and wires, which often contain tens of thousands of atoms. The calculated size-dependent exciton energies and absorption spectra of quantum dots and wires are in good agreement with experiments. We show that the electronic structure of a nanocrystal can be tuned not only by its size,but also by its shape. Finally,we show that defect properties in quantum dots can be significantly different from those in bulk semiconductors.     

A rigorous proof of MIMO channel capacity’s increase with antenna number

It is well known that adding more antennas at the transmitter or at the receiver may offer larger channel capacity in the multiple-input multiple-output（MIMO） communication systems. In this letter, a simple proof is presented for the fact that the channel capacity increases with an increase in the number of receiving antennas. The proof is based on the famous capacity formula of Foschini and Gans with matrix theory.