奥拉西坦治疗血管性痴呆的临床研究

目的评价奥拉西坦治疗血管性痴呆(Vasculardementia ,VaD)的有效性和安全性。方法对89例VaD患者进行了随机、单盲12周临床试验、其中89例为单盲、安慰剂对照研究。结果随机、单盲、安慰剂对照组研究结果表明,每天2 .4克奥拉西坦治疗12周时,奥拉西坦组较安慰剂组简易智能状态量表(MMSE)、临床痴呆程度量表(CDR)及日常生活自理能力量表(ADL)分数显著改变(P <0 .0 1、0 .0 5 )。49例服用奥拉西坦的患者中,3例( 6.1% )出现轻度不良反应,40例安慰剂组中2例( 5 % )出现头昏、恶心,两组差异无显著意义(P >0 .0 5 )。结论奥拉西坦治疗轻、中度VaD患者,对患者的认知功能、痴呆程度和日常生活能力均有改善,耐受性好,安全性高。     

当归多糖抗衰老作用的实验研究

目的:观察不同剂量的当归多糖(ASP)对D-半乳糖致衰老小鼠模型是否具有抗衰老作用。方法:50只小鼠随机分为5组,一组为空白组,另4组用D-半乳糖致衰老。这4组分为模型组及三个不同剂量ASP组(100mg/kg、150mg/kg、200mg/kg)。ASP组每日各自灌胃不同剂量的ASP进行干预。测量小鼠脾脏指数,测定小鼠血清和脑组织SOD、MDA、GSH-PX含量及活性,测定小鼠脑细胞凋亡指数。结果:与模型组比较,ASP可拮抗脾脏的萎缩、增强血清和脑组织SOD活力、减少MDA含量、提高GSH-PX活性、降低脑细胞凋亡指数。结论:当归多糖有很好的抗衰老作用。     

当归多糖对D-半乳糖致衰老小鼠学习记忆的影响

目的:观察不同剂量的当归多糖(ASP)对D-半乳糖致衰老小鼠模型的学习记忆是否具有改善作用。方法:行为学采用Morris水迷宫实验,测定小鼠血清和脑组织SOD、MDA值,观察脑细胞形态学变化,脑细胞凋亡指数。结果:与模型组比较,ASP可明显提高衰老小鼠学习记忆力、增强小鼠血清和脑组织SOD活力、减少MDA含量、改善脑细胞变性和坏死情况、降低脑细胞凋亡指数。结论:当归多糖能改善D-半乳糖致衰老小鼠学习记忆功能,延缓脑组织的衰老。     

血管性痴呆大鼠行为学及海马CA1区CREB改变的研究

目的：观察缺血性痴呆（VD）大鼠神经行为学及海马CREB的改变,并探讨两者间的关系。方法：采用双侧颈总动脉永久性结扎（2 vessels obstruction,2-VO）法建立血管性痴呆模型,8周后采用Morriss水迷宫实验测试大鼠记忆行为,海马HE染色检测神经元损伤,PCR及免疫组化检测海马CAl区CREB表达的变化。结果：模型组与正常组相比,大鼠认知功和神经元损伤程度明显,海马区CREB表达也明显降低（P〈0.01）。结论：2-VO法成功制作了缺血性痴呆大鼠模型。模型大鼠脑内海马区CREB水平明显下降,其空间学习记忆障碍可能与海马区CREB表达下降有关。     

基于外泌体探讨卒中后认知障碍的中医辨治

摘 要:外泌体是细胞分泌的一种微型囊泡,具有特异性、稳定性、靶向性和载体性等生物学特性,可以安全而高效的通过血脑屏障,可作为药物载体,起到靶向治疗的作用。随着研究的逐步进展,发现外泌体在脑血管病和认知障碍疾病的发生、发展、诊断、治疗中起到重要作用。基于此,在“病证结合”整体观的指导下,通过探讨卒中后认知障碍（Post stroke cognitive impairment,PSCI）的中医辨治,为中医药治疗卒中后认知障碍提供新的思路。     

OSAHS患者血清VEGF的动态变化的研究

目的 :探讨血管内皮生长因子 (VEGF)在阻塞性睡眠呼吸暂停低通气综合征 (OSAHS)患者血清中的动态变化。方法 :将 32例OSAHS患者作为OSAHS组 ,30例正常人为对照组 ,对所有受试对象做睡眠前 2 3:0 0和晨起 7:0 0时的血清VEGF的含量测试 ,与对照组相比较。结果 :OSAHS患者在晨起 7:0 0时的血清VEGF含量最高 ,明显高于对照组 ,高于睡前 2 3:0 0时血清VEGF含量。结论 :OSAHS患者晨起血清VEGF含量明显增高。     

CPAP治疗对OSAHS患者心血管系统并发症的影响

阻塞性睡眠呼吸暂停低通气综合征（obstructive sleep apnea—hypopnea syndrome,OSAHS）是一种常见的临床病症,其始动及发展恶化的机理可能是长期反复的缺氧一复氧循环损伤的氧化应激有关。这一方面产生一系列的炎性介质,导致血管内皮细胞的损伤,另一方面使交感和副交感神经过度激活,引发血压升高和心律紊乱及使血管内凝血物质活性增强,患者更容易发生心肌梗塞及中风。     

电针联合安理申治疗轻度认知障碍的临床研究

目的：探讨轻度认知功能障碍（MCI）的临床治疗。方法：78例患者随机分为两组,试验组MCI患者39例,给予电针及安理申口服治疗3个月,同期安理申对照组39例,两组均给予其它高危因素（高血压、糖尿病、心血管疾病等）干预治疗。结果：试验组较对照组MMSE、MoCA、ADL、BBS 评分显著改善（P＜0．01）。结论：电针联合安理申口服能有效改善轻度认知功能障碍患者的认知功能、日常生活自理能力。     

基于ARM的电脑鼠走迷宫的研究

目标是设计制作集传感器与控制于一体的,能够自动穿越迷宫的电脑鼠。该电脑鼠结合了模拟电路、数字电路,自动控制理论等相关专业知识。提出将模块化方法应用于系统软、硬件的设计,不仅提高了软硬件开发效率,而且提高了软硬件在实验及检修过程中的可维护性、可升级性。这里设计的电脑鼠能在迷宫中搜索路径,走出迷宫,并能实现路径优化。     

电脑鼠电路的改进及搜索算法研究

为提高电脑鼠在迷宫中搜索并走出迷宫的速度，对MicroMouse615电路和搜索算法进行改进，采用分组分时的方式驱动红外传感器，使信号采集更加迅速；采用定时器驱动步进电机匀加速的方法，使其运行更加平稳；采用新迷宫算法，使搜索算法更加简洁高效。采用基于RTOS的多进程架构实现各算法，用无线模块实现实时跟踪与可视化，使系统调试更加方便。     

Enhancement of Spatial Learning-Memory in Developing Rats via Mozart Music

This paper studies the effect of musical stimulations on the capability of the spatial learningmemory in developing rats by behavioral and electrophysiological techniques. Rats, which are exposed to Mozart＇s Sonata for Two Pianos in D Major, complete learning tasks of the Moriss water maze with significantly shorter latencies, and the power spectrum of alpha band of electrohippocampogram （EHG） significantly increase, compared with the control rats and rats exposed to the horror music. The results indicate that if given the stimulation of Mozart music in the developmental period of the auditory cortex, the capability of the spatial learning-memory can be significantly changed. The enhancement of alpha band of EHG may be related to the change of this function mainly.     

Enhancement of Spatial Learning-Memory in Developing Rats via Mozart Music

This paper studies the effect of musical stimulations on the capability of the spatial learningmemory in developing rats by behavioral and electrophysiological techniques. Rats, which are exposed to Mozart's Sonata for Two Pianos in D Major, complete learning tasks of the Moriss water maze with significantly shorter latencies, and the power spectrum of alpha band of electrohippocampogram (EHG) significantly increase, compared with the control rats and rats exposed to the horror music. The results indicate that if given the stimulation of Mozart music in the developmental period of the auditory cortex, the capability of the spatial learning-memory can be significantly changed. The enhancement of alpha band of EHG may be related to the change of this function mainly.     

喷泉码在认知无线电网络中的应用

认知无线电网络被认为是实现动态频谱共享、缓解频谱资源紧缺的重要途径。喷泉码能有效抵抗认知无线电网络中来自主用户的突发干扰,且无需反馈重传,从而为认知无线电网络提供了一种有效的信道编码方案。首先简介了数字喷泉码以及认知无线电网络基础知识,然后综述了数字喷泉码在认知无线电网络的链路建立、认知通信以及在资源分配中的应用现状,最后指出了在这一研究领域中需要解决的问题,并展望了发展前景。     

基于认知无线电的频谱检测技术研究

信息时代无线通信飞速发展,许多需要较宽频谱和较高下载速率的业务,如多媒体通信业务,已经成为无线服务的重点对象。认知无线电是一种智能的无线通信技术,可以通过感知周围环境来自动调整其发射机参数,其核心思想是利用已分配但未获得充分利用的频谱,从而提高频谱利用率避免对主用户造成干扰是认知无线电最需要解决的问题,频谱感知则是实现这一目标的前提。     

Routing for cognitive radio networks consisting of opportunistic links

Cognitive radio (CR) has been considered a key technology to enhance overall spectrum utilization by opportunistic transmissions in CR transmitter–receiver link(s). However, CRs must form a cognitive radio network (CRN) so that the messages can be forwarded from source to destination, on top of a number of opportunistic links from co‐existing multi‐radio systems. Unfortunately, appropriate routing in CRN of coexisting multi‐radio systems remains an open problem. We explore the fundamental behaviors of CR links to conclude three major challenges, and thus decompose general CRN into cognitive radio relay network (CRRN), CR uplink relay network, CR downlink relay network, and tunneling (or core) network. Due to extremely dynamic nature of CR links, traditional routing to maintain end‐to‐end routing table for ad hoc networks is not feasible. We locally build up one‐step forward table at each CR to proceed based on spectrum sensing to determine trend of paths from source to destination, while primary systems (PSs) follow original ways to forward packets like tunneling. From simulations over ad hoc with infrastructure network topology and random network topology, we demonstrate such simple routing concept known as CRN local on‐demand (CLOD) routing to be realistic at reasonable routing delay to route packets through. Copyright © 2009 John Wiley & Sons, Ltd.     

Spectrum resource allocation method of maximizing transmission rate in cognitive heterogeneous wireless networks

Aiming at the problem that it is difficult to allocate spectrum resources to secondary users efficiently in cognitive heterogeneous wireless networks with heterogeneous spectrum attributes,dynamic channel conditions and diverse service requirements,a spectrum resource allocation strategy with maximum transmission rate was proposed.Firstly,the strategy aimed at maximizing the total transmission rate,and constrained the limited spectrum resources and user service requirements to construct a non-linear multi-constrained spectrum resource allocation 0-1 planning model.Then a polynomial time complexity simplification method was designed.According to idle spectrum information,channel conditions,business requirements and allocation decision history information,and the benefit matrix was constructed and modified to achieve constraint simplification,and the execution efficiency was improved by improving the coefficient matrix transformation strategy of the traditional Hungarian algorithm.Finally,the performance of the method was compared and analyzed by experiments.Experimental results show that the proposed method has higher transmission rate and execution efficiency.     

An uplink resource allocation scheme for OFDMA‐based cognitive radio networks

Cognitive radio makes it possible for an unlicensed user to access a spectrum unoccupied by licensed users. In cognitive radio networks, extra constraints on interference temperature need to be introduced into radio resource allocation. In this paper, the uplink radio resource allocation is investigated for OFDMA‐based cognitive radio networks. In consideration of the characteristics of cognitive radio and OFDMA, an improved water‐filling power allocation scheme is proposed under the interference temperature constraints for optimal performance. Based on the improved water‐filling power allocation, a simple subcarrier allocation algorithm for uplink is proposed. The subcarrier allocation rules are obtained by theoretical deduction. In the uplink subcarrier allocation algorithm, the subcarriers are allocated to the users with the best channel quality initially and then adjusted to improve the system performance. A cursory water‐filling level estimation method is used to decrease the complexity of the algorithm. Asymptotic performance analysis gives a lower bound of the stability of the water‐filling level estimation. The complexity and performance of the proposed radio resource allocation scheme are investigated by theoretical analysis and numerical results. Copyright © 2008 John Wiley & Sons, Ltd.     

OFDM混合调制信号在认知网络中的应用

对OFDM混合调制信号进行了谱相关分析,并将其应用到认知网络中。在采用OFDM混合调制信号传输的认知网络中,利用信号的循环平稳特性可以快速识别出信道空闲、认知信号传输、主用户信号传输和两种信号混叠这四种状态,为认知网络中认知信号的快速可靠接入和退出提供了保障。进一步利用混合调制的位置来标记不同的认知网络,认知节点可以区分不同认知网络信号。在提出的认知网络应用模型中,传输和接收设备较简单,而且不需专门的信道来传输控制命令,节约了带宽。仿真结果显示,在认知网络中,该模型可以提高频谱利用率,使通信系统的性能得到改善。