共查询到19条相似文献,搜索用时 125 毫秒
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研究了含氟中间体对三氟甲基苯乙酸的合成,以对氯三氟甲苯和丙二酸二乙酯为原料,选用叔丁醇钠作催化剂,经缩合、水解和脱羧制得,总收率达75.4%. 相似文献
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Chemical Peptide Bond Formation with α-Trifluoromethyl Substituted α-Amino Acids The reaction of α-trifluoromethyl substituted N-tbutoxycarbonyl amino acids (Boc-TFM-Xaa-OH) 1 with dicyclohexylcarbodiimide results in formation of 2-tbutoxy-4-trifluoromethyl-5(4H)-oxazolones 2 within minutes. Compounds 2 react with amino acid esters to give Boc protected dipeptide esters 4. However, at room temperature compounds 2 decompose to give Leuchs anhydrides 3 , via retro ene reaction. Therefore, α-trifluoromethyl substituted N-tbutoxycarbonyl amino acids (Boc-TFM-Xaa-OH) are of limited value for peptide synthesis. 相似文献
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介绍了2,6-二氯-4-三氟甲基苯胺的化学合成方法,并对这些方法进行了评价,给出了主要合成路线的具体实例。 相似文献
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François Evariste Zdenek Janousek Christian Maliverney Robert Merényi Prof. Dr. Heinz G. Viehe 《Advanced Synthesis \u0026amp; Catalysis》1993,335(1):35-41
Recently discovered 4-trifluoromethyl-1,3-oxazin-6-ones react with electron-poor dienophiles as 2-aza-1,3-dienes in Diels-Alder cycloadditions to give new 2-trifluoromethyl pyridines ( 3a – d , 4a – c ). Regioselectivity is excellent in the case of unsymmetrical dienophiles. These new pyridines permit further useful transformations. 相似文献