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二萜类化合物是一类重要的天然产物,研究发现微生物能对该类化合物进行多种类型的结构修饰。本文根据十年来二萜类化合物生物转化研究的报道,对二萜类化合物的生物转化菌种及催化反应类型进行综述,以期为二萜类化合物生物转化研究与应用提供参考。 相似文献
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研究了3-溴香豆素磺酰脲类化合物降血糖活性与化学结构之间的关系,为进一步设计合成该类化合物提供理论依据。研究方法是首先选择14个化合物进行药效学研究,然后再对这些化合物利用MM2分子力学计算有关结构参数并进行定量构效关系研究,研究结果表明3-溴香豆素磺酰脲的降血糖活性与化合物的最小能量呈负相关,初步结论是该类化合物脲基取代基为脂肪基时,化合物的能量相对较小,降血糖活性较高。 相似文献
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Chemical Peptide Bond Formation with α-Trifluoromethyl Substituted α-Amino Acids The reaction of α-trifluoromethyl substituted N-tbutoxycarbonyl amino acids (Boc-TFM-Xaa-OH) 1 with dicyclohexylcarbodiimide results in formation of 2-tbutoxy-4-trifluoromethyl-5(4H)-oxazolones 2 within minutes. Compounds 2 react with amino acid esters to give Boc protected dipeptide esters 4. However, at room temperature compounds 2 decompose to give Leuchs anhydrides 3 , via retro ene reaction. Therefore, α-trifluoromethyl substituted N-tbutoxycarbonyl amino acids (Boc-TFM-Xaa-OH) are of limited value for peptide synthesis. 相似文献
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Synthesis of S-(1-Benzoyl-2-bis-methylthio)-vinyl N,N-Pentamethylene-thiocarbamates and Their Reactions with N-Nucleophiles The S-(1-benzoyl-2-bis-methylthio)-vinyl-N,N-pentamethylene-thiocarbamates 3a – d are synthesized by reaction of S-phenacyl-N,N-pentamethylene-thiocarbamates ( 1a – d ) with carbon disulfide under phase-transfer conditions. These compounds 3a – d and the dithiocarbamates 5a – d react with N-nucleophiles forming the ketene-S,N-acetals 6 – 14 , the S-phenacyl α-(imidazolidine-2-ylidene)-N,N-pentamethylene-thio- or -dithiocarbamates 15 – 22 , S-(substituted pyrazol-4-yl)- 23 – 28 and S-(substituted isoxazol-4-yl)-N,N-pentamethylene-thio- or -dithiocarbamates 39 – 46 , respectively. 相似文献
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Reactions with Thio-bis-formamidines N,N,N′-Trisubstituted S-(4-amino-s-triazin-2-yl)-isothioureas 3 are prepared in good yields form trisubstituted thio-bis-formamidine-hydrochlorides 1 and esters of cyanimidocarboxylic acids 2 . In aqueous alkali solutions compounds 1 react with β-dicarbonyl compounds under rearrangement to yield substituted N-(pyrimidin-2-yl)-thioureas 4 and 5 . 相似文献
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K. Burger Kerstin Mütze Wolfgang Hollweck Beate Koksch Peter Kuhl H.-D. Jakubke Jürgen Riede Annette Schier 《Advanced Synthesis \u0026amp; Catalysis》1993,335(4):321-331
Protease Catalyzed and Chemical Peptide Bond Formation with α-Trifluoromethyl Substituted α-Amino Acids Subtilisin, α-chymotrypsin and papain catalyzed hydrolyses of α-trifluoromethyl substituted N-benzyloxycarbonyl amino acid methylesters (Z-TFM-Xaa-OMe) 1 can be achieved only in the case of 3,3,3-trifluoroalanine. Enzymatic incorporation of Z-TFM amino acids 2 into N-terminal position of dipeptides also fails. In contrary, dipeptides with a TFM amino acid moiety in N-terminal position, e.g. TFM-Phg-L-Phe-OMe 5 , react with H-Leu-NH2 to give the corresponding tripeptides 6 in high yield. Z protected dipeptide derivatives 8 with N-terminal TFM amino acids can be obtained via 4-trifluoromethyl-5-(4H)-oxazolones 7 . 相似文献
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Iman A. Gad El-Karim Mahasen S. Amine Amal A. Mahmoud Alaa S. Gouda 《Journal of surfactants and detergents》2014,17(3):509-523
Reaction of stearic acid with semicarbazide in refluxing POCl3 afforded 2-amino-5-heptadecyl 1,3,4-oxadiazole. Acylation of the amino group with acetic anhydride, ethyl chloroacetate and chloroacetic acid gave amide and β-amino acid derivatives. These compounds were cyclized to imidazo[2,1-b]oxadiazole derivatives by two different techniques. Treating the starting oxadiazole compound with P2S5, hydroxyl amine and hydrazine hydrate in benzene afforded thiadiazole and triazole derivatives. Unexpectedly, triazolo[3,4-b][1,3,4]oxadiazole derivative was obtained when 1,3,4-oxadiazole derivative was refluxed with hydrazine hydrate in ethanol. The biological activities of the synthesized compounds were screened in vitro against some gram positive and gram negative bacteria and fungi. Addition of quantitative amount of propylene oxide units (3, 5, 7 mol) to the synthesized compounds afforded new nonionic surfactants. The physico-chemical and surface properties of the novel synthesized surfactants such as surface and interfacial tension, cloud point, wetting time, emulsion stability, foam height, CMC, resistance to hydrolysis and their biodegradability were investigated. In addition, surface parameters including effectiveness (π CMC), efficiency (PC20), maximum surface excess (Γmax) and (A min) were examined. 相似文献
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[目的]为了寻找具有良好生物活性的噁二唑类衍生物。[方法]以苯甲腈为原料,经加成、脱水环化等反应设计合成了一系列未见文献报道的噁二唑类衍生物,并对目标化合物进行了生物活性测试。[结果]其结构通过1H NMR、13C NMR和H RMS图谱得以确证。初步生物活性测试结果显示:部分目标化合物在质量浓度200 mg/L下对南方根结线虫有较好的抑制活性,其中化合物5f、6a、6b和6e对线虫的抑制率达到90%以上,尤其化合物4a、4d对线虫的抑制率达到100%,另外部分目标化合物对南方根结线虫和小菜蛾幼虫都具有一定的抑制活性。[结论]该类结构具有较好的生物活性,有进一步优化的潜力。 相似文献
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The reaction of N‐(2,4‐dinitrophenyl)pyridinium chloride ( 1 ), diaza‐18‐crown 6‐ether (DA18C6) and 2,5‐bis(aminophenyl)‐1,3,4‐oxadiazole ( 2 ) caused the opening of the pyridinium ring and yielded an ionic oligomer (oligomer‐1) comprising a 5‐DA18C6‐penta‐2,4‐dienylideneammonium chloride main chain and 2‐(4‐aminophenyl)‐5‐phenyl‐1,3,4‐oxadiazole or 2‐(4‐N‐phenylpyridinium)‐5‐phenyl‐1,3,4‐oxadiazole end groups. Accordingly, the reaction of 1 , DA18C6 and 2,7‐diaminofluorene ( 3 ) yielded oligomer‐2. The structures of oligomer‐1 and oligomer‐2 were determined by comparing their 1H NMR spectra with those of model compounds, which were synthesized by the 1:1 reaction of 1 with 2 or 3 . Oligomer‐1 and oligomer‐2 exhibited weak bluish‐green photoluminescence (PL) before the inclusion of Ag+ in the DA18C6 receptor, after which they exhibited strong bluish‐green PL. These observations can be explained by the occurrence of photoinduced electron transfer in the oligomers. Copyright © 2011 Society of Chemical Industry 相似文献
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