The use of biologically based cancer risk models in radiation epidemiology

Biologically based risk projection models for radiation carcinogenesis seek to describe the fundamental biological processes involved in neoplastic transformation of somatic cells into malignant cancer cells. A validated biologically based model, whose parameters have a direct biological interpretation, can also be used to extrapolate cancer risks to different exposure conditions with some confidence. In this article biologically based models for radiation carcinogenesis, including the two-stage clonal expansion (TSCE) model and its extensions, are reviewed. The biological and mathematical bases for such models are described, and the implications of key model parameters for cancer risk assessment examined. Specific applications of versions of the TSCE model to important epidemiological datasets are discussed, including the Colorado uranium miners' cohort; a cohort of Chinese tin miners; the lifespan cohort of atomic bomb survivors in Hiroshima and Nagasaki; and a cohort of over 200,000 workers included in the National Dose Registry (NDR) of Canada.     

Meta-analysis of second cancer risk after radiotherapy among childhood cancer survivors

Cancer risks among childhood cancer survivors following radiotherapy have not yet been well characterised in terms of radiation dose. A meta-analysis of studies on the excess relative risk per gray (ERR) of second cancer was conducted previously; unfortunately, the small number of eligible studies restricted quantitative evaluations. To solve this problem, a statistical method to calculate ERR estimates from other estimates was developed, and a meta-analysis was conducted again. The PubMed database was searched and 26 relevant studies were identified. ERR estimates were available in 15 studies, and for the other 11 studies, the regression-based model was used to calculate ERR estimates from other estimates. The overall ERR estimate was 0.40, which was much lower than that of atomic bomb survivors exposed as young children. Heterogeneity of the risk among studies was suggested, and a further study is needed to explore the heterogeneity among studies.     

Radiosensitivity of V79 cells after alpha particle radiation at low doses

Low dose hyper-radiosensitivity (HRS) of V79 cells was demonstrated after irradiation with gamma rays and 4He2+ ions of various linear energy transfer (LET) values (58.9, 79.3 and 101.7 keV.micron-1). In parallel, the cytogenetic analysis showed an LET dependence of aberrations at a dose of 1 Gy, while the observed chromatid fragments appeared to vary with the number of 4He2+ ions traversing the cell nucleus. The results of both studies are correlated so as to achieve a better understanding of the so-called induced radioresistance. The cell mechanism of radioresistance appears to be induced after a certain amount of energy is deposited in the cell nucleus. This amount depends both on the radiation quality as well as the number of particles traversing the cell, inducing chromosome alterations and chromatid damage.     

Possible implications of non-linear radiobiological effects for the estimation of radiation risk at low doses

Possible implications of the effects of low LET radiation on the induction of cancer at low doses are studied. Low dose hypersensitivity and adaptive response were identified as candidates which may give a non-linear dose effect curve for acute exposures, whereas adaptive response may influence protracted exposures. In this paper acute exposures are studied. Several radiobiological reports on studies with mammalian cell lines have indicated the presence of a hypersensitive region in the radiation survival response at low doses followed by an increase in radioresistance. The two step clonal expansion (TSCE) model for the process of carcinogenesis was adapted in such a way that cell killing after acute radiation induces increased clonal expansion for some time and thus gives a promoting effect of radiation. As a first step, the Radiation Effects Research Foundation (RERF) data on the lung cancer incidence are fitted to study how such a model would influence the assessment of the cancer risk at low doses.     

A review of some epidemiological studies on cancer risk from low-dose radiation or other carcinogenic agents

It is extremely difficult to assess cancer risks accurately due to health effects of low-dose radiation exposure or other carcinogens based on epidemiological studies. For the detection of minute increases of the risk at low-level exposure, most of epidemiological studies lack statistical power, and they involve various complicated confounding factors. This paper reports on a literature survey of epidemiological studies published since 2000 on cancer risks associated with low-dose radiation and other carcinogens to gather major epidemiological data. Integrated risk indices were derived from those data by using, where possible, statistical models. Regarding risk assessment of low-dose radiation exposure, it is important to lower the degree of uncertainty arising from risk estimation. Risk assessment of low-dose radiation exposure could be scientific evidence when uncertainty is considered in comparing carcinogenic risks of radiation with those of other carcinogens.     

Complex dynamics of life at different scales: from genomic to global environmental issues

This introduction to the Theme Issue, Complex dynamics of life at different scales: from genomic to global environmental issues, gives a short overview on why the ideas and concepts in complexity and nonlinearity are relevant to the understanding of life in its different manifestations. Also, it discusses how life phenomena can be thought of as composing different scales of organization. Finally, the articles in this thematic publication are briefly commented on in terms of their relevance in helping to understand the complexity of life systems.     

Microhardness of casting LM25 after precipitation treatment at 170 °C

Abstracts are not published in this journal This revised version was published online in November 2006 with corrections to the Cover Date.     

Microhardness of casting LM25 after precipitation treatment at 170 °C

Abstracts are not published in this journal     

Response of silicon-based linear energy transfer spectrometers: implication for radiation risk assessment in space flights

There is considerable interest in developing silicon-based telescopes because of their compactness and low power requirements. Three such telescopes have been flown on board the Space Shuttle to measure the linear energy transfer spectra of trapped, galactic cosmic ray, and solar energetic particles. Dosimeters based on single silicon detectors have also been flown on the Mir orbital station. A comparison of the absorbed dose and radiation quality factors calculated from these telescopes with that estimated from measurements made with a tissue equivalent proportional counter show differences which need to be fully understood if these telescopes are to be used for astronaut radiation risk assessments. Instrument performance is complicated by a variety of factors. A Monte Carlo-based technique was developed to model the behavior of both single element detectors in a proton beam, and the performance of a two-element, wide-angle telescope, in the trapped belt proton field inside the Space Shuttle. The technique is based on: (1) radiation transport intranuclear-evaporation model that takes into account the charge and angular distribution of target fragments, (2) Landau-Vavilov distribution of energy deposition allowing for electron escape, (3) true detector geometry of the telescope, (4) coincidence and discriminator settings, (5) spacecraft shielding geometry, and (6) the external space radiation environment, including albedo protons. The value of such detailed modeling and its implications in astronaut risk assessment is addressed.     

Minimizing the risk of cancer: tissue architecture and cellular replication limits

Normal somatic cells are capable of only a limited number of divisions, which prevents unlimited cell proliferation and the onset of tumours. Cancer cells find ways to circumvent this obstacle, typically by expressing the enzyme telomerase and less often by alternative recombination strategies. Given this fundamental link between cellular replication limits and cancer, it is important to understand how a tissue''s architecture affects the replicative capacity of a cell population. We define this as the average number of remaining divisions at equilibrium. The lower the replication capacity, the lower the chances to escape the replication limit during abnormal growth when a tumour develops. In this paper, we examine how the replication capacity is influenced by defining characteristics of cell lineages, such as the number of intermediate cell compartments, self-renewal capability of cells and division rates. We describe an optimal tissue architecture that minimizes the replication capacity of dividing cells and thus the risk of cancer. Interestingly, some of the features that define an optimal tissue architecture have been documented in a variety of tissues, suggesting that they may have evolved as a cancer-protecting strategy in multicellular organisms.     

Materials aging at the mesoscale: Kinetics of thermal,stress, radiation activations

The complexity of materials aging may be seen as a result of the interplay between several activation processes operating on multiple spatial and temporal scales. Though the disciplines involved may seem disparate at first, material aging fundamentally could be linked by the same set of underlying activations and responses of the system. We examine how recent studies of shear-induced deformation and rheological flow initiated in the soft-matter community can be leveraged to probe the mechanisms of radiation damage in nuclear materials. Bridging these two traditionally separate areas of research demonstrates the emerging notions of mesoscale science as a research frontier concerned with linking macroscale behavior to microscale processes in driven systems. We suggest the combining of microstructure-sensitive measurements with fundamental theories and mechanism-specific simulations is essential to addressing metastable materials responses of strongly activated states.     

Children at risk: predictors of car safety seat misuse in Ontario

When used correctly, child safety seats can reduce the risk of death and serious injury by 54% in toddlers and 71% in infants [National Highway Traffic Safety Administration (NHTSA), 2001. Traffic Safety Facts 2001. Children (DOT HS 809 471), U.S. Department of Transportation, Washington, DC]. The purpose of this study was to identify factors that predict correct use of car safety seats. The study was conducted in a large urban area in Southwestern Ontario and a small urban and rural area in Northern Ontario. Participants were 1263 caregivers who completed a self-report survey on their knowledge and use of car safety seats for their children (N=2199). Logistic regression analysis revealed that female caregivers, caregivers with higher levels of education, and caregivers who reported that finding information about the correct use of child safety seats was "difficult" were more likely to report correctly using car safety seats. The results also showed that children aged 7 months to 8 years old had substantially lower odds of being in the correct car safety seat compared to children aged 6 months or younger, or children aged 9 years or older. The high risk nature of misuse of child seats for infants and younger children may be an important cue to action for health professionals to develop comprehensive prevention strategies.     

Measurement of the radiation dose and assessment of the risk in mammography screening for early detection of cancer of the breast, in Israel

The mean glandular doses to samples of women attending for mammographic screening are measured routinely at screening centres in Israel. As at present, no detailed and systematic data have been collected regarding the average glandular dose in mammography screening procedures carried out in Israel for the last 20 y. Especially data are lacking related to the glandular dose (GD) involved in mammography with the new digital mammography systems. In this work, partial results of the measurements are presented to asses the radiation dose to the breast and to the glandular tissue within the Israeli national mammography programme updated to year 2009.     

Photocatalysis as a potential tertiary treatment of urban wastewater: new photocatalytic materials

Heterogeneous UV-photocatalytic process has been studied as tertiary treatment of real municipal wastewater. Wastewater photocatalytic treatment was carried out using several materials previously developed as photocatalysts: volcanic ashes and nanostructured titania supported over volcanic ashes. Both material activities in particles were compared with Degussa TiO₂ (powder). Photocatalyst amount influence was studied by varying it between 2 and 10 g L^?1. Wastewater decontamination process was evaluated measuring the chemical oxygen demand evolution with phototreatment time in order to choose the best photocatalytic material and its optimal operation concentration. Moreover, the photocatalytic results obtained were compared with those obtained from photolysis and adsorption studies in wastewater using the same operation conditions. In addition, analyses of main wastewater parameters were made in order to evaluate the complete water decontamination process. Possibility of using photocatalysts in particles shows the main advantage of continuous photocatalyst separation from the water effluent once the decontamination process has finished. Good photocatalytic activities were observed, and it allows to conclude that heterogeneous photocatalysis is an effective method for municipal wastewater treatment, achieving water disinfection and phosphates removal.     

实时高温下与热处理后砂岩动态拉伸特性研究

为了开展实时高温下及加热冷却后岩石动态力学性质的对比研究,利用自行设计的加热装置结合SHPB系统对两种温度状态砂岩的动态拉伸特性进行试验研究,处理温度为常温(25℃)～600℃共7组.结果表明:砂岩的率效应在两种温度状态下都存在,热处理后的砂岩拉伸强度除100℃外都比常温状态小,且随着热处理温度的增大,拉伸强度减小,温...     

实时高温下与热处理后砂岩动态拉伸特性研究

为了开展实时高温下及加热冷却后岩石动态力学性质的对比研究,利用自行设计的加热装置结合SHPB系统对两种温度状态砂岩的动态拉伸特性进行试验研究,处理温度为常温(25℃)～600℃共7组。结果表明:砂岩的率效应在两种温度状态下都存在,热处理后的砂岩拉伸强度除100℃外都比常温状态小,且随着热处理温度的增大,拉伸强度减小,温度会影响试样的破坏形态。高温下砂岩的拉伸强度除600℃外都比常温状态大,且拉伸强度随着温度的升高先增大后减小,加载率对破坏模式起主导作用。高温下的热膨胀作用会抑制裂纹相互连接,使得岩石结构更加密实,导致砂岩在实时高温下的拉伸强度相比加热冷却后有很大的区别。     

Gel dosimetry in the BNCT facility for extra-corporeal treatment of liver cancer at the HFR Petten

A thorough evaluation of the dose inside a specially designed and built facility for extra-corporeal treatment of liver cancer by boron neutron capture therapy (BNCT) at the High Flux Reactor (HFR) Petten (The Netherlands) is the necessary step before animal studies can start. The absorbed doses are measured by means of gel dosemeters, which help to validate the Monte Carlo simulations of the spheroidal liver holder that will contain the human liver for irradiation with an epithermal neutron beam. These dosemeters allow imaging of the dose due to gammas and to the charged particles produced by the (10)B reaction. The thermal neutron flux is extrapolated from the boron dose images and compared to that obtained by the calculations. As an additional reference, Au, Cu and Mn foil measurements are performed. All results appear consistent with the calculations and confirm that the BNCT liver facility is able to provide an almost homogeneous thermal neutron distribution in the liver, which is a requirement for a successful treatment of liver metastases.