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Inside Cover: Biosynthetic Gene Cluster for Surugamide A Encompasses an Unrelated Decapeptide,Surugamide F (ChemBioChem 18/2016) 下载免费PDF全文
Akihiro Ninomiya Prof. Yohei Katsuyama Prof. Takefumi Kuranaga Masayuki Miyazaki Dr. Yuichi Nogi Prof. Shigeru Okada Prof. Toshiyuki Wakimoto Prof. Yasuo Ohnishi Prof. Shigeki Matsunaga Prof. Kentaro Takada 《Chembiochem : a European journal of chemical biology》2016,17(18):1677-1677
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Inside Cover: Site‐Specific Immobilization of the Peptidoglycan Synthase PBP1B on a Surface Plasmon Resonance Chip Surface (ChemBioChem 23/2016) 下载免费PDF全文
Dr. Inge L. van't Veer Nadia O. L. Leloup Dr. Alexander J. F. Egan Dr. Bert J. C. Janssen Dr. Nathaniel I. Martin Prof. Dr. Waldemar Vollmer Dr. Eefjan Breukink 《Chembiochem : a European journal of chemical biology》2016,17(23):2207-2207
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Cover Picture: Reconstructing the Discontinuous and Conformational β1/β3‐Loop Binding Site on hFSH/hCG by Using Highly Constrained Multicyclic Peptides (ChemBioChem 1/2015) 下载免费PDF全文
Dr. Linde E. J. Smeenk Drohpatie Timmers‐Parohi Dr. Joris J. Benschop Wouter C. Puijk Prof. Dr. Henk Hiemstra Dr. Jan H. van Maarseveen Prof. Dr. Peter Timmerman 《Chembiochem : a European journal of chemical biology》2015,16(1):1-1
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Cover Picture: Selective Inhibitors of the Protein Tyrosine Phosphatase SHP2 Block Cellular Motility and Growth of Cancer Cells in vitro and in vivo (ChemMedChem 5/2015) 下载免费PDF全文
Dr. Stefanie Grosskopf Chris Eckert Dr. Christoph Arkona Dr. Silke Radetzki Dr. Kerstin Böhm Prof. Dr. Udo Heinemann Prof. Dr. Gerhard Wolber Dr. Jens‐Peter von Kries Prof. Dr. Walter Birchmeier Prof. Dr. Jörg Rademann 《ChemMedChem》2015,10(5):757-757
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Eun Joo Jung Anjugam Paramanantham Hye Jung Kim Sung Chul Shin Gon Sup Kim Jin-Myung Jung Soon Chan Hong Ky Hyun Chung Choong Won Kim Won Sup Lee 《International journal of molecular sciences》2022,23(3)
The anticancer effects of natural phytochemicals are relevant to the modulation of cytokine signaling pathways in various cancer cells with stem-like properties as well as immune cells. The aim of this study was to elucidate a novel anticancer mechanism of Artemisia annua L. polyphenols (pKAL) involved in the regulation of growth factors, cytokines and mediators in stem-like HCT116 colorectal cancer cells. Through RayBiotech human L-1000 antibody array and bioinformatics analysis, we show here that pKAL-induced anticancer effects are associated with downregulation of growth factor and cytokine signaling proteins including TGFA, FGF16, PDGFC, CCL28, CXCR3, IRF6 and SMAD1. Notably, we found that TGF-β signaling proteins such as GDF10, ENG and TGFBR2 and well-known survival proteins such as NGF-β, VEGFD and insulin were significantly upregulated by pKAL. Moreover, the results of hematoxylin staining, cell viability assay and Western blot analysis demonstrated that TGF-β1 and NGF-β attenuated pKAL-induced anticancer effects by inhibiting pKAL-induced downregulation of caspase-8, NF-κB p65 and cyclin D1. These results suggest that certain survival mediators may be activated by pKAL through the TGF-β1 and NGF-β signaling pathways during pKAL-induced cell death and thus, strategies to inhibit the survival signaling are inevitably required for more effective anticancer effects of pKAL. 相似文献