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1.
Thérèse Barbier Sarra Aissani Nicolas Weber Cédric Pasquier Jacques Felblinger 《Magma (New York, N.Y.)》2018,31(5):677-688
Purpose
To evaluate the function of an active implantable medical device (AIMD) during magnetic resonance imaging (MRI) scans. The induced voltages caused by the switching of magnetic field gradients and rectified radio frequency (RF) pulse were measured, along with the AIMD stimulations.Materials and methods
An MRI-compatible voltage probe with a bandwidth of 0–40 kHz was designed. Measurements were carried out both on the bench with an overvoltage protection circuit commonly used for AIMD and with a pacemaker during MRI scans on a 1.5 T (64 MHz) MR scanner.Results
The sensor exhibits a measurement range of?±?15 V with an amplitude resolution of 7 mV and a temporal resolution of 10 µs. Rectification was measured on the bench with the overvoltage protection circuit. Linear proportionality was confirmed between the induced voltage and the magnetic field gradient slew rate. The pacemaker pacing was recorded successfully during MRI scans.Conclusion
The characteristics of this low-frequency voltage probe allow its use with extreme RF transmission power and magnetic field gradient positioning for MR safety test of AIMD during MRI scans.2.
Mustafa Çavuşoğlu Benjamin Emanuel Dietrich David Otto Brunner Markus Weiger Klaas Paul Pruessmann 《Magma (New York, N.Y.)》2017,30(5):473-488
Objectives
The accuracy and precision of the parallel RF excitations are highly dependent on the spatial and temporal fidelity of the magnetic fields involved in spin excitation. The consistency between the nominal and effective fields is typically limited by the imperfections of the employed hardware existing both in the gradient system and the RF chain. In this work, we experimentally presented highly improved spatially tailored parallel excitations by turning the native hardware accuracy challenge into a measurement and control problem using an advanced field camera technology to fully correct parallel RF transmission experiment.Materials and methods
An array of NMR field probes is used to measure the multiple channel RF pulses and gradient waveforms recording the high power RF pulses simultaneously with low frequency gradient fields on equal time basis. The recorded waveforms were integrated in RF pulse design for gradient trajectory correction, time imperfection compensation and introduction of iterative RF pre-emphasis.Results
Superior excitation accuracy was achieved. Two major applications were presented at 7 Tesla including multi-dimensional tailored RF pulses for spatially selective excitation and slice-selective spoke pulses for \(B_{1}^{ + }\) mitigation.Conclusion
Comprehensive field monitoring is a highly effective means of correcting for the field deviations during parallel transmit pulse design.3.
Julia Stabinska Tom Cronenberg Hans-Jörg Wittsack Rotem Shlomo Lanzman Anja Müller-Lutz 《Magma (New York, N.Y.)》2017,30(5):505-516
Objectives
The goal of this study was to quantify CEST related parameters such as chemical exchange rate and fractional concentration of exchanging protons at a clinical 3T scanner. For this purpose, two CEST quantification approaches—the AREX metric (for ‘apparent exchange dependent relaxation’), and the AREX-based Ω-plot method were used. In addition, two different pulsed RF irradiation schemes, using Gaussian-shaped and spin-lock pulses, were compared.Materials and methods
Numerical simulations as well as MRI measurements in phantoms were performed. For simulations, the Bloch–McConnell equations were solved using a two-pool exchange model. MR experiments were performed on a clinical 3T MRI scanner using a cylindrical phantom filled with creatine solution at different pH values and different concentrations.Results
The validity of the Ω-plot method and the AREX approach using spin-lock preparation for determination of the quantitative CEST parameters was demonstrated. Especially promising results were achieved for the Ω-plot method when the spin-lock preparation was employed.Conclusion
Pulsed CEST at 3T could be used to quantify parameters such as exchange rate constants and concentrations of protons exchanging with free water. In the future this technique might be used to estimate the exchange rates and concentrations of biochemical substances in human tissues in vivo.4.
Alexander C. Wright Jonathon H. Yoder Edward J. Vresilovic Dawn M. Elliott 《Magma (New York, N.Y.)》2016,29(4):711-722
Objective
Here we develop a three-dimensional analytic model for MR image contrast of collagen lamellae in the annulus fibrosus of the intervertebral disc of the spine, based on the dependence of the MRI signal on collagen fiber orientation.Materials and methods
High-resolution MRI scans were performed at 1.5 and 7 T on intact whole disc specimens from ovine, bovine, and human spines. An analytic model that approximates the three-dimensional curvature of the disc lamellae was developed to explain inter-lamellar contrast and intensity variations in the annulus. The model is based on the known anisotropic dipolar relaxation of water in tissues with ordered collagen.Results
Simulated MRI data were generated that reproduced many features of the actual MRI data. The calculated inter-lamellar image contrast demonstrated a strong dependence on the collagen fiber angle and on the circumferential location within the annulus.Conclusion
This analytic model may be useful for interpreting MR images of the disc and for predicting experimental conditions that will optimize MR image contrast in the annulus fibrosus.5.
Jason Langley Daniel E. Huddleston Christine J. Liu Xiaoping Hu 《Magma (New York, N.Y.)》2017,30(2):121-125
Objectives
The purpose of this study was to assess the reproducibility of substantia nigra pars compacta (SNpc) and locus coeruleus (LC) delineation and measurement with neuromelanin-sensitive MRI.Materials and methods
Eleven subjects underwent two neuromelanin-sensitive MRI scans. SNpc and LC volumes were extracted for each scan. Reproducibility of volume and magnetization transfer contrast measurements in SNpc and LC was assessed using intraclass correlation coefficients (ICC) and dice similarity coefficients (DSC).Results
SNpc and LC volume measurements showed excellent reproducibility (SNpc-ICC: 0.94, p < 0.001; LC-ICC: 0.96, p < 0.001). SNpc and LC were accurately delineated between scans (SNpc-DSC: 0.80 ± 0.03; LC-DSC: 0.63 ± 0.07).Conclusion
Neuromelanin-sensitive MRI can consistently delineate SNpc and LC.6.
Daniel Giese Kilian Weiss Bettina Baeßler Navid Madershahian Yeong-Hoon Choi David Maintz Alexander C. Bunck 《Magma (New York, N.Y.)》2018,31(1):165-172
Objectives
The objective of the current work was to evaluate flow and turbulent kinetic energy in different transcatheter aortic valve implants using highly undersampled time-resolved multi-point 3-directional phase-contrast measurements (4D Flow MRI) in an in vitro setup.Materials and methods
A pulsatile flow setup was used with a compliant tubing mimicking a stiff left ventricular outflow tract and ascending aorta. Five different implants were measured using a highly undersampled multi-point 4D Flow MRI sequence. Velocities and turbulent kinetic energy values were analysed and compared.Results
Strong variations of turbulent kinetic energy distributions between the valves were observed. Maximum turbulent kinetic energy values ranged from 100 to over 500 J/m3 while through-plane velocities were similar between all valves.Conclusion
Highly accelerated 4D Flow MRI for the measurement of velocities and turbulent kinetic energy values allowed for the assessment of hemodynamic parameters in five different implant models. The presented setup, measurement protocol and analysis methods provides an efficient approach to compare different valve implants and could aid future novel valve designs.7.
Tora Dunås Anders Wåhlin Khalid Ambarki Laleh Zarrinkoob Richard Birgander Jan Malm Anders Eklund 《Magma (New York, N.Y.)》2016,29(1):39-47
Objectives
In order to introduce 4D flow magnetic resonance imaging (MRI) as a standard clinical instrument for studying the cerebrovascular system, new and faster postprocessing tools are necessary. The objective of this study was to construct and evaluate a method for automatic identification of individual cerebral arteries in a 4D flow MRI angiogram.Materials and methods
Forty-six elderly individuals were investigated with 4D flow MRI. Fourteen main cerebral arteries were manually labeled and used to create a probabilistic atlas. An automatic atlas-based artery identification method (AAIM) was developed based on vascular-branch extraction and the atlas was used for identification. The method was evaluated by comparing automatic with manual identification in 4D flow MRI angiograms from 67 additional elderly individuals.Results
Overall accuracy was 93 %, and internal carotid artery and middle cerebral artery labeling was 100 % accurate. Smaller and more distal arteries had lower accuracy; for posterior communicating arteries and vertebral arteries, accuracy was 70 and 89 %, respectively.Conclusion
The AAIM enabled fast and fully automatic labeling of the main cerebral arteries. AAIM functionality provides the basis for creating an automatic and powerful method to analyze arterial cerebral blood flow in clinical routine.8.
Nicholas G. Spencer David P. Lovell Kay Elderfield Brian Austen Franklyn A. Howe 《Magma (New York, N.Y.)》2017,30(2):153-163
Objectives
In the present study, we have tested whether MRI T1 relaxation time is a sensitive marker to detect early stages of amyloidosis and gliosis in the young 5xFAD transgenic mouse, a well-established animal model for Alzheimer’s disease.Materials and methods
5xFAD and wild-type mice were imaged in a 4.7 T Varian horizontal bore MRI system to generate T1 quantitative maps using the spin-echo multi-slice sequence. Following immunostaining for glial fibrillary acidic protein, Iba-1, and amyloid-β, T1 and area fraction of staining were quantified in the posterior parietal and primary somatosensory cortex and corpus callosum.Results
In comparison with age-matched wild-type mice, we observed first signs of amyloidosis in 2.5-month-old 5xFAD mice, and development of gliosis in 5-month-old 5xFAD mice. In contrast, MRI T1 relaxation times of young, i.e., 2.5- and 5-month-old, 5xFAD mice were not significantly different to those of age-matched wild-type controls. Furthermore, although disease progression was detectable by increased amyloid-β load in the brain of 5-month-old 5xFAD mice compared with 2.5-month-old 5xFAD mice, MRI T1 relaxation time did not change.Conclusions
In summary, our data suggest that MRI T1 relaxation time is neither a sensitive measure of disease onset nor progression at early stages in the 5xFAD mouse transgenic mouse model.9.
Maximilian N. Voelker Oliver Kraff Daniel Brenner Astrid Wollrab Oliver Weinberger Moritz C. Berger Simon Robinson Wolfgang Bogner Christopher Wiggins Robert Trampel Tony Stöcker Thoralf Niendorf Harald H. Quick David G. Norris Mark E. Ladd Oliver Speck 《Magma (New York, N.Y.)》2016,29(3):399-415
Objective
This study evaluates the inter-site and intra-site reproducibility of 7 Tesla brain imaging and compares it to literature values for other field strengths.Materials and methods
The same two subjects were imaged at eight different 7 T sites. MP2RAGE, TSE, TOF, SWI, EPI as well as B1 and B0 field maps were analyzed quantitatively to assess inter-site reproducibility. Intra-site reproducibility was measured with rescans at three sites.Results
Quantitative measures of MP2RAGE scans showed high agreement. Inter-site and intra-site reproducibility errors were comparable to 1.5 and 3 T. Other sequences also showed high reproducibility between the sites, but differences were also revealed. The different RF coils used were the main source for systematic differences between the sites.Conclusion
Our results show for the first time that multi-center brain imaging studies of the supratentorial brain can be performed at 7 T with high reproducibility and similar reliability as at 3T. This study develops the basis for future large-scale 7 T multi-site studies.10.
Mads S. Vinding Daniel Brenner Desmond H. Y. Tse Sebastian Vellmer Thomas Vosegaard Dieter Suter Tony Stöcker Ivan I. Maximov 《Magma (New York, N.Y.)》2017,30(1):29-39
Objective
Ultrahigh field MRI provides great opportunities for medical diagnostics and research. However, ultrahigh field MRI also brings challenges, such as larger magnetic susceptibility induced field changes. Parallel-transmit radio-frequency pulses can ameliorate these complications while performing advanced tasks in routine applications. To address one class of such pulses, we propose an optimal-control algorithm as a tool for designing advanced multi-dimensional, large flip-angle, radio-frequency pulses. We contrast initial conditions, constraints, and field correction abilities against increasing pulse trajectory acceleration factors.Materials and methods
On an 8-channel 7T system, we demonstrate the quasi-Newton algorithm with pulse designs for reduced field-of-view imaging with an oil phantom and in vivo with scans of the human brain stem. We used echo-planar imaging with 2D spatial-selective pulses. Pulses are computed sufficiently rapid for routine applications.Results
Our dataset was quantitatively analyzed with the conventional mean-square-error metric and the structural-similarity index from image processing. Analysis of both full and reduced field-of-view scans benefit from utilizing both complementary measures.Conclusion
We obtained excellent outer-volume suppression with our proposed method, thus enabling reduced field-of-view imaging using pulse trajectory acceleration factors up to 4.11.
Elias Kellner Irina Mader Marco Reisert Horst Urbach Valerij Gennadevic Kiselev 《Magma (New York, N.Y.)》2018,31(3):439-448
Object
We aimed to modify our previously published method for arterial input function measurements for evaluation of cerebral perfusion (dynamic susceptibility contrast MRI) such that it can be applied in humans in a clinical setting.Materials and methods
Similarly to our previous work, a conventional measurement sequence for dynamic susceptibility contrast MRI is extended with an additional measurement slice at the neck. Measurement parameters at this slice were optimized for the blood signal (short echo time, background suppression, magnitude and phase images). Phase-based evaluation of the signal in the carotid arteries is used to obtain quantitative arterial input functions.Results
In all pilot measurements, quantitative arterial input functions were obtained. The resulting absolute perfusion parameters agree well with literature values (gray and white matter mean values of 46 and 24 mL/100 g/min, respectively, for cerebral blood flow and 3.0% and 1.6%, respectively, for cerebral blood volume).Conclusions
The proposed method has the potential to quantify arterial input functions in the carotid arteries from a direct measurement without any additional normalization.12.
Gerd Weidemann Frank Seifert Werner Hoffmann Harald Pfeiffer Reiner Seemann Bernd Ittermann 《Magma (New York, N.Y.)》2016,29(3):371-378
Objective
The power balance of multichannel transmit coils is a central consideration in assessing performance and safety issues. At ultrahigh fields, in addition to absorption and reflection, radiofrequency (RF) radiation into the far field becomes a concern.Materials and methods
We engineered a system for in situ measurement of complex-valued scattering parameter (S-parameter) matrices of multichannel transmit coils that allows for the calculation of the reflected and accepted power for arbitrary steering conditions. The radiated power from an RF coil inside a large single-mode waveguide couples to that mode. Finite-difference time-domain simulations were used for the calculations, and E-field probes were used to measure the electric field distribution, and hence the radiated power, in the waveguide. To test this concept, an eight-channel shielded-loop array for 7T imaging was studied inside a 280-cm-long cylindrical waveguide with a 60-cm diameter.Results
For a 7T parallel-transmit coil, the S-parameters were measured and the reflected power calculated as a function of steering conditions. Maximum radiated power was observed for the circularly polarized mode.Conclusion
A system was developed for in situ S-parameter measurements combined with a method for determining radiated power, allowing a complete assessment of the power balance of multichannel transmit coils at 7T.13.
Haining Liu Gregory J. Wilson Niranjan Balu Jeffrey H. Maki Daniel S. Hippe Wei Wu Hiroko Watase Jinnan Wang Martin L. Gunn Chun Yuan 《Magma (New York, N.Y.)》2018,31(1):87-99
Objectives
A postprocessing technique termed 3D true-phase polarity recovery with independent phase estimation using three-tier stacks based region growing (3D-TRIPS) was developed, which directly reconstructs phase-sensitive inversion-recovery images without acquisition of phase-reference images. The utility of this technique is demonstrated in myocardial late gadolinium enhancement (LGE) imaging.Materials and methods
A data structure with three tiers of stacks was used for 3D-TRIPS to directly achieve reliable region growing for successful background-phase estimation. Fifteen patients undergoing postgadolinium 3D phase-sensitive inversion recovery (PSIR) cardiac LGE magnetic resonance imaging (MRI) were recruited, and 3D-TRIPS LGE reconstructions were compared with standard PSIR. Objective voxel-by-voxel comparison was performed. Additionally, blinded review by two radiologists compared scar visibility, clinical acceptability, voxel polarity error, or groups and blurring.Results
3D-TRIPS efficiently reconstructed postcontrast phase-sensitive myocardial LGE images. Objective analysis showed an average 95% voxel-by-voxel agreement between 3D-TRIPS and PSIR images. Blinded radiologist review demonstrated similar image quality between 3D-TRIPS and PSIR reconstruction.Conclusion
3D-TRIPS provided similar image quality to PSIR for phase-sensitive myocardial LGE MRI reconstruction. 3D-TRIPS does not require acquisition of a reference image and can therefore be used to accelerate phase-sensitive LGE imaging.14.
Manushka V. Vaidya Cem M. Deniz Christopher M. Collins Daniel K. Sodickson Riccardo Lattanzi 《Magma (New York, N.Y.)》2018,31(3):355-366
Objective
To use high-permittivity materials (HPM) positioned near radiofrequency (RF) surface coils to manipulate transmit/receive field patterns.Materials and methods
A large HPM pad was placed below the RF coil to extend the field of view (FOV). The resulting signal-to-noise ratio (SNR) was compared with that of other coil configurations covering the same FOV in simulations and experiments at 7 T. Transmit/receive efficiency was evaluated when HPM discs with or without a partial shield were positioned at a distance from the coil. Finally, we evaluated the increase in transmit homogeneity for a four-channel array with HPM discs interposed between adjacent coil elements.Results
Various configurations of HPM increased SNR, transmit/receive efficiency, excitation/reception sensitivity overlap, and FOV when positioned near a surface coil. For a four-channel array driven in quadrature, shielded HPM discs enhanced the field below the discs as well as at the center of the sample as compared with other configurations with or without unshielded HPM discs.Conclusion
Strategically positioning HPM at a distance from a surface coil or array can increase the overlap between excitation/reception sensitivities, and extend the FOV of a single coil for reduction of the number of channels in an array while minimally affecting the SNR.15.
Objective
To retrospectively assess perception of safety of healthy individuals working with human 7 Tesla (T) magnetic resonance imaging (MRI) scanners.Materials and methods
A total of 66 healthy individuals with a mean age of 31 ± 7 years participated in this retrospective multicentre survey study. Nonparametric correlation analysis was conducted to evaluate the relation between self-reported perception of safety and prevalence of sensory effects while working with 7 T MRI scanners for an average 47 months.Results
The results indicated that 98.5 % of the study participants had a neutral or positive feeling about safety aspects at 7 T MRI scanners. 45.5 % reported that they feel very safe and none of the participants stated that they feel moderately or very unsafe while working with 7 T MRI scanners. Perception of safety was not affected by the number of hours per week spent in the vicinity of the 7 T MRI scanner or the duration of experience with 7 T MRI. More than 50 % of individuals experienced vertigo and metallic taste while working with 7 T MRI scanners. However, participants’ perceptions of safety were not affected by the prevalence of MR-related symptoms.Conclusions
The overall data indicated an average perception of a moderately safe work environment. To our knowledge, this study delineates the first attempt to assess the subjective safety perception among 7 T MRI workers and suggests further investigations are indicated.16.
Bixia Chen Tobias Schoemberg Oliver Kraff Philipp Dammann Andreas K. Bitz Marc Schlamann Harald H. Quick Mark E. Ladd Ulrich Sure Karsten H. Wrede 《Magma (New York, N.Y.)》2016,29(3):389-398
Objective
This study assesses and quantifies impairment of postoperative magnetic resonance imaging (MRI) at 7 Tesla (T) after implantation of titanium cranial fixation plates (CFPs) for neurosurgical bone flap fixation.Materials and methods
The study group comprised five patients who were intra-individually examined with 3 and 7 T MRI preoperatively and postoperatively (within 72 h/3 months) after implantation of CFPs. Acquired sequences included T1-weighted magnetization-prepared rapid-acquisition gradient-echo (MPRAGE), T2-weighted turbo-spin-echo (TSE) imaging, and susceptibility-weighted imaging (SWI). Two experienced neurosurgeons and a neuroradiologist rated image quality and the presence of artifacts in consensus reading.Results
Minor artifacts occurred around the CFPs in MPRAGE and T2 TSE at both field strengths, with no significant differences between 3 and 7 T. In SWI, artifacts were accentuated in the early postoperative scans at both field strengths due to intracranial air and hemorrhagic remnants. After resorption, the brain tissue directly adjacent to skull bone could still be assessed. Image quality after 3 months was equal to the preoperative examinations at 3 and 7 T.Conclusion
Image quality after CFP implantation was not significantly impaired in 7 T MRI, and artifacts were comparable to those in 3 T MRI.17.
Objectives
We evaluated the vascularity of retained products of conception (RPOC) using arterial spin-labeling magnetic resonance imaging (ASL-MRI) to clarify the clinical feasibility of this approach.Materials and methods
A pulsed-continuous ASL sequence with echo-planar imaging (EPI) acquisitions was used. Ten consecutive patients with RPOC were enrolled. All ASL images were evaluated visually and semiquantitatively and compared with the findings of Doppler ultrasound (US) and dynamic contrast-enhanced MRI (DCE-MRI).Results
The technical success rate was 93.7% (15/16 scans). One failed case was excluded from the analysis. Six patients showed quite high signals over RPOC, while three patients showed no abnormal signals. Doppler US alone failed to detect the hypervascular area in two cases, and ASL-MRI alone failed in three. A significant linear correlation was found between semiquantitative values of ASL-MRI and DCE-MRI. All six patients showing high signals on ASL-MRI underwent follow-up MRI after therapy. High signals in five patients decreased visually and semiquantitatively, while one patient showed signal increases.Conclusion
Evaluation of RPOC using ASL-MRI was clinically feasible and response to therapy could be evaluated. However, the clinical advantages over conventional imaging remain unclear and need to be evaluated.18.
Jana Kemnitz Felix Eckstein Adam G. Culvenor Anja Ruhdorfer Torben Dannhauer Susanne Ring-Dimitriou Alexandra M. Sänger Wolfgang Wirth 《Magma (New York, N.Y.)》2017,30(5):489-503
Objective
To validate a semi-automated method for thigh muscle and adipose tissue cross-sectional area (CSA) segmentation from MRI.Materials and methods
An active shape model (ASM) was trained using 113 MRI CSAs from the Osteoarthritis Initiative (OAI) and combined with an active contour model and thresholding-based post-processing steps. This method was applied to 20 other MRIs from the OAI and to baseline and follow-up MRIs from a 12-week lower-limb strengthening or endurance training intervention (n = 35 females). The agreement of semi-automated vs. previous manual segmentation was assessed using the Dice similarity coefficient and Bland-Altman analyses. Longitudinal changes observed in the training intervention were compared between semi-automated and manual segmentations.Results
High agreement was observed between manual and semi-automated segmentations for subcutaneous fat, quadriceps and hamstring CSAs. With strength training, both the semi-automated and manual segmentation method detected a significant reduction in adipose tissue CSA and a significant gain in quadriceps, hamstring and adductor CSAs. With endurance training, a significant reduction in adipose tissue CSAs was observed with both methods.Conclusion
The semi-automated approach showed high agreement with manual segmentation of thigh muscle and adipose tissue CSAs and showed longitudinal training effects similar to that observed using manual segmentation.19.
Henry Rusinek Jeremy C. Lim Nicole Wake Jas-mine Seah Elissa Botterill Shawna Farquharson Artem Mikheev Ruth P. Lim 《Magma (New York, N.Y.)》2016,29(2):197-206
Objective
To investigate the precision and accuracy of a new semi-automated method for kidney segmentation from single-breath-hold non-contrast MRI.Materials and methods
The user draws approximate kidney contours on every tenth slice, focusing on separating adjacent organs from the kidney. The program then performs a sequence of fully automatic steps: contour filling, interpolation, non-uniformity correction, sampling of representative parenchyma signal, and 3D binary morphology. Three independent observers applied the method to images of 40 kidneys ranging in volume from 94.6 to 254.5 cm3. Manually constructed reference masks were used to assess accuracy.Results
The volume errors for the three readers were: 4.4 % ± 3.0 %, 2.9 % ± 2.3 %, and 3.1 % ± 2.7 %. The relative discrepancy across readers was 2.5 % ± 2.1 %. The interactive processing time on average was 1.5 min per kidney.Conclusions
Pending further validation, the semi-automated method could be applied for monitoring of renal status using non-contrast MRI.20.
Bernhard Neumayer Eva Amerstorfer Clemens Diwoky Richard A. Lindtner Elisabeth Wadl Eva Scheurer Annelie-Martina Weinberg Rudolf Stollberger 《Magma (New York, N.Y.)》2017,30(5):417-427