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1.
E. E. Sigmund S. H. Baete K. Patel D. Wang D. Stoffel R. Otazo P. Parasoglou J. Bencardino 《Magma (New York, N.Y.)》2018,31(5):599-608
Objectives
We describe measurement of skeletal muscle kinetics with multiple echo diffusion tensor imaging (MEDITI). This approach allows characterization of the microstructural dynamics in healthy and pathologic muscle.Materials and methods
In a Siemens 3-T Skyra scanner, MEDITI was used to collect dynamic DTI with a combination of rapid diffusion encoding, radial imaging, and compressed sensing reconstruction in a multi-compartment agarose gel rotation phantom and within in vivo calf muscle. An MR-compatible ergometer (Ergospect Trispect) was employed to enable in-scanner plantar flexion exercise. In a HIPAA-compliant study with written informed consent, post-exercise recovery of DTI metrics was quantified in eight volunteers. Exercise response of DTI metrics was compared with that of T2-weighted imaging and characterized by a gamma variate model.Results
Phantom results show quantification of diffusivities in each compartment over its full dynamic rotation. In vivo calf imaging results indicate larger radial than axial exercise response and recovery in the plantar flexion-challenged gastrocnemius medialis (fractional response: nT2w?=?0.385?±?0.244, nMD?=?0.163?±?0.130, nλ1?=?0.110?±?0.093, nλrad?=?0.303?±?0.185). Diffusion and T2-weighted response magnitudes were correlated (e.g., r?=?0.792, p?=?0.019 for nMD vs. nT2w).Conclusion
We have demonstrated the feasibility of MEDITI for capturing spatially resolved diffusion tensor data in dynamic systems including post-exercise skeletal muscle recovery following in-scanner plantar flexion.2.
Objective
Recent MRI studies have shown that the orientation of nerve fibres relative to the main magnetic field affects the R2*(= 1/T2*) relaxation rate in white matter (WM) structures. The underlying physical causes have been discussed in several studies but are still not completely understood. However, understanding these effects in detail is of great importance since this might serve as a basis for the development of new diagnostic tools and/or improve quantitative susceptibility mapping techniques. Therefore, in addition to the known angular dependence of R2*, the current study investigates the relationship between fibre orientation and the longitudinal relaxation rate, R1 (= 1/T1), as well as the apparent water content.Materials and methods
For a group of 16 healthy subjects, a series of gradient echo, echo-planar and diffusion weighted images were acquired at 3T from which the decay rates, the apparent water content and the diffusion direction were reconstructed. The diffusion weighted data were used to determine the angle between the principle fibre direction and the main magnetic field to examine the angular dependence of R1 and apparent water content.Results
The obtained results demonstrate that both parameters depend on the fibre orientation and exhibit a positive correlation with the angle between fibre direction and main magnetic field.Conclusion
These observations could be helpful to improve and/or constrain existing biophysical models of brain microstructure by imposing additional constraints resulting from the observed angular dependence R1 and apparent water content in white matter.3.
Mahsa Fatahi Jolanta Karpowicz Krzysztof Gryz Amirmohammad Fattahi Georg Rose Oliver Speck 《Magma (New York, N.Y.)》2017,30(3):255-264
Objective
To assess the individual exposure to the static magnetic field (SMF) and the motion-induced time-varying magnetic field (TVMF) generated by activities in an inhomogeneous SMF near high and ultra-high field magnetic resonance imaging (MRI) scanners. The study provides information on the level of exposure to high and ultra-high field MRI scanners during research activities.Materials and methods
A three-axis Hall magnetometer was used to determine the SMF and TVMF around human 3- and 7-Tesla (T) MRI systems. The 7-T MRI scanner used in this study was passively shielded and the 3-T scanner was actively shielded and both were from the same manufacturer. The results were compared with the exposure restrictions given by the International Commission on Non-Ionizing Radiation Protection (ICNIRP).Results
The recorded exposure was highly variable between individuals, although they followed the same instructions for moving near the scanners. Maximum exposure values of B = 2057 mT and dB/dt = 4347 mT/s for the 3-T scanner and B = 2890 mT, dB/dt = 3900 mT/s for 7 T were recorded. No correlation was found between reporting the MRI-related sensory effects and exceeding the reference values.Conclusions
According to the results of our single-center study with five subjects, violation of the ICNIRP restrictions for max B in MRI research environments was quite unlikely at 3 and 7 T. Occasions of exceeding the dB/dt limit at 3 and 7 T were almost similar (30% of 60 exposure scenarios) and highly variable among the individuals.4.
Maria Filomena Santarelli Antonella Meloni Daniele De Marchi Laura Pistoia Antonella Quarta Anna Spasiano Luigi Landini Alessia Pepe Vincenzo Positano 《Magma (New York, N.Y.)》2018,31(6):757-769
Objectives
To propose a method for estimating pancreatic relaxation rate, R2*, from conventional multi-echo MRI, based on the nonlinear fitting of the acquired magnitude signal decay to MR signal models that take into account both the signal oscillations induced by fat and the different R2* values of pancreatic parenchyma and fat.Materials and methods
Single-peak fat (SPF) and multi-peak fat (MPF) models were introduced. Single-R2* and dual-R2* assumptions were considered as well. Analyses were conducted on simulated data and 20 thalassemia major patients.Results
Simulations revealed the ability of the MPF model to correctly estimate the R2* value in a large range of fat fractions and R2* values. From the comparison between the results obtained with a single R2* value for water and fat and the dual-R2* approach, the latter is more accurate in both water R2* and fat fraction estimation. In patient’s data analysis, a strong concordance was found between SPF and MPF estimated data with measurements done with manual signal correction and from fat-saturated images. The MPF method showed better reproducibility.Conclusion
The MPF dual-R2* approach improves reproducibility and reduces image analysis time in the assessment of pancreatic R2* value in patients with iron overload.5.
Vassilios S. Vassiliou Katharina Wassilew Donnie Cameron Ee Ling Heng Evangelia Nyktari George Asimakopoulos Anthony de Souza Shivraman Giri Iain Pierce Andrew Jabbour David Firmin Michael Frenneaux Peter Gatehouse Dudley J. Pennell Sanjay K. Prasad 《Magma (New York, N.Y.)》2018,31(1):101-113
Objectives
Our objectives involved identifying whether repeated averaging in basal and mid left ventricular myocardial levels improves precision and correlation with collagen volume fraction for 11 heartbeat MOLLI T 1 mapping versus assessment at a single ventricular level.Materials and methods
For assessment of T 1 mapping precision, a cohort of 15 healthy volunteers underwent two CMR scans on separate days using an 11 heartbeat MOLLI with a 5(3)3 beat scheme to measure native T 1 and a 4(1)3(1)2 beat post-contrast scheme to measure post-contrast T 1, allowing calculation of partition coefficient and ECV. To assess correlation of T 1 mapping with collagen volume fraction, a separate cohort of ten aortic stenosis patients scheduled to undergo surgery underwent one CMR scan with this 11 heartbeat MOLLI scheme, followed by intraoperative tru-cut myocardial biopsy. Six models of myocardial diffuse fibrosis assessment were established with incremental inclusion of imaging by averaging of the basal and mid-myocardial left ventricular levels, and each model was assessed for precision and correlation with collagen volume fraction.Results
A model using 11 heart beat MOLLI imaging of two basal and two mid ventricular level averaged T 1 maps provided improved precision (Intraclass correlation 0.93 vs 0.84) and correlation with histology (R 2 = 0.83 vs 0.36) for diffuse fibrosis compared to a single mid-ventricular level alone. ECV was more precise and correlated better than native T 1 mapping.Conclusion
T 1 mapping sequences with repeated averaging could be considered for applications of 11 heartbeat MOLLI, especially when small changes in native T 1/ECV might affect clinical management.6.
Objective
Use of spectroscopically-acquired spin echoes typically involves Fourier transformation of the right side of the echo while largely neglecting the left side. For sufficiently long echo times, the left side may have enough spectral resolution to offer some utility. Since the acquisition of this side is “free”, we deemed it worthy of attention and investigated the spectral properties and information content of this data.Materials and methods
Theoretical expressions for left- and right-side spectra were derived assuming Lorentzian frequency distributions. For left-side spectra, three regimes were identified based upon the relative magnitudes of reversible and irreversible transverse relaxation rates, R 2′ and R 2, respectively. Point-resolved spectroscopy (PRESS) data from muscle, fat deposit and bone marrow were acquired at 1.5 T to test aspects of the theoretical expressions.Results
For muscle water or methylene marrow resonances, left-side signals were substantially or moderately larger than right-side signals but were similar in magnitude for muscle choline and creatine resonances. Left- versus right-side spectral-peak amplitude ratios depend sensitively on the relative values of R 2 and R 2′, which can be estimated given this ratio and a right-side linewidth measurement.Conclusion
Left-side spectra can be used to augment signal-to-noise and to estimate spectral R 2 and R 2′ values under some circumstances.7.
Peter T. While Jose R. Teruel Igor Vidić Tone F. Bathen Pål Erik Goa 《Magma (New York, N.Y.)》2018,31(3):425-438
Objective
To explore the relationship between relative enhanced diffusivity (RED) and intravoxel incoherent motion (IVIM), as well as the impact of noise and the choice of intermediate diffusion weighting (b value) on the RED parameter.Materials and methods
A mathematical derivation was performed to cast RED in terms of the IVIM parameters. Noise analysis and b value optimization was conducted by using Monte Carlo calculations to generate diffusion-weighted imaging data appropriate to breast and liver tissue at three different signal-to-noise ratios.Results
RED was shown to be approximately linearly proportional to the IVIM parameter f, inversely proportional to D and to follow an inverse exponential decay with respect to D*. The choice of intermediate b value was shown to be important in minimizing the impact of noise on RED and in maximizing its discriminatory power. RED was shown to be essentially a reparameterization of the IVIM estimates for f and D obtained with three b values.Conclusion
RED imaging in the breast and liver should be performed with intermediate b values of 100 and 50 s/mm2, respectively. Future clinical studies involving RED should also estimate the IVIM parameters f and D using three b values for comparison.8.
Objective
Intravoxel incoherent motion (IVIM) shows great potential in many applications, e.g., tumor tissue characterization. To reduce image-quality demands, various IVIM analysis approaches restricted to the diffusion coefficient (D) and the perfusion fraction (f) are increasingly being employed. In this work, the impact of estimation approach for D and f is studied.Materials and methods
Four approaches for estimating D and f were studied: segmented IVIM fitting, least-squares fitting of a simplified IVIM model (sIVIM), and Bayesian fitting of the sIVIM model using marginal posterior modes or posterior means. The estimation approaches were evaluated in terms of bias and variability as well as ability for differentiation between tumor and healthy liver tissue using simulated and in vivo data.Results
All estimation approaches had similar variability and ability for differentiation and negligible bias, except for the Bayesian posterior mean of f, which was substantially biased. Combined use of D and f improved tumor-to-liver tissue differentiation compared with using D or f separately.Discussion
The similar performance between estimation approaches renders the segmented one preferable due to lower numerical complexity and shorter computational time. Superior tissue differentiation when combining D and f suggests complementary biologically relevant information.9.
Valentin H. Prevost Olivier M. Girard Gopal Varma David C. Alsop Guillaume Duhamel 《Magma (New York, N.Y.)》2016,29(4):699-709
Objectives
The recently reported inhomogeneous magnetization transfer technique (ihMT) has been proposed for specific imaging of inhomogeneously broadened lines, and has shown great promise for characterizing myelinated tissues. The ihMT contrast is obtained by subtracting magnetization transfer images obtained with simultaneous saturation at positive and negative frequency offsets (dual frequency saturation experiment, MT +/?) from those obtained with single frequency saturation (MT +) at the same total power. Hence, ihMT may be biased by MT-asymmetry, especially at ultra-high magnetic field. Use of the average of single positive and negative frequency offset saturation MT images, i.e., (MT ++MT ?) has been proposed to correct the ihMT signal from MT-asymmetry signal.Materials and methods
The efficiency of this correction method was experimentally assessed in this study, performed at 11.75 T on mice. Quantitative corrected ihMT and MT-asymmetry ratios (ihMTR and MTRasym) were measured in mouse brain structures for several MT-asymmetry magnitudes and different saturation parameter sets.Results
Our results indicated a “safe” range of magnitudes (/MTRasym/<4 %) for which MT-asymmetry signal did not bias the corrected ihMT signal. Moreover, experimental evidence of the different natures of both MT-asymmetry and inhomogeneous MT contrasts were provided. In particular, non-zero ihMT ratios were obtained at zero MTRasym values.Conclusion
MTRasym is not a confounding factor for ihMT quantification, even at ultra-high field, as long as MTRasym is restricted to ±4 %.10.
Florent Eggenschwiler Kieran Robert O’Brien Daniel Gallichan Rolf Gruetter José Pedro Marques 《Magma (New York, N.Y.)》2016,29(3):347-358
Objectives
For turbo spin echo (TSE) sequences to be useful at ultra-high field, they should ideally employ an RF pulse train compensated for the B 1 + inhomogeneity. Previously, it was shown that a single kT-point pulse designed in the small tip-angle regime can replace all the pulses of the sequence (static kT-points). This work demonstrates that the B 1 + dependence of T 2-weighted imaging can be further mitigated by designing a specific kT-point pulse for each pulse of a 3D TSE sequence (dynamic kT-points) even on single-channel transmit systemsMaterials and methods
By combining the spatially resolved extended phase graph formalism (which calculates the echo signals throughout the sequence) with a gradient descent algorithm, dynamic kT-points were optimized such that the difference between the simulated signal and a target was minimized at each echo. Dynamic kT-points were inserted into the TSE sequence to acquire in vivo images at 7T.Results
The improvement provided by the dynamic kT-points over the static kT-point design and conventional hard pulses was demonstrated via simulations. Images acquired with dynamic kT-points showed systematic improvement of signal and contrast at 7T over regular TSE—especially in cerebellar and temporal lobe regions without the need of parallel transmission.Conclusion
Designing dynamic kT-points for a 3D TSE sequence allows the acquisition of T 2-weighted brain images on a single-transmit system at ultra-high field with reduced dropout and only mild residual effects due to the B 1 + inhomogeneity.11.
Maxime Donadieu Yann Le Fur Sylviane Confort-Gouny Arnaud Le Troter Maxime Guye Jean-Philippe Ranjeva 《Magma (New York, N.Y.)》2016,29(3):491-501
Objective
To demonstrate that high resolution 1H semi-LASER MRSI acquired at 7 T permits discrimination of metabolic patterns of different thalamic nuclei.Materials and methods
Thirteen right-handed healthy volunteers were explored at 7 T using a high-resolution 2D-semi-LASER 1H-MRSI sequence to determine the relative levels of N-Acetyl Aspartate (NAA), choline (Cho) and creatine-phosphocreatine (Cr) in eight VOIs (volume <0.3 ml) centered on four different thalamic nuclei located on the Oxford thalamic connectivity atlas. Post-processing was done using the CSIAPO software. Chemical shift displacement of metabolites was evaluated on a phantom and correction factors were applied to in vivo data.Results
The global assessment (ANOVA p < 0.05) of the neurochemical profiles (NAA, Cho and Cr levels) with thalamic nuclei and hemispheres as factors showed a significant global effect (F = 11.98, p < 0.0001), with significant effect of nucleus type (p < 0.0001) and hemisphere (p < 0.0001). Post hoc analyses showed differences in neurochemical profiles between the left and the right hemisphere (p < 0.05), and differences in neurochemical profiles between nuclei within each hemisphere (p < 0.05).Conclusion
For the first time, using high resolution 2D-PRESS semi-LASER 1H-MRSI acquired at 7 T, we demonstrated that the neurochemical profiles were different between thalamic nuclei, and that these profiles were dependent on the brain hemisphere.12.
Katharina E. Schleicher Michael Bock Klaus Düring Stefan Kroboth Axel J. Krafft 《Magma (New York, N.Y.)》2018,31(2):235-242
Objectives
Guidewires are indispensable tools for intravascular MR-guided interventions. Recently, an MR-safe guidewire made from a glass-fiber/epoxy compound material with embedded iron particles was developed. The size of the induced susceptibility artifact, and thus the guidewire’s visibility, depends on its orientation against B 0. We present a radial acquisition scheme with variable echo times that aims to reduce the artifact’s orientation dependency.Materials and methods
The radial acquisition scheme uses sine-squared modulated echo times depending on the physical direction of the spoke to balance the susceptibility artifact of the guidewire. The acquisition scheme was studied in simulations based on dipole fields and in phantom experiments for different orientations of the guidewire against B 0. The simulated and measured artifact widths were quantitatively compared.Results
Compared to acquisitions with non-variable echo times, the proposed acquisition scheme shows a reduced angular variability. For the two main orientations (i.e., parallel and perpendicular to B 0), the ratio of the artifact widths was reduced from about 2.2 (perpendicular vs. parallel) to about 1.2 with the variable echo time approach.Conclusion
The reduction of the orientation dependency of the guidewire’s artifact via sine-squared varying echo times could be verified in simulations and measurements. The more balanced artifact allows for a better overall visibility of the guidewire.13.
14.
Jorge Zavala Bojorquez Stéphanie Bricq François Brunotte Paul M. Walker Alain Lalande 《Magma (New York, N.Y.)》2016,29(5):777-788
Objective
To segment and classify the different attenuation regions from MRI at the pelvis level using the T 1 and T 2 relaxation times and anatomical knowledge as a first step towards the creation of PET/MR attenuation maps.Materials and methods
Relaxation times were calculated by fitting the pixel-wise intensities of acquired T 1- and T 2-weighted images from eight men with inversion-recovery and multi-echo multi-slice spin-echo sequences. A decision binary tree based on relaxation times was implemented to segment and classify fat, muscle, prostate, and air (within the body). Connected component analysis and an anatomical knowledge-based procedure were implemented to localize the background and bone.Results
Relaxation times at 3 T are reported for fat (T 1 = 385 ms, T 2 = 121 ms), muscle (T 1 = 1295 ms, T 2 = 40 ms), and prostate (T 1 = 1700 ms, T 2 = 80 ms). The relaxation times allowed the segmentation–classification of fat, prostate, muscle, and air, and combined with anatomical knowledge, they allowed classification of bone. The good segmentation–classification of prostate [mean Dice similarity score (mDSC) = 0.70] suggests a viable implementation in oncology and that of fat (mDSC = 0.99), muscle (mDSC = 0.99), and bone (mDSCs = 0.78) advocates for its implementation in PET/MR attenuation correction.Conclusion
Our method allows the segmentation and classification of the attenuation-relevant structures required for the generation of the attenuation map of PET/MR systems in prostate imaging: air, background, bone, fat, muscle, and prostate.15.
Jianmin Yuan Ammara Usman Scott A. Reid Kevin F. King Andrew J. Patterson Jonathan H. Gillard Martin J. Graves 《Magma (New York, N.Y.)》2018,31(1):183-190
Objective
The purpose of this work is to evaluate the repeatability of a compressed sensing (CS) accelerated multi-contrast carotid protocol at 3 T.Materials and methods
Twelve volunteers and eight patients with carotid disease were scanned on a 3 T MRI scanner using a CS accelerated 3-D black-blood multi-contrast protocol which comprises T 1w, T 2w and PDw without CS, and with a CS factor of 1.5 and 2.0. The volunteers were scanned twice, the lumen/wall area and wall thickness were measured for each scan. Eight patients were scanned once, the inter/intra-observer reproducibility of the measurements was calculated.Results
In the repeated volunteer scans, the interclass correlation coefficient (ICC) for the wall area measurement using a CS factor of 1.5 in PDw, T 1w and T 2w were 0.95, 0.81, and 0.97, respectively. The ICC for lumen area measurement using a CS factor of 1.5 in PDw, T 1w and T 2w were 0.96, 0.92, and 0.96, respectively. In patients, the ICC for inter/intra-observer measurements of lumen/wall area, and wall thickness were all above 0.81 in all sequences.Conclusion
The results show a CS accelerated 3-D black-blood multi-contrast protocol is a robust and reproducible method for carotid imaging. Future protocol design could use CS to reduce the scanning time.16.
Jianmin Yuan Gregory Makris Andrew Patterson Ammara Usman Tilak Das Andrew Priest Zhongzhao Teng Sarah Hilborne Dario Prudencio Jonathan Gillard Martin Graves 《Magma (New York, N.Y.)》2018,31(1):191-199
Objective
This study aims to explore the relationship between plaque surface morphology and neovascularization using a high temporal and spatial resolution 4D contrast-enhanced MRI/MRA sequence.Materials and methods
Twenty one patients with either recent symptoms or a carotid artery stenosis ≥40% were recruited in this study. Plaque surface morphology and luminal stenosis were determined from the arterial phase MRA images. Carotid neovascularization was evaluated by a previously validated pharmacokinetic (PK) modeling approach. K trans (transfer constant) and v p (partial plasma volume) were calculated in both the adventitia and plaque.Results
Image acquisition and analysis was successfully performed in 28 arteries. Mean luminal stenosis was 44% (range 11–82%). Both adventitial and plaque K trans in ulcerated/irregular plaques were significantly higher than smooth plaques (0.079 ± 0.018 vs. 0.064 ± 0.011 min?1, p = 0.02; 0.065 ± 0.013 vs. 0.055 ± 0.010 min?1, p = 0.03, respectively). Positive correlations between adventitial K trans and v p against stenosis were observed (r = 0.44, p = 0.02; r = 0.55, p = 0.01, respectively).Conclusion
This study demonstrates the feasibility of using a single sequence to acquire both high resolution 4D CE-MRA and DCE-MRI to evaluate both plaque surface morphology and function. The results demonstrate significant relationships between lumen surface morphology and neovascularization.17.
Sophie Schumacher Florence Pache Judith Bellmann-Strobl Janina Behrens Petr Dusek Lutz Harms Klemens Ruprecht Petra Nytrova Sanjeev Chawla Thoralf Niendorf Ilya Kister Friedemann Paul Jens Wuerfel Tim Sinnecker 《Magma (New York, N.Y.)》2016,29(3):535-541
Objective
To quantify the periventricular venous density in neuromyelitis optica spectrum disease (NMOSD) in comparison to that in patients with multiple sclerosis (MS) and healthy control subjects.Materials and methods
Sixteen patients with NMOSD, 16 patients with MS and 16 healthy control subjects underwent 7.0-Tesla (7T) MRI. The imaging protocol included T2*-weighted (T2*w) fast low angle-shot (FLASH) and fluid-attenuated inversion recovery (FLAIR) sequences. The periventricular venous area (PVA) was manually determined by a blinded investigator in order to estimate the periventricular venous density in a region of interest-based approach.Results
No significant differences in periventricular venous density indicated by PVA were detectable in NMOSD versus healthy controls (p = 0.226). In contrast, PVA was significantly reduced in MS patients compared to healthy controls (p = 0.013).Conclusion
Unlike patients with MS, those suffering from NMOSD did not show reduced venous visibility. This finding may underscore primary and secondary pathophysiological differences between these two distinct diseases of the central nervous system.18.
Uten Yarach Chaiya Luengviriya Daniel Stucht Frank Godenschweger Peter Schulze Oliver Speck 《Magma (New York, N.Y.)》2016,29(3):319-332
Objective
Prospective motion correction can effectively fix the imaging volume of interest. For large motion, this can lead to relative motion of coil sensitivities, distortions associated with imaging gradients and B 0 field variations. This work accounts for the B 0 field change due to subject movement, and proposes a method for correcting tissue magnetic susceptibility-related distortion in prospective motion correction.Materials and methods
The B 0 field shifts at the different head orientations were characterized. A volunteer performed large motion with prospective motion correction enabled. The acquired data were divided into multiple groups according to the object positions. The correction of B 0-related distortion was applied to each group of data individually via augmented sensitivity encoding with additionally integrated gradient nonlinearity correction.Results
The relative motion of the gradients, B 0 field and coil sensitivities in prospective motion correction results in residual spatial distortion, blurring, and coil artifacts. These errors can be mitigated by the proposed method. Moreover, iterative conjugate gradient optimization with regularization provided superior results with smaller RMSE in comparison to standard conjugate gradient.Conclusion
The combined correction of B 0-related distortion and gradient nonlinearity leads to a reduction of residual motion artifacts in prospective motion correction data.19.
Jason Langley Daniel E. Huddleston Christine J. Liu Xiaoping Hu 《Magma (New York, N.Y.)》2017,30(2):121-125
Objectives
The purpose of this study was to assess the reproducibility of substantia nigra pars compacta (SNpc) and locus coeruleus (LC) delineation and measurement with neuromelanin-sensitive MRI.Materials and methods
Eleven subjects underwent two neuromelanin-sensitive MRI scans. SNpc and LC volumes were extracted for each scan. Reproducibility of volume and magnetization transfer contrast measurements in SNpc and LC was assessed using intraclass correlation coefficients (ICC) and dice similarity coefficients (DSC).Results
SNpc and LC volume measurements showed excellent reproducibility (SNpc-ICC: 0.94, p < 0.001; LC-ICC: 0.96, p < 0.001). SNpc and LC were accurately delineated between scans (SNpc-DSC: 0.80 ± 0.03; LC-DSC: 0.63 ± 0.07).Conclusion
Neuromelanin-sensitive MRI can consistently delineate SNpc and LC.20.