共查询到17条相似文献,搜索用时 812 毫秒
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本文结合保健食品的功能声称分类, 综述了近年来较常发生非法添加的功能类别的保健食品产品中, 非法添加药物成分的现状, 并对其中每个类别非法添加的特点进行了分析。由于近年来不断出现非法添加药物, 本文通过梳理药物的药理作用机制, 对可能添加的药物进行了归纳。从样品的前处理方法和检测技术2个方面, 对目前非法添加检测的研究现状进行了综述。结合本实验室工作及目前非法添加的现状, 本文对其检测技术的需求、今后研究的发展方向和检测结果的判定等进行了分析。以期为开展保健食品非法添加药物成分检测的科研工作者提供参考, 为保健食品质量安全提供技术支持, 为监管部门打击此类非法行为提供借鉴。 相似文献
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基于功能性和安全性两大特点,保健食品受到越来越多的人青睐。为提高保健食品的功效,在其生产过程中非法添加相关功效的化学药物较为普遍,加强对保健食品中非法添加药物的检测,才能有效预防保健食品非法添加药物的危害。色谱技术是复杂成分分离纯化最有效方法,配以合适的检测手段,广泛用于化学成分的定性定量分析。本文综述了近年来薄层色谱、气相色谱、高效液相色谱和超高效液相色谱等色谱及其与紫外、红外、拉曼和质谱等技术联用在保健食品中非法添加药物检测中的应用,并进行了相应的归纳和分析,为保健食品中非法添加药物检测技术的进一步发展提供了参考。 相似文献
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表面增强拉曼光谱(surface-enhanced Raman spectroscopy,SERS)技术作为一种新型的快速检测技术正在被广泛应用于保健食品非法添加化学药物的检测中。通过设计不同的SERS基底,可以搭建出集样品前处理、上机分析、匹配定性的一体化拉曼光谱检测系统。与传统的检测方式相比,SERS技术具有无损、快速、图谱指纹特性强等优点,在保健食品非法添加化学药物的快速检测中具有巨大潜力。本文主要综述了SERS的技术原理、SERS基底分类以及SERS技术在保健食品中非法添加化学药物检测中的应用,并对SERS技术在保健食品中非法添加化学药物检测方面的应用前景进行了展望,以期为保健食品中未知违禁物的识别提供理论支撑。 相似文献
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糖尿病是常见慢性病之一,现代医学还无法治愈糖尿病,因此糖尿病患者不得不终身服药,各种形式的降糖保健品应运而生。我国《食品安全法》明确规定,保健食品不得添加化学药品,但仍有不少具有降血糖功效的保健食品被检出含有非法添加的化学成分。这种非法添加的行为,对公众健康造成了巨大危害。本文对近年来降糖类中成药和保健食品中非法添加化学药物的仪器检测技术进行研究对比,以其为相关检测部门提供理论参考,消费者身体健康及合法权益受到保护。 相似文献
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目的建立筛查保健食品中非法添加药物的新方法。方法对39种常见减肥类药物进行离子迁移(IMS)检测,建立该39种非法添加药物的IMS检测数据库。称取保健食品一次服用量,用无水乙醇溶解,取上清液点于试纸上,直接进样。通过离子迁移谱对减肥类保健食品中可能非法添加药物进行筛查。结果离子迁移测定39种可能非法添加的药物,其筛查的假阳性率小于10%,假阴性率小于5%。结论 IMS可以用于保健食品中非法添加药物的筛查,并具有较高的筛查效率,可作为保健食品监督检测中更快速、灵敏的技术手段。 相似文献
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保健食品中非法添加化学药物的市场乱象受到广泛关注.本文一方面,总结当前减肥类保健食品非法添加化学药物的种类、化学药物名单.减肥类保健食品非法添加主要包含食欲抑制剂、能量消耗增强剂、利尿剂、吸收抑制剂、缓泻药和其他类药物;通过查阅近年来文献报道的减肥类保健食品非法添加文章和案例,列出当前已纳入监管范围的减肥类保健食品非法... 相似文献
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目的 建立更具准确靶向性的食品和保健食品中非法添加药物的筛查方案.方法 测定9类共195个食品和保健食品样品中的75种非法添加化药,建立包括这195个样品的宣称类别、剂型、主要成分、未知样品颜色、检出的非法添加化药等120个属性指标的数据库,利用主成分分析法和系统聚类分析法分析结果.结果 主成分分析和相关性分析表明,根... 相似文献
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运动员除了合理膳食,还需要摄入高纯度、易吸收的运动补剂强化补充,以促进疲劳恢复、改善机能、提高运动能力。本文综述了运动补剂的监管现状,评价了运动补剂的优缺点,并主要介绍了恢复体能类、提高免疫力类及电解质和微量元素类运动补剂,总结了运动补剂中可能添加的违禁药物,并为运动员选择合适的运动补剂提出建议,以期为运动员的补剂选择提供参考。 相似文献
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目的利用解吸附电晕束电离质谱(DCBI-MS)对减肥类保健食品中违禁药物进行快速筛选,进而用高效液相色谱法(HPLC-UV)对疑似检出样品准确定量。方法通过DCBI-MS直接分析,对比标准物质的一级、二级质谱谱图,对检测样品中非法添加的芬氟拉明、酚酞、西布曲明、单去甲基西布曲明、双去甲基西布曲明进行定性鉴别。HPLC-UV对5种目标化合物准确定量。结果 HPLC-UV方法中各目标物的线性范围为0.25~300 mg/L。12个检测样品中3个样品共3种违禁物被DCBI-MS方法检出。高效液相色谱法准确复检结果显示DCBI-MS的半定量结果可信。结论 DCBI-MS无需样品预处理,单个样品的分析时间不到1 min,辅助高效液相色谱法实现了减肥类违禁药物的快速、高通量、高精度检测。 相似文献
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Tiago Rocha Joana S. Amaral Maria Beatriz P.P. Oliveira 《Comprehensive Reviews in Food Science and Food Safety》2016,15(1):43-62
In the last few years, the consumption of dietary supplements, especially those having plants as ingredients, has been increasing due to the common idea that they are natural products posing no risks to human health. In the European Union and the United States, dietary supplements are legally considered as foods/special category of foods, thus are not being submitted to any safety assessment prior to their commercialization. Among the issues that can affect safety, adulteration by the illegal addition of pharmaceutical substances or their analogs is of major concern since unscrupulous producers can falsify these products to provide for quick effects and to increase sales. This review discusses the various classes of synthetic drugs most frequently described as being illegally added to dietary supplements marketed for weight loss, muscle building/sport performance and sexual performance enhancement. Information regarding regulation and consumption is also presented. Finally, several conventional and advanced analytical techniques used to detect and identify different adulterants in dietary supplements and therefore also in foods, with particular emphasis on plant food supplements, are critically described. This review demonstrates that dietary supplement adulteration is an emerging food safety problem and that an effective control by food regulatory authorities is needed to safeguard consumers. 相似文献
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农业农村部第194号公告的实施,标志着我国在养殖环节全面减抗时代的到来,然而在中兽药中非法添加各类违禁物质的现象屡禁不止,不仅扰乱了市场秩序,降低养殖业经济效益,还对动物和人的身体健康造成不良后果.根据现行农业部公告中兽药中违法添加物的检测方法里提及的非法添加物,结合养殖场养殖的养殖环境和养殖动物的疾病主要集中于呼吸道... 相似文献
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降血糖类保健食品中非法添加的8 种药物检测及实例分析 总被引:1,自引:0,他引:1
目的:建立检测降血糖类保健食品中非法添加8 种药物的方法并用于实际检测。方法:采用高效液相色谱-串联质谱法,以ZORBAX Eclipse Plus C18(2.1 mm×50 mm,1.8 μm)色谱柱,以0.1%甲酸溶液为流动相A,甲醇为流动相B,梯度洗脱。通过分子离子峰、二级碎片、色谱保留时间等信息,对宣称辅助降血糖类保健食品非法添加8 种化学药物进行鉴别和定量测定。结果:8 种药物实现了同时分离与专属鉴定,检出限为5.5~76 ng/g,精密度为0.22%~1.19%,回收率为74.0%~111.9%;本法适用于硬胶囊样品;利用本法,从15 批样品中检测出9 批含非法添加化学药物。结论:本方法专属性强、灵敏度高,结果准确可靠,可作为宣称辅助降血糖类保健食品中检测非法添加化学药物的方法参考。 相似文献
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There have been a number of reports of dietary supplements contaminated with illegal adulterants that threaten consumers’ health because of their adverse pharmacological effects. In the present study, a convenient and economic method was developed to detect illegal pharmaceutics, such as PDE-5 inhibitor and appetite suppressants, using liquid chromatography (LC)/photodiode array (PDA) for screening and LC/mass spectrometry (MS) for successive confirmation. Target peaks were identified by comparison of their chromatographic retention times and PDA spectra with those of synthetic standards and finally confirmed by LC/MS. As a result, tadalafil, a PDE-5 inhibitor, and N-desmethylsibutramine, a derivative of sibutramine, were detected in various dietary supplements at concentrations of 13.5–21.9?mg and 3.0?mg per single dose, respectively. The present study will contribute to the development of an analytical method enabling rapid screening of a variety of health foods, and the result suggests that consumers should be aware of serious health risks related to these illegal compounds. 相似文献
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Jiebiao Guo Wangpei Liu Xianquan Lan Hualong Chen Zijun Xiao 《Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment》2016,33(7):1095-1104
Sildenafil is a phosphodiesterase-5 inhibitor (PDE-5) for the treatment of erectile dysfunction. Undeclared sildenafil and related analogues adulterated in functional foods are a threat to public health. To screen these illegal drugs rapidly in herbal samples, an immunochromatographic (IC) assay was developed based on polyclonal antibodies specific to both sildenafil and its analogues. A group that is pharmacological necessary for sildenafil and its analogues was employed as a representative hapten for the generation antibodies against the target compounds. The desired antisera showed satisfactory specificities to sildenafil and major analogues with IC50 values ranging from 19.3 to 34.6 ng ml–1 in a referring enzyme-linked immunosorbent assay (ELISA). The optimised IC assay showed detection thresholds in the range 5.0–20 μg g–1 for sildenafil and major analogues in herbal samples. Sixty herbal food supplements were screened and six were found to be positive using the IC strip. It was confirmed by ELISA and UPLC-PDA-MS/MS that positive samples contain target illegal additives in levels of 10–40 mg g–1 (1–4%). In this range, sensitivity of the IC strip is adequate to screen sildenafil-type compounds in herbal commodities under a dilution ratio of 1:103. Thus, the current IC assay is a suitable tool for screening sildenafil and its analogues as illegal additives in herbal food supplements. 相似文献