Without a doubt the nitrogen derivatives are the most broadly diversified family of fatty acid derivatives. Today they account
collectively for perhaps 400 million pounds of products per year in the USA alone. Although fatty amides may be produced by
a large number of synthetic routes, industrially only two are of any commercial importance. Diamides are the difunctional
analogs of simple amides, and a typical one that is in medium scale production volume is ethylene bis(stearamide). Industrially,
the production of fatty nitriles in the fatty acid derivative industry is exclusively by ammonolysis of fatty acids at temperatures
somewhat above those required to produce amides, or roughly, 300–320 C. Both vapor phase catalytic and liquid phase ammonolysis
processes may be employed. Nitriles have limited uses as such, but find their utility as fatty derivative intermediates only.
The primary amines, RNH2, are produced industrially by the catalytic hydrogenation of nitriles. The general conditions for the conversion of nitriles
to primary amines with a minimum content of secondary or tertiary amines is with nickel catalyst using an excess of ammonia
at relatively low temperatures (130–140 C). Amine oxides are derived from tertiary amines by a controlled reaction with hydrogen
peroxide. In addition to tertiary amines, the monoalkyl diethoxylated amines can be considered as in the same class. These
are made by the addition of ethylene oxide to primary amine. Two moles of ethylene oxide can be added without catalyst. Additional
ethoxylation does require a basic catalyst. These amines, besides having end uses of their own, can be converted to amine
oxides or can be converted to ethoxylated quaternary ammonium salts. 相似文献
A procedure was developed that examines the effectiveness of nickel catalysts for the hydrogenation of fatty nitriles to amines.
Rates of reaction, selectivity, and olefinic reduction were the parameters studied. The procedure can be used for new catalyst
screening and is ideally suited for quality assurance testing of production catalysts. It involves the reduction of nitriles
to amines at 410°F (210°C) and 500 psig using a .2% Ni loading level. A mixture of primary and secondary amines is obtained
which is characteristic of the catalyst’s selectivity. Both sponge and supported nickel catalysts were tested using tallow
nitriles as the feedstock. 相似文献
Raney metals were studied as heterogeneous catalysts for racemization and dynamic kinetic resolution (DKR) of chiral amines, as an alternative to metals like palladium or ruthenium. Both Raney nickel and cobalt were able to selectively racemize various chiral amines with high selectivity. In the racemization of benzylic primary amines, the minor formation of side products, e.g., secondary amines, can be suppressed by varying the hydrogen pressure. In the racemization of aliphatic amines over Raney catalysts, the selectivity is very high, with the enantiomeric amine as the sole product. DKR of racemic aliphatic amines can be performed with immobilized Candida antarctica lipase B and Raney nickel in one pot; for 2‐hexylamine, a yield of 95 % of the acetylated amide was achieved, with 97 % ee. Attention is devoted to the compatibility of the enzyme and the metal catalyst during the DKR. For benzylic primary amines, a two‐pot process is proposed in which the liquid is alternatingly shuttled between two vessels containing the solid racemization catalyst and the biocatalyst. After 4 such cycles, the amide of (R)‐1‐phenylethylamine was obtained with 94 % yield and more than 90 % ee. 相似文献
This review deals with two of the most commonly used methods for the preparation of amines: the reductive amination of aldehydes and ketones and the hydrogenation of nitriles. There is a great similarity between these two methods, since both have the imine as intermediate. However, due to the high reactivity of this intermediate, primary, secondary and/or tertiary amines are obtained (often simultaneously). The relation of the selectivity to different substrate structures and reaction conditions is briefly summarised, the main focus being on the catalyst as it is the most significant factor that governs the selectivity. Different mechanisms are discussed with the view to correlate the structure of the catalyst and, more particularly, the nature of the metal and the support with selectivity. The crucial point is the presumed location of the condensation and hydrogenation steps. 相似文献
The catalytic behavior of several supported nickel catalysts in the hydrogenation of acetonitrile was studied. It was established that the selectivity of this process is greatly influenced by the nature of the support used. Catalysts consisting of nickel supported on acidic supports catalyzed the formation of condensation products, diethyl- and triethylamine. Nickel supported on basic supports was highly selective with respect to the formation of the primary amine, ethylamine. It was shown that modification of the intrinsic acidity of alumina-based supports by the application of alkaline additives has a large impact on the selectivity of the resulting catalyst. Based on the results obtained from measurements on a basic catalyst diluted with either an acidic or a basic support, a dual-function mechanism is suggested. The mechanism implies that the hydrogenation function of the catalyst is located on the metal, while the acid function, responsible for the condensation reactions, is located on the support. A mechanism, accounting for the occurrence of the acid-catalyzed condensation reactions, is proposed. 相似文献
Fatty alcohols, derived from natural sources, are commercially produced by hydrogenation of fatty acids or methyl esters in
slurry-phase or fixed-bed reactors. One slurry-phase hydrogenation of methyl ester process flows methyl esters and powdered
copper chromite catalyst into tubular reactors under high hydrogen pressure and elevated temperature. In the present investigation,
slurry-phase hydrogenations of C12 methyl ester were carried out in semi-batch reactions at nonoptimal conditions (i.e., low hydrogen pressure and elevated
temperature). These conditions were used to accentuate the host of side reactions that occur during the hydrogenation. Some
14 side reaction routes are outlined. As an extension of this study, copper chromite catalyst was produced under a number
of varying calcination temperatures. Differences in catalytic activity and selectivity were determined by closely following
side reaction products. Both activity and selectivity correlate well with the crystallinity of the copper chromite surface;
they increase with decreasing crystallinity. The ability to follow the wide variety of side reactions may well provide an
additional tool for the optimized design of hydrogenation catalysts. 相似文献
The tris(acetylacetonato)rhodium(III) catalyst is shown to be a versatile catalyst in the presence of DABCO (1,4‐diazabicyclo[2.2.2]octane) as ligand for the α‐alkylation of ketones followed by transfer hydrogenation, for the one‐pot β‐alkylation of secondary alcohols with primary alcohols and for the alkylation of aromatic amines in the presence of an inorganic base in toluene. 相似文献
Amines are important building blocks possessing various applications in agrochemicals, the fine chemical industry, pharmaceuticals, materials science and biotechnology. The catalytic hydrogenation of nitriles is an important reaction for the one‐step synthesis of diverse amines. However, significant amounts of side product formation during the course of the reaction is a major issue. In recent years, an enormous amount of work has been reported using both homogeneous and heterogeneous transition metal complex catalysts for the selective reduction of nitriles. Transition metal catalysts are the most crucial factor that controls the selectivity in this reaction. Therefore, transition metal catalysts are the central point of this review. We have also briefly discussed the effect of reaction parameters, selectivity to different substrate structures and reaction mechanisms. This review provides an overview of recent developments in transition metal‐catalyzed nitrile reduction along with examples which highlight its vast potential in organic transformations.
The chemoselective hydrogenation of cinnamonitrile to 3‐phenylallylamine proceeds with up to 80% selectivity at conversions of >90% with Raney cobalt and up to 60% selectivity with Raney nickel catalysts. Best results were obtained with a doped Raney cobalt catalyst (RaCo/Cr/Ni/Fe 2724) in ammonia saturated methanol at 100 °C and 80 bar. Major problems are the formation of hydrocinnamonitrile and of secondary amines, and overreduction to 3‐phenylpropylamine. Important parameters are the catalyst type and composition, the solvent type and the presence and concentration of ammonia. The catalytic system tolerates functional groups like OH, OMe, Cl, CO, but not aromatic nitro groups. Preliminary experiments indicate that other unsaturated nitriles with di‐ or trisubstituted CC bonds are also suitable substrates. 相似文献
Liquid phase hydrogenation of adiponitrile (ADN) to 6-aminocapronitrile (ACN) and hexamethylenediamine (HMD) was investigated on Ni/SiO2 catalysts prepared under different conditions. In this reaction, the highly reactive imine intermediate forms condensation byproducts by reacting with the primary amine products (ACN and HMD). A highly dispersed Ni/SiO2 catalyst prepared by the direct reduction of Ni(NO3)2/SiO2 was found to suppress the condensation reactions by promoting the hydrogenation of adsorbed imine, and it gave excellent hydrogenation activity and primary amine selectivity. Addition of NaOH increased the primary amine selectivity to 79% at the ADN conversion of 86%. 相似文献
A synthetic method for controlling the Henry reaction products from nitrostyrene to nitroalcohol in heterogeneous catalysis by a simple change of the catalytic sites in organoamine-functionalized mesoporous catalysts is reported. The synthesis resulted in either β-nitrostyrene or β-nitroalcohol by simple change of the types of amine functional groups in the amine-functionalized mesoporous catalysts from primary amines into secondary or tertiary. 相似文献