一种融合上下文多光谱空间通道特征的左心室分割算法研究

针对左心室生理结构复杂以及心脏磁共振成像纹 理不均匀、噪声大、心腔肌肉干扰造 成边界模糊等情况而导致左心室分割效果差等问题,本文提出了一种融合上下文多光谱空间 通道特征的左心室分割算法。本文算法采用U型结构与跳跃连接方式将不同尺度的特征图进行 融合,确保局部特征信息二次利用,提高了特征利用率。采用深度可分离池化通道金字塔(depthwise pooling attention pyramid,DPAP)模 块对多尺度特征的有用信息进行优化;接着采用频域通道空间注意力模块对特征的通道和空 间两个维度进行优化;最后采用组合损失函数缓解正负样本不均衡的问题。结果表明,在MI CCAI2009磁共振左心室挑战赛数据集上,本文算法在相似性系数上验证 集为93.25%、在线集为 93.33%,相比主流分割算法DeepLabV3+有1.6 个点提升,相比医学经 典U-Net算法有6.9个点提升,能对左心室有效分割,分割结果边缘 连续,轮廓清晰。     

Shape statistics variational approach for the outer contour segmentation of left ventricle MR images.

Segmentation of left ventricles is one of the important research topics in cardiac magnetic resonance (MR) imaging. The segmentation precision influences the authenticity of ventricular motion reconstruction. In left ventricle MR images, the weak and broken boundary increases the difficulty of segmenting the outer contour precisely. In this paper, we present an improved shape statistics variational approach for the outer contour segmentation of left ventricle MR images. We use the Mumford-Shah model in an object feature space and incorporate the shape statistics and an edge image to the variational framework. The introduction of shape statistics can improve the segmentation with broken boundaries. The edge image can enhance the weak boundary and thus improve the segmentation precision. The generation of the object feature image, which has homogenous "intensities" in the left ventricle, facilitates the application of the Mumford-Shah model. A comparison of mean absolute distance analysis between different contours generated with our algorithm and that generated by hand demonstrated that our method can achieve a higher segmentation precision and a better stability than various approaches. It is a semiautomatic way for the segmentation of the outer contour of the left ventricle in clinical applications.     

Automatic determination of LV orientation from SPECT data

Presents a new method to determine the orientation or pose of the left ventricle (LV) of the heart from cardiac SPECT (single photon emission computed tomography) data. This proposed approach offers an accurate, fast, and robust delineation of the LV long-axis. The location and shape of the generated long-axis can then be utilized to define automatically the tomographic slices for enhanced visualization and quantification of the clinical data. The methodology is broadly composed of two main steps: (1) volume segmentation of cardiac SPECT data; and (2) topological goniometry, a novel approach incorporating volume visualization and computer graphics ideas to determine the overall shape of 3-D objects. The outcome of the algorithm is a 3-D curve representing the overall pose of the LV long-axis. Experimental results on both phantom and clinical data (50 technetium-99m and 74 thallium-201) are presented. An interactive graphical interface to visualize the volume (3-D) data, the left ventricle, and its pose is an integral part of the overall methodology. This technique is completely data driven and expeditious, making it viable for routine clinical use.     

Image segmentation via adaptive K-mean clustering andknowledge-based morphological operations with biomedical applications

Image segmentation remains one of the major challenges in image analysis. In medical applications, skilled operators are usually employed to extract the desired regions that may be anatomically separate but statistically indistinguishable. Such manual processing is subject to operator errors and biases, is extremely time consuming, and has poor reproducibility. We propose a robust algorithm for the segmentation of three-dimensional (3-D) image data based on a novel combination of adaptive K-mean clustering and knowledge-based morphological operations. The proposed adaptive K-mean clustering algorithm is capable of segmenting the regions of smoothly varying intensity distributions. Spatial constraints are incorporated in the clustering algorithm through the modeling of the regions by Gibbs random fields. Knowledge-based morphological operations are then applied to the segmented regions to identify the desired regions according to the a priori anatomical knowledge of the region-of-interest. This proposed technique has been successfully applied to a sequence of cardiac CT volumetric images to generate the volumes of left ventricle chambers at 16 consecutive temporal frames. Our final segmentation results compare favorably with the results obtained using manual outlining. Extensions of this approach to other applications can be readily made when a priori knowledge of a given object is available.     

Left Ventricle Segmentation Using Model Fitting and Active Surfaces

A method to perform 4D (3D over time) seg mentation of the left ventricle of a mouse heart using a set of B mode cine slices acquired in vivo from a series of short axis scans is described. We incorporate previ ously suggested methods such as temporal propagation, the gradient vector flow active surface, superquadric models, etc. into our proposed 4D segmentation of the left ventricle. The contributions of this paper are incor poration of a novel despeckling method and the use of locally fitted superellipsoid models to provide a better initialization for the active surface segmentation algorithm. Average distances of the improved surface segmentation to a manually segmented surface through out the entire cardiac cycle and cross-sectional contours are provided to demonstrate the improvements pro duced by the proposed 4D segmentation.     

Color Texture Segmentation Based on the Modal Energy of Deformable Surfaces

This paper presents a new approach for the segmentation of color textured images, which is based on a novel energy function. The proposed energy function, which expresses the local smoothness of an image area, is derived by exploiting an intermediate step of modal analysis that is utilized in order to describe and analyze the deformations of a 3-D deformable surface model. The external forces that attract the 3-D deformable surface model combine the intensity of the image pixels with the spatial information of local image regions. The proposed image segmentation algorithm has two steps. First, a color quantization scheme, which is based on the node displacements of the deformable surface model, is utilized in order to decrease the number of colors in the image. Then, the proposed energy function is used as a criterion for a region growing algorithm. The final segmentation of the image is derived by a region merge approach. The proposed method was applied to the Berkeley segmentation database. The obtained results show good segmentation robustness, when compared to other state of the art image segmentation algorithms.     

Postarthroplasty Examination Using X-Ray Images

Arthroplasty, the implantation of prostheses into joints, is a surgical procedure that is affecting a larger and larger number of patients over time. As a result, it is increasingly important to develop imaging techniques to noninvasively examine joints with prostheses after surgery, both statically and dynamically in 3-D. The static problem is considered here, with the aim to create a 3-D shape model of the bone as well as the prosthesis using a set of 2-D X-rays from various viewpoints. The most important challenge to be addressed is the lack of texture, the most common feature to recover shape from multiple views. In order to overcome this limitation, we reformulate the problem using a novel multiview segmentation approach where an active contours 3-D surface evolution with level-set implementation is used to recover the shape of bones and prostheses in postoperative joints. The recovered shape may then be used to track 3-D motions in dynamic X-ray sequences to obtain kinematic information.      

基于时空标记场最大后验概率的多视频对象分割算法

该文提出了一种基于贝叶斯框架的时空标记场最大后验概率的多视频对象分割算法,根据视频序列帧间(时间域)和帧内(空间域)信息的不同特点,建立基于多个对象分割标记场的最大后验概率公式,并导出其最小能量函数,通过求解最小能量使其分割标记的后验概率达到最大。最小能量的优化求解用迭代条件模式(ICM) 方法,初始分割标记场用矢量直方图法得到。实验结果表明, 该文提出的算法对存在局部遮挡的多运动对象分割是有效的。     

B-spline explicit active surfaces: an efficient framework for real-time 3-D region-based segmentation

A new formulation of active contours based on explicit functions has been recently suggested. This novel framework allows real-time 3-D segmentation since it reduces the dimensionality of the segmentation problem. In this paper, we propose a B-spline formulation of this approach, which further improves the computational efficiency of the algorithm. We also show that this framework allows evolving the active contour using local region-based terms, thereby overcoming the limitations of the original method while preserving computational speed. The feasibility of real-time 3-D segmentation is demonstrated using simulated and medical data such as liver computer tomography and cardiac ultrasound images.     

Registration-assisted segmentation of real-time 3-D echocardiographic data using deformable models

Real-time three-dimensional (3-D) echocardiography is a new imaging modality that presents the unique opportunity to visualize the complex 3-D shape and motion of the left ventricle (LV) in vivo and to measure the associated global and local function parameters. To take advantage of this opportunity in routine clinical practice, automatic segmentation of the LV in the 3-D echocardiographic data, usually hundreds of megabytes large, is essential. We report a new segmentation algorithm for this task. Our algorithm has two distinct stages, initialization of a deformable model and its refinement, which are connected by a dual "voxel + wiremesh" template. In the first stage, mutual-information-based registration of the voxel template with the image to be segmented helps initialize the wiremesh template. In the second stage, the wiremesh is refined iteratively under the influence of external and internal forces. The internal forces have been customized to preserve the nonsymmetric shape of the wiremesh template in the absence of external forces, defined using the gradient vector flow approach. The algorithm was validated against expert-defined segmentation and demonstrated acceptable accuracy. Our segmentation algorithm is fully automatic and has the potential to be used clinically together with real-time 3-D echocardiography for improved cardiovascular disease diagnosis.     

Prior shape level set segmentation on multistep generated probability maps of MR datasets for fully automatic kidney parenchyma volumetry

Fully automatic 3-D segmentation techniques for clinical applications or epidemiological studies have proven to be a very challenging task in the domain of medical image analysis. 3-D organ segmentation on magnetic resonance (MR) datasets requires a well-designed segmentation strategy due to imaging artifacts, partial volume effects, and similar tissue properties of adjacent tissues. We developed a 3-D segmentation framework for fully automatic kidney parenchyma volumetry that uses Bayesian concepts for probability map generation. The probability map quality is improved in a multistep refinement approach. An extended prior shape level set segmentation method is then applied on the refined probability maps. The segmentation quality is improved by incorporating an exterior cortex edge alignment technique using cortex probability maps. In contrast to previous approaches, we combine several relevant kidney parenchyma features in a sequence of segmentation techniques for successful parenchyma delineation on native MR datasets. Furthermore, the proposed method is able to recognize and exclude parenchymal cysts from the parenchymal volume. We analyzed four different quality measures showing better results for right parenchymal tissue than for left parenchymal tissue due to an incorporated liver part removal in the segmentation framework. The results show that the outer cortex edge alignment approach successfully improves the quality measures.     

3-D active appearance models: segmentation of cardiac MR and ultrasound images

A model-based method for three-dimensional image segmentation was developed and its performance assessed in segmentation of volumetric cardiac magnetic resonance (MR) images and echocardiographic temporal image sequences. Comprehensive design of a three-dimensional (3-D) active appearance model (AAM) is reported for the first time as an involved extension of the AAM framework introduced by Cootes et al. The model's behavior is learned from manually traced segmentation examples during an automated training stage. Information about shape and image appearance of the cardiac structures is contained in a single model. This ensures a spatially and/or temporally consistent segmentation of three-dimensional cardiac images. The clinical potential of the 3-D AAM is demonstrated in short-axis cardiac MR images and four-chamber echocardiographic sequences. The method's performance was assessed by comparison with manually identified independent standards in 56 clinical MR and 64 clinical echo image sequences. The AAM method showed good agreement with the independent standard using quantitative indexes of border positioning errors, endo- and epicardial volumes, and left ventricular mass. In MR, the endocardial volumes, epicardial volumes, and left ventricular wall mass correlation coefficients between manual and AAM were R2 = 0.94, 0.97, 0.82, respectively. For echocardiographic analysis, the area correlation was R2 = 0.79. The AAM method shows high promise for successful application to MR and echocardiographic image analysis in a clinical setting.     

网格运动分析与形态学滤波相结合的视频对象分割

提出了一种基于二维网格运动分析与改进形态学滤波空域自动分割策略相结合的视频对象时空分割算法。该算法首先利用高阶统计方法对视频图像的二维网格表示进行运动分析，快速得到前景对象区域，通过后处理有效获得前景对象运动检测掩膜。然后，用一种结合交变序列重建滤波算法和自适应阈值判别算法的改进分水岭分割策略有效获得前景对象的精确边缘。最后，用区域基时空融合算法将时域分割结果和空域分割结果结合起来提取出边缘精细的视频对象。实验结果表明，本算法综合了多种算法的优点，主客观分割效果理想。     

Space-time segmentation using level set active contours applied to myocardial gated SPECT

This paper presents a new variational method for the segmentation of a moving object against a still background, over a sequence of [two-dimensional or three-dimensional (3-D)] image frames. The method is illustrated in application to myocardial gated single photon emission computed tomography (SPECT) data, and incorporates a level set framework to handle topological changes while providing closed boundaries. The key innovation is the introduction of a geometrical constraint into the derivation of the Euler-Lagrange equations, such that the segmentation of each individual frame can be interpreted as a closed boundary of an object (an isolevel of a set of hyper-surfaces) while integrating information over the entire sequence. This results in the definition of an evolution velocity normal to the object boundary. Applying this method to 3-D myocardial gated SPECT sequences, the left ventricle endocardial and epicardial limits can be computed in each frame. This space-time segmentation method was tested on simulated and clinical 3-D myocardial gated SPECT sequences and the corresponding ejection fractions were computed.     

一种快速递归红外舰船图像分割新算法

针对背景复杂、对比度低的红外舰船目标分割问题,提出了一种红外舰船图像分割的新算法.由于二维最大类间方差法不仅反映了图像的像素点灰度分布信息,还反映了邻域空间相关信息,因此有较好的抗噪能力.但是由于其解空间维数的增加,计算量的变化是以指数增长的,而粒子群优化算法可实现高效并行、随机、自适应群体搜索.基于这一特点,提出了基于粒子群优化的二维最大类间方差局部递归分割方法,有利于实现红外图像的实时处理.该方法同样适用于复杂背景下的其他红外目标图像的分割.     

Segmentation of VOI from multidimensional dynamic PET images by integrating spatial and temporal features.

Segmentation of multidimensional dynamic positron emission tomography (PET) images into volumes of interest (VOIs) exhibiting similar temporal behavior and spatial features is a challenging task due to inherently poor signal-to-noise ratio and spatial resolution. In this study, we propose VOI segmentation of dynamic PET images by utilizing both the three-dimensional (3-D) spatial and temporal domain information in a hybrid technique that integrates two independent segmentation techniques of cluster analysis and region growing. The proposed technique starts with a cluster analysis that partitions the image based on temporal similarities. The resulting temporal partitions, together with the 3-D spatial information are utilized in the region growing segmentation. The technique was evaluated with dynamic 2-[18F] fluoro-2-deoxy-D-glucose PET simulations and clinical studies of the human brain and compared with the k-means and fuzzy c-means cluster analysis segmentation methods. The quantitative evaluation with simulated images demonstrated that the proposed technique can segment the dynamic PET images into VOIs of different kinetic structures and outperforms the cluster analysis approaches with notable improvements in the smoothness of the segmented VOIs with fewer disconnected or spurious segmentation clusters. In clinical studies, the hybrid technique was only superior to the other techniques in segmenting the white matter. In the gray matter segmentation, the other technique tended to perform slightly better than the hybrid technique, but the differences did not reach significance. The hybrid technique generally formed smoother VOIs with better separation of the background. Overall, the proposed technique demonstrated potential usefulness in the diagnosis and evaluation of dynamic PET neurological imaging studies.     

Coupled nonparametric shape and moment-based intershape pose priors for multiple basal ganglia structure segmentation

This paper presents a new active contour-based, statistical method for simultaneous volumetric segmentation of multiple subcortical structures in the brain. In biological tissues, such as the human brain, neighboring structures exhibit co-dependencies which can aid in segmentation, if properly analyzed and modeled. Motivated by this observation, we formulate the segmentation problem as a maximum a posteriori estimation problem, in which we incorporate statistical prior models on the shapes and intershape (relative) poses of the structures of interest. This provides a principled mechanism to bring high level information about the shapes and the relationships of anatomical structures into the segmentation problem. For learning the prior densities we use a nonparametric multivariate kernel density estimation framework. We combine these priors with data in a variational framework and develop an active contour-based iterative segmentation algorithm. We test our method on the problem of volumetric segmentation of basal ganglia structures in magnetic resonance images. We present a set of 2-D and 3-D experiments as well as a quantitative performance analysis. In addition, we perform a comparison to several existent segmentation methods and demonstrate the improvements provided by our approach in terms of segmentation accuracy.