Relationships of slip morphology,microcracking, and fracture resistance in a lamellar TiAl-alloy

The fracture resistance of a lamellar TiAl-alloy was investigated by J-testing under various displacement rates at ambient temperature. Possible relationships between slip morphology, microcracking, and fracture toughness were studiedvia optical electron microscopy and scanning electron microscopy (SEM). The results indicated that the lamellar TiAl-alloy exhibited a resistance-curve fracture behavior that was relatively rate insensitive in air at ambient temperature. Both interlamellar and translamellar deformation lines were observed in the crack-tip region and in the crack-wake ligaments. Theoretical analyses suggested that the interlamellar deformation lines were likely due to {111}〈110] easy slip, and the translamellar deformation lines were probably produced by both {lll}〈110] easy slip and ordered microtwins. Redistribution of crack-tip normal stresses led to a diffuse process zone of aligned microcracks formed by decohesion of slipbands. Relaxation of plastic constraint and interface decohesion resulted in higher plastic deformation, crack deflection, and redundant fracture in the crackwake ligaments that gave rise to the relatively high fracture resistance observed in the lamellar TiAl-alloy.     

Influence of microstructure on crack-tip micromechanics and fracture behaviors of a two-phase TiAl alloy

The tensile deformation, crack-tip micromechanics, and fracture behaviors of a two-phase (γ + α₂) gamma titanium aluminide alloy, Ti-47Al-2.6Nb-2(Cr+V), heat-treated for the microstructure of either fine duplex (gamma + lamellar) or predominantly lamellar microstructure were studied in the 25 °C to 800 °C range.In situ tensile and fracture toughness tests were performed in vacuum using a high-temperature loading stage in a scanning electron microscope (SEM), while conventional tensile tests were performed in air. The results revealed strong influences of microstructure on the crack-tip deformation, quasi-static crack growth, and the fracture initiation behaviors in the alloy. Intergranular fracture and cleavage were the dominant fracture mechanisms in the duplex microstructure material, whose fracture remained brittle at temperatures up to 600 °C. In contrast, the nearly fully lamellar microstructure resulted in a relatively high crack growth resistance in the 25 °C to 800 °C range, with interface delamination, translamellar fracture, and decohesion of colony boundaries being the main fracture processes. The higher fracture resistance exhibited by the lamellar microstructure can be attributed, at least partly, to toughening by shear ligaments formed as the result of mismatched crack planes in the process zone.     

Normal aging and environmental effects on communication

This article focuses on the role of communication in the successful adjustments and adaptations to normal aging by elders. It views communication as an essential tool for living safely and independently, for maintaining interests and a sense of purpose, for continuing important social and family relationships, and for exercising active control over quality of life and care. The discussion emphasizes the importance of physical and social environments to elders' communication efforts and suggests that an environmental approach to the communication problems of many elders may be more beneficial than the remediation of specific speech-language skills.     

Strain-rate effects on high-temperature fracture behavior of a 2124AI-SiCw composite

The high-temperature fracture behavior of a 2124Al-SiC_w composite compared with a 2124A1 alloy was investigated in this study. Axisymmetric tensile tests were carried out over a temperature range from 25 °C to 550 °C and at strain rates from 5 × 10^-5 s^-1 to 0.3 s^-1. Detailed fractographical observations and cross-sectional microstructure analyses were also made to identify local micromechanical processes of cavity initiation at high temperature. One of the important results is that the cavity initiation sites of the composite are strongly influenced by the strain rate at high temperatures: cavities initiate at whisker ends at low strain rates and at whisker sides at high strain rates. Furthermore, the favored direction of cavity growth is also dependent upon the strain rate, being approximately 45 deg at low strain rates and perpendicular to the tensile axis at high strain rates. Such different local fracture processes at different strain rates are interpreted in terms of the role of the SiC whiskers on the load carrier in the composite at high temperatures. Formerly Research Assistant with the Department of Materials Science and Engineering, Pohang Institute of Science and Technology     

The fracture toughness of WC-Co two-phase alloys—A preliminary model

The fracture toughness of WC-Co alloys was determined using single-edge notched beam specimens. Specimens were tested in air at room temperature and in liquid nitrogen. No significant differences were found between K_IC values due to temperature. A preliminarymodel of the fracture toughness based on the critical strain energy release rate is proposed and compared with the experimental results.     

Oviposition and incubation environmental effects on embryonic diapause in a ground cricket

PURPOSE: Recent studies document the value of early combined modality therapy of small cell lung cancer, but also indicate that early thoracic radiation adds to myelosuppression and can complicate further chemotherapy. Other studies indicate that simultaneous use of growth factors with thoracic radiation may be deleterious. However, temporal separation of growth factor use from cytotoxic therapy may allow dose intensity to be maintained/enhanced during combined modality treatment. We sought to integrate filgrastim into a novel chemoradiation regimen for patients with limited small cell lung cancer using an approach that separated growth factor administration from both chemotherapy and thoracic radiation. METHODS AND MATERIALS: Twenty-seven patients with limited disease small cell lung cancer were enrolled in a Phase I trial of cisplatin, ifosfamide/mesna, oral etoposide, and thoracic radiation (1.5 Gy b.i.d. x 30 fractions days 1-19 cycle 1) +/- filgrastim (5 microg/kg/day). Filgrastim was given on days 20-25 of cycle 1 after completion of radiation and following completion of oral etoposide in subsequent cycles. The primary end point was determination of maximum tolerated dose (MTD) of chemotherapy. Serial cohorts were treated with and without filgrastim. RESULTS: Because of dose-limiting thrombocytopenia, primarily, and nonhematologic toxicity, the MTDs with and without filgrastim were identical (cisplatin 20 mg/m2 i.v. and ifosfamide 1200 mg/m2 i.v., both given days 1-3, and etoposide 40 mg/m2 p.o. days 1-14). Filgrastim use shortened the duration of neutropenia at the MTD (median 4 vs. 7 days), but was not associated with a reduction in febrile neutropenia. Although growth factor administration did not allow dose escalation of this regimen, it did allow chemotherapy doses to be maintained at the MTD more frequently through four cycles of therapy. In the 24 evaluable patients, the overall response rate was 100% (71% partial and 29% complete). CONCLUSIONS: Despite careful attention to the timing of growth factor with chemoradiation, the administration of filgrastim with this regimen did not allow dose escalation. As in many other recent studies of hematopoietic growth factors given prophylactically with chemotherapy, the duration of neutropenia at the MTD was shortened and the need for dose reduction throughout treatment was reduced in patients receiving filgrastim at the MTD.     

Segregation effects on intergranular fracture:

The effects of segregation on the cohesive energy or ideal fracture toughness of a ∑5 [001] twist boundary in Ni-Cu alloys have been examined for a wide range of temperatures and com- positions within the solid solution region of the phase diagram. The cohesive energy 2γ_int is defined as the difference between the free energies of the surfaces created and the grain boundary destroyed when a crack propagates along a grain boundary. Atomistic simulations of the ∑5 [001] twist boundary and (001) surfaces were performed within the framework of the free energy simulation method that is based upon minimizing an approximate free energy functional with respect to both atom positions and solute concentration profile. Three different types of cohesive energies (2γ_int)μ, (2γ_int)_r, and (2γ_int)_c have been evaluated; (2γ_int)μ is the cohesive energy for slow fracture, (2γ_int)_r is the cohesive energy for fast fracture, and (2γ_int)_c is the cohesive energy of the unsegregated boundary. In the normal situation (where the solute segregates more strongly to the surface than the boundary), the inequality (2γ_int)μ ≤ (2γ_int)_r ≤ (2γ_int)_c is always satisfied, and for anomalous segregators (where the solute segregates more strongly to the boundary than the surface), (2γ_int)_c ≤ (2γ_int)μ ≤ (2γ_int)_r is satisfied. For all Ni-Cu alloy bulk compositions (0.05 ≤C ≤ 0.95) and temperatures (400 ≤T(K) ≤ 1000) examined, Cu segregates strongly to both the grain boundary and the free surface. Nonetheless, segregation only results in a small reduction (10 pct) in 2γ_int compared with the unsegregated case. The difference between the fast fracture (2γ_int)_r and slow fracture (2γ_int)μ cohesive energies is very small. Therefore, at least in the Ni-Cu system, the two theoretical bounds on 2γ_int, are tight.     

Deformation and fracture of α-β brass two-phase bicrystals at 150 K

The deformation up to fracture at 150 K was undertaken on α-β brass two-phase bicrystals. The variation of the slip systems during the proceeding deformation was studied and explained on the basis of incompatible stresses. The normal stress-strain curves were analyzed for various types of bicrystals and the bending that appeared in the specimens when unloaded was explained with respect to the occurrence of the Bauschinger effect in the α phase. Fracture modes other than those observed at room temperature were present. The results, and other minor problems, were discussed.     

Pressure effects on flow and fracture of Be-Al alloys

The flow and fracture behavior of Be-Al alloys were determined in tension with different levels of superimposed pressure. The Be-Al alloys were prepared by Brush Wellman, Inc. (Cleveland, OH) from prealloyed powders processed to either a hot isostatically pressed (“hipped”) or cold isostatically pressed and extruded condition. Significant effects of pressure on both the flow and ductility have been observed at room temperature, with implications on the formability of these materials. The effects of changes in processing conditions and stress state on the flow and fracture behavior are summarized in addition to both optical and scanning electron microscopy (SEM) examination of the fracture surfaces. Separate other studies on the alloy constituents (e.g., Al and Be) are also reported. The results are also compared to previous works on monolithic materials and composites tested with high pressure.     

The effects of environmental hormones on reproduction

Considerable attention has been given in the past few years to the possibility that man-made chemicals (xenobiotics) in the environment may pose a hazard to human reproductive health. The endocrine-disrupting effects of many xenobiotics can be interpreted as interference with the normal regulation of reproductive processes by steroid hormones. Evidence reviewed here indicates that xenobiotics bind to androgen and oestrogen receptors in target tissues, and to androgen-binding protein and to sex hormone-binding globulin. Although environmental chemicals have weak hormonal activity, their ability to interact with more than one steroid-sensitive pathway provides a mechanism by which their hazardous nature can be augmented. A given toxicant may be present in low concentration in the environment and, therefore, harmless. However, we are not exposed to one toxicant at a time, but, rather, to all of the xenobiotics present in the environment. Therefore, numerous potential agonists/antagonists working together through several steroid-dependent signalling pathways could prove to be hazardous to human reproductive health.     

Trace element effects on ductility and fracture of Ni-Cr-Ce alloys

The effect of trace additions of Ce, ranging from Oto 180 at. ppm, on the tensile behavior of a Ni-20Cr alloy is presented. For alloys without Ce a transition from ductile transgranular to brittle intergranular fracture mode is observed at high temperatures and for low strain-rate tests. Additions of Ce suppress this transition with a resulting increase in ductility. Maximum effects are observed for temperature and strain rate values where fracture in Ce-free alloys occursvia grain boundary cavitation. The reduced cavitation rate of Ce-containing alloys is suggested to be the result of an increase in both interfacial energy and grain boundary mobility. Formerly Graduate Assistant, Department of Mechanics and Materials Science, Rutgers     

Temporal and environmental effects on quinpirole-induced biphasic locomotion in rats

The dopamine D2/D3 agonist quinpirole induces suppression of locomotor activity at low doses, and suppression followed by activation at high doses when given to rats of 30 days of age and older that are immediately placed in activity monitors. The duration of suppression is longer and the level of activation is lower at 60 than at 30 days of age, suggesting that the mechanism responsible for the suppression may play a role in the lesser activation in the older rats. However, habituation limits the ability to measure the duration of locomotor suppression. Therefore, 0, 0.2, or 0.2 mg/kg quinpirole was injected S.C. either 30, 60, or 120 min before placing male or female rats of 30 or 60 days of age in activity monitors for 30 min. At both ages, both doses of quinpirole suppressed activity when the animal was placed in the monitor 30 or 60 min after injection; at 60 days the drug also suppressed activity at 120 min after injection. Previously, 0.2 mg/kg quinpirole elicited locomotor activity 60 min after injection in rats placed immediately in activity monitors at both ages. Thus, not only time after injection but novelty of the environment are critical factors in the expression of locomotor suppression or activation in response to quinpirole.     

Renal effects of environmental and occupational lead exposure

Environmental and industrial lead exposures continue to pose major public health problems in children and in adults. Acute exposure to high concentrations of lead can result in proximal tubular damage with characteristic histologic features and manifested by glycosuria and aminoaciduria. Chronic occupational exposure to lead, or consumption of illicit alcohol adulterated with lead, has also been linked to a high incidence of renal dysfunction, which is characterized by glomerular and tubulointerstitial changes resulting in chronic renal failure, hypertension, hyperuricemia, and gout. A high incidence of nephropathy was reported during the early part of this century from Queensland, Australia, in persons with a history of childhood lead poisoning. No such sequela has been found in studies of three cohorts of lead-poisoned children from the United States. Studies in individuals with low-level lead exposure have shown a correlation between blood lead levels and serum creatinine or creatinine clearance. Chronic low-level exposure to lead is also associated with increased urinary excretion of low molecular weight proteins and lysosomal enzymes. The relationship between renal dysfunction detected by these sensitive tests and the future development of chronic renal disease remains uncertain. Epidemiologic studies have shown an association between blood lead levels and blood pressure, and hypertension is a cardinal feature of lead nephropathy. Evidence for increased body lead burden is a prerequisite for the diagnosis of lead nephropathy. Blood lead levels are a poor indicator of body lead burden and reflect recent exposure. The EDTA lead mobilization test has been used extensively in the past to assess body lead burden. It is now replaced by the less invasive in vivo X-ray fluorescence for determination of bone lead content.     

The genetic effects of environmental lead

Distribution and metabolism of the thyroid hormone 3,5, 3'-l-triiodothyronine (T3) were studied in several ways to gain insights into these processes in the warm water fish tilapia Oreochromis mossambicus. Trace doses of 125I-labeled T3 (T*3)1 were injected intraarterially, extraarterially, or intraperitoneally in freshwater-reared male tilapia to explore plasma clearance kinetic responses to these different input modalities. Multicompartmental analysis of the plasma clearance data indicated a kinetic distribution of T*3 much like that reported for the rat and human, with about 2% of total body T*3 in plasma, 5% in rapidly exchanging tissues such as kidney and liver, and 93% in slowly exchanging tissues such as muscle. However, plasma clearance rates (PCR, 5.37 mL/h . 100 g body wt) and plasma appearance rates (PAR3 = PCR x [T3] plasma = 36.3 ng/h . 100 g body wt) were quite different than these indices in rat and human and 5 to 50 times larger than values reported for rainbow trout. On a whole-body basis, normalized for body weight, the tilapia we studied produced and accumulated much more T3 than rat, human, or rainbow trout. Enzymatic and chromatographic analyses of the plasma clearance data samples indicated substantial production of labeled glucuronide, but not sulfate, conjugates of iodothyronines (TiG) of unknown origin appearing in plasma. The TiG appeared beginning a few hours postinjection, peaked at 6 hours, and yielded a predicted steady-state TiG level of 8.3% of the T3 level in plasma. In contrast, in published studies, no conjugates were detected in rainbow trout plasma from 2 to 24 h after iv injection of T*3, T*4, or reverse-T*3, although conjugates of all were present in bile. To our knowledge, although T3 and T4 sulfate conjugates are present in the sera of several mammals, this is the first quantification of iodothyronine glucuronides reported in blood of any species under normal conditions. This might have physiological significance for the tilapia, with T3G providing a reversible storage form of T3 in blood, as has been suggested for sulfate conjugates of T3 and T4 in blood of several mammals.     

Microstructural effects on fracture toughness in AA7010 plate

The influence of recrystallization and quench rate after solution treatment on the fracture toughness of 7010 aluminum plate has been studied in longitudinal-transverse (L-T) and short-longitudinal (S-L) orientations for T76-type heat treatments. Extensive fractographic analysis was carried out to identify the failure mechanisms, including simultaneous scanning electron microscope (SEM) observation of fracture surfaces and underlying microstructures. A slow quench rate was strongly detrimental because it modified the dominant failure mode from a relatively high energy primary void growth mechanism to lower energy transgranular shear and grain boundary ductile failure in the L-T and S-L orientations, respectively. Low energy failure was associated with coarse ν precipitation during the quench in both L-T and S-L orientation tests, with intragranular and intersubgranular particles contributing to L-T quench sensitivity, and intergranular particles contributing to S-L sensitivity. Partial recrystallization was generally detrimental, with recrystallized grains being shown to be a preferential crack path. The commonly supposed susceptibility of recrystallized grains to intergranular failure did not explain this behavior, particularly in fast quench materials, as recrystallized grains primarily failed by transgranular void growth from the large intermetallics with which they were intrinsically associated. Exceptional S-L orientation quench sensitivity was observed in unrecrystallized material and attributed to a synergistic interaction between heterogeneous boundary precipitation and the specific location of coarse intermetallics along grain boundaries in the unrecrystallized condition. Quantitative assessment of individual contributions to overall fracture resistance is discussed for cases where multiple failure mechanisms occur, highlighting the importance of interacting and noninteracting mechanisms.     

Testing hypotheses on specific environmental causal effects on behavior.

There have been strong critiques of the notion that environmental influences can have an important effect on psychological functioning. The substance of these criticisms is considered in order to infer the methodological challenges that have to be met. Concepts of cause and of the testing of causal effects are discussed with a particular focus on the need to consider sample selection and the value (and limitations) of longitudinal data. The designs that may be used to test hypotheses on specific environmental risk mechanisms for psychopathology are discussed in relation to a range of adoption strategies, twin designs, various types of "natural experiments," migration designs, the study of secular change, and intervention designs. In each case, consideration is given to the need for samples that "pull-apart" variables that ordinarily go together, specific hypotheses on possible causal processes, and the specification and testing of key assumptions. It is concluded that environmental risk hypotheses can be (and have been) put to the test but that it is usually necessary to use a combination of research strategies. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Examining genetic and environmental effects on reactive versus proactive aggression.

This study compared the contribution of genes and environment to teacher-rated reactive and proactive aggression in 6-year-old twin pairs (172 pairs: 55 monozygotic girls, 48 monozygotic boys, 33 dizygotic girls, 36 dizygotic boys). Genetic effects accounted for 39% of the variance of reactive aggression and for 41% of the variance of proactive aggression. The remainder of the variance was explained by unique environmental effects. Genetic as well as unique environmental effects were significantly correlated across reactive and proactive aggression (genetic correlation = .87, environmental correlation = .34), but this overlap was largely due to a common underlying form of aggression (i.e., teacher-rated physical aggression). Once common etiological factors due to physical aggression were accounted for, reactive and proactive aggression shared no other genes and only a few environmental influences, although additional specific genetic and environmental effects were observed for both reactive and proactive aggression. These specific effects indicate that both reactive and proactive aggression may be influenced mostly by socialization experiences that are specific to each type of aggression and only to a very small degree by specific genes. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Health and environmental effects on the academic readiness of school-age children.

Secondary analysis was used to examine how health and environmental risk affect mathematics and reading readiness in a sample of 867 5- and 6-year-old children from the National Longitudinal Survey of Youth. Measures of risk included low birth weight, length of hospitalization at birth, rehospitalization during the first year of life, family income, maternal education, and the quality of the home environment. Although academic readiness was largely explained by environmental risk, child morbidity had a significant independent impact on reading performance. Furthermore, interaction analyses indicated that child morbidity was predictive of poor mathematics performance only for children from impoverished homes. In contrast, results also indicated that low birth weight children may be less able to benefit from higher levels of maternal education in terms of reading performance. These findings are discussed in the context of developmental risk. (PsycINFO Database Record (c) 2010 APA, all rights reserved)