甾体雌激素类化合物的氢解脱苄研究

报道了１３种甾体雌激素化合物的氢解脱苄反应，并比较了苄氧基在雌甾结构中不同位置对氢解反应的影响。     

合成聚苄研究的进展

本文综述了在以氯千为单体合成聚苄研究方面的进展，分析了难以得到线性聚苄的原因，探讨了有关反应机理，并简要介绍了聚苄的表征方法。     

苄醇相转移催化合成乙酸苄酯

以ＣＴＡＢ为相转移催化剂，用苄醇、冰乙酸为原料，在乙酸钠－乙酸形成的ｐＨ＝４的缓冲溶液环境下合成乙酸苄酯。以正交实验设计优化反应参数，产品红外光谱图与Ｓａｄｔｌｅｒ标准图谱完全一致。     

苯甲酸苄酯的相转移催化合成

苯甲酸苄酯的相转移催化合成刘永军，刘英，刘振东（曲阜师范大学化学系，曲阜２７３１６５）苯甲酸菜酯又名安息香书酯，广泛存在于天然吐鲁香酯、秘鲁香酯、月下香和洋水仙中＊］。由于其具弱香味，沸点高（ｓｚｓ～ｓｚｖｏｃ），广泛用于多种花香香精的定香剂和溶剂，...     

2—氨基—1—[（4—苄氧基—3—硝基）苯基]乙醇的合成

合成了4－苄氧基－3－硝基－α－氨基苯乙酮及2－氨基－1－[（4－苄氧基－3－硝基）苯基]乙醇两个未见文献报道的新化合物，该合成方法简便，收率高。     

对硝基叠氮苄的合成

有机叠氮化合物在合成反应中有着重要意义。对硝基溴化苄和叠氮化钠在一定条件下反应，得到对硝基叠氮苄。     

氯苄羰化合成苯乙酸

应用氯化钴和低价含硫化合物低压合成四羰基钴盐的技术于氯苄羰化合成苯乙酸的生产中。结果表明甲醇－水溶剂系统有利于低压合成四羰基钴盐；氢氧化钙作中和剂作用，要求羰化产物后处理的温度提高，以保证苯乙酸的产率；碱的用量和浓度是影响苯乙酸产率的重要因素     

苄醚和芳醚的简易合成

苄醚和芳醚的简易合成唐艳春，俞善信（湖南师范大学化学系，长沙４１００８１）芳香族混合醚的经典会成，通常采用Ｗｉｌｌｉａｍｓｏｎ法．也就是先将酚与氢氧化钠（或氢氧化钾、碳酸钾等）反应制成酚钠（或酚钾），再与卤代芳烃反应来合成［１］，该法反应条件苛刻，某...     

1,3;2,4-二苄叉山梨醇的合成及应用

介绍了１，３；２，４－二苄叉山梨醇的合成新方法，并叙述了其在塑料、油墨、粘结剂、日用化学品等方面的应用情况。     

苯甲醛的制备研究

本文探索了以苄叉二氯为原料，在锌催化剂作用下制备苯甲醛的新方法，其工艺设备简单、反应条件温和，产品纯度好、产率高。     

BENZYL ACETATE FROM PHASE TRANSFER CATALYZED ACETATE DISPLACEMENT OF BENZYL CHLORIDE

The overall production rate equation of benzyl acetate by L-L phase transfer catalyzed acetate displacement of benzyl chloride were derived. The experimental results of the effects of stirring speed, structure and amount of catalyst, reaction temperature, amount of sodium acetate, and phase volume-ratio on the production rate of benzyl acetate are elucidated with the rate equation. Benzyltributylammonium chloride is the recommended catalyst. The apparent activation energy of the displacement of benzyl chloride with the ion pairs of benzyltributylammonium acetate is 8.13kcal/mol. Sodium sulfate is a suitable salt to improve the partition coefficient of the phase transfer catalyst. The cocatalyst, sodium iodide, can greatly improve the production rate of benzyl acetate when its amount do not exceed 3 mol% of the substrate, benzyl chloride. Under the conditions of 5mol% benzyltributylammonium chloride, phase volume-ratio 0.429, stirring speed 520 rpm, reaction temperature 70°C, and 50% aqueous sodium acetate, about 80% yield of benzyl acetate can be obtained within 2 hrs. of reaction time.     

乙酸苄酯新工艺探讨

简要介绍了乙酸苄酯的应用,物化性质,介绍了一些较早生产方法,重点介绍了新工艺合成乙酸苄酯及其几项关键控制技术。     

BENZYL ALCOHOL FROM PHASE TRANSFER CATALYZED WEAKLY ALKALINE HYDROLYSIS OF BENZYL CHLORIDE

The chemical and mass transfer processes were formulated and explained for the system initially composed of BzCl/BzR₃”NCI, R'COONa, H₂O. The effects of the size of the alkyl group of benzyltrialkylammonium chloride, the pH of the aqueous phase, the concentration of the pH controlling agent, aqueous NaOH, the stirring speed, the reaction temperature, the amounts of the cocatalysts, sodium formate and sodium acetate, and the initial volume-ratio of benzyl chloride to water on the product distribution and the production rate of benzyl alcohol were investigated experimentally.

The experimental results show that the pH of the aqueous phase is the most important factor. With sodium formate as the cocatalyst it should be controlled within 7.2-7.7, while with sodium acetate it should be within 9.5-10. Under the suitable pH and 110°C and other suitable conditions, 95% yield of benzyl alcohol can be obtained within 3 hrs of reaction time.     

固体酸催化合成乙酸苄酯

以固体酸氨基磺酸为催化剂，以苄醇、冰乙酸为原料合成乙酸苄酯。酯化反应时间短，收率达到９６％，催化剂可重复使用。     

Kinetics of reaction of benzyl chloride with sodium acetate using tetrahexylammonium chloride as a phase-transfer catalyst

Benzyl acetate was synthesized by the reaction of benzyl chloride with sodium acetate in a two-phase system of an aqueous solution and toluene using tetrahexylammonium chloride (QCl) as a phase-transfer catalyst at 85 °C. The distribution coefficient and chemical equilibrium constants of QCl and tetrahexylammonium acetate were used to analyze the kinetics of the esterification. Two models such as the simple ion exchange across the interface (interface model) and the anion exchange in the aqueous phase (bulk model) were used to obtain the reaction rate constant.

The overall reaction can be described by a first-order reaction with respect to the molar concentration of benzyl chloride and the active intermediate (tetrahexylammonium acetate) produced by the reaction between QCl and acetate ion in the aqueous phase, respectively.     

乙酸苄酯的合成

以氯化苄和无水乙酸钠为原料,三乙基苄基氯化铵(TEBAC)为催化剂合成乙酸苄酯。考察了水的加量、反应温度、原料配比、催化剂用量、反应时间等因素对反应收率的影响。结果表明:当n(氯化苄):n(无水乙酸钠):n(TEBAC):n(水)=1:1.25:0.02:0.45,反应温度110℃,反应时间4h,产物摩尔收率可达94.50%。     

相转移催化法制备乙酸苄酯

研究了以苯基三乙基氯化铵为相转移催化剂制备乙酸苄酯，得出了最佳操作条件，使反应收率达８６％。     

稀土掺杂纳米固体超强酸催化合成乙酸苄酯的研究

采用溶胶-凝胶法及改性技术制备了稀土掺杂纳米固体超强酸SO4^2-／TiO2-Y3＋催化剂,主要研究了它的制备、表征以及应用于催化合成乙酸苄酯,并用正交设计实验法确定了催化合成反应的最佳条件。实验结果表明：SO4^2-／TiO2-Y3＋具有良好的催化活性;在催化剂焙烧温度550℃,催化剂用量2．O％（质量分数）,反应物n（乙酸）：n（苯甲醇）=1：2．0,反应时间2．0h,带水剂苯用量15％（质量分数）的最佳条件下,乙酸苄酯的酯化率可达95％以上。     

Gold–palladium supported on porous steel fiber matrix: Structured catalyst for benzyl alcohol oxidation and benzyl amine oxidation

Au, Pd and Au-Pd alloy are deposited on porous steel fiber matrices via sputtering technique. By this technique the preparation of the heterogeneous catalysts is clean, simple and fast as noble metal complexes, solvents or reducing agents are not needed. The studied Au-Pd catalyst exhibits good activity in the aerobic oxidation of benzyl alcohol and benzyl amines. Especially in the oxidation of benzyl amines, the Au-Pd catalyst shows a great synergistic enhancement in the activity.     

甲烷磺酸铜催化合成异丁酸苄酯的性能

以甲烷磺酸铜为催化剂合成异丁酸苄酯,考察了催化剂用量、反应时间、醇酸物质的量比对酯化率的影响。实验结果表明异丁酸0.1mol,醇酸物质的量比1.21,甲烷磺酸铜用量0.125%(基于异丁酸的摩尔百分数),反应时间2.5h,环己烷5mL作带水剂,在回流温度下酯化率可达96.2%;与CuSO4·5H2O等其它几种Lewis酸相比,甲烷磺酸铜具有较高的催化活性,反应后易与产物分离,催化剂重复使用6次,酯化率仍达到89%以上。