Operationalized psychodynamic diagnosis in childhood and adolescence--a contribution to quality assurance

Adopting a therapeutic view on diagnosis in child and adolescent psychiatry a psychodynamic diagnostic manual seems to be necessary, that may provide reliability in the assessment of intrapsychic processes. Multiaxial diagnosis of children's and adolescent's psychiatric disturbances may thus be completed with additional psychodynamic assessment procedures. In adults an operationalized procedure of psychodynamic assessment (OPD) already exists. In child and adolescent psychiatry a working group for psychodynamic diagnostic (OPD-KJ) has been founded. In 4 areas (subjective experiences of disturbances, relationships, intrapsychic conflicts and psychic structure) diagnostic manuals are being worked out. Fundamental questions of developmental psychopathology and diagnostic procedures have to be addressed. The basic proposition takes into account that children should not be psychodynamically compared with adults, but normally have a basic capacity to adapt to environment on a high level of psychic organisation in all developmental stages. Reports of the ongoing work are being given.     

Eyeglass MEDRETE: practical considerations (a user''s guide)

Humans are exposed to a variety of potential developmental toxicants. This fact, combined with the knowledge that human development can be disrupted by "environmental" agents, has led to the development of methods designed to identify potential developmental toxicants. Currently, the principal method used to screen drugs and chemicals that are potential human developmental toxicants is the segment II study (i.e., a study in which prospective drugs and chemicals are tested in pregnant animals). Because of the cost and time involved in such studies and the pressure to reduce the number of animals used in such testing, alternative methods for developmental toxicity testing have been sought. This has resulted in a number of in vitro tests whose aim is to screen large numbers of agents quickly and inexpensively. Although numerous in vitro tests of developmental toxicity have been developed during the last 15 years, no one system or combination of tests have been validated for the purpose intended. Nonetheless, two systems--the limb bud/CNS micromass, and the chick embryo neural retina cell culture (CERC)--continue to be advanced as viable in vitro developmental toxicology tests. The purpose of this commentary is to evaluate the prospects for the development of an in vitro test system(s) that can screen the universe of drugs and chemicals and reliably identify those that require further study and those that do not. The conclusion of this investigator is that the prospects for validating such in vitro tests are not promising. This conclusion is based primarily on the lack of basic knowledge regarding the relevance of end points assayed in the micromass and CERC test systems to those end points known or thought to be critical for normal development.     

The future of psychotherapy with children: Developmental psychotherapy.

Discusses the concept of developmental psychotherapy for children as a way of integrating information about human development, basic biological processes, and psychopathology with knowledge gained from studies of therapeutic change. In developmental psychotherapy, rather than trying to provide a permanent cure, the therapist tries using a variety of methods to help the child regain a footing on a developmental pathway more likely to lead to adequate adaptation in subsequent periods of life. Research in this field should concentrate on continuing refinement of models for developmental pathways leading to specific outcomes in a number of domains, particularly those involving externalizing disorders and substance abuse. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Epilogue: Bridging the gap between research on attachment and psychopathology.

Clinicians and researchers are beginning to acknowledge the importance of integrating a developmental perspective into the understanding of clinical disorders. The application of findings from basic attachment research to this understanding of psychopathology is a prototype for interdisciplinary research. However, major gaps continue to exist between basic research on attachment processes and clinical issues of assessment, classification, and treatment of mental disorders from infancy through adolescence. This epilogue highlights the importance of more integrative research. As a reflection of growth in this direction, National Institute of Mental Health funding patterns are reviewed, and promising areas for future research are suggested. The field is well positioned for conceptual advancement if more integrative approaches are used. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

On inhibition/disinhibition in developmental psychopathology: Views from cognitive and personality psychology and a working inhibition taxonomy.

Disinhibition is a common focus in psychopathology research. However, use of inhibition-models often is piecemeal, lacking an overarching taxonomy of inhibitory processes. The author organizes key concepts and models pertaining to different kinds of inhibitory control from the cognitive and temperament/personality literatures. Within the rubrics of executive inhibitory processes, motivational inhibitory processes, and automatic attentional inhibition processes, 8 kinds of inhibition are distinguished. Three basic temperament traits may address key executive and motivational inhibitory processes. Future developmental psychopathology research should be based on a systematic conceptual taxonomy of the kinds of inhibitory function relevant to a given disorder. Such an approach can clarify which inhibition distinctions are correct and which inhibition deficits go with which disorders. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Slug, a zinc finger gene previously implicated in the early patterning of the mesoderm and the neural crest, is also involved in chick limb development

The great advances made over the last few years in the identification of signalling molecules that pattern the limb bud along the three axes make the limb an excellent model system with which to study developmental mechanisms in vertebrates. The understanding of the signalling networks and their mutual interactions during limb development requires the characterisation of the corresponding downstream genes. In this study we report the expression pattern of Slug, a zinc-finger-containing gene of the snail family, during the development of the limb, and its regulation by distinct axial signalling systems. Slug expression is highly dynamic, and at different stages of limb development can be correlated with the zone of polarizing activity, the progress zone and the interdigital areas. We show that the maintenance of its expression is dependent on signals from the apical ectodermal ridge and independent of Sonic Hedgehog. We also report that, in the interdigit, apoptotic cells lie outside of the domains of Slug expression. The correlation of Slug expression with areas of undifferentiated mesenchyme at stages of tissue differentiation is consistent with its role in early development, in maintaining the mesenchymal phenotype and repressing differentiation processes. We suggest that Slug is involved in the epithelial-mesenchymal interactions that lead to the maintenance of the progress zone.     

Numerical Analysis of River Channel Processes with Bank Erosion

This paper presents a numerical analysis of river channel processes with bank erosion. The model can be used for investigating both bed-deformation and bankline shifting in 2D plan form. The basic equations are used in a moving boundary fitted-coordinate system, and a new formulation of nonequilibrium sediment transport is introduced to reproduce the channel processes. The model was applied to examine the morphological behavior of experimental channels. Temporal changes in the plan form in a meandering channel can be classified into two patterns: meander developing and meander straightening. Comparison of the observed and calculated results indicates that the model is applicable to both channel changes under various hydraulic conditions. On the basis of the numerical findings, the paper clarifies the influence of hydraulic variables on the location of bank erosion and bed scouring. The model also was used to investigate the effect of alternate bars on bank erosion and to investigate the development of channel meandering from an initially straight channel.     

Hyperactivity and attention deficits.

Substantive progress has been made in our understanding of children considered hyperactive, especially in the interpersonal sphere. Evolving conceptualizations of hyperactivity and attention deficits are reviewed briefly, including changes in clinical diagnostic practices and in knowledge about developmental course. The hypothesis is advanced that the cognitive and social difficulties of hyperactive children may be better understood in terms of motivational and self-regulatory processes than as deficiencies in basic information processing. The role of stimulant medication is emphasized, both as a controversial treatment approach and as an adjunct to research on the children's problems. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Temperament and dyadic contributions to affect regulation: Implications from developmental research for clinical practice.

The temperamental trait of inhibition offers a setting to examine the characteristics of the interplay between intraindividual factors and contextual influences. This article drew from both the developmental psychoanalytic model on mutual regulation of affect and developmental research on temperament to portray the mechanisms and consequences of the dynamic processes of change, in which both the individual and the environment are constantly changing. The portrait presents a unique case of a very inhibited girl at age 3, who gradually shifts from a frozen, fearful stance into a spontaneous, active behavior. The examination uses the paradigm of coconstruction of play narratives, a paradigm that combines both projective techniques and developmental research perspectives. The function of the adults as stress buffers is explored. Possible implications for psychoanalysis, treatment processes and developmental psychopathology are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Cannabis for migraine treatment: the once and future prescription? An historical and scientific review

Over the past ten years, the discovery and functional characterisation of murine Hox genes has led to a better understanding of some of the molecular mechanisms underlying limb development. It has also shed some light on the potential genetic events which have accompanied the fin-to-limb transition, an evolutionary step of critical importance which opened the way to the evolution of higher vertebrates. This convergence between developmental biology and the sciences of evolution is one of the synergistic interface that has been established recently thanks to the use of genetic engineering and transgenic animals. The increasing number of human genetic syndromes which are derived from mutations in developmental control genes remind us that many human genetic diseases are nothing else but alterations in our developmental programme. Here, we illustrate these various issues by discussing the function of Hox genes during limb development.     

Cellular and developmental aspects of androgenetic alopecia

The hair follicle is a highly complex system that can be investigated at many levels and from multiple perspectives. However, underlying the cyclic production of all hair fibres are a set of common developmental processes. Many current investigations of androgenetic alopecia concentrate on the direct influences of hormones on hair follicles at the cellular or intracellular level. This paper attempts to step back from this and consider the process of terminal to vellus transition in androgenetic alopecia in terms of basic cellular and developmental mechanisms. Ideas about the mechanism and timing of follicle size reduction are put forward, but the paper also tries to point out inherent difficulties in the investigation of androgenetic alopecia and important gaps in current knowledge.     

No more than skin deep: Ethnic and racial similarity in developmental process.

Many studies adduce evidence of ethnic or racial dissimilarities in developmental outcomes (e.g., delinquency and achievement). Many researchers fail to distinguish between group average levels and developmental processes (correlations). Evidence is reviewed that developmental processes are nearly identical for US Black, Hispanic, White, and Asian ethnic and racial groups. Using diverse and representative data sources, covariance matrices were computed for these ethnic groups and then compared by using a LISREL goodness-of-fit test. Not only were these matrices nearly identical but they also were no less alike than covariance matrices computed from random halves within 1 ethnic or racial group. This article documents the importance of accepting ethnic and racial similarity of developmental processes. Thus, group average level differences may result from different levels of developmental antecedents working through common developmental pathways. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Expression of regeneration-associated cytoskeletal proteins reveals differences and similarities between regenerating organs

The unique events which allow regeneration of an entire organ to occur are formation of a specialized wound epidermis and accumulation of progenitor cells (blastemal cells) at the amputated surface to form a blastema. In order to identify some of the molecular events underlying the early stages of the regenerative process which are either common to different systems or specific to one of them, we have investigated whether molecules which are induced in limb blastemas are also expressed in skin repair and during regeneration of other complex body structures (lower jaws, upper jaws, and tails). In addition, we have addressed the issue of the identity of progenitor cells during jaw development and regeneration by analyzing the expression of limb blastemal markers in the developing head and face. We have focused on cytoskeletal components, and particularly on the epidermal keratin NvKII, the simple epithelial keratins 8 and 18 and 22/18, because they are among the few molecules which have been shown to be associated with regeneration in the limb and may play significant roles in various developmental processes. Some important findings emerge from this study: 1) Expression of the epidermal keratin NvKII, unlike that of its mammalian homologue K6, is not simply induced in response to wounding, but is associated with regeneration of specific organs. In fact, NvKII is expressed in regenerating limbs and tails, but not in upper or in lower jaw regenerates, demonstrating the existence of molecular differences in the composition of the wound epidermis in these systems. This, together with the fact that NvKII mRNA is regulated by retinoic acid, which differentially affects patterning of limbs and jaws, argues for distinct inductive abilities of the wound epidermis in different organs. 2) In contrast to the differential expression of the epidermal keratin NvKII, the regeneration-associated cytoskeletal molecules identified in limb blastemal cells are expressed in a similar fashion in jaw and tail blastemas. Therefore, it appears that similar cellular events lead to the establishment of an actively proliferating population of progenitor cells from the stump of different organs. Finally, the mesenchyme of the facial rudiments, unlike that of developing limb buds, expresses simple epithelial keratins. Thus, it appears that mesenchymal progenitor cells of developing and regenerating jaws are alike in regard to their intermediate filament content, and this may be related to nerve-dependent growth control of progenitor cells in different developing and regenerating systems.     

EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract

Members of the Eph family of tyrosine kinase receptors have been implicated in the regulation of developmental processes and, in particular, axon guidance in the developing nervous system. The function of the EphA4 (Sek1) receptor was explored through creation of a null mutant mouse. Mice with a null mutation in the EphA4 gene are viable and fertile but have a gross motor dysfunction, which is evidenced by a loss of coordination of limb movement and a resultant hopping, kangaroo-like gait. Consistent with the observed phenotype, anatomical studies and anterograde tracing experiments reveal major disruptions of the corticospinal tract within the medulla and spinal cord in the null mutant animals. These results demonstrate a critical role for EphA4 in establishing the corticospinal projection.     

Segmental set: The adaptive process in schizophrenia.

Discusses "generalized set" (i.e., adaptation disposing an S to perceive and respond to situations adequately) in terms of appropriate integration of the cognitive-conative-affective components of basic information processing. Generalized set is also contrasted with segmentalized set, characterized by inconsistency within one of these aspects or in their integration into a spontaneous unit. Hypotheses are proposed to account for the schizophrenic's vulnerability to segmentalization. Paranoid and hebephrenic Ss exemplify the extremes of bipolar behavior that characterize the inappropriate coping efforts prevalent in schizophrenia. Deterioration, regression, etc, are terms designated to characterize schizophrenic behavior. Overcoming the tendency to segmentalize involves rebuilding the personality through reconstituted developmental processes. Emphasis is placed on the role and standards of research in working with schizophrenics. (36 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Temperament and personality: Origins and outcomes.

This article reviews how a temperament approach emphasizing biological and developmental processes can integrate constructs from subdisciplines of psychology to further the study of personality. Basic measurement strategies and findings in the investigation of temperament in infancy and childhood are reviewed. These include linkage of temperament dimensions with basic affective–motivational and attentional systems, including positive affect/approach, fear, frustration/anger, and effortful control. Contributions of biological models that may support these processes are then reviewed. Research indicating how a temperament approach can lead researchers of social and personality development to investigate important person–environment interactions is also discussed. Lastly, adult research suggesting links between temperament dispositions and the Big Five personality factors is described. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Temperament and the development of personality.

Presents a psychobiological approach to personality development, incorporating developmental principles outlined by R. B. Cairns (1979). The authors review individual differences in temperament and ask how a temperamental approach to personality might be congruent with these complex and flexible principles. Then, the nature of temperamental processes is illustrated by considering several developmental topics. The interaction of infant distress-proneness and maternal behavior in the development of attachment is considered, and the development of self-regulatory mechanisms, emphasizing development of conscience, aggression, and mastery motivation, is described. Finally, mechanisms of temperament and environment interaction, illustrating these processes through variable developmental pathways for risk of adolescent and adult psychopathology, are reviewed. Throughout, the idea that temperamental models of personality development are dynamic, interactive, and fit well with Cairns's developmental principles is stressed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)