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The paper provides the evidence on interaction of the endocrine system hypophysis-gonads with varicocele. Gonadotropic hormones and sexual steroids were measured in the blood of varicocele males (47 cases) and of fertile healthy males (17 cases), testosterone in the tissue of the sexual glands and blood of white noninbred rats (40 test against 20 control animals). It was found that in 18% of varicocele patients high levels of FSH were associated with oligo-, pathospermia and changes in spermatogenic epithelium. Interstitial cell stimulating hormone did not shift above the standard in all varicocele patients, while testosterone was low in 15% of them and combined with hypogonadism manifestations. Progesterone rose high in 38% of the examinees. The discussion covers the problem of hyperprogesteronemia origin. Recommendations are given on gonadotropic hormones and sexual steroids assays which are thought useful in examination of the patients to validate pathogenetic treatment.  相似文献   

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Lichen planus is a chronic oral disorder that is often painful and annoying. The patients have been described as usually over 50 years old, with a high educational level, anxious and high-strung. In previous research studies, these patients have reported unusual and highly stressful life events. Because dentists are in a position to advise their patients about chronic illness, this study was designed to (1) determine what information was given to lichen planus patients by their dentists; (2) determine what questions the patients asked their dentists; and (3) assess what educational materials would be helpful for this group of patients. A survey was sent to 151 biopsy-confirmed lichen planus patients, with a response rate of 55 percent. The results indicated that the patients were concerned about the possibility of malignancy and of contagion, and that they were frustrated by the lack of available patient education.  相似文献   

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This paper reviews the themes related to work ability of young adults. Premature working discapacity causes significant economical and social costs in Finland compared to other Nordic countries and has for that reason been studied most intensively there. Work ability is an interaction of social, environmental and individual factors such as physical fitness, coping skills, social support behaviour and health behaviour. Environmental factors influencing work ability can be concrete, like physical and chemical exposures or more abstract like unemployment. The work ability of ageing people has been studied intensively, while work ability of young adults has not been properly evaluated so far. The worsened economic situation in Finland has meant an excessive work load for those who still have work. At the same time the risk of permanent unemployment is increasing. This polarizationing affects especially the young because they may fail to enter the working life. Also factors related to childhood may affect and even determine work ability in adulthood.  相似文献   

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A national sample of 148 directors of hospice social service departments (or persons most familiar with the delivery of social services in the hospice) participated in an exploratory study investigating the effects of the acquired immune deficiency syndrome (AIDS) epidemic on the delivery of hospice social services. Findings suggest, as does the literature, that the psychosocial needs of persons dying from AIDS present different challenges than those of traditional hospice patients. Furthermore, the results indicate the need for greater collaborative efforts among community agencies as well as specific and ongoing training for staff and volunteers who work with persons with AIDS (PWAs). Implications for the delivery of hospice social services to this population are discussed.  相似文献   

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Among 47 blood donors tested positive with HCV EIA 2.0 Abbott, 27 (57.4%) also reacted with four ?third-generation' EIAs. The presence of anti-HCV antibodies was confirmed with 3 different immunoblot assays in 16 of 27 sera (34.0%) while 10 samples (21.3%) had indeterminate profile with antibodies usually directed against structural core antigen. Anti-HCV core IgM response was found in 12 of 47 sera (25.5%) and HCV viremia detected by the polymerase chain reaction (PCR) procedure was observed in 15 samples (31.9%). A comparative study of the different markers confirmed a good correlation between a strong antibody response in EIAs and immunoblot assays and the presence of HCV RNA in the serum; only 2 immunoblot indeterminate samples were PCR positive. An association was observed between IgM antibodies against "core' epitopes and HCV RNA carriage: all IgM-positive sera were found positive by PCR. However, the direct detection of viral genome remains the best method for identifying HCV carriers in the blood donor population.  相似文献   

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Early clinical trials for new anti-cancer drug treatments typically use patients with cancer as research subjects. This paper identifies some of the ethical and practical concerns that arise from the recruitment of a vulnerable group of patients and their exposure to a drug of unknown risk or benefit. This review discusses the ethical principles related to recruitment and informed consent in cancer trials, and indicates that there is a lack of consensus concerning the requirements, process and practice of informed consent. It is suggested that, as yet, little is known about patients' decision making framework in this situation, and the need for further work that concentrates on the patient's point of view is highlighted. The paper concludes by discussing some of the difficulties associated with obtaining patients' opinions, and suggests that the use of a qualitative approach may overcome some of these problems.  相似文献   

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Previous research has demonstrated that older adults prefer less autonomy and seek less information when making decisions on their own relative to young adults (for a review, see M. Mather, 2006). Would older adults also prefer fewer options from which to choose? The authors tested this hypothesis in the context of different decision domains. Participants completed a choice preferences survey in which they indicated their desired number of choices across 6 domains of health care and everyday decisions. The hypothesis was confirmed across all decision domains. The authors discuss implications from these results as they relate to theories of aging and health care policy. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

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PM Flynn 《Canadian Metallurgical Quarterly》1994,95(1):59-60, 65-8, 72-4
The number of HIV-infected children and adolescents is expected to increase during the next decade. Most of these patients are likely to receive nearly all of their healthcare from primary care physicians. Management must be multifaceted and consist of medical care for acute illnesses, routine pediatric care that includes immunizations, and social service intervention.  相似文献   

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Children grieve differently than adults. Although the unit of care in hospice is the patient and family, emphasis is often on the grown members of the family and the anticipatory grief and bereavement needs of children and adolescents are sometimes not met adequately. In this paper, hands-on strategies for working with children both before and after a significant death are presented, as well as appropriate context information on the grieving process for youth under age 18.  相似文献   

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Many patients require oxygen therapy as part of their postoperative care. A study to assess whether patients were actually given the supplementary oxygen prescribed showed many received only intermittent therapy. Placing more emphasis on oxygen therapy in nurse education would do much to improve its use in practice.  相似文献   

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Stereotactic posteroventral pallidotomy can improve motor performance in Parkinson's disease. Interruption of inhibitory pallidal projections to ventrolateral thalamus, components of a cortical-basal ganglia motor loop allows for this clinical benefit. We hypothesized that pallidotomy would lead to increased movement related activity in motor cortical areas receiving projections from ventrolateral thalamus. This was tested in 6 Parkinson's disease patients who underwent stereotactic posteroventral pallidotomy. Each patient was imaged with positron emission tomography (PET) measures of regional cerebral blood flow (rCBF) during performance of a simple prehension task and at rest. Scans were acquired before and 17 weeks after surgery. After pallidotomy, movement-related changes of rCBF increased significantly in both the supplementary motor area (SMA) and premotor cortex but not in primary motor cortex. The results demonstrate the importance of pallidothalamic circuitry for regulating volitional movements and confirm that disruption of inhibitory input to the ventrolateral thalamus can augment movement-related activity in motor association areas.  相似文献   

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During the last twenty years, school psychology has experienced extensive growth. While the origins of practice can be traced to the beginning of the century, subsequent alteration of services has been gradual, and usually in response to changes in education. The focus of this paper is the future, with an emphasis upon possible roles, functions, and areas of contribution. Appropriate projection, however, includes understanding the dynamic implications of past and current functioning and a commitment to the need for a changing education. School psychologists have an obligation not only in reflecting needs, but also in the establishment and implementation of appropriate educational objectives. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

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Examines (a) current barriers to the use of mental health services by Asian Americans (including racism, language barriers, and cultural attitudes); (b) advantages and disadvantages of 3 prototypical forms of culturally sensitive service delivery systems; and (c) conditions under which the 3 prototypes may be useful. The policy options include providing services (1) in mainstream facilities in which all of the personnel are trained to provide culturally sensitive services, (2) in mainstream facilities in which there are teams of culturally sensitive service providers, and (3) in physically segregated facilities in which all of the personnel are trained to provide culturally sensitive services. (35 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

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Fifteen children, aged 7-18 years, were interviewed an average of five months after the murder of an older sibling. Although most showed significant symptoms of depression, anxiety, post-traumatic stress disorder, and psychosocial impairment, few had received any community or mental health system support or services for these symptoms. Specific problems and needs are identified, and implications for research and practice are discussed.  相似文献   

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Schizophrenic memory following an experimenter-imposed encoding task was examined in a levels-of-processing framework. In Session 1, 17 schizophrenics (mean age 23.5 yrs), 17 nonschizophrenic psychiatric patients (mean age 24.3 yrs), and 17 normal college students (mean age 20.0 yrs) were required to make yes–no judgments about whether a probe word contained 2 letters, rhymed with a word, belonged to a conceptual category, or fitted into a sentence. In Session 2, they were required to produce an appropriate word for each question. The 3 groups recalled semantically processed words better than nonsemantically processed words and "yes" words better than "no" words and revealed similar recall and recognition patterns over the different levels of encodings. However, the schizophrenics' recall for "yes" words (Session 1) and for the self-generated words (Session 2) was inferior to that of normals. Theoretical implications are discussed. (31 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

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