酸性橙RXL及酸性黄A-4R合成研究

本文就酸性橙RXL及酸性黄A-4R合成工艺进行了分析,重点讨论了关键中间体的合成。优化工艺为:硫酸与氯苯的质量比为10∶1,磺化温度在60℃～70℃,硝酸与氯苯的分子比为1.05∶1,适宜的硝化温度范围为15℃～30℃,对苯二胺与邻硝基氯苯-4-磺酸摩尔比在0.95～0.98∶1,采用季铵盐相转移催化剂。     

酸性橙E—3R无盐工艺制取的研究

本文叙述采用相转移催化合成酸性橙Ｅ３Ｒ（Ｃ．１．Ａｅｉｄ ０ｏｒａｎｇｅ３）之工艺研究,并确立了催化无盐法制取工艺,提出了在相关合成产品上之应用事宜。     

新型Combretastatin A-4衍生物的合成及生物活性研究

Combretastatin A-4是一类结构独特的天然产物,具有较好的抗肿瘤活性。为了进一步研究该类化合物的构效关系,以3,4,5-三甲氧基苯甲醛和3-羟基-4-甲氧基苯乙酸为原料,在碱性条件下经缩合、酰化反应合成了5个未见文献报道的Combretastatin A-4衍生物。并通过~1HNMR、~(13)CNMR和MS对其结构进行确证。采用MTT法对合成的目标产物体外抗肿瘤活性进行了初步测定。结果表明,(E)-N-(2-(二甲氨基)乙基)-2-(3-羟基-4-甲氧基苯基)-3-(3,4,5-三甲氧基苯基)丙烯酰胺和(E)-2-(3-羟基-4-甲氧基苯基)-N-(2-(吡咯烷-1-基)乙基)-3-(3,4,5-三甲氧基苯基)丙烯酰胺对K562肿瘤细胞有较弱的抑制作用。     

(-)-1R,2S,5R-8-(4-溴苯)薄荷醇的合成与表征

以R-( )-长叶薄荷酮为起始原料,经1,4-加成、还原、溴代、水解等4步反应合成了标题化合物,总产率77%。其结构用1HNMR、13CNMR和IR进行了表征。     

4-[2-(4,6-二甲氧基嘧啶基)]-3-硫代脲酸苯酯合成工艺及生物活性研究

采用二步反应考察了4-[2-(4,6-二甲氧基嘧啶基)]-3-硫代脲酸苯酯合成的最优反应条件,通过氢谱(1H NMR)、红外光谱(IR)、元素分析和熔点测定,对所合成的产物进行结构分析。采用离体含毒介质法,对合成产物进行杀菌毒力活性的测定。结果表明,0.1 mol氯甲酸苯酯和0.2 mol硫氰酸钾,在乙酸乙酯中50℃反应2 h,滤去生成的氯化钾,加入4,6-二甲氧基嘧啶-2-胺0.08 mol,在60℃下反应4 h,产品总得率不低于75%。产品对植物病害菌有良好的抑制和杀灭作用。     

从桔皮中提取柑桔黄,桔油,果胶的技术研究

本文介绍了从柑桔皮中提取昂贵的天然柑桔黄、桔油、果胶等系列产品的研究，结果表明，将其逐步推向工业化将具有十分重要的意义。     

Unstationary Film Model for the Determination of Absolute Gas-Liquid Kinetic Rate Constants: Ozonation of Acid Red 27, Acid Orange 7, and Acid Blue 129

A method for the determination of absolute kinetic rate constants is proposed using an unstationary film model. This methodology avoids the experimental determination of parameters like the enhancement factor or the Hatta number which are usually model-dependent. The mathematical model is general for gas-liquid systems with irreversible second order reactions. An optimization procedure based on artificial neural networks is used to estimate the initial guess of the parameters and the subsequent application of Gauss-Newton algorithm for the final nonlinear parameter estimation. The model is tested with the ozonation reaction of Acid Red 27, Acid Orange 7 and Acid Blue 129. The second-order kinetic rate constants for the direct reaction with O₃ are 1615 ± 93, 609 ± 83, and 49 ± 2 M^?1s^?1, respectively.     

Preparation of Acid Dye Molecule Surface-Imprinted Material for Effective Removal of Acid Dyes from Water and Study on its Molecule Recognition Performance

An acid dye molecule surface-imprinted material was prepared successfully for the dye removal from water by using a novel molecular surface-imprinting technique. The cationic monomer acryloyloxyethyl trimethyl ammonium chloride (DAC) was used as functional monomer, and sunset yellow was used as a model compound of water-soluble acid dyes. In the aqueous solution, DAC molecules were combined around sunset yellow molecules via electrostatic interaction. The graft/cross-linking copolymerization of DAC and the crosslinker on SiO₂ particles was initiated by a surface-initiating system of –NH₂/S₂O₈^2-, resulting in the sunset yellow molecule surface-imprinted material MIP-PDAC/SiO₂. MIP-PDAC/SiO₂ possesses special recognition property for sunset yellow.     

Structural peculiarities of TiO2 and Pt/TiO2 catalysts for the photocatalytic oxidation of aqueous solution of Acid Orange 7 Dye upon ultraviolet light

TiO₂ (anatase) with different microstructure was synthesized by thermal hydrolysis of the titanyl sulfate and studied by X-ray powder diffraction, high resolution transmission electron microscopy and UV–vis diffuse reflectance spectroscopy. The effect of titanium dioxide structure, regular or distorted, on the photocatalytic degradation of Acid Orange 7 Dye (AO7) in water upon ultraviolet light was studied. It was found that synthesized TiO₂ possesses a relatively high reactivity when illuminated but also show different adsorption in the dark. The relationship between these behaviors depends on the real structure of the catalysts. Catalysts with a perfect structural ordering formed after heating at temperature higher than 500 °C show better photocatalytic performance. Small amount of Pt added into the TiO₂ structure was found to improve further the catalyst reactivity. Pt-modified titania catalysts oxidize AO7 more efficiently than P-25 Degussa TiO₂. Doping effect of Pt on the structural and photocatalytic properties of the samples is discussed.