Corrosion Protection Behavior of Poly(N-(p-bromophenyl)-2-methacrylamide-co-ethyl methacrylate) Coatings on Low Nickel Stainless Steel

The copolymer poly(N-(pbromophenyl)-2-methacrylamide-co-ethyl methacrylate) has been synthesized by free radical solution polymerization. Thermal stability of the synthesized copolymer was analyzed using thermogravimetric analysis and differential thermal analysis techniques. The corrosion performances of low nickel stainless steel specimens coated with different mole ratios of poly(PBPMA-co-EMA) were investigated with 1 M H₂SO₄ using potentiodynamic polarization, electrochemical impedance spectroscopic studies and chronoamperometric studies. Moreover, all the mole ratios of this copolymer showed good protection against corrosion. Surface and morphological investigation of the product have been studied with the help of scanning electron microscopic, atomic force microscopic, and energy dispersive X-ray analysis techniques, they were used to characterize the adherence and uniformity of the coatings, electrochemical corrosion test and surface analysis results have proved that poly(PBPMA-co-EMA) coatings served as a stable host matrix on low nickel stainless steel as environmentally more favored and best anticorrosive coating.     

2-(2-咪唑基)-(4-正丁氧基)苯甲酰苯胺的合成工艺改进

2-(2-咪唑基)-(4-正丁氧基)苯甲酰苯胺具有潜在的抗肿瘤效应。本文通过改进合成路径,经过关环反应、还原反应以及酰化反应,成功合成了化合物2-(2-咪唑基)-(4-正丁氧基)苯甲酰苯胺(6),六步反应总收率达到30%,且各步反应都能放量反应,反应中间体及目标化合物结构经MS、1H NMR、13C NMR确证。     

The preparation of molecularly imprinted poly(o‐phenylenediamine) membranes for the specific O,O‐dimethyl‐α‐hydroxylphenyl phosphonate sensor and its characterization by AC impedance and cyclic voltammetry

A molecularly imprinted polymer (MIP) membrane for sensing O,O‐dimethyl‐α‐hydroxylphenyl phosphonate (DHP) has been prepared by electropolymerizing o‐phenylenediamine on the glassy carbon electrodes in the presence of DHP. Optimization studies with the aim to enhance insulating properties and response kinetics of the polymer membrane were carried out with respect to template molecular concentration, the monomers concentration, the polymer membrane thick and scan rate. Cyclic voltammetry and electrochemical impedance have been used to characterize the behavior of MIP polymer membrane. The capacitive measurements were also certified the imprinting effect of the polymer layers. The experimental results showed that DHP imprinted polymer has better recognition property for the template than that of a blank polymer. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 101: 2222–2227, 2006     

Synthesis,Properties, and Ammonia Gas Sensing Applications of Poly-[1-(4-nitronaphthalen-1-yl)-2,5-di(thiophen-2-yl)-1H-pyrrole]

A chemical synthesis of poly-[1-(4-nitronaphthalen-1-yl)-2,5-di(thiophen-2-yl)-1H-pyrrole] and its optical, electrical, thermal, and ammonia gas sensing properties are well studied. The polymer showed maximum absorption bands at ~280?nm for π–π* transition of π-conjugated systems, and at ~660 and ~770?nm due to the polaron–bipolaron states, respectively. An increase in electrical conductivity with increase in temperature confirmed the thermally activated electronic conduction of the polymer. Thermogravimetric analysis showed that the polymer can withstand up to 435°C with a weight loss of just 10%. The polymer characterized for its ammonia sensing behavior showed linear increase in its resistance with increase in ammonia concentrations.     

N-{5-[1-(间氯苯氧)乙基]-1,3,4-噻二唑-2-基}-N''''-芳酰基脲的合成及生物活性

设计合成了12个未见文献报道的含取代1，3，4-噻二唑的芳甲酰基脲类化合物，所有化合物的结构经IR、^1HNMR和元素分析确证。初步生物测试结果表明，部分化合物具有较好的植物生长调节活性。     

Crystal structure and thermal decomposition kinetics of 1-(pyridinium-1-yl)propane-(1-methylpiperidinium) bi[bis(trifluoromethanesulfonyl)imide], [PyC3Pi][NTf2]2

The structure of a room temperature asymmetrical dicationic ionic liquid (ADIL), 1-(pyridinium-1-yl) propane-(1-methylpiperidinium) bi[bis(trifluoromethanesulfonyl)imide] ([PyC3Pi][NTf2]2), was studied by the X-ray dif-fraction method. Meanwhile, thermal analysis of [PyC3Pi][NTf2]2 was also studied using non-isothermal thermo-gravimetric analysis (TGA). The title crystal belongs to the triclinic with space group Pīand unit-cell parameters a=0.95217 (8) nm, b=1.05129 (11) nm, c=1.70523 (14) nm,α=89.759 (8)°,β=80.657 (7)°,γ=68.007 (9)°, and F(000)=792. Thermal stability and thermal decomposition kinetics of the title compound were also investigated using TGA under the atmosphere of highly pure nitrogen. Heating curves at different rates were cor-related with kinetic equations Friedman and ASTM (also called iso-conversion method). The values of average activation E (kJ·mol-1) and pre-exponential constant lgA are 149.58 kJ·mol-1 and 8.83, respectively, which were obtained by the two methods. The kinetic model function, activation energy and pre-exponential constant of this reaction using the multivariate non-linear-regression method were f(α)=(1-α)(1+4.1870α), 151.04 kJ·mol-1 and 8.81, respectively, which were basically consistent with iso-conversion methods.     

Chitosan functionalized by citric acid: an efficient catalyst for one-pot synthesis of 2,4-diamino-5H-[1]benzopyrano[2,3-b]pyridine-3-carbonitriles 5-(arylthio) or 5-[(arylmethyl)thio] substituted

Chitosan (CS) functionalized by citric acid has been used as an efficient catalyst for the preparation of 2,4-diamino-5H-[1]benzopyrano[2,3-b]pyridine-3-carbonitriles 5-(arylthio) or 5-[(arylmethyl)thio] substituted by a multicomponent reaction of salicylaldehydes, thiols and 2 equiv. of malononitrile under reflux condition in ethanol. Use of simple and readily available starting materials, excellent yields in short times, reusability of the catalyst and little catalyst loading are some of the important features of this protocol. The structure of CS functionalized by citric acid was confirmed by infrared spectroscopy (FT-IR), X-ray diffraction, thermogravimetric analysis and differential scanning calorimetry.     

2-[4-(3-甲基-1-咪唑)]苯基丙二腈类两性离子化合物的合成及结构表征

以4-碘苯胺为基础,通过氨基引入咪唑环,再通过卤素碘引入丙二氰,合成了一种新型的2-[4-(3-甲基-1-咪唑)]苯基丙二腈类两性离子化合物,其结构经1H NMR表征,性质经紫外光谱分析,结果表明该化合物具有优良的光学透过性。     

N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a scaffold for the synthesis of inhibitors of Bcr-Abl

N‐[2‐Methyl‐5‐(triazol‐1‐yl)phenyl]pyrimidin‐2‐amine derivatives were synthesized and evaluated in vitro for their potential use as inhibitors of Bcr‐Abl. The design is based on the bioisosterism between the 1,2,3‐triazole ring and the amide group. The synthesis involves a copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) as the key step, with the exclusive production of anti‐(1,4)‐triazole derivatives. One of the compounds obtained shows general activity similar to that of imatinib; in particular, it was observed to be more effective in decreasing the fundamental function of cdc25A phosphatases in the K‐562 cell line.     

1-[7-氟-4-炔丙基-1,4-苯并嗪-3-酮-6-基]-3-正丙基-2-硫代咪唑啉三酮的合成及其除草活性

标题化合物(SYP-300)是沈阳化工研究院的试验除草剂。由丙基异硫氰酸酯与6-氨基-7-氟-4-炔丙基-1,4-苯并嗪-3-酮经两步反应制得。其结构经核磁共振谱、红外光谱和元素分析确证。SYP-300在温室条件下100ga.i./hm2可防除多种阔叶杂草,在200ga.i./hm2对小麦和水稻安全。     

Antibacterial Co(II) and Ni(II) Complexes of N-(2-Furanylmethylene)-2-Aminothiadiazole and Role of SO(4), NO(3), C(2)O(4) and CH(3)CO(2) anions on Biological Properties

Co(II) and Ni(II) complexes with a Schiff base, N-(2-furanylmethylene)-2-aminothiadiazole have been prepared and characterized by their physical, spectral and analytical data. The synthesized Schiff-bases act as tridentate ligands during the complexation reaction with Co(II) and Ni(II. metal ions. They possess the composition [M(L)(2)]X(n) (where M=Co(II) or Ni(II), L=, X=NO(3) (-), SO(4) (2-), C(2)O(4) (2-) or CH(3)CO(2) (-) and n=1 or 2) and show an octahedral geometry. In order to evaluate the effect of anions upon chelation, the Schiff-base and its complexes have been screened for antibacterial activity against bacterial strains e.g., Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa.     

N-[2,4-二取代-5-(3-甲基-2,6-二氧-4-三氟甲基-2,3-二氢嘧啶-1(6H)-基)苯基]磺酰胺类化合物的合成及生物活性研究

合成了9个N-[2,4-二取代-5-(3-甲基-2,6-二氧-4-三氟甲基-2,3-二氢嘧啶-1(6H)-基)苯基]酰胺类化合物。其化学结构经1H NMR、LC-MASS、IR元素分析确证。初步生物活性测定表明:标题化合物具有较好的除草活性,如在有效成分75 g/hm2剂量下,采取茎叶处理,化合物8b、8c对双子叶杂草苘麻、刺苋和藜的抑制率均不低于90%。     

2-[7-氟-4-(3-碘-丙-2-炔基)-3-氧-3,4-二氢-2H-苯并(噁)嗪[b][1,4]-6-基]-4,5,6,7-四氢-2H-异吲哚-1,3-二酮的合成

标题化合物(B2055)是具有较高原卟啉原氧化酶抑制剂除草活性的N-苯基酞酰亚胺类新化合物,合成该化合物的关键步骤是2-[7-氟-4-(丙-2-炔基)-3-氧-3,4-二氢-2H-苯并噁嗪[b][1,4]-6-基]-4,5,6,7-四氢-2H-异吲哚-1,3-二酮(丙炔氟草胺,flumioxazin)的碘化。为寻求更经济和可工业化的合成路线,考察了不同的碘化剂、溶剂、原料配比、反应温度及反应时间对丙炔氟草胺的转化率和产品B2055收率的影响,在以醋酸为溶剂,氯化碘为碘化剂,原料丙炔氟草胺与氯化碘的物质的量比为1∶3,反应温度为20℃,反应时间为60 min的工艺条件下,原料丙炔氟草胺转化率为92.2%,产品B2055收率为90.7%。     

甲黄隆钠盐在麦田土壤中残留动态的研究

本文研究了甲黄隆钠盐在天津及武汉两地土壤中的残留消解动态。实验结果表明，甲黄隆钠盐在土壤中的降解符合方程Ｃ＝Ｃ０Ｅ＾ｂｔ，相关系数在０．９０以上。在南方土壤中其半衰期为１８．４天，而在北方则为２１．５天。     

Evidence for Dual Activation of IK(M) and IK(Ca) Caused by QO-58 (5-(2,6-Dichloro-5-fluoropyridin-3-yl)-3-phenyl-2-(trifluoromethyl)-1H-pyrazolol[1,5-a]pyrimidin-7-one)

QO-58 (5-(2,6-dichloro-5-fluoropyridin-3-yl)-3-phenyl-2-(trifluoromethyl)-1H-pyrazolol[1,5-a]pyrimidin-7-one) has been regarded to be an activator of K_V7 channels with analgesic properties. However, whether and how the presence of this compound can result in any modifications of other types of membrane ion channels in native cells are not thoroughly investigated. In this study, we investigated its perturbations on M-type K⁺ current (I_K(M)), Ca²⁺-activated K⁺ current (I_K(Ca)), large-conductance Ca²⁺-activated K⁺ (BK_Ca) channels, and erg-mediated K⁺ current (I_K(erg)) identified from pituitary tumor (GH₃) cells. Addition of QO-58 can increase the amplitude of I_K(M) and I_K(Ca) in a concentration-dependent fashion, with effective EC₅₀ of 3.1 and 4.2 μM, respectively. This compound could shift the activation curve of I_K(M) toward a leftward direction with being void of changes in the gating charge. The strength in voltage-dependent hysteresis (V_hys) of I_K(M) evoked by upright triangular ramp pulse (V_ramp) was enhanced by adding QO-58. The probabilities of M-type K⁺ (K_M) channels that will be open increased upon the exposure to QO-58, although no modification in single-channel conductance was seen. Furthermore, GH₃-cell exposure to QO-58 effectively increased the amplitude of I_K(Ca) as well as enhanced the activity of BK_Ca channels. Under inside-out configuration, QO-58, applied at the cytosolic leaflet of the channel, activated BK_Ca-channel activity, and its increase could be attenuated by further addition of verruculogen, but not by linopirdine (10 μM). The application of QO-58 could lead to a leftward shift in the activation curve of BK_Ca channels with neither change in the gating charge nor in single-channel conductance. Moreover, cell exposure of QO-58 (10 μM) resulted in a minor suppression of I_K(erg) amplitude in response to membrane hyperpolarization. The docking results also revealed that there are possible interactions of the QO-58 molecule with the KCNQ or K_Ca1.1 channel. Overall, dual activation of I_K(M) and I_K(Ca) caused by the presence of QO-58 eventually may have high impacts on the functional activity (e.g., anti-nociceptive effect) residing in electrically excitable cells. Care must be exercised when interpreting data generated with QO-58 as it is not entirely KCNQ/K_V7 selective.     

Polymeric [Eu(L)3(H2O)] (HL = 1-(pyridin-4-yl)butane-1,3-dione and Dimeric [Eu2(L)6(H2O)2] (HL = 1,3-di(pyridin-3-yl)propane-1,3-dione) as selective and sensitive chemosensors for Hg(II) ion

Eu(III) complexes, [Eu(L1)₃(H₂O)] (1) and [Eu₂(L2)₆(H₂O)₂] (2) have been prepared and structurally characterized. They are highly selective and sensitive chemosensors for Hg²⁺. These Eu-containing materials show fluorescent enhancement only for Hg²⁺. The complexation of other metal ions leads to fluorescence quenching or no response.     

Biologically Active Transition Metal Chelates of Ni(II), Cu(II) and Zn(II) With 2-Aminothiazole-Derived Schiff-bases: Their Synthesis, Characterization and the Role of Anions (NO(3), SO(4), C(2)O(4)and CH(3)CO(2-)) on Their Antibacterial Properties

Biologically active nickel(ll), copper(ll) and zinc(ll) chelates with thiazole-derived nitro- and chlorosalicylaldehyde Schiff-bases having the same metal ion but different anions, e.g. nitrate, sulfate, oxalate and acetate have been synthesized and characterized on the basis of their physical, spectral and analytical data. In order to evaluate the possible participating role of anions on the antibacterial properties, these ligands and their synthesized metal chelates with various anions have been screened against bacterial species Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus.