Why integrity testing remains controversial.

Comments on W. J. Camara and D. L. Schneider's (see record 1994-23870-001) summary of reports on integrity tests (ITs). S. O. Lilienfeld et al contend that 3 issues remain unresolved: There are virtually no data regarding types of classification errors made by ITs; the extent to which ITs are susceptible to impression management was not addressed; and many writers in the integrity testing field use the same language and logic that are typically applied to ability testing. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A reply to Bagnato and Neisworth: Intelligent versus intelligence testing of preschoolers.

Replies to the article by S. J. Bagnato and J. T. Neisworth (see record 1995-04117-001) discussing the use of intelligence tests (ITs) with infants and preschool children. Bagnato and Neisworth are seen as assuming that all ITs are the same and as ignoring the differences between testing infants and young children. They also overemphasize the importance of IT scores and overlook the observations of a competent tester. An ideal assessment would use both a curriculum-based approach and ITs, since they provide answers to different questions. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Unresolved issues in honesty and integrity testing.

Comments on W. J. Camara and D. L. Schneider's (see record 1994-23870-001) summary of reports on integrity tests (ITs). It is argued that the construct of honesty or integrity remains vague and ill-defined. Evidence for the criterion validation of ITs is not very compelling. It seems unlikely that the present applications of ITs will ever meet established American Psychological Association ethical standards. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Role of cross-linking agents in determining the biochemical and pharmacokinetic properties of Mgr6-clavin immunotoxins

Several immunotoxins (ITs) were synthesized by the attachment of clavin, a recombinant toxic protein derived from Aspergillus clavatus, to the monoclonal antibody Mgr6 that recognizes an epitope of the gp185(HER-2) extracellular domain expressed on breast and ovarian carcinoma cells. Conjugation and purification parameters were analyzed in an effort to optimize the antitumor activity and stability of the ITs in vivo. To modulate the in vitro and in vivo properties of the immunotoxins, different coupling procedures were used and both disulfide and thioether linkages were obtained. Unhindered and hindered disulfide with a methyl group linkage ethyl S-acetyl 3-mercaptopropionthioimidate ester hydrochloride (AMPT) or ethyl S-acetyl 3-mercaptobutyrothioimidate ester hydrochloride (M-AMPT) were obtained by reaction with recombinant clavin, while the monoclonal antibody Mgr6 was derivatized with ethyl 3-[(4-carboxamidophenyl)dithio]propionthioimidate ester hydrochloride (CDPT). To achieve higher hindrance (a disulfide bond with a geminal dimethyl group), Mgr6 was derivatized with the N-hydroxysuccinimidyl 3-methyl-3-(acetylthio)butanoate (SAMBA) and clavin with CDPT. To evaluate the relevance of the disulfide bond in the potency and pharmacokinetic behavior of the ITs, a conjugate consisting of a stable thioether bond was also prepared by derivatizing Mgr6 with the N-hydroxysuccinimidyl ester of iodoacetic acid (SIA) and clavin with AMPT. The immunotoxins were purified and characterized using a single-step chromatographic procedure. Specificity and cytotoxicity were assayed on target and unrelated cell lines. The data indicate that the introduction of a hindered disulfide linkage into ITs has little or no effect on antitumor activity and suggest that disulfide cleavage is essential for activity; indeed, the intracellularly unbreakable thioether linkage produced an inactive IT. Analysis of IT stability in vitro showed that the release of mAb by incubation with glutathione is proportional to the presence of methyl groups and increases exponentially with the increase in steric hindrance. Analysis of the pharmacokinetic behavior of ITs in Balb/c mice given intravenous bolus injections indicated that ITs with higher in vitro stability were eliminated more slowly; i.e., the disulfide bearing a methyl group doubled the beta-phase half-life (from 3.5 to 7.1 h) compared with that of the unhindered, while a geminal dimethyl protection increased the elimination phase to 24 h. The thioether linkage showed its intrinsic stability with a beta-phase half-life of 46 h. The thioether linkage also increased the distribution phase from 17 to 32 min. The in vitro characteristics and in vivo stability of Mgr6-clavin conjugates composed of a methyl and dimethyl steric hindered disulfide suggest clinical usefulness.     

Purging of mammary carcinoma cells during ex vivo culture of CD34+ hematopoietic progenitor cells with recombinant immunotoxins

Tumor cells have been found in autologous hematopoietic cell transplants used after high-dose chemotherapy. To specifically eliminate contaminating mammary tumor cells during ex vivo expansion of CD34+ hematopoietic progenitor cells, we used recombinant immunotoxins (ITs) directed against cell-surface antigens expressed on mammary carcinoma cells. ITs were expressed from fusion cDNAs combining a single-chain antibody fragment (scFv) directed against the Erb-B2 or epidermal growth factor (EGF) receptors with a truncated Pseudomonas exotoxin A fragment devoid of its cell-binding domain. CD34+ hematopoietic progenitor cells did not express Erb-B2 and EGF receptors as detected by Western blotting. Ex vivo expansion of total hematopoietic cells or of colony-forming cells from CD34+ progenitors in the presence of stem-cell factor (SCF), interleukin-1 (IL-1), IL-3, IL-6, and erythropoietin (Epo) was not affected when ITs were added to the cultures. In contrast, MDA-MB 453 and MCF-7 mammary carcinoma cells were depleted in a dose- and time-dependent manner by more than 3 log in coculture with CD34+ cells over a period of 7 days in the presence of 100 to 1,000 ng/mL of anti-Erb-B2 IT. This included elimination of the subpopulations with regrowth potential. Similarly, addition of either anti-Erb-B2 or anti-EGF receptor ITs to primary breast cancer cells isolated from patients with metastatic disease resulted in elimination of cytokeratin-positive cells in seven of seven samples. ITs are highly efficient and convenient to use for the depletion of mammary tumor cells during ex vivo expansion of hematopoietic progenitor-cell autografts.     

Clinical trials with an anti-CD25 ricin A-chain experimental and immunotoxin (RFT5-SMPT-dgA) in Hodgkin's lymphoma

Immunotoxins (ITs) consisting of a cell-binding component and a potent toxin were developed as a new class of biological anti-tumor agents to improve adjuvant therapy. Hodgkin's lymphoma (HL) has been demonstrated to be an excellent target for ITs because high concentrations of lymphocyte activation markers such as CD25 and CD30 are expressed on Hodgkin and Reed-Sternberg (H-RS). Several ITs against these antigens have shown potent antitumor effects against H-RS cells in vitro and in different HL animal models. On the basis of its superiority in preclinical models, the anti-CD25 IT RFT5-SMPT-dgA was subsequently evaluated in a phase I study in patients with refractory Hodgkin's lymphoma. The IT was constructed by linking the monoclonal antibody (Moab) RFT5 via a sterically hindered disulfide linker (SMPT) to deglycosylated ricin A-chain (dgA). All 15 patients enrolled in this trial were heavily pretreated with a mean of five different prior therapies. The IT was administered intravenously over four hours on days 1-3-5-7 for total doses per cycle of 5, 10, 15, or 20 mg/m2. Side effects were reversible and related to the vascular leak syndrome (VLS), i.e. decrease in serum albumin, edema, weight gain, hypotension, tachycardia, myalgia, and weakness. In all three patients receiving 20 mg/m2 NCI toxicity grade III was observed. Thus, 15 mg/m2 is the maximal tolerated dose (MTD) of RFT5-SMPT-dgA. 50% of the patients developed human anti-ricin A-chain antibodies (HARA) and/or human anti-mouse antibodies (HAMA). Clinical results included two partial remissions (PR), one minor response (MR), three stable disease (SD) and nine progressive disease (PD). In an extension of the phase I trial, five additional patients have been treated at the MTD.     

Experimental effects and person effects in delay of gratification.

Elaborates on findings included in W. Mischel's (see record 1985-06679-001) article regarding the effect of personality factors and experimental manipulations on delayed gratification by presenting a meta-analysis of experimental studies related to delay of gratification and by suggesting that broad range effect sizes are larger and more important than they are generally considered to be. (16 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Where Is the Evidence for Pancultural Self-Enhancement? A Reply to Sedikides, Gaertner, and Toguchi (2003).

C. Sedikides, L. Gaertner, and Y. Toguchi (2003; see record 2002-08440-007) maintained that the self-enhancement motivation (as defined by tendencies to view oneself in overly positive terms) is universal. The present article challenges their claim. A review of the literature revealed that many studies contradict their findings regarding the domain-specific nature of East Asian self-enhancement. It is argued that Sedikides et al. did not replicate past research because they did not measure self-enhancement in their studies. The present article provides a theoretical basis for understanding cross-cultural differences in self-enhancement and considers the question of universality by exploring 2 different conceptualizations of positive self-regard. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Sex stereotyping in Price Waterhouse v. Hopkins..

Comments on the article by S. T. Fiske et al (see record 1992-07509-001) praising the American Psychological Association's (APA's) amicus brief intended to inform the Supreme Court of current scientific thinking regarding gender stereotyping. A balanced perspective, it is argued, should include both research supporting an argument and findings that are inconsistent with that argument. The APA brief gave no indication of contradictory findings. Moreover, review of the research cited indicates that more than half of the studies do not support the argument for which they were cited. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Deconstructing multicultural counseling competencies research: Comment on Owen, Leach, Wampold, and Rodolfa (2011).

The present article offers a commentary and critique of the research presented by J. Owen, M. M. Leach, B. Wampold and E. Rodolfa (see record 2010-24976-001). Given the complexity of the research methodology, findings, and conclusions, the authors provide a concise summary of findings, study limitations, and conclusions followed by a detailed critique of the study. The authors respect and appreciate the ambitious efforts made by Owen et al. to address gaps in the literature regarding outcome research using client ratings of counselors' multicultural counseling competencies (MCCs). The authors provide a critical analysis of some of J. Owen et al.'s specific conclusions and offer alternative conclusions based on conceptual and methodological bases. The authors use the opportunity to comment on this study as a means of advancing recommendations regarding future research on MCCs that might contribute to substantive revisions to the long-standing theoretical foundation in this area. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

(Mis-) Direction of effect sizes.

Comments on an article by Dixon et al. (see record 2007-06671-001) regarding the effect sizes they presented in their meta-analysis of psychological interventions for arthritis pain management. The author of this comment claims that some of the individual effect sizes that they presented are erroneous and have therefore undermined their cumulative effect size estimates. After examining findings from other studies, he concludes that the Dixon et al. meta-analysis reports cumulative effect sizes (Hedge’s g) that overestimate the effects of psychological treatments upon arthritis pain. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The internet and relational theory.

Comments on the article by R. Kraut et al (see record 1998-10886-001) regarding the relationship of internet usage and social relationships, loneliness, and depression. Silverman notes that Kraut et al directed criticism to studies that reported positive findings regarding Internet usage on the grounds that they were anecdotal rather than empirical. The author argues that anecdotal evidence is usually the first step in setting up hypotheses that have empirical merit, and provides anecdotal evidence from members of a training institute on relational psychology who continued their dialog on line. The author argues that the Internet has given participants in the group a voice and an outlet to be heard and validated. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Response to Knittle.

Responds to comments by K. P. Knittle (see record 2009-14439-017) on the authors' original article (see record 2007-06671-001) regarding the effect sizes they presented in their meta-analysis of psychological interventions for arthritis pain management. After conducting a re-analysis and reporting the results, the authors conclude that the findings still support their original conclusions with regard to the fact that psychosocial interventions can produce modest, but significant effects on pain that are within the range reported for other disease-related and chronic pain conditions. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Assessing the comparative cost-effectiveness of alcoholism treatments: a comment on Holder, Longabaugh, Miller and Rubonis

Holder, Longabaugh, Miller and Rubonis (JSA, vol. 53, pp. 517-540, 1991) discuss the shortcomings of the empirical literature relevant to an assessment of the comparative cost-effectiveness of alcoholism treatment modalities. Their analysis is rooted in an attempt to conjoin the literatures pertaining to clinical efficacy and costs of alcohol dependence treatment. Holder et al.'s methodology is flawed in a number of respects and they exceed the bounds of the evidence when they endorse particular treatment modalities as comparatively cost-effective. Generalizations as to the relative cost-effectiveness of particular modalities are forwarded despite the fact that treatments are applied to persons with alcohol problems of widely varying severity. Additional points of contention are raised regarding the authors' selection of acceptable studies and interpretation of findings. Despite these limitations, Holder et al.'s (1991) analysis is a seminal heuristic contribution to the discussion of cost-effectiveness in the alcoholism field.     

Behavioral and characterological attributional styles as predictors of depression and loneliness: Review, refinement, and test.

The literature on self-blame and depression reveals 2 interrelated problems. First, although R. Janoff-Bulman's (see record 1981-01320-001) conceptualizations of self-blame are clear, empirical operationalization is difficult and has resulted in approaches that do not capture the richness of the constructs. Second, past research has produced inconsistent findings. A comprehensive literature review revealed that the inconsistencies are related to the method of assessing attributions. A correlational study, with 2 samples of 680 and 321 undergraduates, designed to more accurately represent the self-blame conceptualization revealed that both behavioral and characterological self-blame contribute uniquely to depression and loneliness. Supplementary results regarding circumstantial attributions and regarding attributional styles for success were presented. Empirical issues regarding possible methodological refinements and effect size, as well as the value of categorical approaches to the study of attributional style were discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Psychology, serendipity, and public health: A reply to Suls and O'Leary.

Responds to comments by J. M. Suls and K. D. O'Leary (see PA, Vol 75:11530, and 11521, respectively) regarding their study on motivation for health behavior with adolescents. They agree with Suls' suggestion that a systems approach may eventually provide the necessary understanding of preventive health behavior and with O'Leary's comments on the effect of rewards, but they uphold their conclusions. It is noted that some societal changes in health behavior have occurred (i.e., less smoking, less sugar consumption) that are serendipitous to the findings of their study. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Small, robust, and important: Reply to Sloan and Bagiella (2001).

Responds to R. P. Sloan and E. Bagiella's (see record 2001-06506-009)comments on the M. E. McCullough, et al (see record 2000-03769-001) article regarding religious involvement and morality. McCullough et al note that Sloan and Bagiella compared their findings with results from individual studies of hopelessness and physical activity that used criteria other than morality. The present authors argue that such comparisons are meaningless. Sloan and Bagiella's questioning of the statistical nonsignificance of the fully adjusted association is addressed. Methodological issues are also discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effects of methylphenidate and expectancy on ADHD children's performance, self-evaluations, persistence, and attributions on a cognitive task.

The effects of 0.3 mg/kg methylphenidate (MPH) and expectancy regarding medication on the performance and task persistence of 60 boys with attention deficit hyperactivity disorder (ADHD) were investigated. In a balanced-placebo design, boys in 4 groups (received placebo–drug crossed with told placebo–drug) completed the task in success and failure conditions. Medication improved participants' task persistence following failure. Participants' task performance was not affected by whether they thought they had received medication or placebo. Children made internal attributions for success and made external attributions for failure, regardless of medication or expectancy. These findings confirm previous reports that it is the pharmacological activity of MPH that affects ADHD children's self-evaluations and persistence. The results contradict anecdotal reports that MPH causes dysfunctional attributions and confirm previous studies showing that medication does not produce adverse effects on the causal attributions of children with ADHD. (PsycINFO Database Record (c) 2010 APA, all rights reserved)