共查询到19条相似文献,搜索用时 171 毫秒
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棉酚化学结构研究进展 总被引:1,自引:0,他引:1
介绍了棉酚的结构、立体化学、互变异构现象以及氢键等方面的研究进展.并从药理活性的差异、化学结构与生物活性以及各个官能团在化学结构变化中的作用进行了阐述。认为通过化学结构修饰和改造及棉酚衍生物大批量的合成,可以增加新化学实体、先导化合物的生成几率,从而为获得与医药学应用相适应的衍生物夯实基础。 相似文献
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为达到并保持棉酚抗生育性能 ,降低棉酚毒副作用 ,合成了牛磺酸棉酚。经动物试验发现 ,牛磺酸棉酚仍然保持了棉酚抗生育活性 ,而且作用部位及效果与棉酚基本一致 ,其毒性远远低于棉酚。 相似文献
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为简化双液相溶剂浸出棉仁的流程,探讨了应用饱和甲醇的己烷溶液一步脱除棉仁中棉油和棉酚的可行性,并用串级试验进行了验证。结果表明此设想是可行的。在浸出温度 50℃、4级浸取、溶剂与棉仁比值 8. 7L/kg的条件下,棉粕中残油质量分数低于 1. 3%,游离棉酚和结合棉酚含量可分别低于 450mg/kg和4 000mg/kg,达到了饲料标准。 相似文献
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Reaction chemistry of gossypol and its derivatives 总被引:1,自引:0,他引:1
James A. Kenar 《Journal of the American Oil Chemists' Society》2006,83(4):269-302
Gossypol, a complex polyphenolic compound, is a naturally occurring highly colored yellow pigment found in the small intercellular
pigment glands in the leaves, stems, roots, and seed of cotton plants. In cottonseed, gossypol contributes to its toxicity
and therefore it is regarded as an unwanted processing component. It was not until its antitumor and male infertility activities
were discovered that gossypol was considered as a valueadded natural product from cottonseed with useful physiological and
chemical properties. These serendipitous discoveries created much excitement, and an enormous amount of research on gossypol
has ensued. Since then, much research has focused on the preparation of suitable gossypol derivatives for medicinal applications.
This review summarizes current knowledge about gossypol, its stereochemistry, tautomerism, and the many varied reactions the
gossypol molecule can undergo. 相似文献
12.
An improved ultrasound‐assisted extraction process of gossypol acetic acid from cottonseed soapstock
Guangfeng Jia Yonghua Zhan Daocheng Wu Yang Meng Liang Xu 《American Institute of Chemical Engineers》2009,55(3):797-806
To investigate the extracted process of gossypol acetic acid (G‐AA) from cottonseed soapstock and explore the improvement of its yield and purity, a novel ultrasound‐assisted extraction and crystallization method was introduced to this process. Under the optimized conditions, preliminary G‐AA with the yield of 1300 mg and the purity of 95.9% could be obtained from 100 g of fresh soapstock by ultrasound‐assisted extraction. In addition, UV, IR, and NMR spectrum further confirmed the detailed chemical structure of G‐AA. Assay of inhibiting human prostate tumor cell line PC‐3 and human breast cancer cell line MDA‐MB‐231 revealed its biological activity, the values of IC50 are 9.096 μmol/L and 14.37 μmol/L respectively. In comparison with the conventional solvent extraction, this novel process increases the content of G‐AA over 90%, reduces the time of crystallization by 75%, and retains the anticancer activity of gossypol. © 2009 American Institute of Chemical Engineers AIChE J, 2009 相似文献
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PE, one of the major phospholipids in oilseed soapstock, may react with gossypol to form Schiff bases. PE amounts to 20–30%
of the phosphorus compounds in soap-stock. In this report, the dependence on pH of the Schiff base products between PE and
gossypol was investigated using a spectrophotometer, an HPLC equipped with an ELSD, and an LC-MS system. We observed that
at pH 7 the Schiff reaction product and reactants were clearly detected by ELSD, absorption, and LC-MS spectra. The absorption
spectra displayed the characteristic peak for the Schiff bases around 430–440 nm. The absorption spectra also indicated that
the reaction was pH dependent. The reaction temperatures were 60 and 90°C. The LC-MS spectra supported the formation of Schiff
bases as well as methyl ether derivatives of gossypol in alcohol at the elevated temperatures. The implications of these experimental
findings are presented in this paper. 相似文献
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Michael K. Dowd Leonard M. Thomas Millard C. Calhoun 《Journal of the American Oil Chemists' Society》1999,76(11):1343-1350
Single crystals of gossypol with three molecules of acetic acid (gossypol triacetic acid) were grown from solutions of gossypol acetic acid and acetone. The crystals were unstable in air but could be stabilized for X-ray diffraction analysis by coating the crystal surfaces with a thin layer of mineral oil. The gossypol triacetic acid complex (C30H30O8·3C2H4O2) forms an orthorhombic crystal system with P212121 (Z=4) symmetry. Unit cell dimensions were a=9.0208(7) Å, b=17.4884(10) Å, and c=24.358(2), Å yielding a volume of 3842.7(5) Å3 and a density of 1.2077(2) g/cm3. As with all previously reported crystals of gossypol, the gossypol molecules were of the aldehyde tautomer, and the two planar naphthalene rings were approximately perpendicular. Acetic acid molecules were found to lie in channels within the gossypol matrix. Individual crystals contained only one gossypol enantiomer, but both enantiomers crystallized from solution. Although the crystal habit could not be used to distinguish between the gossypol enantiomers, a fragment of the crystal could be derivatized and analyzed by high-performance liquid chromatography for this purpose. The ability to grow large, nonracemic crystals leads to a simple procedure for separating small quantities of the individual gossypol enantiomers. 相似文献
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A solvent system, consisting of isohexane and 5 to 25% alcohol, either ethanol (EtOH) or isopropyl alcohol (IPA), was tested
for extracting gossypol and oil from cottonseed. The test results indicate that this new solvent system not only is effective
in removing free and total gossypol but also is as efficient as n-hexane when extracting oil. The amino acid analysis of cottonseed meal, produced by the new solvent system, is similar to
that produced by commercial n-hexane. Present commercial cottonseed extraction and downstream processing of cottonseed oil refining may need little change
to adopt this new solvent system. This new solvent system may lead to a solution to the gossypol problem of cottonseed extraction. 相似文献
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A new method was developed to determine the gossypol content in cottonseed oil using FTIR spectroscopy with a NaCl transmission
cell. The wavelengths used were selected by spiking clean cottonseed oil to gossypol concentrations of 0–5% and noting the
regions of maximal absorbance. Transmittance values from the wavelength regions 3600–2520 and 1900–800 cm−1 and a partial least squares (PLS) method were used to derive FTIR spectroscopic calibration models for crude cottonseed,
semirefined cottonseed, and gossypol-spiked cottonseed oils. The coefficients of determination (R
2) for the models were computed by comparing the results from the FTIR spectroscopy against those obtained by AOCS method Ba
8-78. The R
2 were 0.9511, 0.9116, and 0.9363 for crude cottonseed, semirefined cottonseed, and gossypol-spiked cottonseed oils, respectively.
The SE of calibration were 0.042, 0.009, and 0.060, respectively. The calibration models were cross-validated within the same
set of oil samples. The SD of the difference for repeatability and accuracy of the FTIR method were better than those for
the chemical method. With its speed (ca. 2 min) and ease of data manipulation, FTIR spectroscopy is a useful alternative to standard wet chemical methods for rapid
and routine determination of gossypol in process and/or quality control for cottonseed oil. 相似文献
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Masood Jan Zhixin Liu Chenxi Guo Yaping Zhou Xuwu Sun 《International journal of molecular sciences》2022,23(9)
Cotton refers to species in the genus Gossypium that bear spinnable seed coat fibers. A total of 50 species in the genus Gossypium have been described to date. Of these, only four species, viz. Gossypium, hirsutum, G. barbadense, G. arboretum, and G. herbaceum are cultivated; the rest are wild. The black dot-like structures on the surfaces of cotton organs or tissues, such as the leaves, stem, calyx, bracts, and boll surface, are called gossypol glands or pigment glands, which store terpenoid aldehydes, including gossypol. The cotton (Gossypium hirsutum) pigment gland is a distinctive structure that stores gossypol and its derivatives. It provides an ideal system for studying cell differentiation and organogenesis. However, only a few genes involved in the process of gland formation have been identified to date, and the molecular mechanisms underlying gland initiation remain unclear. The terpenoid aldehydes in the lysigenous glands of Gossypium species are important secondary phytoalexins (with gossypol being the most important) and one of the main defenses of plants against pests and diseases. Here, we review recent research on the development of gossypol glands in Gossypium species, the regulation of the terpenoid aldehyde biosynthesis pathway, discoveries from genetic engineering studies, and future research directions. 相似文献
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Michael K. Dowd 《Journal of the American Oil Chemists' Society》1996,73(10):1287-1295
Cottonseed soapstock samples, collected during the 1993–1994 crushing season from oilseed extraction mills throughout the
United States Cotton Belt, were analyzed by chemical and chromatographic methods. Volatiles averaged 48.7±10.6% (mean±SD,n=39). On a dry basis, the samples averaged 33.3±7.3% fatty acids, 26.3±6.9% phospholipids, 8.4±6.4% triglycerides, and 7.5±3.0%
gossypol. The analytical techniques accounted for 93.3±8.6% of the dry soapstock matter. The AOCS method for total fatty acids
in soapstock yielded values in agreement with the chromatographic and phosphorus analyses. In contrast, the AOCS method for
neutral oil in soapstock gave values that were significantly higher than those obtained by chromatography. The amount of nonlipid
material in the samples correlated with the phosphorus content. Total gossypol and nitrogen levels were also related. 相似文献