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1.
Inclusion behavior of oxybutynin (OBN) with hydroxypropyl-β-cyclodextrin (HP-β-CD) was investigated by ultraviolet absorption spectrum and fluorescence spectrum. A reliable determination of the complex
stoichiometry was provided by the continuous variation technique. Alcohol was added to further investigate the mechanism of
the inclusion behavior. Thermodynamic constants ΔG, ΔH and ΔS for inclusion interaction of OBN and HP-β-CD were determined. The results show that host-guest complex with molar ratio of 1:1 is formed, and inclusion stability constant
between OBN and HP-β-CD is 54.9 L/mol determined by ultraviolet spectrum and 11.1 L/mol determined by fluorescence spectrum. OBN has weak binding
ability with HP-β-CD in aqueous solution (stability constant <102 L/mol) and addition of alcohol leads to a decrease of stability constant, which indicates that the hydrophobic force contributes
to the inclusion process. ΔG, ΔH and ΔS are all less than zero, which indicates that the inclusion process is a spontaneous and exothermic process. 相似文献
2.
Three new ehiral stationary phases, 2, 6-di-O-heptyl-3-O-trimethylsilyl-β-cyclodextrin( DHTBCD), 2,6-di-O-pentyl-3-O-trimethylsilyl-β-cyclodextrin (DPTBCD) and 2,6-di-O-butyl-3-O-trimethylsilyl-β-cyclodextrin (DBTBCD), were synthesized. Chromatographie properties sueh as eolumn efficieney, thermal stability and eolumn life span, were studied. The separations of enantiomers, sueh as ketone, esters, alcohols and olefines, were investigated on the alkylated and silylated β-eyelodextrin stationary phases. The influenee of diluent on ehiral separation was studied. The experimental results indieate that the stationary phases show good ehromatographie properties in separating enantiomers. It is observed that inelusion eomplexafion and hydrogen bonding interaction hardly play a role in separating enantiomers. 相似文献
3.
Two new chiral stationary phases, 2,3-di-O-acetyl-6-O-trimethylsilyl-β-cyclodextrin (DATBCD) and 2, 6-di-O-trimethylsilyl-3-O-acetyl-β-cyclodextrin
(DTABCD), were synthesized, their structures were identified by means of infrared and NMR spectra. Capillary columns were
coated with the two stationary phases by dynamic method. The chromatographic properties, and enantiomers separation, such
as ketone, esters, alcohols and olefines, were investigated on the silylated and acetylated β-cyclodextrin stationary phases.
The experimental results show that the silylated and acetylated β-cyclodextrins are suitable to be used as capillary gas chromatographic
stationary phases, the relative polarity of DATBCD and DTABCD stationary phases is respectively 4143 and 3928, the column
efficiencies are respectively 3084 and 4198, and DATBCD is of stronger enantioselectivity than DTABCD, capacity factor of
the first eluted enantiomer (k
1) and separation factor(α)of α-phenylethanol on DATBCD stationary phase are respectively 8.23 and 1.019.
Biography of first author: TANG Ke-wen, doctoral student, born in 1970, majoring in applied chemistry. 相似文献
4.
建立了以羧甲基-β-环糊精为手性流动相添加剂,在反相液谱条件下拆分巴氯芬对映体的方法。研究了手性添加剂的种类及浓度、流动相组成、pH值及流速等尉崇对拆分的影响。流动千H为甲醇、乙腈、水,体积比为90:5:5,其中含2.00g/LCM-β-CD,pH值5.95,流速0.60mL/min,检测波长231nm,分离度为1.31。该方法简便、快速、相对偏差小。 相似文献
5.
采用新型商品反相手性色谱柱Chiral PAKR AD-RH,建立了β-受体阻滞剂类药物吲哚洛尔的手性拆分方法.考察了流动相组成、pH、柱温、流速及缓冲盐浓度对吲哚洛尔手性拆分的影响.通过优化实验条件,吲哚洛尔达到基线分离,可用于常规分析.在此基础上,进一步考察了制备条件,取得了满意的结果. 相似文献
6.
A new efficient method for preparing o-L-α-glycerylphosphoryl-L-serine was presented. D-α, β-isopropylidene glycerol was phosphorylated with phenylphosphoryl dichloride and the resulting o-D-α,β-isopropylidene glycerylphenylphosphoryl chloride was esterified with N-tert-butoxycarbonyl-L-serine ethyl ester in the presence of pyridine to give acetone L-α-glycerylphenylphosphoryl-N-tert-butoxycarbonyl-L-serine ethyl ester. Finally, the protective groups were removed by two-step hydrolysis while strictly controlling pH value.
The reaction to produce (1, 2), (5, 6)-diisopropylidene-D-mannitol, which is the key precursor for the preparation of D-α, β-isopropylidene glycerol, was monitored by using gas chromatography-mass spectrometer in order to obtain an optimum yield
of 65%. All compounds were characterized through elemental analysis, infrared spectra, 1H, 13C, 31P-nuclear magnetic resonance spectra and mass spectra.
Foundation item: Project (2004018) supported by the Scientific Research Foundation for the Returned Overseas Chinese Scholars 相似文献
7.
The evolution of microstructure on aging of an (α+β) titanium alloy (Ti-5Al-5Mo-5V-1Cr-1Fe) in the β and (α+β) solution-treated and quenched conditions was investigated. The presence of very fine ω phase was detected by electron diffraction for samples aged below 400 °C. The fine α aggregates are uniformly formed within β grains by nucleating at the ω particles or β/ω interfaces. At higher temperature, the formation of ω phase is avoided and the α lamellae are precipitated at the preferred site of grain boundary and then within the matrix. The highest hardness values
are found when the alloys are aged at 450 °C for β condition and 350 °C for (α+β) condition.
Foundation item: Project (50634030) supported by the National Natural Science Foundation of China; Project (2007DS04014) supported by the
Program of Science and Technology of Shandong Province, China; Project supported by the Open Research Fund from the State
Key Laboratory of Rolling and Automation, Northeastern University, China 相似文献
8.
An insoluble β-cyclodextrin polymer cross-linked with epichlorohydrin was prepared, and its structure was identified with
infrared spectrum. Colloid stationary phase was prepared by dissolving the polymer in the mixed solvent of diisopropyl ether,
methylene dichloride and benzene and treated for 0.5 h by ultrasonication, and then was coated on a fused silica capillary
column. The optimun reaction conditions are as follows: the mole ratio of epichlohydrin to β-cyclodextrin is 12.1:1, reacting
at 65 °C for 24 h. The Chromatographic performance such as column efficiency, thermal stabilities and polarity were studied,
two kinds of disubstituted benzene isomers and eight pairs of enantiomers were separated on the capillary column. The results
show that the β-cyclodextrin polymer is suitable for use as a capillary gas chromatographic stationary phase, and possess
excellent chromatographic properties in separating enantiomers and position isomers.
Foundation item: The Natural Science Foundation of Hunan Province
Biography of the first author: YI Jian-ming, associate professor, born in 1957, majoring in applied chemistry. 相似文献
9.
Yu Tian JianZhong Wang WeiFeng Yu RongGen Cao Yun Song XiJing Ning 《中国科学E辑(英文版)》2009,52(6):1698-1702
Electrochemical deposition method was employed to prepare CNx thin film from methanol-urea solution,and it was shown that adding a little acetic acid in the solution significantly affected the deposition process.After optimizing the experiment conditions,we obtained polycrystalline grains with sizes of about 3―7μm on the faces of single crystal silicon.X-ray diffraction spectrua indicate that the grains are mainly composed of cubic phase mixed with a small amount of β and α phases. 相似文献
10.
齐志涛 《武汉理工大学学报(材料科学英文版)》2007,22(1):98-101
The osteoblast with the β-TCP ceramic was co-cultured. Scanning electron microscopy shows the cells adhered onto β-TCP ceramic surface and grew better, proving the β-TCP ceramic has a biocompatible property. The Coomassie brilliant blue G-250 stain shows that the total protein in the experimental groups was highly increased compared with the control group (p〈0.05). Flow-cytometric analysis shows that β-TCP ceramic could promote the osteoblast transform from the G0/G1 phase to S phase. Those all demonstrate the product of the degradation of the β-TCP ceramic may take part in the protein metabolism of osteoblast. 相似文献
11.
合成了一种新的环糊精接枝聚硅氧烷衍生物,单环(2,6-二-O-苄基-3-O-丙基(3'))-六环(2,6-二-O-苄基-3-O-甲基)-β-环糊精接枝聚硅氧烷衍生物,并考察了其毛细管气相色谱性能.结果表明其对一些二取代苯的位置异构体及一些光学异构体具有分离能力,是一种良好的毛细管气相色谱固定相.研究发现将环糊精衍生物接枝聚硅氧烷以及将未接枝的环糊精衍生物与OV-7混涂均可降低环糊精衍生物的极性.在较低的测试温度下,环糊精接枝聚硅氧烷固定相的分离能力比未接枝的环糊精衍生物及其与OV-7混涂固定相的分离能力强,而在高温下,三者的分离能力接近.氢硅烷化反应是降低环糊精衍生物使用温度的有效方法. 相似文献
12.
The simulations of Cr atom substitution character during the formation of L12 and DO22 phases in Ni-Cr-Al alloy were performed at 873 K based on microscopic phase-field model. It is found that the substitution of Cr is affected by Cr and Al contents and limits of occupation probabilities of Cr atom in L12 phase are present. The precipitate is single L12 phase when the component is less than the limit, Cr atoms substitute the Al sublattices in Ll2 phase, and both of atoms Al and Cr occupy the β-sites and complex phases Ni3(Al1-xCrx) are formed; Cr atoms enter Ni sites when Al and Cr contents exceed the limit, and substitute β-sites or both of α- and β-sites. The DO22 phase is formed at the boundary of Ll2 phase. 相似文献
13.
王子明 《武汉理工大学学报(材料科学英文版)》2007,22(2):337-340
The chemical structures of four types of superplasticizers (SPs) and their adsorptive behaviors on β-C2S were investigated. The adsorption properties of SPs on β-C2S were measured and the relationship between the adsorption quantity and the specific surface of β-C2S was analyzed. The experimental results show that the adsorption quantity increases with the surface area increase of β-C2S, but the adsorption quantity per surface area is similar, which means that the main adsorbent is β-C2S itself. Polycarboxylic ester (PCE) showed the highest adsorption amount on β-C2S, followed by β-naphthalene sulfonates (NSF) and formaldehyde-acetone condensates sulfonates (FAS), amino sulphonate (AS) showed the least adsorption amount on β-C2S. PCE affected the surface potential of β-C2S particles in water differently in comparison with other types of SPs. The adsorption capacity of SPs on β-C2S is determined by factors such as molecular structure, functional groups and molecular weight of SPs. 相似文献
14.
Enantioseparation of salbutamol solute was carried out in liquid-supported membrane by using a polyvinylidene fluoride hollow-fiber module. The enantioselective transport of solute was facilitated by combinatorial chiral selectors, which were dissolved in toluene organic solvent. The effects of molar concentration ratios of salbutamol to combinatorial chiral selectors, and the pH value of buffer solution on enantioseparation were investigated. The results show that when the molar concentration ratio is 2 : 1 : 1, the maximum separation factor and enantiomer excess are 1.49 and 19.74%, respectively, and the R-enantiomer flux is more than S-enantiomer; the pH value of buffer solution influences the performances of enantioseparartion obviously, and the appropriate range of pH value is 7.0-7.2. 相似文献
15.
Failure mode and strength anisotropic characteristic of stratified rock mass under uniaxial compressive situation 总被引:1,自引:1,他引:0
A stratified rock mass model was founded by FLAC3D. The failure mode and anisotropic characteristic of strength for stratified rock mass were analyzed. The analysis results
show that the numerical simulation can visually reflect the failure modes of rock samples under different inclination angles
β of structural plane. The stiffness of rock sample before peak strength changes in the compressive procedure. With the increase
of β, the compressive strength σ
c of rock sample decreases firstly and then increases; when β is in the range of 20°–30° and 80°–90°, σ
c has the largest sensitivity to β; while β falls in the range of 30°–70°, σ
c varies little. When ϕ
j
<β<90° (β
j
is friction angle of structure plane), the results obtained from numerical simulation and theoretical analysis are in almost
the same values; while β⩽ ϕ
j
or β=90°, they are in great different values. The results obtained from theoretical analysis are obvious larger than those from
numerical simulation; and the results from numerical simulation can reflect the difference of compressive strength of rock
samples for the two situations of β⩾ ϕ
j
and β=90°, which is in more accordance with the real situation.
Foundation item: Project (50099620) supported by the National Natural Science Foundation of China 相似文献
16.
(ZrO2)
x
(SiO2)1−x
(Zr-Si-O) films with different compositions were deposited on p-Si(100) substrates by using pulsed laser deposition technique.
X-ray photoelectron spectra (XPS) showed that these films remained amorphous after annealing at 800°C with RTA process in
N2 for 60 s. The XPS spectra indicated that Zr-Si-O films with x=0.5 suffered no obvious phase separation after annealing at 800°C, and no interface layer was formed between Zr-Si-O film
and Si substrate. While Zr-Si-O films with x >0.5 suffered phase separation to precipitate ZrO2 after annealing under the same condition, and SiO2 was formed at the interface. To get a good interface between Zr-Si-O films and Si substrate, Zr-Si-O films with bi-layer
structure (ZrO2)0.7(SiO2)0.3/(ZrO2)0.5(SiO2)0.5/Si was deposited. The electrical properties showed that the bi-layer Zr-Si-O film is of the lowest equivalent oxide thickness
and good interface with Si substrate.
Supported by the National Nature Science Foundation of China (Grant No. 60636010) and the National Basic Research Program
of China (“973” Program) (Grant No. 2004CB619004) 相似文献
17.
Chitosan and β-cyclodextrin were used to prepare microspheres with theophylline for pulmonary delivery by spray drying method. The characteristics, mucociliotoxicity, permeation rate and drug release were studied. The drug entrapments of microspheres Ⅰ, Ⅱ and Ⅲ were from 35.70% to 21.09% and 13.33%, while yields and encapsulation efficiencies were higher than 45% and about 90% respectively. The microspheres possessed low tap densities (0.34-0.48 g/cm^3), appropriate diameters (3.35-3.94 μm) and theoretical aerodynamics diameters (2.20-3.04 μm). SEM images showed the microspheres were spherical with smooth or wrinkled surface surfaces. FT-IR demonstrated theophylline had formed hydrogen bonds with chitosan and fl-cyclodextrin. The microspheres could effectively reduce the ciliotoxicity and easy to penetrate the memberine. The in vitro release of the microspheres was related to the ratio of drug/polymer and microspheres Ⅱ had a prolong release, providing the release of 72.00% in 12 h. The results suggestes that chitosan/β-cyclodextrin microspheres Ⅱ are a promising carrier as sustained release for pulmonary delivery. 相似文献
18.
Peripheral nerve regeneration using a novel nerve conduit (PRGD/PDLLA/β TCP/NGF) was evaluated, which was made of RGD peptide modified poly{(lactic acid)-co-[(glycolic acid)-alt-(L-lysine)]} (PRGD),
poly(d,l-lactic acid) (PDLLA) and β-tricalcium phosphate (β-TCP). And the effectiveness was compared with that of PRGD/PDLLA/β-TCP, PDLLA and autograft in terms of nerve regeneration across a gap. Both of biodegradablity and cell-biocompatibility of
the novel nerve conduit were evaluated in vitro. The results show that PRGD/PDLLA/β-TCP/NGF composite materials have better biodegradation properties and cell affinity than PDLLA, and could promote the RSC96
Schwann cells adhesion, proliferation and growth on the surface of materials. PRGD/PDLLA/β-TCP/NGF composite conduit was significantly superior to that of the PDLLA conduit in histological and axon morphologic index.
PRGD/PDLLA/β-TCP/NGF conduit is more beneficial to nerve regeneration than PDLLA conduit. The biodegradable PDLLA/PRGD/β-TCP/NGF conduit has a good biocompatibility with rats tissue and it could effectively promote the nerve regeneration after
bridging sciatic nerve defect of rats, the effect is as good as that of the autograft nerve, significantly superior to the
PRGD/PDLLA/β-TCP conduit and PDLLA conduit. PDLLA/PRGD/β-TCP/NGF composite conduit is a potential ideal conduit.
Funded by 973 State Key Fundamental Research and Development (No. G2005CB623905) 相似文献
19.
The crosslinked chitosan was grafted by 4'-formal benzo-15-crown-5 to obtaine crosslinked chitosan with 4'-formal benzo- 15-crown-5(CCTS-N=CH-B- 15-C-5). Then it was loaded with palldium chloride to gain the heterogeneous catalyst, which was easily isolated from the reaction system. The influences of the Pd content of the catalyst, solvent, and temperature on asymmetric hydrogenation of a-phenylethanone have been studied. The catalyst has been found to catalyze the hydrogenation ofa-phenylethanone into the chiral alcohol, α-phenyl ethanol under the mild condition. The optical yield of (R)- 1-phenylethanol could be obtained as 97.1% under the following conditions: temperature, 30℃; solvent, ethanol; Pd content, 1.43 mmol/g; substrate concentration, 0.02 g/mL due to the cooperative effect of crown ether and chitosan polymer. The stability of this catalyst was also studied at the same time. This chiral natural crosslinked chitosan-palladium complex catalyst could be reused without appreciable change in optical catalytic activity, which will be useful for designing crosslinked-chitosan-based adsorption for metal ions for asymmetric hydrogenation. 相似文献
20.
Simultaneous determination of adenine, uridine and adenosine in cordyceps sinensis and its substitutes by LC/ESI-MS 总被引:1,自引:0,他引:1
A simple, sensitive and reproducible high performance liquid chromatography-mass spectrometry coupled with electrospray ionization method for simultaneous separation and determination of adenine, adenosine and uridine was developed. The analytical column is a 2.0 mm× 150 mm Shimadzu VP-ODS column and volume fraction of the mobile phase is 86.5 %water, 12.0%methanol and 1.5%formic acid. 2-chloroadenosine was used as internal standard. Selective ion monitoring mode and selective ion monitoring ions at ratio of mass to electric charge of 136 for adenine, 268 for adenosine and 267 for uridine were chosen for quantitative analysis of the three active components. The results show that the regression equations and linear range are Y=0. 062X 0. 005 and 2.0 - 140.0μg · mL 1for adenine, Y=0. 049X 0. 004 and 4. 0 - 115.0 μg · mL-1 for uridine, Y=0. 154X 0. 014 and 1.0 - 125.0 μg · mL 1 for adenosine. The limits of detection are 0.6 μg · mL 1 for adenine, 1.0μg · mL-1 for uri dine and 0.2 μg · mL 1 for adenosine.The recoveries of the three constituents are from 96.6% to 103.2%. 相似文献