Early attachment: A passing fancy or a long term affair?

Discusses 4 contributions of attachment theory and research: (1) the construct of parent/child bonds as an enduring rather than short-term phenomenon, (2) a validated measure of that construct in infancy, (3) an organizational approach to behavioral observation, and (4) new connections between researchers and clinicians. It is suggested that future research will focus on ontogenetic development and intergenerational transmission of attachment. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Prostate carcinoma and long term survival

BACKGROUND: The long term survival of patients with prostate carcinoma is not well understood. The objective of the current study was to investigate the temporal trend of prostate carcinoma mortality in patients who survived > or = 10 years after diagnosis. METHODS: Men with prostate carcinoma diagnosed from 1958 through 1983 in the Stockholm/Gotland region in Sweden and who survived > or = 10 years after the diagnosis were investigated regarding survival beyond 10 years. The expected survival was calculated from an annually selected age and time-matched cohort of men from the general population in the same geographic region. The relative survival was expressed as the annual quotient of the observed survival over the expected survival. RESULTS: The authors identified 1896 patients who had survived > or = 10 years. The relative survival decreased up to approximately 18 years after the diagnosis, whereupon it reached a plateau that was constant up to 30 years after diagnosis. CONCLUSIONS: Men with prostate carcinoma surviving > or = 10 years have an excess mortality compared with age-matched controls. This excess mortality ceases 20 to 23 years after diagnosis and the observed and the expected survival are similar, indicating few, if any, deaths from prostate carcinoma from there on.     

Readily releasable pool size changes associated with long term depression

We have estimated, for hippocampal neurons in culture, the size of the autaptic readily releasable pool before and after stimulation of the sort that produces culture long term depression (LTD). This stimulation protocol causes a decrease in the pool size that is proportional to the depression of synaptic currents. To determine if depression in this system is synapse specific rather than general, we have also monitored synaptic transmission between pairs of cultured hippocampal neurons that are autaptically and reciprocally interconnected. We find that the change in synaptic strength is restricted to the synapses on the target neuron that were active during LTD induction. When viewed from the perspective of the presynaptic neuron, however, synapse specificity is partial rather than complete: synapses active during induction that were not on the target neuron were partially depressed.     

Study of immunization promotion against influenza in nursing homes and long term care facilities in Quebec

This study measured the rate of influenza immunization in nursing homes and long-term care facilities, and evaluated the effectiveness of a promotion program in reaching the national objective of 95% coverage. At the end of 1993, data were provided by 55 of the 79 nursing homes in the region of Montérégie, Quebec. The mean reported immunization rate was 78%, minimum 19% and maximum 100%. In 70% of cases, non-vaccination was due to patient refusal. In 1994, an intervention was carried out in a random sample of 28 nursing homes. Directors, chiefs of nursing and consulting physicians were informed of the coverage achieved in their institution in relation to the national objective. In addition, presentations were given to the nursing personnel and residents. These presentations were made by post-graduate medical students in 22 of the 28 nursing homes in the experimental group. No increase in the mean immunization rate was observed, indicating that it will be more difficult than expected to reach the desired level of coverage.     

Language therapy effects in long term aphasia

This report describes the results of language therapy initiated 1 to 6 years after the onset of aphasia in 14 patients. During the course of treatment, each of the 14 patients improved strongly in their communicative abilities (PICA), according to clinical observation and reports from family, hospital ward personnel, or both.     

Perforated peptic ulcer: a comparison of long term results following partial gastric resection or simple closure

The results of simple closure were compared with those of partial resection in the treatment of perforated peptic ulcer. The investigation was carried out 7-13 years after the primary operation on 126 patients who had been allotted to one of the two treatment methods on the basis of an almost randomized schedule. Better late results were obtained with partial resection than with simple closure in patients in the age range 50-59 years at operation, with short duration of perforation and with a long history of symptoms before perforation. None of the patients treated with partial resection later underwent surgical treatment for recurrence of symptoms. In the simple closure group 27.3 per cent needed further surgery at 3 months to 10 years after perforation.     

Distributed memory for both short and long term

The present study examined the behavioral effects of dopamine receptor agonists, antagonists, or N-methyl-D-aspartate (NMDA) glutamate receptor antagonist in rats with a unilateral excitotoxic lesion of the globus pallidus (GP). After the unilateral GP lesions were made by injections of the ibotenic acid, drugs were systemically given and the elicited behaviors were quantitatively assessed. Systemic administration of haloperidol, but not SCH23390, dose-dependently induced contraversive dystonic posturing in unilateral GP-lesioned rats. On the other hand, systemic administration of quinpirole, but not SKF38393, induced ipsiversive circling. MK-801, only when given at a high dose, unilateral GP-lesioned rat, the D2 receptor agonist and antagonist caused ipsiversive and contraversive posturing or circling, respectively. Since the rotational behavior is induced on the basis of asymmetry of the basal ganglia output activity, there must be a marked difference between the GP ablation and the administration of D2 receptor blockade on the basal ganglia output activity, supporting a speculation that overactivity of the basal ganglia under dopamine depletion is not solely a result of the disinhibition from the inhibitory GP efferents. The present unilateral GP-lesion model appears to be a useful one for the pharmacobehavioral investigation of D2-mediated mechanisms.     

Intravenous long term infusions of the rat without anesthesia

The lumbar-spine radiographs of 67 patients with idiopathic chondrocalcinosis articularis were reviewed for disc calcification and other changes. Calcification was present in 21 (31%) of the patients, seen most frequently at the L 2-3 disc space. The 21 patients as a group were significantly older than the 46 patients without disc calcification, and also had a much higher incidence of chondrocalcinosis in peripheral joints. There was no association with back pain or spinal stiffness. The 21 patients with disc calcification included six patients with a destructive peripheral arthropathy, and three of them had destructive changes affecting the lumbar spine. Three patients with a destructive peripheral arthropathy were also included in the group without disc calcification, and one of these had a destructive arthritis of the lumbar spine. For comparison, there was a 55% incidence of spinal chondrocalcinosis in nine patients with primary hyperparathyroidism and peripheral joint chondrocalcinosis, and a 6% incidence in 100 anteroposterior lumbar spine radiograph 'controls', taken before intravenous urography, although in this latter group the changes were minimal and confined to the margin of a single disc in each case.     

拓展企业质量管理创造培育长销产品

阐述了企业在市场竞争中,必须拓展质量管理,不但要对内部现场进行质量管理,而且还要对外部市场进行质量管理,作到产品设计,创造消费;市场开发,培育消费;品牌塑造,满足消费;市场管理,围绕消费,这样才能创造、培育企业的长销产品,增加经济效益.     

Are smaller weight losses or more achievable weight loss goals better in the long term for obese patients?

Weight losses and psychological well-being were examined at 30 months in 69 men and 61 women initially treated with behavior therapy as a function of (a) initial weight loss and (b) weight-loss goals. Initial weight losses were positively, not negatively, related to weight loss at 30 months. Weight loss goals did not predict short-term or long-term weight loss. People who reached weight goals had better long-term weight losses than those who did not, but this finding was largely due to differences in initial weight loss. Psychological well-being at 30 months was not related to initial weight losses or goals. Although correlational rather than experimental, these results do not support the hypothesis that obese patients should be encouraged to set lower weight-loss goals. (PsycINFO Database Record (c) 2010 APA, all rights reserved)