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《Journal of Sulfur Chemistry》2013,34(1):99-127
Abstract An overview of new synthetic methods for the construction of α-thiodisulfides is presented. α-Sulfone disulfide construction is prominently featured in the synthetic discussion. Biological test results on α-thiodisulfides, aryl disulfides, and thiosulfonates are reviewed and some organic-chemical mechanistic discussion is provided to rationalize them. 相似文献
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《Journal of Sulfur Chemistry》2013,34(5):605-617
The review includes synthetic methodologies of dithiocarbamic acid salts, their S-substituted derivatives, and nano particles (NP's) in their synthesis. This review also deals with the utility of dithiocarbamates in synthesis of: (a) heterocycles, (b) some organic reagents and (c) NP's. 相似文献
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《Journal of Sulfur Chemistry》2013,34(3):205-229
The chemistry of aminobenzo[b]thiophenes has gained increased interest in both synthetic organic chemistry and biological fields and has considerable value. Some of the reactions have been successfully applied for the production of various fused heterocycles. The present review covers the literature up to date for the synthesis, reactions and applications of such compounds. 相似文献
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《Journal of Sulfur Chemistry》2013,34(6):611-647
This review describes the synthesis and properties of thiocarbohydrazide and its utility as a building block for the synthesis of heterocyclic systems with pharmacological interest. 相似文献
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《Journal of Sulfur Chemistry》2013,34(6):623-653
The aim of this paper is to present the synthesis and reactions of thiochroman-4-ones. These compounds are used as precursors for the synthesis of many heterocyclic rings. The reactions of thiochroman-4-ones are subdivided into groups that cover reactions yielding heterocycles such as pyrazoles, imidazoles, thiazoles, indoles, pyridines, pyrimidines, and thiazepines. 相似文献
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Pathak T 《Chemical reviews》2002,102(5):1623-1668
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A. A. Khalil 《应用聚合物科学杂志》2011,121(2):1160-1165
8‐Methacryloxyquinoline (MAQ) was prepared through the reaction of 8‐hydroxyquinoline with either methacryloyl chloride or methacrylic acid in the presence of triethylamine or N,N‐dicyclohexylcarbodiimide, respectively. MAQ was polymerized in dimethylformamide with 2,2‐azobisisobutyronitrile as the initiator. The reactions of the resulting polymers with hydroxyl and amino compounds were studied. The polymers were characterized with IR, 1H‐NMR, and mass spectroscopy. Some of the synthesized polymers were tested for their antimicrobial activity against bacteria and fungi. Generally, all the polymers were effective against the tested microorganisms, but their growth‐inhibition effects varied. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011 相似文献
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采用分子杂交策略,设计合成15个氨基酸结构的磺酰胺衍生物进行抗菌活性评价。首先,苯磺酰氯与氨基酸反应制得苯磺酰氨基酸(中间体Ⅰ),然后,以芳香醛、亚磷酸酯、乙酸铵和三氟甲磺酸铝为原料,一锅法制得α-氨基膦酸酯(中间体Ⅱ),最后,中间体Ⅰ与Ⅱ缩合,制得目标物,经1H NMR 、13C NMR和MS确认结构。结果表明,该类化合物对大肠杆菌(E. coli)和耐氟喹诺酮大肠杆菌(FREC)活性最为显著。其中,化合物Ⅲb〔{(2-氟苯基) [2-(苯基磺酰氨基)苯丙酰氨基]甲基}膦酸二乙酯〕、Ⅲc〔{(2-氟苯基) [2-(苯基磺酰氨基)苯丙酰氨基]甲基}膦酸二乙酯〕、Ⅲh〔{(2-氟苯基) [2-(苯基磺酰基氨)异戊酰氨基]甲基}膦酸二乙酯〕和Ⅲm〔{(苯基) [2-(苯基磺酰基氨)乙酰氨基]甲基}膦酸二乙酯〕对E. coli的MIC(Minimum Inhibitory Concentration)均为16 μg/mL,化合物Ⅲn〔{(2-氟苯基) [2-(苯基磺酰氨基)乙酰氨基]甲基}膦酸二乙酯〕对E. coli的MIC为8 μg/mL,抗菌活性不低于对照药苯唑西林;化合物Ⅲb、Ⅲh、Ⅲm和Ⅲn对FREC的MIC分别为32、32、32和16 μg/mL,优于对照药苯唑西林和诺氟沙星。 相似文献
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《Journal of Sulfur Chemistry》2013,34(3):308-316
The electrosynthesis of new 2,4-dialkylcarbonotrithioates, in satisfactory yields, starting from arylthiols and carbon disulfide using an electrogenerated base (EGB) that is reported to promote the reaction is reported. The EGB was prepared by pro-base-free electrolysis of acetonitrile under galvanostatic conditions using a sacrificial magnesium anode. The as-prepared compounds were fully characterized by 1H, 13C, 19F NMR spectroscopy and mass spectrometry. The antimicrobial and cytotoxic activities of some representative compounds were investigated against human pathogenic bacteria, colon and lung cancer cell lines. Promising results were found against gram-positive and gram-negative bacteria and DLD-1 and A-549 cancer cell lines. 相似文献
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As a class of compounds, oxysterols have demonstrated a wide variety of biological properties. Due to the general interest
in these compounds, new methods of chemical synthesis have been developed to provide them for biological investigation. The
specific inhibition by oxysterols of cholesterol biosynthesis in mammalian cells has been shown to result primarily from a
decrease in cellular levels of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity. Recent evidence suggests
these cellular responses may be mediated by an oxysterol binding protein found in the cytosol of many lines of cultured cells.
In certain instances, oxysterols have been shown to be produced in biological systems. These results support the supposition
that oxysterols may regulate sterol biosynthesis at the cellular level. Included herein are the inhibitory effects of 9α,
11α-epoxycholest-7-en-3β-ol cholest-8-en-3β-ol-7-one and cholest-8-en-3β-ol-11-one on HMG-CoA reductase activity and their
relative affinities for a cytosolic binding protein. 相似文献
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烷基三唑硫酮席夫碱的合成和生物活性研究 总被引:1,自引:1,他引:0
为进一步研究三唑席夫碱化合物的合成与性质,以自制的5-烷基-4-氨基-1,2,4-三唑-3-硫酮与对甲氧基苯乙酮和取代芳醛为原料,在冰醋酸催化下,回流反应0.5 h,合成了1,2,4-三唑硫酮席夫碱化合物,其结构通过元素分析、红外光谱(IR)和核磁共振(1H NMR)进行表征。分析结果表明:在IR图谱中,目标产物在波数1 587—1 603 cm-l处出现席夫碱亚胺结构CHN的特征吸收峰;在1H NMR中,席夫碱亚胺结构CHN的质子化学位移δ在10.5附近出现,NC—CH3结构中H的化学位移在2.4左右。研究了化合物对烟草赤星病、马铃薯干腐病、小麦赤霉病、番茄早疫病、西瓜枯萎病5种植物病原菌的生物活性,得到毒力回归方程及相关系数,计算EC50和EC95值,结果表明它们具有较好的抑菌活性。含有吸电子取代基的席夫碱杀菌效果比给电子取代基的好。 相似文献
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Navjeet Kaur 《Journal of Sulfur Chemistry》2018,39(5):544-577
Solid-phase organic synthesis by combinatorial techniques is a widely exploited area in the discovery of new pharmacologically active compounds and is a rapidly expanding area of synthetic organic chemistry. Because of many biological activities possessed by heterocycles, a large number of reports related to their solid-phase synthesis have appeared in recent decades. In this review article, I have described the importance of solid-phase synthetic strategies for the synthesis of sulfur atom containing heterocycles. 相似文献