Smoking, caffeine, and stress: Effects on blood pressure and heart rate in male and female college students.

Examined the independent and joint effects of cigarette smoking and caffeine consumption on blood pressure (BP) and heart rate (HR) reactions to stress in 38 male and 38 female college students. Following an initial physiological baseline, Ss received 1 of 4 experimental treatments (paced smoking, caffeine, smoking plus caffeine, or neither) and had BP and HR measured before, during, and after 2 stressful tasks. Compared with the control condition, caffeine ingestion enhanced the magnitude of stress-induced systolic BP and HR reactions. Smoking combined with stress, and the joint effect of smoking and caffeine was no greater than either taken alone. Males and females were generally similar in their responses to smoking, caffeine, and stress. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Cardiovascular reactivity as a predictor of relapse in male and female smokers.

Examined the role of psychophysiological reactivity to general stressors measured before smoking cessation as a predictor of relapse in individuals who quit for a minimum of 12 hrs and were then followed for a 12-mo interval. The study group consisted of 132 (56.9%) female and 100 (43.1%) male participants in a formal smoking cessation program. The reactivity measures were taken while the Ss were still smoking. Heart rate and blood pressure measurements were taken while Ss were resting, performing mental arithmetic, and delivering a speech and after Ss had been standing for 2 min. In the sample as a whole and for women, a higher level of systolic blood pressure reactivity to the cognitive challenge was associated with a shorter time to relapse. In men, greater systolic blood pressure decline to standing was significantly associated with a shorter time to relapse. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Selective cardiovascular effects of stress and cigarette smoking in young women.

Used a 2?×?2 (smoke/no smoke?×?stress/no stress) factorial design to evaluate the impact of stress and smoking on the cardiovascular responses of 43 female undergraduates and college staff (mean age 20.7 yrs). The stressor was a video game. Results reveal that the combination of stress and cigarette smoking produced blood pressure and heart rate responses that were larger than the additive effects of smoking and stress taken separately. (36 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Autonomic feedback: The perception of autonomic activity.

The 19 highest scoring Ss and the 13 lowest scoring on a questionnaire dealing with autonomic self-perceptions were exposed to an intellectual stress situation. Subsequently they were interviewed as to their autonomic perceptions. Records of the 14 Ss who obtained high scores, and the 9 Ss who obtained low scores on both the questionnaire and interview were then examined for level of autonomic reactivity, using measurements of heart rate, psychogalvanic response, respiration, face temperature, and blood volume. Results showed: positive correlations between the questionnaire and other paper-and-pencil tests of anxiety reactions; perceivers reporting a high level of autonomic feedback showed significantly greater autonomic reactivity than low perceivers; high perceivers tended to overestimate their autonomic responses, low perceivers to under-estimate them. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Autonomic functioning in process and reactive schizophrenia.

Compared the autonomic functioning of male process schizophrenics, reactive schizophrenics, and normal ss (n = 30) under rest and arousal conditions. Ss were exposed to 6 arousal conditions: (a) white noise, (b) electric shock, (c) paired associate learning, (d) word activity test, (e) finger dexterity task, and (f) pursuit rotor task. Rest periods preceded each arousal condition. Heart rate, skin resistance, respiration rate, diastolic and systolic blood pressures were recorded under all 6 conditions. Results show that under stress the levels of physiological functioning for normal ss and reactive schizophrenics were similar on skin resistance and blood pressure, with process schizophrenics showing a higher level of arousal on skin resistance and a lower level on blood pressure. Reactive schizophrenics had the fastest heart rate, with process schizophrenics next, and normals the lowest. Respiration did not reliably differentiate among the groups. Reactive schizophrenics and normals generally showed greater increments to the arousal conditions (compared with prestress base lines) than the process schizophrenics in all measures except heart rate and skin resistance. In those 2 measures, reactive and process schizophrenics were similar in their reactions to the stress conditons, and both groups showed less reactivity in general than normals. (french summary) (31 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Age-related differences in cardiovascular reactions to mental stress tests in women.

Tested 84 healthy, sedentary women in the laboratory during performance of difficult and easy problem-solving tasks. Ss were divided into 3 equal age groups: 19–32 yrs, 33–43 yrs, and 44–60 yrs. Baseline systolic blood pressure (SBP) and diastolic blood pressure increased with age, whereas skin conductance level was lower in older Ss. Initial SBP reactions to tasks were positively related to age, even after controlling for baseline blood pressure, aerobic fitness, and Framingham Type A Scale (S. G. Haynes et al; see PA, Vol 68:10702) behavior scores. There were no differences in heart rate (HR) or additional HR reactions, so the anticipated decline in cardiac sympathetic response with age was not observed. Mechanisms underlying age-related reactions to mental stress are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Behavioral and physiological effects of low-nicotine cigarettes during rapid smoking.

Compared the effects of rapid smoking using medium-tar/nicotine or low-tar/nicotine cigarettes on physiological and behavioral responses in a randomized, double-blind clinical trial with 24 Ss. Results show equivalent heart rate, blood pressure, and carbon monoxide levels after rapid smoking either low- or medium-yield cigarettes. Behavioral topography measures differed significantly when low-nicotine cigarettes were smoked. Also, Ss who did remain abstinent at subsequent follow-up showed less change in rated aversiveness during rapid smoking than Ss who did not remain abstinent. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Oral contraceptive use and hemodynamic, lipid, and fibrinogen responses to smoking and stress in women.

The effects of acute smoking and oral contraceptive (OC) use on cardiovascular, lipid, and fibrinogen stress responses were examined in 52 female smokers and nonsmokers, half of whom were using OCs. Women smoked or sham-smoked a cigarette and then performed 2 stressful tasks. Stress elicited increases in total and low-density lipoprotein cholesterol, and in triglycerides among women who smoked, and in fibrinogen among all women. Smokers who used OCs had greater blood pressure increases to smoking and to stress than did smokers who did not use OCs. OC use was also associated with enhanced total peripheral resistance stress responses among women who smoked and cardiac output stress responses among women who sham-smoked. Results suggest that OC use moderates cardiovascular reactivity in smokers but not nonsmokers, enhancing vascular responsivity to smoking combined with stress and myocardial responsivity to stress alone. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Chronic stress as a factor in physiologic reactivity to challenge.

Examined the hypothesis that chronic stress contributes to heightened cardiovascular reactivity. 17 residents (mean age 35 yrs) of crowded neighborhoods and 24 residents (mean age 39 yrs) of uncrowded neighborhoods worked on a challenging task while blood pressure and heart rate were measured. Self-report and biochemical measures indicate that the 2 groups differed in level of chronic stress. Results also indicate that chronic stress contributed to cardiovascular reactivity. Crowded residents showed greater increases in systolic and diastolic blood pressure and heart rate and took longer to return to baseline than did uncrowded residents. The few differences found between Type A (coronary prone) and Type B (noncoronary prone) residents were found only in the low-stress group. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Stress, reactivity, and immune function in healthy men.

Examined the effects of acute psychological stress on lymphocyte proliferation and circulating levels of interleukin-1 and -2. 20 healthy men were exposed to 2 viewings of a gruesome surgery film and were asked to recall details of the film twice during a 20-min period. These Ss were compared to a nonstress control group of 9 Ss. Lymphocyte proliferation to the mitogen concanavalin-A was decreased during and after exposure to the stressor when compared to the control group. This decrease was more pronounced in Ss exhibiting greater blood pressure reactivity while viewing the film than in Ss showing smaller blood pressure responses. None of the other immunological measures was significantly affected by the stressor. Cortisol was not correlated with lymphocyte responsiveness. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Caffeine enhances the physiological response to occupational stress in medical students.

Tested caffeine (3.3 mg/kg) against a placebo in 20 male medical students (aged 19–31 yrs) during periods of low (no exams) vs high (final exams) work stress. On each of 8 test days, heart rate and blood pressure were measured at baseline and over a 40-min postdrug interval; immediately afterward, blood was drawn to test plasma cortisol and serum lipid concentrations. Exams increased heart rate and systolic blood pressure. Caffeine decreased heart rate and increased systolic blood pressure, diastolic blood pressure, plasma cortisol levels, and serum cholesterol levels. Caffeine effects were additive with those of exams, and together they increased the number of Ss showing systolic blood pressures in the borderline hypertensive range. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Physiological and neuropsychological correlates of hostility

This experiment tested two hypotheses linking right cerebral arousal to hostility and physiological arousal. A replication of previous research supporting heightened physiological (systolic blood pressure, diastolic blood pressure and heart rate) reactivity among high-hostility subjects was partially successful. Hemispheric lateralization of cerebral activity in response to stress was also measured. Low- and high-hostility subjects were identified using the Cook-Medley Hostility Scale (CMHS). Physiological measures (systolic blood pressure, diastolic blood pressure and heart rate) were recorded and dichotic listening procedures were administered before and after administration of the cold-pressor paradigm. The primary finding of this research was greater right cerebral activation to stress among high-hostility subjects, as indicated by their enhanced ability to identify syllables presented to the left ear. Data further supported previous findings of heightened physiological reactivity to stress among high-hostility subjects and suggest a positive relationship between right cerebral activity and cardiovascular arousal.     

Aerobic fitness, psychological characteristics, and cardiovascular reactivity to stress.

Examined relations among aerobic fitness (AF), psychological characteristics, and cardiovascular reactivity, using 62 men (mean age 42 yrs) divided into highly fit and less fit groups based on a treadmill exercise test. Several psychological and physiological variables were measured, and Ss' cardiovascular reactivity was assessed during a mental arithmetic task and a video game task. Highly fit Ss showed a significantly smaller increase in diastolic blood pressure (DBP) and heart rate (HR) and reported themselves to be less anxious and less angry than did less fit Ss. Controlling for Ss' scores on a scale assessing angry temperament reduced the relationship between AF and DBP reactivity to nonsignificant levels. Degree of dispositional anger, which covaries with increased fitness, may contribute to the relationship between AF and DBP, but not HR, reactivity. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Task demand and cardiovascular response magnitude: Further evidence of the mediating role of success importance.

The interactive effects of success importance and task demand on cardiovascular reactivity were investigated in 2 experiments. In Exp 1, Ss learned that success on an easy or difficult memory task would allow them to avoid a mild or severe noise. As expected, pretask and task elevations in heart rate and systolic blood pressure increased with difficulty only when the noise was to be severe. In Exp 2, Ss listened to a victim, attending either to how she must feel or to technical features of the presentation. Then they were given the chance to earn a donation by succeeding on an easy or difficult memory task. Pretask cardiovascular data accorded with predictions predicated on the assumption that the need to help would be greater among victim perspective Ss. For them, systolic elevations increased with difficulty, whereas for technical perspective Ss systolic elevations were low regardless of task demand. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Establishment of xenografts and cell lines from well-differentiated human thyroid carcinoma

OBJECTIVE: To investigate the acute effect of cigarette smoking on glucose tolerance, insulin sensitivity, serum lipids, blood pressure, and heart rate. RESEARCH DESIGN AND METHODS: This nonrandomized experimental control trial in a tertiary care center included 20 healthy chronic smokers and 20 age-, sex-, and BMI-matched healthy volunteers. Two oral glucose tolerance tests (OGTTs) were performed on each subject. Three cigarettes were smoked during the first 30 min in one of the tests. Serum glucose, insulin, and C-peptide levels were measured every 30 min; the area under the curve (AUC) and the insulin sensitivity index (ISI) were calculated; serum total cholesterol, LDL cholesterol, HDL cholesterol, and triglyceride levels were measured at 0 and 180 min; and blood pressure and heart rate were recorded every 5 min throughout 180 min. RESULTS: Smoking acutely impaired glucose tolerance: the AUC for glucose in smokers was 25.5 +/- 1.03 mmol/l (mean +/- SE) (95% CI 22.9-28) during the smoking OGTT and 21.8 +/- 0.85 mmol/l (CI 19.2-24.3) in the control OGTT (P < 0.01); in nonsmokers, it was 19.7 +/- 0.3 mmol/l (CI 18.8-20.5) in the smoking OGTT and 18.7 +/- 0.35 mmol/l (CI 17.8-19.5) in the control OGTT (P < 0.05). Smoking acutely increased serum insulin and C-peptide levels and decreased ISI only in smokers: ISI in smokers was 55 +/- 2.8 (CI 47.4-62.6) in the control OGTT and 43 +/- 2.7 (CI 35.4-50.6) in the smoking OGTT (P < 0.05). Smoking acutely caused a rise of serum total cholesterol levels in both groups and increased LDL cholesterol and triglyceride serum levels significantly only in smokers (P < 0.05). A significant rise of blood pressure and heart rate while smoking was present in all the subjects. CONCLUSIONS: Smoking acutely impaired glucose tolerance and insulin sensitivity, enhanced serum cholesterol and triglyceride levels, and raised blood pressure and heart rate. These findings support the pathogenetic role of cigarette smoking on cardiovascular risk factors.     

Age-related changes in cardiovascular response as a function of a chronic stressor and social support.

The effects of aging, chronic stress, and social support on cardiovascular functioning were examined using a cross-sectional design. 36 family caregivers of Alzheimer's disease victims and 34 control Ss performed 2 active coping tasks while continuous noninvasive measures of cardiovascular activity were monitored. Results revealed that caregivers high in social support displayed typical age-related decreases in heart-rate reactivity, whereas caregivers low in social support displayed age-related increases in heart-rate reactivity. Analyses further indicated that only Ss with low social support were characterized by age-related increases in systolic blood pressure. These results suggest that social support can moderate age-related changes in cardiovascular functioning, particularly in Ss exposed to a chronic stressor. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Smoking behavior in offspring of heart disease patients: A response to cognitive dissonance.

Offspring of heart disease patients, with their variety of health concerns, were compared to a control group with respect to cigarette smoking behavior. Contrary to common-sense expectations, a significantly greater proportion of both male and female offspring were current smokers, and smoked to a greater degree (heavy) than control Ss. The MMPI, however, did not discriminate between Ss on the basis of smoking behavior. In accordance with previous research, it was theorized that the differences observed could be attributed to the higher state of cognitive dissonance associated with cigarette smoking in the offspring group. The fact that a relationship existed between quitting and age, for male and female offspring, suggests that more research is required to study the effects of extreme states of cognitive dissonance. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Physiological reactivity and recent life-stress experience.

Administered the Life Experiences Survey to 126 undergraduates; subsamples of 13 high- and 13 low-stress Ss were then selected for a subsequent experiment involving a novel laboratory stressor. Heart rate and systolic and diastolic blood pressure were monitored during baseline anticipation, testing, and recovery periods of the experiment. Results indicate differences between groups in the patterning of changes in heart rate and systolic blood pressure during the recovery periods. High-stress Ss maintained their elevated stressor levels throughout recovery, whereas low-stress Ss' arousal levels returned to prestress baseline values. Compared with the low-stress group, high-stress Ss showed significantly higher systolic recovery levels. Findings demonstrate that evidence concerning the predictive efficiency of life-stress measures can be gathered through psychophysiological research. (5 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Rapid smoking: A cautionary note.

Although rapid smoking has proved to be a successful treatment strategy for smokers, its hazard potential has been recently debated. In the present study, 6 Ss (mean age 30.8 yrs) were monitored throughout 8 standard sessions of rapid smoking. Heart rate, blood pressure, and carboxyhemoglobin increases were generally higher than those reported in the few extant physiological studies of rapid smoking, and EKG abnormalities occurred in several Ss during rapid smoking. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Spouse and parent-offspring similarities in cardiovascular response to mental arithmetic and isometric hand-grip.

30 couples (members aged 41–70 yrs) completed a stress protocol consisting of alternating stress and relaxation periods. Repeated measurements of blood pressure, heart rate, and blood volume pulse were obtained. Although spouses exhibited some behavioral similarities, there were no significant similarities in cardiovascular (CV) response to stress. However, significant parent–offspring similarities in heart rate response to mental arithmetic and diastolic blood pressure response to isometric hand-grip were observed, as were several behavioral similarities. Findings suggest that assortative mating and current home environment are less important in the familial aggregation of CV reactivity to stress than are early environmental and/or genetic factors. (PsycINFO Database Record (c) 2010 APA, all rights reserved)