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L-苯丙氨酸是人体必需、但自身无法合成的8大氨基酸之一,也是医用氨基酸和食品添加剂的重要组分之一。近年来随着氨基酸类抗癌药物、营养保健品的开发应用和新型高强度甜味剂阿斯巴甜的广泛生产与使用,促进了L-苯丙氨酸的需求迅速增加,尤其是目前国际市场上主导的甜味剂产品阿斯巴甜,在食品、饮料等行业得到广泛的应用,大大刺激和推动了L-苯丙氨酸的生产与发展。 相似文献
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L—苯丙氨酸的生产和市场分析 总被引:1,自引:0,他引:1
L-苯丙氨酸是人和动物必需的 8种氨基酸之一,人体自身不能合成。在医药行业和食品加工行业中均有应用。在医药行业中, L-苯丙氨酸用于制备氨基酸输液、综合氨基酸制剂;它还是某些氨基酸类抗癌药物的中间体,也是生产肾上腺素、甲状腺素和黑色素的原料。在食品加工行业中, L-苯丙氨酸可添加于焙烤食品中,除具有强化营养作用外,还与糖类起氨基-羧基反应,以改善食品香味。目前, L-苯丙氨酸最有潜力的应用领域是作为合成新型保健甜味剂阿斯巴甜 (Aspartame,简称 APM)的原料。每生产 1 t阿斯巴甜需消耗 1 2 t L-苯丙氨酸。 … 相似文献
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DL-苯丙氨酸合成新方法 总被引:6,自引:0,他引:6
L-苯丙氨酸是一种人体必需的氨基酸,在药物合成及日常生活中有广泛的用途,近年发现D-苯丙氨酸也有重要的用途。随着生物化工技术的进展,DL-苯丙氨酸的拆分已经得到完满的解决。因而,DL-苯丙氨酸是一种重要的有机化工产品及基础原料,其工业合成方法也显得更为重要。本文在总结了现有DL-苯丙氨酸工业合成及其它合成路线的基础上,对其中一种方法进行了改进,使收率有所提高;且将合成中间体进行了精制,使工业化生产成为可能并使生产成本降低,收到较好的结果,并将其实现了工业化。 相似文献
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L苯丙氨酸开发前景诱人 总被引:3,自引:0,他引:3
L-苯丙氨酸是具有生理活性的芳香族氨基酸,是人体和动物不能靠自身自然合成的必需氨基酸之一,正常人每天需求2.2g。在食品加工行业中,可添加于焙烤食品中,除可强化苯丙氨酸的寄养作用外,还与糖类发生氨基-羧化反应以改善食品香味。在医药行业中,L-苯丙氨酸是氨基酸类药物,用于制备氨基酸输液;综合氨基酸制剂及营养强化剂;是某些氨基酸类抗癌药物的中间体,也是生产肾上腺素、甲状腺素和黑色素的原料。目前,L-苯丙氨酸的最具潜力的应用领域是作为合成新型保健甜味阿斯巴甜的原料,每生产1t阿斯巴甜需消耗1.2tL-苯丙… 相似文献
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以二(2-乙基己基)磷酸(D2EHPA)-正辛烷萃取L-苯丙氨酸为对象,研究了D2EHPA浓度、L-苯丙氨酸初始浓度以及pH值对萃取平衡分配系数的影响。不同pH值下负载有机相的红外谱图分析表明,D2EHPA与L-苯丙氨酸形成的萃合物结构与pH值无关。提出了在萃取过程中同时存在着离子交换反应和质子转移反应的观点。1个氨基酸分子与2个二(2-乙基己基)磷酸二聚体相结合。本文建立的萃取平衡分配系数关联式,拟合精度令人满意。 相似文献
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苯丙氨酸脱氨酶发酵工艺及其酶学性质研究 总被引:1,自引:0,他引:1
选育出一株具有较高苯丙氨酸脱氨酶活性的菌株巨大芽孢杆菌AS1.127-NJU10。考察了该菌的发酵产酶条件,结果表明:蔗糖为最佳碳源、酵母浸膏和NH4C l组成最佳氮源,其质量浓度分别为:ρ(蔗糖)=20 g/L,ρ(酵母浸膏)=2 g/L和ρ(NH4C l)=10 g/L;发酵培养基最适pH=6.5,培养温度为37℃;诱导物ρ(L-苯丙氨酸)=1 g/L时,酶活最高达1 070 U。同时对苯丙氨酸脱氨酶的性质进行了研究,结果表明:该酶最适pH=5.8,最适温度为40℃,反应液中添加φ(吐温-80)=0.2%和c(K+)=10-5mol/L能明显提高酶活。 相似文献
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Su‐Hsia Lin Chia‐Nan Chen Ruey‐Shin Juang 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》2006,81(3):406-412
The distribution equilibria of single and binary L ‐phenylalanine and L ‐aspartic acid between water and a kerosene solution of di(2‐ethylhexyl)phosphoric acid (D2EHPA) were studied. It was shown that the distribution ratios of phenylalanine generally increased with increasing aqueous pH (2–5) in the D2EHPA concentration range 0.1–0.5 mol dm?3, but those of aspartic acid decreased with increasing solution pH. Different reaction stoichiometries were proposed for the extraction of phenylalanine and aspartic acid under the conditions studied. The extraction equilibrium constants were obtained. Competitive extraction in binary systems was more apparent in the pH range where the cationic form of amino acids was not predominant. The present results indicated that selective separation of phenylalanine to aspartic acid was possible with this cationic extractant when they were extracted at higher pH and stripped using higher acidity of HCl solution. Copyright © 2006 Society of Chemical Industry 相似文献
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采用绿色合成方法,利用椰子油与含芳香环取代基的组氨酸钠、苯丙氨酸钠、酪氨酸钠直接进行酰胺化反应制备了3种椰子油酰基芳香族氨基酸盐.采用HPLC-MS、FTIR对产物组成和结构进行了表征,并对合成产品的性能进行了测定.结果表明,椰子油酰基氨基酸盐表面活性剂的界面性能受氨基酸结构的影响较大,椰子油酰基苯丙氨酸钠与椰子油酰基组氨酸钠的临界胶束浓度(CMC)分别为9.84×10–5和6.79×10–5 mol/L,均远小于椰子油酰基酪氨酸钠的CMC(1.54×10–2 mol/L).3种椰子油酰基氨基酸盐表面活性剂均具有良好的乳化性、起泡性及泡沫稳定性,乳液分出10 mL水相最长需要342 s,泡沫高度最高达到157 mm,稳泡性参数,即发泡结束后30 min时泡沫高度(H5)与0 min泡沫高度(H1)比值(H5/H1)最高达到0.898;耐硬水性等同或优于皂类;在蒸馏水中的去污力与十二烷基苯磺酸钠(LAS)、α-烯基磺酸钠(AOS)、椰子油钠皂等传统表面活性剂相当. 相似文献
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以L-苯丙氨酸或L-色氨酸为基本骨架,甲酯化后与4-取代苯乙酸酰胺化,经水解与2-(1H-咪唑-1-基)乙胺反应得到六个新型2-(4-取代苯乙酰胺基)丙酰胺衍生物5a~5f。化合物结构通过IR、1H NMR和元素分析进行确证。通过MTT法测试了目标化合物对人非小细胞肺癌细胞A-549的抑制活性。初步抗癌活性测试表明,化合物5e具有明显的抑制肿瘤细胞增殖活性。 相似文献
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Nylon 6, nylon 6,6, and terephthalic phenylene polyamide (TPPP) were functionalized by phase‐inversion molecular imprinting to add L ‐phenylalanine recognition ability. Formic acid containing 20 wt % nylon and 8 wt % L ‐phenylalanine was used as the solvent for the cast solution of the imprinting process. The resultant porous membranes behaved as membrane adsorbents that separated the L /D mixture of the substrate. The imprinted nylon 6 and nylon 6,6 presented high selectivity to the L ‐form substrate with respect to the TPPP membranes, but the imprinted TPPP membranes showed higher binding capacity with 0.57 μmol/g for L ‐phenylalanine. The apparent partition coefficients of L ‐ and D ‐forms by the imprinted membranes were 6.8, 4.2, and 1.7 for nylon 6, nylon 6,6, and TPPP, respectively. The separation manner of the L ‐ and D ‐forms from the mixture was also confirmed by membrane filtration under 1.5 kgf/cm2 of applied pressure. The imprinted nylon 6, nylon 6,6, and TPPP membranes had separation factors of L ‐ and D ‐phenylalanines of 1.1, 1.1, and 1.2, respectively. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 97: 620–626, 2005 相似文献
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The effects of the composition of a surfactant colloidal solution containing nonylphenylpolyoxyethylene ether, theracemic mixture of L,D-phenylalanine, trans-4-hydroxy-L-proline and/or their copper complexes upon the flux of permeate and the resistance of the hydrophilic membrane and additional layer formed during ultrafiltration were studied. It was found that colloidal solutions containing the nonionic surfactant and additionally phenylalanine, the selector and their complexes with copper can be ultrafiltrated through hydrophilic membranes made of regenerated cellulose with a cut-off of 10 kDa with satisfactory fluxes. Both the permeate flux and resistance depend upon the concentration of the surfactant, but the effect of phenylalanine and the selector is negligible. The decisive effect was observed for copper complexes with phenylalanine and the selector as the complexes significantly decrease the permeate flux and increase the resistance of the additional layer. 相似文献