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Faye M Dong Barbara A Rasco Sahl S Gazzaz Maria L San Buenaventura Liisa M Holcomb 《Journal of the science of food and agriculture》1990,51(3):299-308
This study examined the body composition and serum and liver lipids in weanling rats fed diets containing distillers' dried grains with solubles (DDGS) from either white wheat (WW), red wheat (RW), corn (CO) or WW fortified with essential amino acids (FWW) as a sole protein source (1.6 % N in the diet). Although the DDGS-fed groups had significantly lower body weights compared with the casein control (RC) after a 28-day feeding trial, there were no significant differences among the dietary groups in percentages of body water, protein, lipid or ash. Serum cholesterol was significantly higher in rats fed the RW diet, and serum triglyceride was higher in the RC and FWW groups compared with the other dietary groups. Liver cholesterol and triglyceride concentrations (mg g?1 liver) were not significantly different among the five dietary groups. 相似文献
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Felix L Elorza Antonio Jimnez‐Caliani Silvia Jimnez‐Jorge Maria C Naranjo Latifa Naji Maria I Estevez Jose M Mateos‐Romero Joaquin Mateo Juan M Guerrero 《Journal of the science of food and agriculture》2004,84(7):613-615
Moderate intake of sherry by rats resulted in a decrease in serum total cholesterol and an increase in the proportion of high‐density lipoprotein cholesterol. Oloroso, manzanilla, fino and amontillado sherries all exerted similar effects. These effects were apparently not related to the ethanol content, since an aqueous solution of ethanol did not modify cholesterol levels. Therefore other compounds must be responsible for the effects observed. This paper shows that, in addition to typical red and white wines, sherries should be included in the list of wines with beneficial physiological effects following moderate consumption. Copyright © 2004 Society of Chemical Industry 相似文献
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研究荞麦槲皮素对高胆固醇大鼠脂质代谢及肝损伤的防治效果。将54只SD大鼠随机分为对照组、模型组、阳性组、荞麦槲皮素低(50 mg/kg)、中(100 mg/kg)、高(200 mg/kg)剂量组。建立高脂血症大鼠模型5周后,灌胃荞麦槲皮素干预治疗,测定各组大鼠血清脂质、抗氧化水平,以及肝脏抗氧化水平,并观察肝脏组织病理切片。结果表明:与模型组相比,荞麦槲皮素能够降低TC、TG、LDL-C的含量,回调HDL-C的含量,较模型组差异极显著;荞麦槲皮素各剂量组的ALT、AST活力有不同程度降低,剂量越高,下降幅度越大。同时,荞麦槲皮素高剂量组上调了血清中141.17 U/mgprot的SOD酶活力,下调了血清中1.21 U/mgprot的MDA含量,肝脏中SOD、MDA含量亦出现此趋势,HE染色结果表明,荞麦槲皮素各剂量组肝细胞排列整齐,脂肪滴变小,肝脏病变减轻。由此可见,荞麦槲皮素能显著调节高胆固醇膳食大鼠血脂异常,降低体内脂质蓄积,提高肝脏抗氧化能力,修复肝损伤。 相似文献
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Sabrine Louala Sherazed Hamza-Reguig Aicha Benyahia-Mostefaoui Ahmed Boualga Myriem Y. Lamri-Senhadji 《Journal of Functional Foods》2011,3(4):321-328
The effect of highly purified sardine proteins was compared with that of casein on serum and lipoproteins lipid peroxidation and reverse cholesterol transport. Lecithin:cholesterol acyltransferase (LCAT) activity, high density lipoproteins (HDL2 and HDL3) composition and serum lipid and lipoproteins peroxidation were determined in rats fed a cholesterol-rich diet. Hypercholesterolemic rats were divided into two groups fed diets enriched with cholesterol and containing 20% of highly purified sardine proteins (SPc) or casein (CASc) for 28 days. A control group was fed a standard diet (CAS). Compared with CAS and CASc, the thiobarbituric acid reactive substances (TBARS) concentrations of low density lipoprotein (LDL)–HDL1 in SPc were 3.5- and 1.7-fold higher compared with casein diets. TBARS in HDL2 and HDL3 were, respectively, 2.3- and 1.6-fold lower in SPc compared with CASc. In SPc group, LCAT activity was higher compared to CASc and CAS (P < 0.05). Purified sardine proteins had no beneficial effects on LDL-cholesterol and lipid peroxidation. However, they reduced HDL oxidation and improved reverse cholesterol transport, in the hypercholesterolemic rat. 相似文献
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Hypolipidaemic and anti‐oxidative potential of encapsulated herb (Terminalia arjuna) added vanilla chocolate milk in high cholesterol fed rats
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Pravin Digambar Sawale Ramesh Pothuraju Shaik Abdul Hussain Anuj Kumar Suman Kapila Girdhari Ramdas Patil 《Journal of the science of food and agriculture》2016,96(4):1380-1385
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《Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment》2013,30(11):1722-1739
ABSTRACTMale Wistar rats were intraperitoneally dosed with fumonisin B1 (FB1; 0, 20, 50 and 100 mg kg?1 dietary dose equivalent) for 5 & 10 days to assess dose- and time-dependent effects on renal and hepatic phosphatidylcholine (PC), phosphatidylinositol (PI) and phosphatidylethanolamine (PE) fatty acid (FA) profiles. Renal PC showed increasing FA saturation (SAT) after 5 days; after 10 days polyunsaturation (PUFA) decreased markedly (Σ n3 (total n3), Σ n6, PUFA, unsaturation index (UI) and average FA chain length (ACL)), mostly with linear dose response. In the PI FAs similar changes were observed, decreasing monounsaturated FA, PUFA, UI and ACL (5 & 10 days), while the PE fraction was responsive in Σ n6 (↓) and SAT (↑), but only after 5 days (without dose response for both PI & PE). Liver PC exhibited increasing saturation (C16:0), decreasing polyunsaturation (C20:3 n6 [dihomo-γ-linolenic acid, DGLA]; C20:3 n3); the PI FA profile showed similar alterations after 5 days. PC & PI FA failed to respond in a dose-dependent manner to FB1. In PE FA profile DGLA decreased, with a decrease of the total n6 FA proportion and dose-dependent increase of n3 FAs. Results revealed expressed renal sensitivity, supporting our earlier published results in terms of oxidative stress and histopathological modifications. 相似文献
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Long-Yan Zhao Wei Huang Qing-Xia Yuan Jie Cheng Zhen-Chi Huang Le-Jun Ouyang Fu-Hua Zeng 《Food chemistry》2012
The antihyperlipidaemic effects of ODP-Ia, one of the main components of Opuntia dillenii Haw. polysaccharides, were studied. Gavage administration of ODP-Ia was observed to significantly decrease serum lipid levels and to increase serum high-density lipoprotein cholesterol level in hyperlipidaemic rats. Similar suppressive patterns were also seen in hepatic total cholesterol and triglyceride levels. Moreover, the ODP-Ia administration significantly increased serum lecithin:cholesterol acyltransferase activity, increased the production of serum NO, inhibited hepatic HMG-CoA reductase activity, augmented serum and hepatic superoxide dismutase activities and decreased the serum and hepatic malondialdehyde contents in hyperlipidaemic rats. In addition, a histopathological examination revealed that ODP-Ia administration significantly suppressed inflammatory cell infiltration and the expression of VCAM-1. Together, these results indicate that ODP-Ia is a potential natural product for the treatment of hyperlipidaemia-related diseases by improving antioxidant levels, modulating the activities of enzymes involved in cholesterol metabolism, promoting the production of NO and suppressing the expression of VCAM-1, thereby suppressing lipid accumulation and inflammatory cell infiltration. 相似文献
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Ka Ying Ma Nan Yang Rui Jiao Cheng Peng Lei Guan Yu Huang Zhen‐Yu Chen 《Molecular nutrition & food research》2011,55(2):247-258
Scope: It has been shown that calcium supplementation favorably modifies plasma lipoprotein profile in postmenopausal women. The present study investigated the interaction of dietary calcium with genes of transporters, receptors and enzymes involved in cholesterol metabolism. Methods and results: Forty‐eight ovariectomized hamsters were fed one of the four diets containing 0, 2, 6 and 8 g calcium per kg. Plasma total cholesterol (TC), triacylglycerols (TG), and non‐high density lipoprotein cholesterol were dose‐dependently decreased, whereas high‐density lipoprotein cholesterol (HDL‐C) was dose‐dependently increased with the increasing dietary calcium levels. Dietary calcium had no effect on protein mass of hepatic sterol regulatory element binding protein‐2 (SREBP), liver X receptor‐alpha (LXR), 3‐hydroxy‐3‐methylglutaryl‐CoA reductase (HMGR), LDL receptor (LDLR) and cholesterol‐7α‐hydroxylase (CYP7A1). However, dietary calcium up‐regulated the mRNA levels of hepatic CYP7A1 and intestinal ATP binding cassette transporters (ABCG5/8) whereas it down‐regulated the intestinal Niemann‐Pick C1 like 1 (NPC1L1) and microsomal triacylglycerol transport protein (MTP). In addition, dietary calcium increased the activity of intestinal acyl coenzyme A: cholesterol acyltransferase 2, while it decreased plasma cholesteryl ester transport protein (CETP). Conclusion: Beneficial modification of lipoprotein profile by dietary calcium was mediated by sequestering bile acid absorption and enhancing excretion of fecal cholesterol, via up‐regulation of mRNA CYP7A1 and intestinal ABCG 5/8 with down‐regulation of mRNA NPC1L1 and MTP. 相似文献
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为了了解不同n-6、n-3系多不饱和脂肪酸配比对小鼠机体抗氧化能力和血脂的影响,通过测定饲喂6周不同饲料C57小鼠血浆中总抗氧化能力(T-AOC)、超氧化物岐化酶(SOD)、丙二醛(MDA)、总胆固醇(TC)、甘油三酯(TC)、高密度脂蛋白胆固醇(HDL)、低密度脂蛋白胆固醇(LDL)和致动脉粥样硬化指数(A11并进行统计分析.实验结果表明,从改善血脂、提高机体抗氧化能力来看,n-6、n-3不饱和脂肪酸比例10:1组效果好于5:1组,若添加抗氧化剂LA,有利于改善机体脂质过氧化产生的不良影响,对预防动脉粥样硬化会起到积极的作用. 相似文献
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Carnosic acid alleviates chronic alcoholic liver injury by regulating the SIRT1/ChREBP and SIRT1/p66shc pathways in rats
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Wenjing Zeng Yan Hu Guangzhi Wang Xiaofeng Tian Ning Zhang Xue Shi Yan Zhao Chunchun Ding Feng Zhang Kexin Liu Jihong Yao 《Molecular nutrition & food research》2016,60(9):1902-1911
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Marlène Godard Kelly Décordé Emilie Ventura Gisèle Soteras Jean-Claude Baccou Jean-Paul Cristol Jean-Max Rouanet 《Food chemistry》2009
We investigated the effects of Ulva in hypercholesterolemic hamsters, before and after processing. Three groups of 12 hamsters were fed a high cholesterol diet for 12 wk (Control) or a high cholesterol diet where cellulose has been replaced for an equivalent fibre weight from Ulva or processed Ulva. Plasma cholesterol, non-HDL cholesterol and specially triglycerides were reduced by Ulva. Liver glutathione peroxidase activity was increased and thiobarbituric acid reactive substances were efficiently reduced by dietary treatments compared with controls, whereas plasma antioxidant capacity was increased and aortic fatty streak area was decreased by 70%. The results show for the first time that chronic consumption of polysaccharides supplied by Ulva prevent the fall of antioxidant defences and the development of atherosclerosis in hamsters. The underlying mechanism is related mainly to increased antioxidant status although improvement of the serum lipid profile was not ruled out. 相似文献
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The period of brain development in rats occurs during the late pregnancy and early lactation periods. During that time a large quantity of omega-3 (ω3) long-chain polyunsaturated fatty acids, mostly decosahexaenoic acid, is deposited in the brain lipids of the developing and growing pup. A dietary source of ω3 fatty acid should be provided during this period to the dams' diet to assure sufficient of ω3 fatty acids to the developing progeny. Although a wide variety of lipids from plants and marine animals was examined in this respect, we provide herein for the first time, experimental data that indicate that the marine unicellular alga Nannochloropsis can be efficiently used as a dietary source of the ω3 fatty acid eicosapentaenoic acid for pregnant and lactating dams. Furthermore, the dietary ω3 lipids of the alga are efficiently transferred to the developing foetus and pups to support the requirements for normal brain development. 相似文献
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A synbiotic composed of Lactobacillus fermentum CECT5716 and FOS prevents the development of fatty acid liver and glycemic alterations in rats fed a high fructose diet associated with changes in the microbiota
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Belén Rivero‐Gutiérrez Reyes Gámez‐Belmonte María Dolores Suárez José Luis Lavín Ana María Aransay Mónica Olivares Olga Martínez‐Augustin Fermín Sánchez de Medina Antonio Zarzuelo 《Molecular nutrition & food research》2017,61(8)
We investigated the effect of a high fructose diet (HFD) on Sprague Dawley rats and the impact of a synbiotic composed of Lactobacillus fermentum CECT5716 and fructooligosaccharides. Feeding the HFD for 5 weeks resulted in liver steatosis and insulin resistance but not obesity. These changes were associated with increased production of short‐chain fatty acids and increased Bacteroidetes in feces, with an augmented Bacteroidetes/Firmicutes ratio, among other changes in the microbiota. In addition, barrier function was weakened, with increased LPS plasma levels. These data are consistent with increased fructose availability in the distal gut due to saturation of absorptive mechanisms, leading to dysbiosis, endotoxemia, hepatic steatosis, and insulin resistance. Treatment with the synbiotic prevented some of the pathological effects, so that treated rats did not develop steatosis or systemic inflammation, while dysbiosis and barrier function were greatly ameliorated. In addition, the synbiotic had hypolipidemic effects. The synbiotic composed by L. fermentum CECT5716 and fructooligosaccharides has beneficial effects in a model of metabolic syndrome induced by a HFD, suggesting it might be clinically useful in this type of condition, particularly considering that high fructose intake has been related to metabolic syndrome in humans. 相似文献
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N. Mahnine G. Meca A. Elabidi M. Fekhaoui A. Saoiabi G. Font J. Mañes A. Zinedine 《Food chemistry》2011
Sixty-eight samples of cereals products, including breakfast cereals (n = 48) and infant cereals (n = 20), purchased from supermarkets and pharmacies in Rabat-Salé area from Morocco were analysed for the determination of six emerging mycotoxins: four enniatins ENs (ENA, ENA1, ENB and ENB1), beauvericin (BEA) and fusaproliferin (FUS). Samples were extracted with a mixture of acetonitrile:water (85:15, v/v), using an Ultra-Turrax® homogeniser. Mycotoxins were then identified and quantified by liquid chromatography (LC) with diode array detection (DAD). Positive samples were confirmed by LC–MS/MS. 相似文献
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Adriana R. Schultz Moreira Juana Benedí Laura González-Torres Raul Olivero-David Sara Bastida Maria Isabel Sánchez-Reus María José González-Muñoz Francisco J. Sánchez-Muniz 《Food chemistry》2011
Meat and pork consumptions are very high in Spain. Seaweeds are rich in fibre, minerals, and bioactive substances. Due to the growing demand for healthier meats, this work studied the effect of diets containing restructured pork (RP) enriched with Himanthalia elongata (Sea Spaghetti) on: (1) cholesterolaemia; (2) liver cytochrome P450 7A1 (CYP7A1) expression; (3) liver antioxidant enzyme activities and gene expression; (4) the liver antioxidant substrate concentrations. Four groups of 10 Wistar rats each were fed a mix of 85% AIN-93 M rodent diet and 15% freeze-dried RM for 35 days. The control group (C) consumed control RP; the Sea Spaghetti (SS) group, RP with 5% Sea Spaghetti. Animals on added cholesterol diets (CholC and CholSS) consumed their basal C and SS diets enriched with cholesterol and cholic acid as hypercholesterolaemic agent. Food intake was significantly affected by the alga × cholesterol interaction and by dietary cholesterol (both p < 0.001). Plasma cholesterol was significantly affected by the cholesterol × alga interaction (p < 0.05). CholC rats showed significantly higher plasma cholesterol (p < 0.001) than did their C counterparts, whilst serum cholesterol of CholSS was significantly lower (p < 0.05) than that of CholC. The glutathione peroxide (GSSG) concentrations and all mRNA expressions were significantly affected by the cholesterol × alga interaction (at least p < 0.05). SS vs C group showed significant (at least p < 0.05) increases in superoxide dismutase (Mn-SOD and Cu,Zn-SOD), glutathione peroxidase (GPx) and decrease of glutathione reductase (GR) expressions, and increased GR activity, GSSG and the redox index. CholSS vs CholC showed significant (at least p < 0.05) increases of CYP7A1, GR and Cu,Zn-SOD expression but decreases in catalase, Mn-SOD and GPx expression, and increase of GR activity. In conclusion, Sea Spaghetti could be widely used in RP design. Its addition to non-cholesterol enriched RP diet reduced oxidation mechanisms. SS-RP partially blocked the effect of the hypercholesterolaemic agent, giving rise to a new balance of the antioxidant enzyme expression. 相似文献
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《Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment》2013,30(3):541-549
Animal feed can be contaminated with various mycotoxins. To ensure animal health and safe food and feed production, the European Commission has recommended increased monitoring of the co-occurrence of deoxynivalenol, zearalenone, ochratoxin A, fumonisin B1 and B2, T-2 and HT-2 toxin in feed. Thus, there is a need for an analytical method that enables their simultaneous detection and quantification. This paper describes the development and in-house validation of such a method, in which the mycotoxins were extracted from spiked and naturally contaminated cereal-based compound feed, corn and wheat. The extracts were divided into two aliquots where one was diluted and then analysed directly and the other was cleaned by using MultiSep®226 and then diluted and analysed. Separation and detection was achieved with LC-ESI-MS/MS by using a triple quadrupole instrument in the SRM mode. The precision (in terms of intra-day repeatability and inter-day reproducibility), accuracy, linearity, apparent recovery and expanded measurement uncertainty in feed, corn and wheat were evaluated. The LODs ranged from 1.0 to 72?μg/kg, and the LOQs ranged from 2.5 to 115?μg/kg. The apparent recovery was higher than 86% for all the mycotoxins, and the precision was better than that defined by the Horwitz equation for all concentrations. Proficiency test materials were analysed to assess the accuracy of the method, and the results were satisfactory for all seven mycotoxins. The method will be used to monitor the occurrence of these mycotoxins in products intended for animal feeding in Sweden. 相似文献