共查询到15条相似文献,搜索用时 7 毫秒
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Fatemeh Ostadhossein Indu Tripathi Lily Benig Denae LoBato Mahdieh Moghiseh Chiara Lowe Aamir Raja Anthony Butler Raj Panta Marzieh Anjomrouz Alex Chernoglazov Dipanjan Pan 《Advanced functional materials》2020,30(4)
The early detection of bone microdamages is crucial to make informed decisions about the therapy and taking precautionary treatments to avoid catastrophic fractures. Conventional computed tomography (CT) imaging faces obstacles in detecting bone microdamages due to the strong self‐attenuation of photons from bone and poor spatial resolution. Recent advances in CT technology as well as novel imaging probes can address this problem effectively. Herein, the bone microdamage imaging is demonstrated using ligand‐directed nanoparticles in conjunction with photon counting spectral CT. For the first time, Gram‐scale synthesis of hafnia (HfO2) nanoparticles is reported with surface modification by a chelator moiety. The feasibility of delineating these nanoparticles from bone and soft tissue of muscle is demonstrated with photon counting spectral CT equipped with advanced detector technology. The ex vivo and in vivo studies point to the accumulation of hafnia nanoparticles at microdamage site featuring distinct spectral signal. Due to their small sub‐5 nm size, hafnia nanoparticles are excreted through reticuloendothelial system organs without noticeable aggregation while not triggering any adverse side effects based on histological and liver enzyme function assessments. These preclinical studies highlight the potential of HfO2‐based nanoparticle contrast agents for skeletal system diseases due to their well‐placed K‐edge binding energy. 相似文献
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Cancer Nanotheranostics: Actively Targeted Deep Tissue Imaging and Photothermal‐Chemo Therapy of Breast Cancer by Antibody‐Functionalized Drug‐Loaded X‐Ray‐Responsive Bismuth Sulfide@Mesoporous Silica Core–Shell Nanoparticles (Adv. Funct. Mater. 5/2018) 下载免费PDF全文
Lihua Li Yao Lu Chunyan Jiang Ye Zhu Xianfeng Yang Xiaoming Hu Zefeng Lin Yu Zhang Mingying Peng Hong Xia Chuanbin Mao 《Advanced functional materials》2018,28(5)
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Catalysts: “Naked” Magnetically Recyclable Mesoporous Au–γ‐Fe2O3 Nanocrystal Clusters: A Highly Integrated Catalyst System (Adv. Funct. Mater. 9/2017) 下载免费PDF全文
Lu Shang Yunhui Liang Mengzhu Li Geoffrey I. N. Waterhouse Pei Tang Ding Ma Li‐Zhu Wu Chen‐Ho Tung Tierui Zhang 《Advanced functional materials》2017,27(9)
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