共查询到20条相似文献,搜索用时 15 毫秒
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Naresh Kuthala Raviraj Vankayala Chi‐Shiun Chiang Kuo Chu Hwang 《Advanced functional materials》2020,30(36)
Tumor hypoxia and chemoresistance are long‐lasting challenges in clinical cancer treatments resulting in treatment failures and low patient survival rates. Application of phototherapies to treat deep tissue‐buried tumors has been hampered by the lack of near infrared photosensitizers, and consumption of tissue oxygen, worsening the tumor hypoxia problem. Herein, an unprecedented theranostic lanthanum hexaboride‐based nanodrug is engineered to act as bimodal computed tomographic/magnetic resonance imaging contrast agents, absorb long near infrared (NIR) light in the biological window IIb (1500–1700 nm), generate hydroxyl radicals without using oxygen, and destroy drug‐resistant NCI‐H23 lung tumors completely, leading to an amazingly long average half‐life of 180 days, far exceeding than those of doxorubicin‐treated (21 days) and untreated mice groups (13 days). This work pioneers the field of photodynamic therapy in conquering hypoxia and chemodrug resistance problems for NIR‐IIb oxygen‐independent cancer treatments. 相似文献
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Cancer Therapy: Photo‐Induced Charge‐Variable Conjugated Polyelectrolyte Brushes Encapsulating Upconversion Nanoparticles for Promoted siRNA Release and Collaborative Photodynamic Therapy under NIR Light Irradiation (Adv. Funct. Mater. 44/2017) 下载免费PDF全文
Hui Zhao Wenbo Hu Hengheng Ma Rongcui Jiang Yufu Tang Yu Ji Xiaomei Lu Bing Hou Weixing Deng Wei Huang Quli Fan 《Advanced functional materials》2017,27(44)
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Cancer Therapy: Nucleus‐Targeting Gold Nanoclusters for Simultaneous In Vivo Fluorescence Imaging,Gene Delivery,and NIR‐Light Activated Photodynamic Therapy (Adv. Funct. Mater. 37/2015) 下载免费PDF全文
Raviraj Vankayala Chien‐Lin Kuo Karthik Nuthalapati Chi‐Shiun Chiang Kuo Chu Hwang 《Advanced functional materials》2015,25(37):5933-5933
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Photodynamic Therapy: Porous Porphyrin‐Based Organosilica Nanoparticles for NIR Two‐Photon Photodynamic Therapy and Gene Delivery in Zebrafish (Adv. Funct. Mater. 21/2018) 下载免费PDF全文
Chiara Mauriello Jimenez Dina Aggad Jonas G. Croissant Karen Tresfield Danielle Laurencin Dorothée Berthomieu Nicolas Cubedo Mireille Rossel Shahad Alsaiari Dalaver H. Anjum Rachid Sougrat Manuel A. Roldan‐Gutierrez Sébastien Richeter Erwan Oliviero Laurence Raehm Clarence Charnay Xavier Cattoën Sébastien Clément Michel Wong Chi Man Marie Maynadier Vincent Chaleix Vincent Sol Marcel Garcia Magali Gary‐Bobo Niveen M. Khashab Nadir Bettache Jean‐Olivier Durand 《Advanced functional materials》2018,28(21)
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Photodynamic Therapy: Highly Biocompatible Carbon Nanodots for Simultaneous Bioimaging and Targeted Photodynamic Therapy In Vitro and In Vivo (Adv. Funct. Mater. 37/2014) 下载免费PDF全文
Yuri Choi Seongchan Kim Myung‐Ho Choi Soo‐Ryoon Ryoo Jongnam Park Dal‐Hee Min Byeong‐Su Kim 《Advanced functional materials》2014,24(37):5774-5774
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Chao Wang Liang Cheng Yumeng Liu Xiaojing Wang Xinxing Ma Zhaoyi Deng Yonggang Li Zhuang Liu 《Advanced functional materials》2013,23(24):3018-3018
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Cancer Therapy: Programmed Multiresponsive Vesicles for Enhanced Tumor Penetration and Combination Therapy of Triple‐Negative Breast Cancer (Adv. Funct. Mater. 20/2017) 下载免费PDF全文
Fangyuan Zhou Bing Feng Tingting Wang Dangge Wang Qingshuo Meng Jianfeng Zeng Zhiwen Zhang Siling Wang Haijun Yu Yaping Li 《Advanced functional materials》2017,27(20)
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Sarah J. Leung Xenia M. Kachur Michael C. Bobnick Marek Romanowski 《Advanced functional materials》2011,21(6):1010-1010
Biodegradable, spectrally tunable plasmon resonant nanocapsules are created via the deposition of gold onto the surface of 100 nm diameter thermosensitive liposomes. These nanocapsules exhibit selective release of encapsulated contents upon illumination with light of a wavelength matching their distinct resonance bands. In this study, 760 and 1210 nm laser illumination elicits complete release from gold‐coated liposomes with a corresponding resonance, while causing minimal release from liposomes with an unmatching resonance. Spectrally selective release is accomplished through the use of multiple, low‐intensity laser pulses delivered over a period of minutes, ensuring that illumination affects the gold‐coated liposomes without heating the surrounding media. The use of pulsed illumination to achieve spectral selectivity is validated experimentally and through modeling of the heat equation. The result of this illumination scheme for selective release using multiple wavelengths of light is a biologically safe mechanism for realizing drug delivery, microfluidic, and sensor applications. 相似文献
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Theranostics: Theranostic Prodrug Vesicles for Reactive Oxygen Species‐Triggered Ultrafast Drug Release and Local‐Regional Therapy of Metastatic Triple‐Negative Breast Cancer (Adv. Funct. Mater. 46/2017) 下载免费PDF全文
Fangyuan Zhou Bing Feng Tingting Wang Dangge Wang Zhirui Cui Siling Wang Chunyong Ding Zhiwen Zhang Jian Liu Haijun Yu Yaping Li 《Advanced functional materials》2017,27(46)