Executive Functioning and Alcohol-Related Aggression.

The primary goal of this investigation was to determine whether executive functioning (EF) would moderate the alcohol-aggression relation. Participants were 310 (152 men and 158 women) healthy social drinkers between 21 and 35 years of age. EF as well as non-EF skills were measured with 13 validated neuropsychological tests. Following the consumption of either an alcoholic or a placebo beverage, participants were tested on a modified version of the Taylor Aggression Paradigm (S. Taylor, 1967), in which mild electric shocks were received from, and administered to, a fictitious opponent. Aggressive behavior was operationalized as the shock intensities administered to the fictitious opponent. EF was negatively related to aggressive behavior for men, regardless of beverage group, even when controlling for non-EF skills. Furthermore, alcohol increased aggression only for men with lower EF scores. Finally, the mere belief that alcohol was consumed suppressed aggression for women but not for men. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Men and women, alcohol and aggression.

The purpose of this study was to examine the acute effects of alcohol on aggressive behavior in men and women in a laboratory setting. Participants were 526 (261 men and 265 women) healthy social drinkers between 21 and 35 years of age. They were randomly assigned to either an alcohol or a placebo group. Aggression was measured using a modified version of the Taylor Aggression Paradigm in which electric shocks are received from, and delivered to, a same gender fictitious opponent during a supposed competitive interpersonal task. Aggression was operationalized as the intensity and duration of shocks that participants administered to their “opponent.” Overall, men were more aggressive than women. Alcohol increased aggression for both men and women but this effect was stronger for men. This is one of the first laboratory studies to demonstrate that alcohol increases aggression in women. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The biphasic effects of alcohol on human physical aggression.

The authors assessed the biphasic effects of alcohol on human physical aggression. Sixty male social drinkers were assigned to 1 of 4 groups: alcohol ascending limb (AAL), alcohol descending limb (ADL), or 1 of 2 sober control groups. Aggression was assessed in the AAL and ADL groups at respective ascending or descending blood alcohol concentrations (BAC) of 0.08%. Each participant in the control groups was respectively yoked with a participant in either the AAL or the ADL group to control for the longer period of time needed to reach a BAC of 0.08% on the descending limb compared with the ascending limb (i.e., passage of time effect). The authors measured aggression using a modified version of the Taylor aggression paradigm (S. Taylor, 1967), in which electric shocks are received from and administered to a fictitious opponent during a competitive task. The AAL group was more aggressive than the ADL group. There were no differences between the ADL group and the control groups, which suggests that alcohol does not appear to increase aggression on the descending limb. The control groups did not differ in aggression, thus ruling out a passage of time effect. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The role of women's alcohol consumption in evaluation of vulnerability to sexual aggression.

The authors examined the impact of alcohol consumption on women's risk perceptions and intended behaviors in a hypothetical situation in which the potential for establishing a relationship with an attractive man was coupled with the potential for sexual aggression. Fifty-nine single women, ages 21–29, were randomly assigned to 1 of 3 beverage conditions: (a) alcohol (dose sufficient to raise blood alcohol level to .08); (b) placebo, in which they were led to believe that they had consumed alcohol but had not; or (c) no alcohol, in which they neither expected nor received alcohol. Compared with women in the no–alcohol condition, women in the alcohol condition (a) rated the male character in the vignette more positively, (b) anticipated less risk and more benefit resulting from a series of behaviors likely to facilitate the relationship while increasing sexual vulnerability (e.g., engaging in consensual sexual activities), and (c) anticipated greater involvement in those behaviors. The placebo appeared to exert similar but weaker effects. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The moderating effects of dispositional empathy on alcohol-related aggression in men and women.

The author investigated the influence of dispositional empathy on alcohol-related aggression in men and women. Participants were 204 (111 men, 93 women) healthy social drinkers, 21-35 years old. Dispositional empathy was measured with the Interpersonal Reactivity Index. Following the consumption of either an alcoholic or a placebo beverage, participants were tested on a modified version of the Taylor Aggression Paradigm in which mild electric shocks were received from, and administered to, a fictitious opponent during a competitive task. Alcohol increased aggression for persons (particularly men) with lower, as opposed to higher, levels of empathy. Men with lower empathy levels exhibited the most aggression followed by men with higher empathy levels. Women displayed the least aggression regardless of their empathy levels. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A Comparison of Anticonvulsants in the Treatment of Impulsive Aggression.

This study compared the behavioral effects of 3 anticonvulsants in impulsive aggressive men. In a double-blind, placebo-controlled, parallel groups design, participants were randomly assigned to 1 of 4 6-week treatments: phenytoin (n = 7), carbamazepine (n = 7), valproate (n = 7), or placebo (n = 8). The efficacy measure was the average aggression score, a global severity index from the Overt Aggression Scale (J. M. Silver & S. C. Yudofsky, 1991). Analysis showed a significant reduction in impulsive aggression during all 3 anticonvulsant conditions compared with placebo. However, the treatment effect during carbamazepine administration was slightly delayed compared with phenytoin and valproate. These findings suggest that increased use of anticonvulsants could make a significant impact in the control of impulsive aggression in both mental health and criminal justice settings. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Executive functioning, irritability, and alcohol-related aggression.

The purpose of this investigation was to examine (a) whether irritability mediates the relation between executive functioning (EF) and alcohol-related aggression and (b) whether the alcohol-aggression relation is better explained by the interactive effects of EF and irritability above and beyond the effects of either variable alone. EF was measured using seven well-established neuropsychological tests. Irritability was assessed with the Caprara Irritability Scale. Participants were 313 male and female social drinkers between 21 and 35 years of age. Following the consumption of an alcohol or a placebo beverage, participants were tested on a laboratory aggression task in which electric shocks were given to and received from a fictitious opponent under the guise of a competitive reaction-time task. Aggression was operationalized as the shock intensities administered to the fictitious opponent. Results indicated that irritability successfully mediated the relation between EF and intoxicated aggression for men only. Despite the fact that irritability and EF both independently moderated the alcohol-aggression relation in previous studies, no significant interaction for their combined effect was detected here. The findings are discussed, in part, within a cognitive neoassociationistic framework for aggressive behavior. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Agreeableness and alcohol-related aggression: The mediating effect of trait aggressivity.

This study investigated the mediating effect of trait aggressivity on the relation between agreeableness and alcohol-related aggression in a laboratory setting. Participants were 116 healthy male social drinkers between 21 and 30 years of age. Agreeableness and trait aggressivity were measured using the Big Five Inventory and the Buss-Perry Aggression Questionnaire, respectively. Following the consumption of an alcohol or no-alcohol control beverage, participants completed a modified version of the Taylor Aggression Paradigm, in which electric shocks were received from and administered to a fictitious opponent during a competitive task. Aggression was operationalized as the proportion of the most extreme shocks delivered to the fictitious opponent under conditions of low and high provocation. Results indicated that lower levels of agreeableness were associated with higher levels of trait aggressivity. In turn, higher levels of trait aggressivity predicted extreme aggression in intoxicated, but not sober, participants under low, but not high, provocation. Findings highlight the importance of examining determinants of intoxicated aggression within a broader theoretical framework of personality. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The effects of triazolam on aggression in men.

To assess the effects of triazolam on human aggression, 46 male participants received either placebo or 0.25 mg triazolam using double-blind procedures. Approximately 60 min after drug ingestion, participants were given the opportunity to administer electric shocks to an increasingly provocative fictitious opponent during a competitive reaction time task. Aggression was defined as the level of shock the participant was willing to administer to the opponent. The results suggest that triazolam consumption was associated with increased levels of aggression. On average, participants who received triazolam set more intense levels of shock for the opponent, and selected the most extreme shock response available more frequently, than participants who received placebo. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Attribution and alcohol-mediated aggression.

48 males participated in an aggression task after receiving either alcoholic or placebo beverages and after being told that they had received either a high or a low dose of alcohol. All Ss in the alcohol group actually received the same dose. Measures of aggression were the intensity and duration of shock given to a bogus partner in a RT-pain perception task and a score on a posttask attitude questionnaire. Blood alcohol readings were taken 3 times during the session, and a locus of control scale was administered before and after drinking. For Ss in the alcohol conditions, blood alcohol levels averaged .079% before the task and .085% afterwards. Alcohol resulted in higher aggression scores only on the questionnaire measure, and an interaction between drug and attribution was found for the measure of shock duration. Attribution alone resulted in greater aggression on the measure of shock intensity. Ss in groups where the attribution was discrepant with the drug condition were the most aggressive on the measures of shock intensity and duration. These Ss became more external, reflecting a high correlation between their aggression and a stimulus tone. Results suggest that a person's increased aggressiveness when intoxicated results from an interaction between alcohol and an altered responsivity to provoking stimuli. (37 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Alcohol's Effect on Triggered Displaced Aggression.

The authors examined alcohol's effect on triggered displaced aggression, the hostile reaction to a second provoking person after provocation from a first. Participants consumed an alcoholic or a nonalcoholic beverage. Subsequently, one individual provoked all of them with moderate intensity. Then, 2 groups were studied: those who received or who failed to receive a second provocation of minimal intensity. Consistent with prior research, participants who received a second, minimal provocation displayed more aggression than those who did not. After participants drank alcohol, the magnitude of this difference was significantly greater, indicating that alcohol increases triggered displaced aggression. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effects of Transdermal Nicotine During Imaginal Exposure to Anxiety and Smoking Cues in College Smokers.

In a 2 (patch) × 2 (smoking) × 2 (anxiety) mixed design, 52 undergraduate smokers randomly received a nicotine (21 mg) or placebo patch. After a 4-hr nicotine absorption/deprivation period, participants imagined several scenarios varying in cue content: (a) anxiety plus smoking, (b) anxiety, (c) smoking, and (d) neutral. Although smoking urge increased in both the nicotine and placebo conditions after the absorption/deprivation period, those who received the placebo reported significantly greater urge. During the cue reactivity trials, a significant Patch × Smoking × Anxiety interaction effect was observed for urge. However, participants who received nicotine still experienced moderate urges, indicating that nicotine did not attenuate cue-elicited urge. Transdermal nicotine did not diminish anxiety during the absorption/deprivation period or in response to the cues. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Primary structure of apolipophorin-III from the greater wax moth, Galleria mellonella

BACKGROUND: Neurobiological research has implicated the dopamine and serotonin systems in the pathogenesis of autism. Open-label reports suggest that the serotonin2A-dopamine D2 antagonist risperidone may be safe and effective in reducing the interfering symptoms of patients with autism. METHODS: Thirty-one adults (age [mean+/-SD], 28.1+/-7.3 years) with autistic disorder (n=17) or pervasive developmental disorder not otherwise specified (n=14) participated in a 12-week double-blind, placebo-controlled trial of risperidone. Patients treated with placebo subsequently received a 12-week open-label trial of risperidone. RESULTS: For persons completing the study, 8 (57%) of 14 patients treated with risperidone were categorized as responders (daily dose [mean+/-SD], 2.9+/-1.4 mg) compared with none of 16 in the placebo group (P<.002). Risperidone was superior to placebo in reducing repetitive behavior (P<.001), aggression (P<.001), anxiety or nervousness (P<.02), depression (P<.03), irritability (P<.01), and the overall behavioral symptoms of autism (P<.02). Objective, measurable change in social behavior and language did not occur. Nine (60%) of 15 patients who received treatment with open-label risperidone following the double-blind placebo phase responded. Other than mild, transient sedation, risperidone was well tolerated, with no evidence of extrapyramidal effects, cardiac events, or seizures. CONCLUSION: Risperidone is more effective than placebo in the short-term treatment of symptoms of autism in adults.     

Differences in alcohol expectancy between aggressive and nonaggressive social drinkers

Previous reports have shown that drinkers with aggressive personalities not only hold the strongest beliefs that alcohol facilitates aggressive behavior, but they also display the greatest increases in laboratory aggression after receiving alcohol. Given that several studies have demonstrated that a portion of the behavioral and subjective effects of alcohol are due to psychological expectancy, this study explored whether aggressive drinkers have elevated intoxication expectancies from laboratory beverages with unknown alcohol content. The rates of aggressive responses emitted in a money subtraction aggression model under baseline conditions were used to select an aggressive group and a nonaggressive group, each with five male and five female participants. Subjects then ingested and rated each of three placebo (1 ml alcohol) beverages administered hourly during a subsequent laboratory visit, and rated a series of three 0.35 g/kg of alcohol beverages the following day. Whereas nonaggressive subjects clearly discriminated the relative alcohol content of alcohol and placebo drinks, aggressive subjects gave progressively elevated shot equivalent ratings to placebo drinks, similar to their ratings of alcohol doses. However, despite similar self-reported drinking histories, aggressive subjects reported anticipating only half the intoxication from the alcohol doses (and in fact achieved a lower peak breath alcohol concentration) than was expected by nonaggressive subjects.     

Self-efficacy change as a mediator of associations between therapeutic bond and one-year outcomes in treatments for alcohol dependence.

Empirically-supported treatments for alcohol dependence exist, yet understanding of influences contributing to the intended behavior change is limited. The current study, a secondary analysis of the recent multisite COMBINE trial (The COMBINE Study Research Group, 2003), tested a mediational model wherein change in client self-efficacy for abstinence was examined as a potential mediator of associations between client report of the therapeutic bond and one-year outcomes of drinking frequency, drinking consequences, and psychiatric functioning. For analyses, the 1383 COMBINE trial participants were grouped as follows: 1) those receiving study medications (naltrexone, acamprosate, naltrexone + acamprosate, placebo) and enrolled in medication management (MM) only (n = 607), 2) those receiving study medications/MM and also enrolled in a combination behavioral intervention (CBI) as well (n = 619), and 3) those enrolled in CBI only (n = 157). Mediation analyses using the product-of-coefficients approach indicated self-efficacy change during treatment significantly mediated associations between the therapeutic bond with the CBI therapist and each of the three one-year outcomes among those exclusively receiving CBI, but failed to do so among those receiving pills/MM (with or without CBI). Effect sizes were small, but indicated that variance in bond-outcome associations was partially mediated by self-efficacy change for trial participants. Findings advance understanding of proximal client change processes during delivery of treatments for alcohol dependence. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Alcohol and depression: Effects on mood and biased processing of self-relevant information.

Alcohol's effects on mood and processing of self-relevant information were studied in a sample of 57 college students (39 men and 18 women). Participants were blocked on level of depression and were randomly assigned to alcohol or placebo conditions. After beverage consumption, participants processed trait adjectives under self-relevant and semantic-processing instructions. Results showed that biased processing of depressed content adjectives by depressed participants under placebo conditions was reversed after consuming alcohol. Further, reduced recall of depressed-content, self-relevant information after alcohol consumption was significantly related to alcohol-enhanced mood in depressed participants. Results are discussed in relation to mechanisms of reinforcement that may link the coexistence of alcohol abuse and affective disorders. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Psychomotor performance under alcohol and under caffeine: Expectancy and pharmacological effects.

Tested the hypothesis that Ss' expectancies about drug effects on psychomotor performance would predict their responses to drug and placebo. 40 male undergraduates were assigned to 1 of 5 treatments: alcohol (0.56 g/kg), placebo alcohol, caffeine (2.93 mg/kg), placebo caffeine, or no treatment. Groups received preliminary training on a pursuit rotor task before rating the effect that caffeine or alcohol was expected to have on their performance. Ss' performance was measured under the treatments and showed impairment under alcohol and improvement under caffeine. However, regardless of whether they received a drug or placebo, those who expected the most impairment performed the most poorly. Results indicate the importance of expectancies in understanding individual differences in response to drugs and placebos. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The occurrence of partner physical aggression on days of alcohol consumption: A longitudinal diary study.

The likelihood of partner physical aggression on days of male partners' alcohol consumption, during a 15-month period, was examined for men entering a domestic violence treatment program (n=137) and domestically violent men entering an alcoholism treatment program (n=135). For men entering the domestic violence treatment program (alcoholism treatment program odds in parentheses), the odds of any male-to-female physical aggression were more than 8 times (11 times) higher on days when men drank than on days of no alcohol consumption. The odds of severe male-to-female physical aggression were more than 11 times (11 times) higher on days of men's drinking than on days of no drinking. These findings support the proximal effect model of alcohol use and partner violence. (PsycINFO Database Record (c) 2010 APA, all rights reserved)