Why are most drowning victims men? Sex differences in aquatic skills and behaviors

Two biopsy cases of elastofibroma--one unilateral and one bilateral--are described. A study of 100 autopsies revealed 13 elderly patients with elastofibroma. Males (n = 10; 16.9%) were more affected than females (n = 3; 7.3%). Pre-elastofibroma-like morphological changes (e.g. few or many degenerated elastic fibres) were observed in 81% of the autopsies. Minor pre-elastofibroma-like changes were seen in males and major changes predominantly in females. In addition to physiological ageing as yet unknown factors, rather than abnormal elastogenesis or degeneration, seem to be involved in this pseudotumour.     

Ontogeny of suckling in rats: Transitions toward adult ingestion.

Studied the suckling behavior of neonatal Sprague-Dawley rats on their own anesthetized mother from the day of birth until after weaning (35 days). Even newborn Ss were capable of nipple attachment without maternal assistance. Before 11–23 days of age, pups deprived of suckling for 22 hrs and nondeprived pups quickly attached to their mother's nipples, sucked, and remained attached to the nipple though no milk delivery occurred. Then behavior underwent at least 3 changes: (a) After 11–23 days of age, latency to attach became considerably elevated in nondeprived pups; (b) a 2nd change in latency occurred at 23–25 days of age, when nondeprived pups no longer even attached to the nipples of anesthetized mothers; and (c) about 14 days of age, deprived pups began to shift from 1 nipple to the next after initial attachment. These developmental changes were seen in other test situations in which pups were placed directly on a nipple and not required to search and when various periods of deprivation were utilized. These transitions were not critically dependent on the onset of visual function or on the pup's experience with food other than mother's milk. Suckling, therefore, in not an unmodified reflex but is an appetitive behavior that undergoes a series of changes during development. These transitions constitute major developmental events in the ontogeny of rat ingestive behavior. (48 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Hepatitis B injury, male gender, aflatoxin, and p53 expression each contribute to hepatocarcinogenesis in transgenic mice

The major risk factors for human liver cancer: hepatitis B virus (HBV) related liver injury, male gender, aflatoxin exposure, and p53 expression, are evaluated and compared in experimental transgenic mouse models. Transgenic mice that express hepatitis B surface antigen (HBsAg) in their liver and develop liver tumors at 18 months of age (HBV+ mice) were bred to p53 null mice (p53-/-) to produce mice p53+/-, HBV+ mice. These mice and control littermates ([p53+/+, HBV+], [p53+/-, HBV-], and [p53+/+, HBV-) were divided into groups that did or did not receive an injection of aflatoxin at 1 week of age. At sacrifice at 13 months of age, 100% (7/7) of male mice with each of the three risk factors (p53+/-, HBV+, AFB1+) developed high-grade hepatocellular carcinomas (HCC). If any one of the risk factors was absent, the incidence drops: if both p53 alleles are present, 62% (10/16); if HBsAg is not expressed, 14% (1/7); if AFB1 is not given, 25% (2/8). If only one of the risk factors is present no tumors above grade I are found. Similar results were observed in female mice except that HCC incidence in each group is less than in male mice. Some of the tumors in mice with more than one risk factor are of unusual histological types, such as hepatocholangio-carcinomas, adenocarcinomas and undifferentiated carcinomas that are not usually seen in HBV transgenic C57BL/6 mice. No loss or mutation of the p53 gene is detected in any of the tumors. Possibilities of how the four major risk factors for HCC interact to produce malignant liver tumors in these transgenic mouse models of hepatocarcinogenesis are discussed.     

Some psychosocial consequences of a change to a replacement birthrate in the United States.

Considers that a change to a replacement birthrate and a stable population would include changes in the population age distribution. Estimates of such age distribution changes were used to estimate changes in several psychological characteristics of the US population, including average abilities, personality patterns, and incidence of important life transitions. Results indicate that these age distribution changes alone would produce no major changes in the average psychological characteristics. Age distribution-related psychological changes do not appear to pose any serious objection to a replacement birthrate in the US. (22 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The ageing entero-insular axis

Ageing is one of the major risk factors for glucose intolerance including impaired glucose tolerance and Type II (non-insulin-dependent) diabetes mellitus. Reduced insulin secretion has been described as part of normal ageing although there is no information on age-related changes in the secretion of the major insulinotropic hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide (7-36 amide) (GLP-1). We assessed the entero-insular axis in 6 young premenopausal and 6 older postmenopausal women following treatment with oral carbohydrate. Insulin and glucose integrated responses were similar in the younger and older groups. Total integrated responses for GIP and GLP-1 were considerably greater in the older subjects. A positive correlation between age and total integrated responses for glucose (r = 0.65; p < 0.02) as well as GLP-1 (r = 0.85; p < 0.001) was seen. We hypothesise that an age-related impairment of insulin secretion to insulinotropic hormones, GIP and GLP-1, contributes to a reduction in glucose tolerance in this age group. The pronounced compensatory increase in postprandial secretion of GIP and GLP-1 provides further evidence not only for the negative feedback relation between incretin and insulin secretion but also for the importance of the entero-insular axis in the regulation of insulin secretion.     

Ischaemic disease in men and women with familial hypercholesterolaemia and xanthomatosis. A comparative study of genetic and environmental factors in 274 heterozygous cases

The incidence of ischaemic diseases in familial hypercholesterolaemia and xanthomatosis (familial Type II) was studied in a group of 158 men and 116 women. (1) Men and women did not differ with regard to the inherited metabolic disease. Levels of serum cholesterol, the marker of the genetic defect, were not statistically different, and cholesterol deposition in tissues, visualized by skin tendon xanthomas, was not sex related. (2) Men and women were different with regard to ischaemic diseases. The incidence was much lower in women, and the mean age of onset 9 years later. Moreover, there was a sex difference in the nature of the ischaemic disease, with a high male predominance of myocardial infarction. (3) Since the major risk factor hypercholesterolaemia could not explain such a difference, the role of other risk factors was investigated. It was shown that the incidence of ischaemic diseases was increased in women by cigarette smoking and hypertension, and that the difference in age of onset between males and females was no longer seen in smoking women. It is suggested that the genetic factor is responsible for the atherosclerotic lesion in both sexes and that other factors playing a role in ischaemic complications including tobacco and hypertension may explain the difference between men and women.     

Changes in choroidal innervation in Royal College of Surgeons rats with hereditary retinal degeneration

In Royal College of Surgeons (RCS) rats with hereditary retinal degeneration loss of retinal pigmented epithelium (RPE) and choriocapillaris is most pronounced in the upper-temporal quadrant. To investigate whether changes in choroidal vasodilative innervation might be involved in the RPE degeneration, we analyzed whole mount preparations of the retina and choroid stained for nitric oxide synthase and for NADPH-diaphorase (d) of 19 dystrophic RCS rats and 24 age-matched congenic controls of different age groups. Density of NADPH-d-positive nerve fibers was quantitatively evaluated in the upper-temporal and lower-nasal quadrant. Our results revealed that even in control animals there were much less positively stained nerve fibers in the upper-temporal than in the lower-nasal quadrant. Nerve fiber density in both quadrants increased for up to 3 months and remained nearly constant throughout life. In the dystrophic animals up to 3 months of age nerve fiber density was similar to that seen in the controls. In dystrophic animals older than 3 months nerve fiber density in the upper-temporal quadrant decreased significantly, whereas density in the lower-nasal quadrant revealed nearly the same values as in the age-matched controls. Decrease of NADPH-d stained nerve fibers in this quadrant occurred prior to the vascular changes in the choriocapillaris. In the retina of RCS dystrophic rats an increase of NADPH-d-positive amacrine cells was found only in 3-month-old animals. Most of these cells were located in the vicinity of irregularly arranged branches of the central retinal artery. In animals 5 months of age and older the number of cells decreased to the same values found in controls, so that we assume that increase of NADPH-d-positive amacrine cells is involved in capillary degeneration or sprouting.     

Cardiovascular changes in a group of patients with heredoataxia. Clinical, electrocardiographic and echocardiographic findings

INTRODUCTION: Heredoataxias form a group of degenerative diseases of the nervous system, which are progressive and hand sound in particular families. MATERIAL AND METHODS: Between August 1994 and September 1995. 14 patients diagnosed as having heredoataxia were studied after admission to our hospital. Eight of these had Friedrich's ataxia (group A) and 6 had other types of ataxia (group B). A standard set of investigations were done, including clinical examination, laboratory tests (such as glycaemia and a lipidogram) to evaluate coronary risk factors. A 12 lead electrocardiogram and bidimensional and m mode echocardiogram were also done to detect disorders of conduction, changes in morphology and cardiac function, together with functional cardiovascular and neurological scales. The patients studied were between 14 and 41 years of age. RESULTS: The most frequent cardiovascular symptom was dyspnoea of effort. Changes on the electrocardiogram were seen in 92% of the patients, mainly from Group A (100%) and were due to alterations of ventricular repolarization and non-specific alterations of conduction and of rhythm. Echocardiogram changes were found in 42.8% of the patients, most frequently due to an increase in the myocardial mass of the left ventricle. CONCLUSIONS: Close correlation between age of onset and duration of the illness, and functional cardiovascular impairment was only seen in patients of Group A, in whom there was an earlier onset of the condition.     

The timing of psychosocial changes in women's lives: The years 25 to 45.

60 30–45 yr old women participated in a retrospective interview concerning psychosocial changes in their adult lives. Ss' responses provided self-report data concerning specific psychosocial changes, and 3 judges who read the interview protocols provided independent ratings of major psychosocial transitions. The distributions of self-reported changes and rated transitions across both age and family cycle phases were examined statistically. Rated transitions were reliably related to age but not to family cycle phase. Specifically, 78% of the Ss manifested a major transition commencing between ages 27 and 30 yrs. That transition was characterized initially by personal disruption, followed by reassessment, and finally by increased psychological well-being. Both age and family cycle phase were reliably related to self-reported changes such as geographic moves, career commitments, and childrearing responsibilities. Implications for conceptions of adult developmental changes are discussed. (64 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Renal protective effects of efonidipine in partially nephrectomized spontaneously hypertensive rats

The influence of the internal features (eyes, nose, and mouth) in the age processing of unfamiliar faces was examined. Younger and older versions of the faces of six individuals (covering three different age ranges, from infancy to maturity) were used as donor stimuli. For each individual in turn, the effects on age estimates of placing older features in the younger face version (or vice versa) were investigated. Age estimates were heavily influenced by the age of the internal facial features. Experiment 2 replicated these effects with a larger number of faces within a narrower age range (after growth is complete and before major skin changes have occurred). Taken together, these two experiments show that the internal facial features may be influential in conveying age information to the perceiver. However, the mechanisms by which features exert their influence remain difficult to determine: although age estimates might be based on local information from the features themselves, an alternative possibility is that featural changes indirectly influence age estimates by altering the global three-dimensional shape of the head.     

Latent variable analyses of age trends of cognition in the Health and Retirement Study, 1992-2004.

The present study was conducted to better describe age trends in cognition among older adults in the longitudinal Health and Retirement Study (HRS) from 1992 to 2004 (N = 17,000). The authors used contemporary latent variable models to organize this information in terms of both cross-sectional and longitudinal inferences about age and cognition. Common factor analysis results yielded evidence for at least 2 common factors, labeled Episodic Memory and Mental Status, largely separable from vocabulary. Latent path models with these common factors were based on demographic characteristics. Multilevel models of factorial invariance over age indicated that at least 2 common factors were needed. Latent curve models of episodic memory were based on age at testing and showed substantial age differences and age changes, including impacts due to retesting as well as several time-invariant and time-varying predictors. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Risk factors in learning difficulties

OBJECTIVE: To review the literature of the risk factors in learning difficulties (LD) and to assess these factors in children diagnosed as having LD in the Neuropaediatric Department of the Hospital Universitario Infantil La Fe in Valencia, in 1996 and 1997. MATERIAL AND METHODS: A retrospective study was done of children diagnosed in the Hospital Infantil Universitario La Fe in Valencia as having learning difficulties. The different factors related to LD were assessed. RESULTS: Between 1 January 1996 and 31 December 1997 a total of 32 children were diagnosed as having learning difficulties. There were 62.5% boys and 37.5% girls of an average age of 10 years and 10 months. The average intelligence quotient was 82.1. The commonest LD was difficulty with reading and writing. CONCLUSION: Learning difficulties form a large proportion of the routine pathology seen in the Neuropaediatric Department. It must be remembered that in most children with learning difficulties there is undiagnosed underlying neurological pathology which becomes noticeable on reaching an age at which schooling becomes more demanding.     

An ultrathin frozen section is suitable for demonstrating cytochrome c oxidase activity at electron microscopic level

Multiple factors influence the outcome of in vitro fertilisation and embryo transfer (IVF-ET). In our prospective study different factors have been subject of examination concerning their effect on the outcome of in vitro fertilisation and embryo transfer. 1237 couples undergoing 1675 consecutive treatment cycles between 1.1.1990-31.12.1991 were included in this study. Prior to treatment, couples were divided into "good" and "poor" prognosis groups. Cycles were prospectively labelled as carrying a potentially "poor prognosis", if one or more of the following factors were noted: 1) female age > 35; 2) an existence of male factor; 3) couples with more than 3 previous unsuccessful treatment cycles. Couples with none of these factors were assigned to the "good" prognosis group. The pregnancy rate per cycle in the "poor" prognosis group was 5.96%, compared with 17.92% per cycle in the "good" prognosis group (p < 0.001). The most important factors determining pregnancy rates were female age and male factor, and we observed that the rate of pregnancy declined after the third treatment cycle. An explanation may be seen in lower fertilisation rates after the age of 35 and cases of poor semen quality. Both will result in poor embryo quality.     

Endocrine syndromes in schizophrenia in the light of pathologoanatomic studies

A study of the endocrine profile (all glands of endocrine secretion) in 33 cases of schizophrenia, where the autopsy was performed not later than 6 hours after death, permitted the author to distinguish 4 syndromes: normal functional activity (24%), hypofunction (30%), the stress-syndrome (33%) and dysfunction (12%). It is stressed that their formation is effected by several factors: the age of the patient, duration of illness, medication, cause of death, etc. The found changes in the glands are less severe in comparison to the previously described changes seen in senile dementia. These changes are considered in the aspect of pathomorphosis of schizophrenia.     

Use of the deaf in language studies: A reply to Furth.

Furth, in a recent review (see: 39: 3964), concludes that studies of the deaf indicate that intellectual development proceeds independently of the acquisition of language. In this paper several issues were seen as limiting the premature acceptance of this conclusion. Among these were: (a) the deaf, through special training from 3 yr of age, often possess a verbal system; (b) the conclusion in the review can never be disproven, since any deficient performance by the deaf can almost always be attributed to numerous environmental factors rather than a language handicap; and (c) many tasks were arbitrarily assumed to require symbolic activity without recognizing that this assumption is still open to investigation. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Relationship between cognitive style and cognitive development: A 2-year longitudinal study.

Examined developmental changes in the relationship between reflection–impulsivity, spatial perspective taking, and conservation behavior in 40 4–8 yr olds. Ss were administered the Matching Familiar Figures Test. Results indicate no relationship between these variables for 4-yr-olds. At 6 and 8 yrs of age, however, moderately strong negative correlations were found between impulsivity and the expression of operative knowledge. Structural regression analyses suggested that the expression of a reflective cognitive style at 6 yrs of age was causally linked to the emergence of operativity at 8 yrs of age. Longitudinal data confirmed a developmental shift from what is seen in perspective-taking tasks to how it is seen. Discussion focuses on the role of cognitive styles in the development and use of cognitive structures and on the nature of perspective-taking development. (36 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Continuities and changes in emotion expressions during brief separation at 13 and 18 months.

16 children were videotaped at 13 and 18 mo of age during the strange-situation procedure (M. D. Ainsworth et al, 1978). Facial expressions (interest, anger, sadness, and emotion blends) during the 2nd separation episode were coded using a system for identifying affect expressions by holistic judgments (Affex) developed by the 2nd author and colleagues (1980). Results show significant continuities in proportion of interest expressions, anger, emotion blends and frequency of expression changes. The major developmental change was seen in an age?×?emotion interaction, showing an increase in the use of facial expression blends or combinations from 13 to 18 mo. Results support the belief that patterns of emotion reflect early, persistent individual differences; they also reflect a developmental trend toward increasing complexity of emotional responses. (16 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Factors influencing word naming in younger and older adults.

The present study examined age differences in the influence of 3 factors that previous research has shown to influence word-naming performance. The influence of word frequency, orthographic length, and orthographic neighborhood measures was examined using large-scale regression analyses on the naming latencies for 2,820 words. Thirty-one younger adults and 29 older adults named all of these words, and age differences in the influence of these factors were examined. The results revealed that all 3 factors predicted reliable amounts of variance in word-naming latencies for both groups. However, older adults showed a larger influence of word frequency and reduced influences of orthographic length and orthographic neighborhood density compared with younger adults. Overall, these results suggest that lexical level factors increase in influence in older adults whereas sublexical factors decrease in influence. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Analysis of fMRI time-series revisited--again

M-mode echocardiography was used to examine in male subjects the physical properties of the ascending aorta, 3 cm above the valvular plane. Subjects were divided into three groups based on age, lifestyle and presence or absence of vascular disease: Group A (10 recruited military young men, age 20.87 +/- 0.834 years) in good health; Group B (14 senior competitive athletes, age 49.92 +/- 8.17 years); Group C (10 patients with effort-angina, age 53.1 +/- 11.18 years). We observed that: the inner diastolic diameter of the ascending aorta was different between Group A and B (p < 0.001) and between Group A and C (p < 0.001), and it increased with aging (r = 0.7) whereas no relationship to body surface was seen (r = 0.3); the elasticity-stiffness parameters (aortic wall distensibility, aortic wall stress, wall stiffness index, wall elasticity index and modulus) of major vessels in senior athletes (Group B), were not different (p > 0.05) from military young men (Group A), although they were significantly lower (p < 0.001) in Group C patients; wall elasticity was lower in Group C patients (versus both Group A and B). Altered compliance might be the consequence of vessel structural changes and may contribute to reduce blood flow to the coronary arteries. Our data suggest that sports activity has beneficial effects; physical characteristics of great vessels do not show age-related changes.     

Adolescents' Performance on the Iowa Gambling Task: Implications for the Development of Decision Making and Ventromedial Prefrontal Cortex.

Healthy adolescents (79 girls, 66 boys), ages 9-17, completed the Iowa Gambling Task (IGT; A. Bechara, A. R. Damasio, H. Damasio, & S. W. Anderson, 1994) as well as working memory (digit span) and behavioral inhibition (go/no-go) tasks. Cross-sectional age-related changes were seen on all 3 tasks. Gender differences were seen in IGT deck preference and attentional variables (i.e., go/no-go hit rate and forward digit span). After age, gender, and general intellectual abilities were controlled for, IGT performance was not predicted by working memory or behavioral inhibition scores. Findings suggest that the ventromedial prefrontal cortex or its connections are functionally maturing during adolescence in a manner that can be distinguished from maturation of other prefrontal regions. Development of these functions may continue into young adulthood. (PsycINFO Database Record (c) 2010 APA, all rights reserved)