Frequent hypomethylation in Wilms tumors of pericentromeric DNA in chromosomes 1 and 16

RATIONALE AND OBJECTIVES: The purpose of this study was to test the effectiveness of resident-prepared, independent learning cases in teaching residents chest radiology. MATERIALS AND METHODS: Three 2nd-year residents (one each from the University of Wisconsin, the Oregon Health Sciences University, and the University of Michigan) prepared four chest radiology teaching cases each (total, 12 cases). Radiology residents from each institution were randomly divided into control (n = 30) and experimental (n = 35) groups. Residents from both groups took a pretest of 36 multiple-choice questions covering the material from the 12 teaching cases. Residents in the experimental group reviewed these cases independently, and both groups took the same test (posttest) immediately after the teaching cases had been reviewed and again 3 months later (final test). RESULTS: Test scores were similar across institutions (P > .05) but differed across time and treatment groups (experimental vs control) (P < .0001). Mean differences in test scores between the experimental and control groups at pretest, posttest, and final test were -0.4, +9.0, +4.0, respectively, demonstrating increased performance at posttesting that was still present (though somewhat attenuated) 3 months later at final testing. CONCLUSION: Independent study of resident-prepared chest radiology teaching cases increases the resident's knowledge for as long as 3 months after instruction.     

Mental rotation: Cross-task training and generalization.

It is well established that performance on standard mental rotation tasks improves with training (Peters et al., 1995), but thus far there is little consensus regarding the degree of transfer to other tasks which also involve mental rotation. In Experiment 1, we assessed the effect of mental rotation training on participants' Mental Rotation Test (MRT) scores. Twenty-eight participants were randomly assigned to one of three groups: a “One-Day Training,” “Spaced Training,” or “No Training” group. Participants who received training achieved higher scores on the MRT, an advantage that was still evident after 1 week. Distribution of training did not affect performance. Experiment 2 assessed generalization of mental rotation training to a more complex mental rotation task, laparoscopic surgery. Laparoscopic surgical skills were assessed using Fundamentals of Laparoscopic Surgery (FLS) tasks. Thirty-four participants were randomly assigned to a “Full Mental Rotation Training, MRT and FLS,” “MRT and FLS,” or “FLS-only” group. MRT results from Experiment 1 were replicated and mental rotation training was found to elicit higher scores on the MRT. Further, mental rotation training was found to generalize to certain laparoscopic surgical tasks. Participants who obtained mental rotation training performed significantly better on mental-rotation dependent surgical tasks than participants who did not receive training. Therefore, surgical training programs can use simple computer or paper-based mental rotation training instead of more expensive materials to enhance certain aspects of surgical performance of trainees. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Extraction treatment of a Class II, Division 1 malocclusion with anterior open bite with headgear and vertical elastics

Needlestick injuries, which lead to the transmission of hepatitis B, hepatitis C, and the AIDS virus, are a potentially serious threat to students during their clinical experiences. Exposure to infectious diseases, blood, and hazardous body fluids is one of the most frequently reported injury events by medical students at a health science center in the southwestern region of the United States. This study was conducted to determine the effectiveness of a customized intervention about infection control for second-year medical students (N = 200). Preparation for the intervention included a needs assessment, which included both qualitative and quantitative research methods that incorporated input from fourth-year medical students, medical staff members, and local hospital infection control specialists. The intervention included a pretest, a lecture, a demonstration of standard precautions and infection control procedure with 2 clinical scenarios, an exercise on proper handwashing, and a posttest. The evaluation of the intervention demonstrated a significant increase in posttest knowledge scores about infection control (from 12.6 +/- 2.1 pretest to 16.5 +/- 1.8 posttest, P < .001). Medical students showed a significant knowledge increase about infection control after participating in the intervention . Thus we recommend that all medical colleges and universities develop and evaluate a similar customized intervention for their medical students.     

A consciousness-sampling analysis of test anxiety and performance.

To evaluate cognitive-interference, reassertion, and reaction-to-performance models of test anxiety, 82 university students completed the Test Anxiety Scale, provided state measures of anxiety just before and after a course examination, described their preparation for the test, and reported thought content and state anxiety up to 6 times during the test. Test Anxiety Scale scores were predictive of pre- and posttest state anxiety but not performance or problem-solving thought frequency during the test. Thought content was significantly but weakly correlated with performance, which was well correlated with posttest state anxiety but not with pretest anxiety. Pretest state anxiety was virtually uncorrelated with posttest state anxiety, with the correlations gradually declining during the test. Question-answering thought content correlated inversely with anxiety during the test. There was no group for whom anxiety appeared to facilitate performance. Preparation correlated only with performance. Results appear inconsistent with a cognitive-interference interpretation of test anxiety and suggest that, in the naturalistic setting used, anxiety is more clearly an effect than a cause of poor performance. (39 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A comparison of preschool curricula for disadvantaged children: A Canadian study.

The effects of a Piaget-based preschool curriculum for disadvantaged Canadian children ( N = 35) were compared with the effects of both a traditional program ( N = 18) and a no-treatment condition ( N = 18). Gain scores from pre- to posttest revealed significant differences between the Piagetian group and the no-treatment control condition on measures of verbal IQ (Peabody Picture Vocabulary Test), mental age, seriation, and conservation. Moreover, the Piagetian group made significantly greater gains than the traditional class on measures of mental age, seriation, and classification. The only significant gain score (classification) difference between the children attending the traditional nursery and those not attending preschool at all favored the latter group. (16 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Relative importance of aptitude and prior domain knowledge on immediate and delayed posttests.

Two groups of college students were given a pretest covering basketball knowledge and asked to read a passage about basketball history. One group (IDP) took an immediate posttest of 27 items and a delayed posttest 1 wk later of the original items and 27 new items. The 2nd group (DPO) took only the delayed posttest of 54 items. Finally, a control group simply took the pretest and the 54-item posttest and scored at chance level on the posttest. Correlational analyses determined that, for the IDP group, pretest scores were significantly related to the immediate posttest. For the delayed posttest, both Scholastic Aptitude Test—Verbal subtest and pretest scores accounted for significant and unique portions of the variance. The latter results were replicated for the DPO group. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Molecular and genetic features of fragile X syndrome

This study explored the claim that superior disembedding performance in autism reflects "less capture by meaning" and/or reduced "central coherence" [Shah & Frith, Journal of Child Psychology & Psychiatry, 24, 613-620 (1983); Shah & Frith, Journal of Child Psychology & Psychiatry, 34, 1351-1364 (1993)]. Meaningless as well as meaningful disembedding contexts were used, and memory for contextual information was examined. Neither qualitative (search strategy) nor quantitative (RT or accuracy) data indicated that high-functioning individuals with autism/PDD were superior to younger, developmentally matched controls. For both groups, disembedding was slowest from meaningful contexts, which generally were remembered best. No evidence was provided for "less capture by meaning" or reduced "central coherence" in autism/PDD, raising the possibility that earlier findings reflect a developmental, rather than a stable autism-specific, phenomenon.     

Mental rotation of facial profiles: Age-, sex-, and ability-related differences.

48 adults (mean age 28 yrs 4 mo), 48 8th graders, and 48 4th graders determined what the left–right orientations of rotated facial profiles would be were the profiles upright. There were 24 males and 24 females in each group. Ss were all administered the Raven Standard Progressive Matrices and the Picture Vocabulary and Spatial Ability subtests of the Woodcock-Johnson Psycho-Educational Battery. Results indicate that rate of mental rotation and combined rate of encoding, comparison, and response increased with age. Findings are consistent with a speed–accuracy tradeoff explanation of previous discrepancies in developmental studies of mental rotation. Female Ss' rates of mental rotation were slower on average and more variable than male Ss. Within the entire sample, there was a modest correlation between the ability test scores and both latency and error parameters derived from the rotation task. Only error rate was discriminantly related to spatial ability, however. Patterns of correlations between processing parameters and test scores differed between age groups and, within age groups, between sexes. Mental rotation showed a significant relation to spatial ability only in 4th graders. (32 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Long-term effectiveness of translational manipulation for adhesive capsulitis

Long term effects of glenohumeral joint translational (gliding) manipulation on range of motion, pain, and function in patients with adhesive capsulitis were studied. Thirty-one patients underwent brachial plexus block followed by translational manipulation of the glenohumeral joint. Changes in range of motion and pain were assessed before manipulation with the patient under anesthesia, immediately after manipulation with the patient still under anesthesia, at early followup (5.3 +/- 3.2 weeks), and at long term followup (14.4 +/- 7.3 months). Passive range of motion increased significantly for flexion, abduction, external rotation, and internal rotation. Significant decreases in visual analog pain scores between initial evaluation and the followup assessments also occurred. Furthermore, Wolfgang's criteria score increased significantly between initial evaluation and followup assessments. Translational manipulation provides a safe, effective treatment option for adhesive capsulitis.     

How Did It Work? Who Did It Work for? Mediation in the Context of a Moderated Prevention Effect for Children of Divorce.

This study presents a reanalysis of data from an effective preventive intervention for children from divorced families (S. A. Wolchik et al., 2000) to test mediation of program effects. The study involved 157 children, age 9-12 years, who were randomly assigned to a parenting program or a literature control condition. Program effects to reduce posttest internalizing problems were mediated through improvement in mother-child relationship quality. Program effects to reduce externalizing problems at posttest and 6 months were mediated through improvement in posttest parental methods of discipline and mother-child relationship quality. The study also describes a new methodology to test mediation of Program x Baseline Status interactions. Analyses demonstrate mediation effects primarily for children who began the program with poorer scores on discipline, mother-child relationship quality, and externalizing problems. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Différences entre adolescents et adolescentes à quatre taches de visualisation spatiale.

Compared the performance of 64 adolescent boys and 42 adolescent girls (aged 15–17 yrs) on 4 visual-spatial skills tasks. The administrative conditions of these computerized tasks are highly standardized. Three of these tasks, Spatial Visualization, Perception and Spatial Relations, are taken from the Computerized Aptitude Test for adolescents and adults, whereas the 4th task is an adaptation for adolescents of the Puzzle subtest of the Computerized Aptitude Test for infants. The dependent variables are the average success scores and the speed of execution scores derived from latency times in a group of the best scores for each of the 4 tasks. The results show that the adolescent boys are more successful at the Spatial Visualization and Spatial Relations tasks. On the whole, the boys and the girls showed a comparable speed of success, except in the Spatial Relations subtest, where the girls were much faster. The observed differences are interpreted as reflecting the better strategies adopted by the boys to solve mental rotation tasks. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Evidence in support of a model that predicts how biological and environmental factors interact to influence spatial skills.

It was proposed, based on M. Annett (1985), that individuals biologically predisposed to poorer spatial skills are less likely to capitalize on opportunities to develop these skills. Using an analysis of variance design assessing mental rotation skills in 2 cohorts of 8th graders (365 students), the authors found a significant 3-way interaction (Brothers?×?Family Handedness?×?Gender). For the girls with brothers, those from all right-handed families had lower mental rotation scores than did the other girls. For the 2nd cohort, among those children who participated in mental-rotation-type activities with their brothers, both boys and girls from all right-handed families performed more poorly on the mental rotation test than did the other children with brothers. Thus, compared with other children, the children from all right-handed families do not appear to be able to use their spatial experiences with male siblings to increase their spatial skills. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The effect of occupational therapy education on students' perceived attitudes toward persons with disabilities

OBJECTIVES: The effect of occupational therapy education on students' perceived attitudes toward persons with disabilities was studied. METHOD: The perceived attitudes of 144 occupational therapy students toward persons with disabilities were measured before (retrospective pretest) and after (posttest) the students attended formal professional education at the University of Alberta. RESULTS: Posttest scores were significantly higher than the retrospective pretest scores, indicating that students' attitudes became more positive after they commenced formal professional education. The posttest scores of students at various levels of education, however, did not show any significant difference. CONCLUSION: On the basis of these observations, a positive but nonlinear relationship between occupational therapy education and attitudes toward persons with disabilities was postulated.     

Precise measurement of individual rapid eye movements in REM sleep of humans

An automated analyzer for individual eye movements (EMs) has been developed that enables precise analyses of their incidence. Three new parameters for each EM are obtained: EM magnitude, the angle and speed of eyeball rotation, and the energy of each EM. All rapid eye movement (REM) sleep EMs from 40 nights of polysomnography for 20 healthy young men were analyzed. The mean frequency of eye movement (EM frequency) was 15.9 per minute. Compared to conventionally analyzed rapid eye movement (REM) density, EM frequency was more sensitive to differences among sleep cycles, nights, and individuals. The mean EM rotation was 6.27 +/- 0.021 degrees, the mean speed of rotation was 58.73 +/- 0.18 degrees/second, and mean energy was 525.85 +/- 3.82 degrees2/second. The distribution of changes in these new parameters differed from conventional measures across REM episodes. The conventional measures, REM episode duration, and REM density increased progressively in successive REM episodes in an ascent-to-right pattern. However, the new parameters peaked in the second, followed by relatively low values, producing an inverted V pattern. This discrepancy could indicate physiological mechanisms of EM that are not revealed in conventional measures of REM sleep intensity.     

Executive dysfunction and Alzheimer's disease: Performance on a test of planning ability, the Porteus Maze Test.

Planning ability, as measured by the Porteus Maze Test, was evaluated in 85 Alzheimer's disease (AD) patients and 65 controls. AD patients performed worse on Test Age and 2 of 5 qualitative error scores. Principal components analysis revealed 3 Porteus components: Test Age and First Third Errors; Cut Corner and Cross Line Errors; and Last Third Errors. Among AD patients, factor analysis of Porteus measures and other cognitive tests revealed 4 factors. A nonverbal factor included Test Age and 3 nonverbal measures. A verbal factor included no Porteus measure. The remaining factors resembled the last 2 components from the analysis of Porteus scores alone. Test Age and 4 other cognitive measures correlated with ratings on an activities of daily living scale. Porteus Maze performance was impaired in a substantial number of patients with dementia and may be a useful measure of executive function in this population. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Age differences in the speed of mental rotation.

66 Ss in 4 age groups (mean ages 20.9, 32.4, 50.9, and 63.3 yrs) participated in a mental rotation task for 4 consecutive days. ANOVAs revealed significant age differences in the linear function relating median RT to degrees of rotation: Older Ss had higher intercepts and higher slopes. There were no significant age differences in error rates. Practice reduced slopes and intercepts for all groups, but it neither eliminated nor systematically reduced age differences in mental rotation performance. Mental rotation slopes and intercepts were significantly correlated with performance on the Figures subtest of the Primary Mental Abilities Test but not the Vocabulary subtest of the Nelson-Denny Reading Test. Results point toward age changes in the speed of spatial information processing that may contribute to age changes in performance on tests of spatial ability. (32 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Pharmacokinetics of orally administered estradiol valerate. Results of a single-dose cross-over bioequivalence study in postmenopausal women

A randomized, single-dose cross-over study in 32 postmenopausal women was performed to demonstrate bioequivalence of two estradiol valerate containing formulations (first sequence of Klimonorm as test preparation). The serum levels of estradiol, free and conjugated estrone were measured until 48 h after an oral dosage of 4 mg estradiol valerate (CAS 979-32-8). The mean AUC(0-48) of estradiol was calculated as 1006.6 +/- 479.4 h x pg x ml-1 (Test) and 1015.2 +/- 555.2 h x pg x ml-1 (Reference). The corresponding (AUC(0-48) of the active metabolite, free estrone, exceeded that of estradiol at 3578.3 h x pg x ml-1 (Test) and 3485.1 h x pg x ml-1 (Reference). Much higher was the AUC(0-48) for conjugated estrone at 132.4 h x ng x ml-1 (Test) and 133.6 h x ng x ml-1 (Reference). Mean estradiol Cmax values of 39.8 +/- 17.7 pg/ml (Test) and 42.9 +/- 21.0 pg/ml (Reference) were attained 8.2 +/- 4.5 h (Test) and 10.0 +/- 5.9 h (Reference) after the administration of 4 mg estradiol valerate. Maximal free estrone concentrations of 163 pg/ml (Test) and 174.3 pg/ml (Reference) were reached after 7.2 h (Test) and 7.5 h (Reference). Maximal conjugated estrone concentrations of 15.5 ng/ml (Test) and 16.2 ng/ml (Reference) were reached after 2.4 h (Test) and 2.0 h (Reference). The terminal elimination half-life of estradiol was calculated at 16.9 +/- 6.0 h (Test) and 15.0 +/- 4.8 h (Reference), that of free estrone at 16.3 h (Test) and 13.5 h (Reference), that of conjugated estrone at 11.8 h (Test) and 10.6 h (Reference). After logarithmic transformation, the 90% confidence intervals of the AUC(0-48) and Cmax ratios for estradiol and also for the metabolites (free and conjugated estrone) were within the acceptance ranges for bioequivalence. Therefore the test preparation and the reference preparation are bioequivalent.     

Neurodevelopmental outcomes of Ugandan infants with HIV infection: An application of growth curve analysis.

Neurodevelopmental outcomes of human immunodeficiency virus Type 1 (HIV-1)-infected infants of non-drug-using mothers were assessed in a controlled, prospective study from birth to 24 months with 3 groups: 61 infants of HIV-infected mothers, 234 uninfected infants of HIV-infected mothers (seroreverters), and 115 uninfected infants of uninfected mothers. Compared with seroreverters; and uninfected infants, HIV-infected infants demonstrated lower mental and motor development on the Bayley Scales and greater deceleration in their rate of motor development. HIV-infected infants with abnormal neurologic exams had lower motor and mental test scores and lower rates of motor Bayley Scales scores than their HIV-infected counterparts with normal neurologic exams. Contrary to prediction, no group differences in mean performance or growth rates were found on visual information processing on the Fagan Test of Infant Intelligence. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

An algorithm for noninvasive identification of angiographic three-vessel and/or left main coronary artery disease in symptomatic patients on the basis of cardiac risk and electron-beam computed tomographic calcium scores

OBJECTIVES: We sought to model an algorithm for noninvasive identification of angiographically obstructive three-vessel and/or left main disease based on conventional cardiac risk assessment and site and extent of coronary calcium determined by electron-beam computed tomography (EBCT). BACKGROUND: Such an algorithm would greatly facilitate clinical triage in symptomatic patients with no previous diagnosis of coronary artery disease (CAD). METHODS: We examined 291 patients with suspected, but not previously diagnosed, CAD who underwent coronary angiography for clinical indications. Cardiac risk factors were determined as defined by the National Cholesterol Education Program. An EBCT scan was performed in all patients, and a coronary calcium score (Agatston method) was computed. Total per-patient calcium scores and separate scores for the major coronary arteries were generated. These scores were also analyzed for localization of coronary calcium in the more distal versus proximal tomographic sections. These parameters and the risk factors were considered for the model described in the following section. RESULTS: Sixty-eight patients (23%) had angiographic three-vessel and/or left main CAD. Multiple logistic regression analysis determined male sex, presence of diabetes and left anterior descending (LAD) and circumflex (LCx) coronary calcium scores, independent from more distal calcium localization, as independent predictors for identification of three-vessel and/or left main CAD. Based on this four variable model, a simple noninvasive index (NI) was constructed as the following: loge(LAD score) + log(e)(LCx score) + 2[if diabetic] + 3[if male]. Receiver operating characteristic curve analysis for this NI yielded an area under the curve of 0.88+/-0.03 (p < 0.0001) for separating patients with, versus without, angiographic three-vessel and/or left main CAD. Various NI cutpoints demonstrated sensitivities from 87-97% and specificities from 46-74%. The NI values >14 increased the probability of angiographic three-vessel and/or left main CAD from 23% (pretest) to 65-100% (posttest), and NI values <10 increased the probability of no three-vessel and/or left main CAD from 77% (pretest) to 95-100% (posttest). CONCLUSIONS: On the basis of a simple algorithm ("noninvasive index"), EBCT calcium scanning in conjunction with risk factor analysis can rule in or rule out angiographically severe disease, i.e., three-vessel and/or left main CAD, in symptomatic patients.