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1.
The effects of goat- or cow-milk-based diets, whether normal or supplemented with calcium (5 or 10 g kg?1 Ca, respectively), on the nutritive utilization of Zn and its deposition in organs, were evaluated in rats with and without nutritional ferropenic anaemia (NFA). The digestive and metabolic utilization of Zn in anaemic and control groups was higher for rats on the goat milk diet than those on the cow milk diet. The most noteworthy result is that Ca supplementation in the diet improved Zn metabolism in all experimental groups, but especially in anaemic rats fed the goat milk diet. This fact is reflected in the higher levels of Zn deposition found with the goat milk diet. It appears that goat milk, especially when supplemented with Ca, had beneficial effects on nutritive utilization of Zn and Zn deposition in target organs in both control rats and, especially, rats with NFA.  相似文献   

2.
The short-term effects of Ca-supplemented goat or cow milk on the nutritive utilization of Fe were evaluated in a metabolic balance study of rats with nutritional ferropenic anaemia (NFA). Control and Fe-deficient rats were fed for 14 d with goat or cow milk diets containing high-Ca content (10,000 mg/kg diet). The consumption of diets containing high levels of Ca for 14 d had no adverse effects on Fe absorption when the goat milk-based diet was provided, whereas for the cow milk-based diet, there was a significant fall in the apparent digestibility coefficient (ADC) of Fe. Moreover, the ADC and Fe retention/intake ratio (R/I) were higher in the anaemic rats fed the goat milk diet than among those fed the cow milk diet. These results suggest that despite a high dietary Ca content, goat milk minimizes Ca–Fe interactions and has no adverse effects on Fe absorption in rats with NFA.  相似文献   

3.
Ca-Fe interactions are known, but no studies are available about the effects of Ca-enriched goat or cow milk on Fe status in nutritional ferropenic anaemia (NFA). To examine this matter, control and Fe-deficient rats were fed for 14 d with goat or cow milk diets containing either normal or high Ca content (5000 or 10,000 mg/kg diet), and different indices and parameters related to iron status were measured. The apparent digestibility coefficient (ADC) and the Fe retention/intake (R/I) ratio were higher in control and anaemic rats fed goat milk diet (G diet), despite high-Ca content. Ca enrichment decreased Fe stores in liver and sternum in anaemic rats fed cow milk diet (C diet), however G diet did not modify Fe content in the organs studied in control and anaemic rats. In anaemic rats, Ca-supplementation decreased haematocrit, but platelets and serum Fe were not affected, however, in control rats platelets increased except for Ca-enriched G diet, this fact reveals that Ca-Fe interaction is minimized with G diet. Serum ferritin was always higher in rats fed G vs. C diet, both in control and anaemic rats fed either normal or Ca-enriched diets. Ca-supplementation decreased ferritin levels in control and anaemic rats fed C diet and also, though to a lesser extent, in those given the G diet. This indicates that with this G diet there is a better recovery of body Fe stores in anaemic rats, despite Ca-supplementation. In this study it is noteworthy that despite high Ca content, a goat milk diet resulted in minimal Ca-Fe interactions and did not adversely affect Fe status in rats with NFA.  相似文献   

4.
Using rats with induced iron (Fe)-deficiency anaemia, this study investigated the effects of diets based on goat milk (GM) or cow milk (CM) lyophilates on the nutritive utilization of Fe, its deposit in target organs and haematic parameters involved in Fe metabolism. GM improved Fe metabolism, especially in Fe-deficient rats, leading to a higher Fe content in the spleen, liver, sternum and femur in comparison with CM. After feeding the rats for 2 weeks with the different diets, the anaemia had decreased, especially with GM, as assessed by higher haemoglobin regeneration efficiency (HRE), serum Fe, red blood cells (RBC) and packed cellular volume (PCV) levels and lower platelet count. We conclude that dietary GM improves Fe bioavailability in both control and anaemic rats, increasing Fe deposits in target organs and favouring the recovery of haematological parameters after ferropenic nutritional anaemia.  相似文献   

5.
The search for diets that improve the digestive and metabolic use of iron and copper in malabsorption syndrome led us to study goat milk for particular nutritional characteristics and compare it with cow milk, which is usually supplied. We studied the metabolism of iron and copper in transected rats (control) and in resected rats (resection of 50% of the distal small intestine). The diets used were the standard diet recommended by the American Institute of Nutrition and diets based on goat or cow milk. Intestinal resection reduced the apparent digestibility coefficient (ADC) of iron in the three diets tested. In the transected and resected rats, the ADC of iron was highest with the goat milk diet, followed by the standard diet and lowest with the cow milk diet. The ADC of copper was not affected by intestinal resection in the animals fed the goat milk diet, and was higher than that in the two groups of animals fed the other diets. Intestinal resection reduced the ADC of copper with the standard diet and the cow milk diet. When both groups of animals were fed the goat milk diet, the deposit of iron in the organs was greater than with those fed the cow milk diet and similar to that in those animals given the standard diet. The copper content in the kidneys was lower in the resected than in the transected animals, except in the case of those fed the goat milk diet, in which it was similar to that of the control (transected) rats. This study shows the beneficial effect of goat milk, with respect to cow milk, on the metabolism of iron and copper in control rats, especially those with malabsorption syndrome.  相似文献   

6.
We studied the effects of goat and cow milk fat on the digestive utilization of this nutrient and on some of the biochemical parameters that are related to the metabolisim of lipids, using rats with a resection of 50% of the distal small intestine and control animals (transected). The fat content in all the diets was 10% but the lipid quality was varied: the standard diet was based on olive oil, while the other two diets included fat obtained from lyophilized goat milk and cow milk, respectively. The digestive utilization of the fat was lower in the resected animals than in the transected ones for all three diets studied. In both resected and transected animals. the apparent digestibility coefficient (ADC) of the fat was greater with the standard diet (olive oil) than with diets whose fat content was provided by goat or cow milk. The digestive utilization of the fat was greater in the transected and resected rats receiving a diet of goat's milk (rich in medium-chain triglycerides) than those given a cow-milk-based diet and more closely approached the values obtained for olive oil. The consumption of goat milk reduced levels of cholesterol while levels of triglycerides, HDL, GOT and GPT remained with in the normal ranges, for both transected and resected animals. The advantageous effect of goat milk on the metabolisim of lipids with respect to cow milk suggests that the former should be included in the diet in eases of malabsorption snydrome.  相似文献   

7.
The search for diets to improve the nutritive utilization of protein and magnesium in malabsorption syndrome led us to study goat milk, because of its particular nutritional characteristics, and to compare it with cow milk, which is most commonly consumed. We studied the nutritive utilization of protein and magnesium in transected rats (control) and in rats with resection of 50% of the distal small intestine. The diets used were the standard diet recommended by the American Institute of Nutrition and diets based on lyophilized goat or cow milk. The consumption of goat milk produces better protein efficiency ratio and food conversion efficiency values, particularly in rats with intestinal resection, together with a higher nutritive utilization of protein. Magnesium apparent digestibility coefficient is not modified by intestinal resection in rats fed with goat milk-based diet, on the contrary to the standard and cow milk diets. Magnesium apparent digestibility coefficient is greater for the goat milk group, which is reflected in the greater quantity of this mineral stored in bone. These results demonstrate the beneficial effect of goat milk on the nutritive utilization of protein and on magnesium bioavailability, especially in animals with resection of the distal small intestine.  相似文献   

8.
The hypocholesterolemic effect of goat milk with respect to cow milk observed in a previous study led us to examine the influence of goat and cow milk in the diet on certain aspects of biliary physiology in normal rats. The fat content in all diets was 10% but the lipid quality was varied: the standard diet was based on virgin olive oil, and the other 2 diets included fat obtained from lyophilized cow milk and goat milk. We characterized the bile secretion, including biliary phospholipid, cholesterol, and bile acid outputs, the interrelation between bile acids and bile lipids, and the lithogenic index. The consumption of goat milk in the diet, compared with that of cow milk, caused an increase in the biliary secretion of cholesterol together with a decrease in plasma cholesterol concentration, whereas values for bile phospholipids, biliary acid concentrations, and the lithogenic index remained normal. Moreover, consumption of this type of milk decreased plasma triglyceride concentration and therefore had a positive effect, similar to that of olive oil (standard diet), on the lipid metabolism; hence, it may be recommended for consumption by the general population.  相似文献   

9.
This study investigates the effects of consumption of dietary caprine and bovine milk on Ca and P bioavailability, their distribution in different target organs, and parathormone (PTH) and corticosterone levels in rats with induced nutritional ferropenic anaemia (NFA). NFA increased the absorption of Ca and P, while their deposition in the femur was significantly lower, resulting in a significant degree of bone demineralization. Furthermore, anaemia led to an increased concentration in PTH and corticosterone in serum. Dietary caprine milk had a beneficial effect on Ca and P bioavailability in NFA, increasing the digestive and metabolic utilization of these elements and their deposits in the corresponding target organs, especially in the femur, together with lower levels of serum PTH. The opposite effect was observed for bovine milk diet. The consumption of caprine milk appears able to restore, at least in part, the impaired Ca and P metabolism and bone demineralization observed in rats with NFA.  相似文献   

10.
The effects of dietary inclusion of freeze-dried goat and cow milk on the utilization of zinc and selenium, and on the metabolic fate of zinc, were studied in transected (control) and resected rats (resection of 50% of the distal small intestine). Intestinal resection reduced the apparent digestibility coefficient and zinc retention in the cow milk diet, whereas these biological indices were similar in transected (control) and resected rats with standard (without milk) and goat milk diets. The apparent digestibility coefficient and retention of selenium were not affected by intestinal resection in the animals fed with the three diets studied. In transected (control) and resected rats, the apparent digestibility coefficient and retention of zinc and selenium were higher for the goat milk diet than for the other two diets. Zinc deposits in the organs, expressed as microg/g dry weight were in order of decreasing concentrations: femur, testes, sternum, liver, kidney, heart, spleen, longissimus dorsi muscle and brain. Deposits were greatest with the goat milk diet, followed by the standard diet and were lowest for the rats given the cow milk diet, both for transected (control) and resected animals. We conclude that consumption of the goat milk diet produces a greater bioavailability of zinc and selenium and a greater deposit of zinc in key organs, for both the transected (control) and the resected rats, with respect to the standard diet and the cow milk diet.  相似文献   

11.
The effect of goat or cow milk-based diets, with either normal Fe content or an Fe overload, on bone turnover and the mineralization process was studied in control and anemic rats during chronic Fe repletion. One hundred eighty male Wistar rats were studied during a pre-experimental period of 40 d in which they were randomly divided into 2 groups, a control group receiving the AIN-93G diet with normal Fe content (45 mg/kg of diet) and the Fe-deficient group receiving the AIN-93G diet with low Fe content (5 mg/kg of diet) for 40 d. After the pre-experimental period, the rats were fed for 10, 30, or 50 d with goat or cow milk-based diets with a normal Fe content (45 mg/kg of diet) or an Fe overload (450 mg/kg of diet). In anemic rats, goat milk with normal Fe content increased levels of the biomarker of bone formation N-terminal propeptides of type I procollagen and diminished parathyroid hormone levels after only 10 d of supplying this diet, indicating the beginning of restoration of the bone demineralization induced by the anemia, which was not observed with cow milk. After 30 d of supplying the milk-based diets with normal Fe content or an Fe overload, biomarkers of bone formation and bone resorption were not different between control and anemic rats, indicating that the bone demineralization induced by the Fe-deficiency anemia had recovered, although the process of stabilization of bone turnover began earlier in the animals fed goat milk. In addition, a higher Ca deposit was observed in femur, which positively affects bone mineralization, as well as an increase of Fe in sternum, which indicates that the hematopoietic process essentially recovered earlier on the goat milk diet compared with the cow milk diet.  相似文献   

12.
The effect of cow or goat milk-based diets, either normal or Fe-overloaded, on DNA stability was studied in control and anaemic rats for 30 or 50 days of chronic Fe repletion. DNA damage was assessed using the alkaline comet assay. Background DNA damage in lymphocytes of peripheral blood was much lower in control and anaemic rats, given the normal or Fe-overloaded goat milk-based diet after 30 and 50 days versus cow milk-based diet. Chronic Fe-overload had no adverse effect on DNA stability in control and anaemic fed the goat milk-based diet versus the same diet with normal-Fe content at the end of the study. The quality of goat milk fat, together with the high levels of bioavailable Mg and Zn may be responsible for its protective effect on DNA of peripheral blood lymphocytes under the different experimental conditions, even during chronic Fe-overload.  相似文献   

13.
Iron deficiency is the most prevalent micronutrient deficiency worldwide. In spite of the crucial role of hepatocyte divalent metal transporter 1 (DMT1) and hepcidin in Fe metabolism, to date, no studies have directly tested the role of these proteins in liver Fe metabolism during Fe repletion after induced Fe-deficiency anemia. Therefore, the aim of the current study was to assess the effect of goat or cow milk-based diets on Fe metabolism in one of the main body storage organs, the liver, during the course of Fe repletion with goat or cow milk-based diets in anemic rats. Animals were placed on a preexperimental period of 40 d, a control group receiving a normal-Fe diet and the Fe-deficient group receiving a low-Fe diet (5 mg of Fe/kg of diet). Rats were fed for 30 d with goat or cow milk-based diets with normal Fe content (45 mg of Fe/kg of diet). The hematological parameters, serum hepcidin, hepatosomatic index, liver Fe content, and liver DMT1 expression were determined. During the recovery of the anemia with milk-based diets, the restoration of liver Fe content and hematological parameters, especially with goat milk, increased the red blood cell count, favoring the oxygen supply and weight gain. Moreover, goat milk consumption potentiates liver DMT1 expression, enhancing Fe metabolism and storage. In addition, the increase in serum hepcidin in anemic rats observed in the current study also explains and supports the higher liver Fe content after supplying goat milk, because it blocks the liberation of Fe from hepatocytes, increasing its storage in liver.  相似文献   

14.
Bioavailabilities of iron from dehydrated whole and skim goat milk were investigated using iron-deficient rats. Hemoglobin regeneration efficiencies were determined as the percent conversion of dietary iron into hemoglobin. The respective hemoglobin regeneration efficiencies for groups fed whole goat milk, whole cow milk, skim goat milk, and skim cow milk were 50.6, 13.1, 26.0, and 13.0%, indicating that iron bioavailability of goat milk was greater than cow milk. However, rats fed each milk had negative net increases in hemoglobin concentrations, implying that the iron contents of each milk were not adequate. For animals consuming whole goat milk supplemented with ferrous sulfate, the slope relating hemoglobin iron gained versus iron intake was .95. Respective bioavailabilities relative to ferrous sulfate were 54, 14, 28, and 14% for the four sources of milk. Iron bioavailability of goat milk is superior to cow milk when fed to anemic rats.  相似文献   

15.
山羊奶与牛奶和人奶营养成分的比较   总被引:1,自引:0,他引:1  
对山羊奶、牛奶和人奶中蛋白质、脂肪、维生素、矿物质等主要营养成分进行了比较,分析了3种奶中主要营养成分的差别。通过比较发现,山羊奶在总体营养成分方面优于牛奶,更接近人奶。但山羊奶存在铁、叶酸和维生素B12含量较低以及羊奶膻味的问题,应在营养上对这方面加以重视。  相似文献   

16.
The study was conducted to evaluate the nutritional, textural and sensory characteristics of Camembert cheese made from goat milk, cow milk and their blends. The type of milk used affected yield, physicochemical properties and fatty acid profile of the cheeses. The percentages of C6:0, C8:0 and C10:0 acids were higher in the cheeses containing ≥ 75% goat milk. The sensory evaluation results showed differences in texture, colour, aroma and flavour among the cheeses. Cheeses made with the mixture of cow and goat milk particularly 50% goat milk mixed with 50% cow milk (50G:50C) maintained particular positive nutritional characteristics especially with respect to the mineral contents, fatty acids and consumer acceptability.  相似文献   

17.
Goat milk and cow milk are commonly used in infant formula preparations and, as such, understanding the nutritional characteristics of infant formulas made from these milks is important. In this study, a goat milk infant formula was compared with an adapted (whey-enhanced) cow milk infant formula with respect to mineral absorption and deposition using the 3-wk-old piglet as a model for the 3-mo-old infant. Equal numbers of piglets (n = 8) were fed either the goat milk formula or the cow milk formula. The mineral composition of the prepared goat milk formula was higher than that of the prepared cow milk formula for most minerals, including calcium (75.1 vs. 56.7 mg/100 mL) but excluding iron, which was higher in the prepared cow milk formula (0.92 vs. 0.74 mg/100 mL). The amounts of calcium, phosphorus, and manganese absorbed by the piglets were significantly higher for the goat milk formula, whereas the amounts of zinc, iron, and magnesium absorbed were significantly higher for the cow milk formula. Apparent mineral absorption, relative to intake, was statistically higher in the cow milk formula for calcium and phosphorus, although the actual differences were very small (less than 1.3%). For copper, zinc, iron, and magnesium there was no significant difference between treatments in apparent mineral absorption, whereas for manganese, absorption was higher for the goat milk infant formula. The absolute mineral deposition was higher in piglets fed the goat milk formula for calcium, phosphorus, and manganese, whereas iron deposition was higher in the piglets fed cow milk formula. For all other minerals tested, there were no significant differences between treatments. The goat milk infant formula provided a pattern of mineral retention in the 3-wk-old piglet very similar to that of the adapted cow milk infant formula. The minor differences observed between the 2 appeared to be due to the different mineral contents of the 2 formulas.  相似文献   

18.
Eight 1st-lactation cows were given four dietary treatments in a duplicated 4×4 Latin square experiment. Diets consisted of hay and soya bean meal together with barley, formaldehyde-treated barley, oats or formaldehydetreated oats (approximately 34:12:54 on a dry matter basis). Barley diets supplied 211 g fatty acids d?1, oats diets supplied 537 g d?1. The fatty acid composition (g kg?1 total fatty acids) for barley diets was: 300 (16:0); 20 (18:0); 150 (18:1); 470 (18:2); 60 (18:3). Corresponding values for oats diets were 180, 20, 390, 380 and 30 g kg?1. Formaldehyde treatment of the cereals tended to increase milk yield and reduce milk fat content (P<0·01 for barley) but did not affect milk fatty acid composition. Feeding oats in replacement for barley significantly (P<0·05) increased milk yield and lactose yield and reduced milk fat content (P<0·05 for the untreated cereals) and protein contents (P<0·01) without significant effects on milk fat or protein yields. Oats diets led to significant (P<0·001) reductions in the content of 8:0–16:0 fatty acids in milk fat with associated increases (P<0·001) in the content of 18:0 and 18:1. Changes in milk fat content of 18:2 and 18:3 acids were small. The results show the inclusion of oats in the cow's diet to be a means of reducing the saturated fatty acid content of milk fat thereby improving the nutritional value of milk and milk products and their appeal to the health-conscious consumer.  相似文献   

19.
The effect of fructooligosaccharide on protein digestibility and mineral absorption was studied in rats fed diets containing 5 g kg?1 fructooligosaccharide, 5 g kg?1 cellulose/fructooligosaccharide (1:1) or 5 g kg?1 cellulose as a source of dietary fibre. Addition of cellulose/fructooligosaccharide or fructooligosaccharide to the diet did not significantly modify the daily food intake and food efficiency. However, the fructooligosaccharide‐fed group showed a significant decrease in body weight gain compared with cellulose‐fed groups. Faecal excretion was significantly lower when there was fructooligosaccharide intake, despite there being no significant differences in cellulose‐fed groups. Intake of fructooligosaccharide produced an increase in caecal content and an enlargement of the caecal wall. This trophic effect could be attributed to short‐chain fatty acids produced from the anaerobic fermentation of fructooligosaccharide by intestinal bacteria. Cellulose/fructooligosaccharide enhanced the apparent absorption and apparent retention of Ca, Mg, Zn and Fe. Fructooligosaccharide‐fed rats experienced an increase in apparent absorption and apparent retention of Mg compared with cellulose‐fed rats. Fructooligosaccharide intake at the lowest dose was enough to provide a desirable effect on mineral bioavailability in rats without any modification of nutritional parameters. © 2002 Society of Chemical Industry  相似文献   

20.
The effect of infant formulas supplemented with functional ingredients on calcium (Ca), magnesium (Mg) and phosphorus (P) bioavailability was investigated in rats. Seven follow‐up infant formulas containing probiotics (Bifidobacterium bifidum and Bifidobacterium longum), prebiotics (galactooligosaccharides at 12, 50 and 100 g kg?1) or synbiotics (bifidobacteria and galactooligosacccharides) were administered to weanling rats for 30 days. A 3 day mineral balance was performed over three periods (8–10, 18–20 and 28–30 days) to monitor mineral apparent absorption and retention ratios and physiological and nutritional parameters. Feeding rats on infant formula‐based diets showed high feed efficiency (≥0.46). It was found that infant formulas supplemented with probiotics and/or prebiotics for 30 days increased Ca, Mg and P bioavailability in rats. Mineral apparent absorption and retention ratios were higher than 90% for Ca and P and 80% for Mg during the first balance period regardless of the infant formula used, but they decreased during the next two balance periods. Although it was not possible to select one infant formula as the best to improve mineral absorption, the 100 g kg?1 prebiotic and 50 and 100 g kg?1 synbiotic infant formulas were the most efficient at increasing Ca, Mg and P bioavailability compared with the control group. Copyright © 2006 Society of Chemical Industry  相似文献   

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