共查询到18条相似文献,搜索用时 156 毫秒
1.
介绍了对161例冠心病患者采用^99mTc-MIBI心肌显像潘生丁试验一天法方案进行检测的结果,其中20例与冠状动脉造影进行了对比观察。患者先作^99mTc-MIBI静态平面与断层心肌显像,接着进行潘生丁试验,再于静脉注射^99mTc-MIBI后1h作平面与断层心肌显像。采用本方法诊断冠心病的灵敏度为91%。其检测LAD的灵敏度为88%;诊断RCA及Lcx的灵敏度分别为81%与77%、特异性分别为 相似文献
2.
^99mTc标记抗心肌肌凝蛋白单克隆抗体在实验性心肌梗塞中的研究 总被引:4,自引:0,他引:4
为比较^99mTc-AMLA的特异性,将两组心肌梗塞24h大鼠分别注射^99mTc-AMLA(n=24)和^99mTc-N-IgG(n=18),为研究不同心肌梗塞时间对摄取抗体的影响,将另一组不同心肌梗塞时间(2h到14d共8个亚组)的大鼠注射^99mTc-AMLA,计算三组的ID%/g和梗塞心肌摄取/正常心肌摄取比(IM/NM)用一只心肌梗塞的狗注射^99mTc-AMLA后离体心肌显像,结果表明 相似文献
3.
^99mTc(V)—DMSA及^99mTc—MIBI肺显像诊断原发性肺癌的应用研究 总被引:2,自引:0,他引:2
对30例原发性肺癌患者分别应用^99mTc(v)-DMSA及^99mTc-MIBI显像。结果表明:^99mTc9V)-DMSA,^99mTc-MIBI敏感度分别为90%,76.7%。两者结合显像阳性率为96.7%。鳞状上皮细胞癌对^99mTc(V)-DMSA及^99mTc(V)-DMSA,^99mTc-MIBI摄取程度比其它类型的肺癌高。 相似文献
4.
应用^99mTC-MIBI对家兔缺血/再灌注心肌细胞及线粒体代谢和活力进行了评价,将家兔LAD阻断20min,3h再灌主,于灌注后2-5min静脉注射^99mTc-MIBI,结果缺血3h组缺血心肌再灌注早期(10min)晚期(3h)相对放射性活度,心肌ATP含量均明显低于缺前20min组,非缺血心肌和缺血20min心肌^99mTc-MIBI亚细胞分布与SDH活性呈显著正相关(r=0.88,P〈0. 相似文献
5.
对30例原发性肺癌患者分别应用99mTc(Ⅴ)-DMSA及99mTc-MIBI显像。结果表明:99mTc(Ⅴ)-DMSA、99mTc-MIBI敏感度分别为90%、76.7%。两者结合显像阳性率为96.7%。鳞状上皮细胞癌对99mTc(Ⅴ)-DMSA及99mTc-MIBI摄取程度比其它类型的肺癌高。 相似文献
6.
7.
用^99mTc-MIBI显像法对56例经病理证实的甲状腺“冷”结节患者鉴别,结果血流丰富的共22例,^99mTc-MIBI显像T/NT比值,恶性病变中乳头状癌、滤泡状癌,髓样癌,未分化癌均与^99mTcO^-5显像有非常显著性差异,而良性病变中仅腺瘤有显著性差异,其余均无显著性差异。 相似文献
8.
^99mTc标记环己二酮二肟及其甲基硼酸加成物和初步动物实验 总被引:2,自引:0,他引:2
实验结果表明,^99mTc-CDO的标记率受体系的pH值影响较小,而^99mTc-CDO-MeB只有在pH=3.5-4.0时标记率才能大于90%。小鼠体内分布实验表明,^99mTc-CDO-MeB在动物心肌中较高的吸收,但随时间延长而迅速清除。心/肝比值在给药后1、5和10min时分别为3、1.5和0.8。^99mTc-CDO在心、脑中的浓聚明显低于99mTc-CDO-MeB。 相似文献
9.
对28例经过治疗的胶质瘤患者进行Gd-DTPAMRI和^18F-FDGPET显像,其中14例同时进行^99mTc-MIBISPECT显像,并与治疗前解剖影像对比,PET结果发现14例高代谢,10例低代谢,4例瘤灶中心坏死,周边FDG环状摄取,8例首次手术病理I-Ⅱ级星形细胞瘤患者中5例为高代谢,^18F-FDGPET和^99mTC-MIBISPECT诊断胶质瘤复发及恶变的灵敏度依次为93.3%,9 相似文献
10.
报道了肾显像剂^99mTc-1,2-二羟基丙基磷酸的制备方法及其动物实验研究。结果显示,^99Tc-Diol注入小鼠体内5min后在肾脏达最大摄取度;注入家兔5min后双肾动态显像最清晰。表明^99mTc-Diol是一种肾脏摄取率高,摄取速度快的新型肾显像剂。 相似文献
11.
1 INTRODUCTIONRe-perfusion therapy is one of the important progresses of acute myocardial infarction (AMI) therapy. It is established that early intravenous thrombolysis is effective and convenient for patency-related artery (IRA)[']. But obvious limitation existsfor thrombolysis application such as low IRA patency rate, recuxrent ischeAnc events,high re-infarction rate, hemorrhage complication and so many contraindications. Recentyearst primary coronary steming has been developed as … 相似文献
12.
ZHANG Jiayin KONG Ye ZHOU Jian ZHANG Jianfeng ZHANG Liying WANG Chao ZHU Chengmo LI Biao 《核技术(英文版)》2008,19(1):32-38
PET myocardial viability imaging is the"gold standard"for the non-invasive assessment of myocardial viability.The research aims to find out the best methods of imaging interpretation in predicting the postoperative functional recovery.Twenty-one CAD patients with multi-vessel involvement Were recruited.All pailents underwent gated myocardial perfusion imaging(G-MPI) and FDG PET myocardial imaging within 2 weeks before coronary artery bypass grafting.The postoperative G-MPI was performed in all patients 3 months after the surgery.Out of the total 420 segments,164 segments of ischemic myocardium were detected by preoperative G-MPI.Among them,93ischemic segments were identified as non-viable(difference score≥0)and the rest 71 segments Were identified as viable(difference score<0).The proportion of viable segments(the ratio of viabl esegments versus iscbemic segments)and summed difference score of metabolism to perfusion were calculated.The patients were further divided into 2 groups according to the proportion of viable myocardium:group Ⅰ(the proportion≥50%,12 cases)and group Ⅱ(the proportion<50%,9 cases)while another division was made according to SDS:group A(SDSE≥0),group B(-5≤SDS<0)and group C(SDS<-5).The diagnostic accuracy of proportion of viable segments and SDS in predicting the post-revascularization improvement in the left ventricular ejection fraction by at least 5 or more ejection fraction units was 88.89%(8/9)and 55.56%(5/9)respectively.It is concluded that both approaches allow accurate evaluation of myocardial viability.Furthermore,the proportion of viable myocardium is more reliable in predicting the postoperative functional recovery. 相似文献
13.
14.
15.
16.
99mTc-TEBO为临床批准的快速心肌灌注显像药物,该药物初始摄取高,但心肌滞留不稳定,为此,本研究通过优化其硼酸结构,分别制备标记物99mTc-2SP、99mTc-4LPA及99mTc-2MDM,制备时间均为30 min,均为无色澄明液体,放化纯度均>95%,分别在健康小型猪体内进行SPECT动态显像,并与99mTc TEBO进行对比。结果表明:99mTc-TEBO注射后0~5 min,左室心肌快速摄取,但随后心肌放射性迅速洗脱,在10 min时心肌约洗脱至峰值的75%,与心血池放射性浓度比值为1.63。99mTc-2SP引入2-甲磺酰基吡啶-5-硼酸基后心肌初始摄取高,心肌滞留时间明显延长,心肌洗脱较缓慢,左室心肌均清晰显影,在第10 min时心肌摄取仍可保持峰值的95%,与心血池放射性浓度比值为3.75,明显高于99mTc-TEBO。而另外两种显像剂99mTc-4LPA和99mTc-2MDM在注射后15 min内显像不理想。因此,99mTc-2SP是有潜力的心肌灌注显像药物。 相似文献
17.
Juan ZHAO Yujin QI Qiusheng DAI Xuezhu ZHANG Xiaomei QU Jia HUANG Xingdang LIU 《核技术(英文版)》2008,19(2):105-108
In this paper, 99mTc-TRODAT-1 Micro-SPECT (single-photon emission computed tomography) was used for imaging dopamine transporter (DAT) in retinas and to investigate the changes of DAT in retinas of guinea pigs with form deprivation myopia. Pigmented guinea pigs aged 3 weeks were devided into form deprivation myopia (FDM) group (n=6) and normal control group (n=6). The test group wore translucent goggles randomly for 4 weeks,and both groups underwent biometric measurement (refraction and axial length) before and after the experiment.Micro-SPECT retinas imaging was performed at the 4th week after injection of 99nTc-TRODAT-1. The retinas were clearly resolved in the images. The ratio of 99mTc-TRODAT-1 uptake in the myopic retinas (11.55±2.80) was 3.64±1.40 lower than that in the control eye (15.20±1.98), and 2.35 1.05 lower than that in the fellow eyes (13.90±2.04). The results showed that 99mTc-TRODAT-1 Micro-SPECT eye imaging can be used to trace the distribution and changes of DAT in retina, and DAT in the myopic retinas were lower than that in the normal control eyes and fellow eyes. Micro-SPECT may provide a new approach for further studies on the role of dopamine system in the experimental myopia. 相似文献
18.
将6只20kg的小型猪制作心肌梗死模型,进行心肌99Tcm-甲氧基异丁基异腈(99Tcm-sestamibi,99Tcm-MIBI)血流灌注显像确定梗死区,用18F-脱氧葡萄糖(18F-fluorodeoxyglucose,18F-FDG)观察空腹与糖负荷图像的差别,确定心肌坏死或存活区.制作模型前进行自身对照形成对照组.并进行B超心功能检查.结果显示:心肌梗死区大部分心肌没有活力,99Tcm-MIBI和18F-FDG都没有摄取.空腹时有部分心肌显影,糖负荷时该区域显影程度减轻. 相似文献