Wearable Microfluidic Diaphragm Pressure Sensor for Health and Tactile Touch Monitoring

Flexible pressure sensors have many potential applications in wearable electronics, robotics, health monitoring, and more. In particular, liquid‐metal‐based sensors are especially promising as they can undergo strains of over 200% without failure. However, current liquid‐metal‐based strain sensors are incapable of resolving small pressure changes in the few kPa range, making them unsuitable for applications such as heart‐rate monitoring, which require a much lower pressure detection resolution. In this paper, a microfluidic tactile diaphragm pressure sensor based on embedded Galinstan microchannels (70 µm width × 70 µm height) capable of resolving sub‐50 Pa changes in pressure with sub‐100 Pa detection limits and a response time of 90 ms is demonstrated. An embedded equivalent Wheatstone bridge circuit makes the most of tangential and radial strain fields, leading to high sensitivities of a 0.0835 kPa^?1 change in output voltage. The Wheatstone bridge also provides temperature self‐compensation, allowing for operation in the range of 20–50 °C. As examples of potential applications, a polydimethylsiloxane (PDMS) wristband with an embedded microfluidic diaphragm pressure sensor capable of real‐time pulse monitoring and a PDMS glove with multiple embedded sensors to provide comprehensive tactile feedback of a human hand when touching or holding objects are demonstrated.     

A Wearable Nutrition Tracker

Nutrients are essential for the healthy development and proper maintenance of body functions in humans. For adequate nourishment, it is important to keep track of nutrients level in the body, apart from consuming sufficient nutrition that is in line with dietary guidelines. Sweat, which contains rich chemical information, is an attractive biofluid for routine non‐invasive assessment of nutrient levels. Herein, a wearable sensor that can selectively measure vitamin C concentration in biofluids, including sweat, urine, and blood is developed. Detection through an electrochemical sensor modified with Au nanostructures, LiClO₄‐doped conductive polymer, and an enzymes‐immobilized membrane is utilized to achieve wide detection linearity, high selectivity, and long‐term stability. The sensor allows monitoring of temporal changes in vitamin C levels. The effect of vitamin C intake on the sweat and urine profile is explored by monitoring concentration changes upon consuming different amounts of vitamin C. A longitudinal study of sweat's and urine's vitamin C correlation with blood is performed on two individuals. The results suggest that sweat and urine analysis can be a promising method to routinely monitor nutrition through the sweat sensor and that this sensor can facilitate applications such as nutritional screening and dietary intervention.     

Flexible Sensing Electronics for Wearable/Attachable Health Monitoring

Wearable or attachable health monitoring smart systems are considered to be the next generation of personal portable devices for remote medicine practices. Smart flexible sensing electronics are components crucial in endowing health monitoring systems with the capability of real‐time tracking of physiological signals. These signals are closely associated with body conditions, such as heart rate, wrist pulse, body temperature, blood/intraocular pressure and blood/sweat bio‐information. Monitoring such physiological signals provides a convenient and non‐invasive way for disease diagnoses and health assessments. This Review summarizes the recent progress of flexible sensing electronics for their use in wearable/attachable health monitoring systems. Meanwhile, we present an overview of different materials and configurations for flexible sensors, including piezo‐resistive, piezo‐electrical, capacitive, and field effect transistor based devices, and analyze the working principles in monitoring physiological signals. In addition, the future perspectives of wearable healthcare systems and the technical demands on their commercialization are briefly discussed.     

High Sensitivity,Wearable, Piezoresistive Pressure Sensors Based on Irregular Microhump Structures and Its Applications in Body Motion Sensing

A pressure sensor based on irregular microhump patterns has been proposed and developed. The devices show high sensitivity and broad operating pressure regime while comparing with regular micropattern devices. Finite element analysis (FEA) is utilized to confirm the sensing mechanism and predict the performance of the pressure sensor based on the microhump structures. Silicon carbide sandpaper is employed as the mold to develop polydimethylsiloxane (PDMS) microhump patterns with various sizes. The active layer of the piezoresistive pressure sensor is developed by spin coating PEDOT:PSS on top of the patterned PDMS. The devices show an averaged sensitivity as high as 851 kPa^?1, broad operating pressure range (20 kPa), low operating power (100 nW), and fast response speed (6.7 kHz). Owing to their flexible properties, the devices are applied to human body motion sensing and radial artery pulse. These flexible high sensitivity devices show great potential in the next generation of smart sensors for robotics, real‐time health monitoring, and biomedical applications.     

Advanced Wearable Microfluidic Sensors for Healthcare Monitoring

Wearable flexible sensors based on integrated microfluidic networks with multiplex analysis capability are emerging as a new paradigm to assess human health status and show great potential in application fields such as clinical medicine and athletic monitoring. Well‐designed microfluidic sensors can be attached to the skin surface to acquire various pieces of physiological information with high precision, such as sweat loss, information regarding metabolites, and electrolyte balance. Herein, the recent progress of wearable microfluidic sensors for applications in healthcare monitoring is summarized, including analysis principles and microfabrication methods. Finally, the challenges and opportunities for wearable microfluidic sensors in practical applications are discussed.     

Sensitive Wearable Temperature Sensor with Seamless Monolithic Integration

Accurate temperature field measurement provides critical information in many scientific problems. Herein, a new paradigm for highly sensitive, flexible, negative temperature coefficient (NTC) thermistor-based artificial skin is reported, with the highest temperature sensing ability reported to date among previously reported NTC thermistors. This artificial skin is achieved through the development of a novel monolithic laser-induced reductive sintering scheme and unique monolithic structures. The unique seamless monolithic structure simultaneously integrates two different components (a metal electrode and metal oxide sensing channel) from the same material at ambient pressure, which cannot be achieved by conventional heterogeneous integration through multiple, complex steps of photolithography or vacuum deposition. In addition to superior performance, electronic skin with high temperature sensitivity can be fabricated on heat-sensitive polymer substrates due to the low-temperature requirements of the process. As a proof of concept, temperature-sensitive artificial skin is tested with conformally attachable physiological temperature sensor arrays in the measurement of the temperatures of exhaled breath for the early detection of pathogenic progression in the respiratory system. The proposed highly sensitive flexible temperature sensor and monolithic selective laser reductive sintering are expected to greatly contribute to the development of essential components in various emerging research fields, including soft robotics and healthcare systems.     

Disruptive,Soft, Wearable Sensors

The wearable industry is on the rise, with a myriad of technical applications ranging from real-time health monitoring, the Internet of Things, and robotics, to name but a few. However, there is a saying “wearable is not wearable” because the current market-available wearable sensors are largely bulky and rigid, leading to uncomfortable wearing experience, motion artefacts, and poor data accuracy. This has aroused a world-wide intensive research quest for novel materials, with the aim of fabricating next-generation ultra-lightweight and soft wearable devices. Such disruptive second-skin-like biosensing technologies may enable a paradigm shift from current wearable 1.0 to future wearable 2.0 products. Here, the state-of-the-art progress made in the key phases for future wearable technology, namely, wear → sense → communicate → analyze → interpret → decide, is summarized. Without a doubt, materials innovation is the key, which is the main focus of the discussion. In addition, emphasis is also given to wearable energy, multicomponent integration, and wireless communication.     

Bioinspired Composite Microfibers for Skin Adhesion and Signal Amplification of Wearable Sensors

A facile approach is proposed for superior conformation and adhesion of wearable sensors to dry and wet skin. Bioinspired skin‐adhesive films are composed of elastomeric microfibers decorated with conformal and mushroom‐shaped vinylsiloxane tips. Strong skin adhesion is achieved by crosslinking the viscous vinylsiloxane tips directly on the skin surface. Furthermore, composite microfibrillar adhesive films possess a high adhesion strength of 18 kPa due to the excellent shape adaptation of the vinylsiloxane tips to the multiscale roughness of the skin. As a utility of the skin‐adhesive films in wearable‐device applications, they are integrated with wearable strain sensors for respiratory and heart‐rate monitoring. The signal‐to‐noise ratio of the strain sensor is significantly improved to 59.7 because of the considerable signal amplification of microfibrillar skin‐adhesive films.     

Smart Textile-Integrated Microelectronic Systems for Wearable Applications

The programmable nature of smart textiles makes them an indispensable part of an emerging new technology field. Smart textile-integrated microelectronic systems (STIMES), which combine microelectronics and technology such as artificial intelligence and augmented or virtual reality, have been intensively explored. A vast range of research activities have been reported. Many promising applications in healthcare, the internet of things (IoT), smart city management, robotics, etc., have been demonstrated around the world. A timely overview and comprehensive review of progress of this field in the last five years are provided. Several main aspects are covered: functional materials, major fabrication processes of smart textile components, functional devices, system architectures and heterogeneous integration, wearable applications in human and nonhuman-related areas, and the safety and security of STIMES. The major types of textile-integrated nonconventional functional devices are discussed in detail: sensors, actuators, displays, antennas, energy harvesters and their hybrids, batteries and supercapacitors, circuit boards, and memory devices.     

Mechano‐Based Transductive Sensing for Wearable Healthcare

Wearable healthcare presents exciting opportunities for continuous, real‐time, and noninvasive monitoring of health status. Even though electrochemical and optical sensing have already made great advances, there is still an urgent demand for alternative signal transformation in terms of miniaturization, wearability, conformability, and stretchability. Mechano‐based transductive sensing, referred to the efficient transformation of biosignals into measureable mechanical signals, is claimed to exhibit the aforementioned desirable properties, and ultrasensitivity. In this Concept, a focus on pressure, strain, deflection, and swelling transductive principles based on micro‐/nanostructures for wearable healthcare is presented. Special attention is paid to biophysical sensors based on pressure/strain, and biochemical sensors based on microfluidic pressure, microcantilever, and photonic crystals. There are still many challenges to be confronted in terms of sample collection, miniaturization, and wireless data readout. With continuing efforts toward solving those problems, it is anticipated that mechano‐based transduction will provide an accessible route for multimode wearable healthcare systems integrated with physical, electrophysiological, and biochemical sensors.     

Self-Powered Integrated Sensing System with In-Plane Micro-Supercapacitors for Wearable Electronics

Self-powered integrated sensor with high-sensitivity physiological signals detection is indispensable for next-generation wearable electronic devices. Herein, a Ti₃C₂T_x/CNTs-based self-powered resistive sensor with solar cells and in-plane micro-supercapacitors (MSCs) is successfully realized on a flexible styrene–ethylene/butylene–styrene (SEBS) electrospinning film. The prepared Ti₃C₂T_x/CNTs@SEBS/CNTs nanofiber membranes exhibit high electrical conductivity and mechanical flexibility. The laser-assisted fabricated Ti₃C₂T_x/CNTs based-MSCs demonstrate a high areal energy density of 52.89 and 9.56 µWh cm⁻² with a corresponding areal power density of 0.2 and 4 mW cm⁻². Additionally, the MSCs exhibit remarkable capacity retention of 90.62% after 10 000 cycles. Furthermore, the Ti₃C₂T_x/CNTs based-sensor exhibits real-time detection capability for human facial micro-expressions and pulse single under physiological conditions. The repeated bending/release tests indicate the long-time cycle stability of the Ti₃C₂T_x/CNTs based-sensor. Owing to the excellent sensing performance, the sensing array was also fabricated. It is believed that this work develops a route for designing a self-powered sensor system with flexible production, high performance, and human-friendly characteristics for wearable electronics.     

Advanced Carbon for Flexible and Wearable Electronics

Flexible and wearable electronics are attracting wide attention due to their potential applications in wearable human health monitoring and care systems. Carbon materials have combined superiorities such as good electrical conductivity, intrinsic and structural flexibility, light weight, high chemical and thermal stability, ease of chemical functionalization, as well as potential mass production, enabling them to be promising candidate materials for flexible and wearable electronics. Consequently, great efforts are devoted to the controlled fabrication of carbon materials with rationally designed structures for applications in next‐generation electronics. Herein, the latest advances in the rational design and controlled fabrication of carbon materials toward applications in flexible and wearable electronics are reviewed. Various carbon materials (carbon nanotubes, graphene, natural‐biomaterial‐derived carbon, etc.) with controlled micro/nanostructures and designed macroscopic morphologies for high‐performance flexible electronics are introduced. The fabrication strategies, working mechanism, performance, and applications of carbon‐based flexible devices are reviewed and discussed, including strain/pressure sensors, temperature/humidity sensors, electrochemical sensors, flexible conductive electrodes/wires, and flexible power devices. Furthermore, the integration of multiple devices toward multifunctional wearable systems is briefly reviewed. Finally, the existing challenges and future opportunities in this field are summarized.