共查询到20条相似文献,搜索用时 0 毫秒
1.
Biotransporting Self‐Assembled Nanofactories Using Polymer Vesicles with Molecular Permeability for Enzyme Prodrug Cancer Therapy 下载免费PDF全文
Tomoki Nishimura Yoshihiro Sasaki Kazunari Akiyoshi 《Advanced materials (Deerfield Beach, Fla.)》2017,29(36)
As “biotransporting nanofactories”, in vivo therapeutic biocatalyst nanoreactors would enable encapsulated enzymes to transform inert prodrugs or neutralize toxic compounds at target disease sites. This would offer outstanding potential for next‐generation therapeutic platforms, such as enzyme prodrug therapy. Designing such advanced materials has, however, proven challenging. Here, it is shown that self‐assembled nanofactories formulate with polymeric vesicles with an intrinsically permeable membrane. The vesicles, CAPsomes, are composed of carbohydrate‐b‐poly(propylene glycol) and show molecular‐weight‐depended permeability. This property enables CAPsomes to act as biocatalyst nanoreactors, protecting encapsulated enzymes from degradation while acting on low‐molecular‐weight substrates. In tumor bearing mice, combined treatment with enzyme‐loaded CAPsomes and doxorubicin prodrug inhibit tumor growth in these mice without any observable toxicity. The results demonstrate, for the first time, in vivo therapeutic efficacy of CAPsomes as nanofactories for enzyme prodrug cancer therapy. 相似文献
2.
Cancer Therapy: Esterase‐Activated Charge‐Reversal Polymer for Fibroblast‐Exempt Cancer Gene Therapy (Adv. Mater. 48/2016) 下载免费PDF全文
Nasha Qiu Xiangrui Liu Yin Zhong Zhuxian Zhou Ying Piao Lei Miao Qianzhi Zhang Jianbin Tang Leaf Huang Youqing Shen 《Advanced materials (Deerfield Beach, Fla.)》2016,28(48):10578-10578
3.
4.
5.
Cancer Immunotherapy: PD‐1 Blockade Cellular Vesicles for Cancer Immunotherapy (Adv. Mater. 22/2018) 下载免费PDF全文
Xudong Zhang Chao Wang Jinqiang Wang Quanyin Hu Benjamin Langworthy Yanqi Ye Wujin Sun Jing Lin Tianfu Wang Jason Fine Hao Cheng Gianpietro Dotti Peng Huang Zhen Gu 《Advanced materials (Deerfield Beach, Fla.)》2018,30(22)
6.
7.
Cancer Theranostics: A Novel Top‐Down Synthesis of Ultrathin 2D Boron Nanosheets for Multimodal Imaging‐Guided Cancer Therapy (Adv. Mater. 36/2018) 下载免费PDF全文
Xiaoyuan Ji Na Kong Junqing Wang Wenliang Li Yuling Xiao Silvia Tian Gan Ye Zhang Yujing Li Xiangrong Song Qingqing Xiong Sanjun Shi Zhongjun Li Wei Tao Han Zhang Lin Mei Jinjun Shi 《Advanced materials (Deerfield Beach, Fla.)》2018,30(36)
8.
9.
10.
11.
Polymer Solar Cells: Simplified Tandem Polymer Solar Cells with an Ideal Self‐Organized Recombination Layer (Adv. Mater. 8/2015) 下载免费PDF全文
Hongkyu Kang Seyoung Kee Kilho Yu Jinho Lee Geunjin Kim Junghwan Kim Jae‐Ryoung Kim Jaemin Kong Kwanghee Lee 《Advanced materials (Deerfield Beach, Fla.)》2015,27(8):1468-1468
12.
Drug Delivery: Engineering the Surface of Smart Nanocarriers Using a pH‐/Thermal‐/GSH‐Responsive Polymer Zipper for Precise Tumor Targeting Therapy In Vivo (Adv. Mater. 36/2017) 下载免费PDF全文
Penghui Zhang Yan Wang Jing Lian Qi Shen Chen Wang Bohan Ma Yuchao Zhang Tingting Xu Jianxin Li Yongping Shao Feng Xu Jun‐Jie Zhu 《Advanced materials (Deerfield Beach, Fla.)》2017,29(36)
13.
14.
15.
16.
17.
Photoconversion‐Tunable Fluorophore Vesicles for Wavelength‐Dependent Photoinduced Cancer Therapy 下载免费PDF全文
Hui He Shuangshuang Ji Yang He Aijun Zhu Yelin Zou Yibin Deng Hengte Ke Hong Yang Youliang Zhao Zhengqing Guo Huabing Chen 《Advanced materials (Deerfield Beach, Fla.)》2017,29(19)
Photoconversion tunability of fluorophore dye is of great interest in cancer nanomedicine such as fluorescence imaging, photodynamic therapy (PDT), and photothermal therapy (PTT). Herein, this paper reports wavelength‐dependent photoconversional polymeric vesicles of boron dipyrromethene (Bodipy) fluorophore for either PDT under 660 nm irradiation or PTT under 785 nm irradiation. After being assembled within polymeric vesicles at a high drug loading, Bodipy molecules aggregate in the conformations of both J‐type and H‐type, thereby causing red‐shifted absorption into near‐infrared region, ultralow radiative transition, and ideal resistance to photobleaching. Such vesicles further possess enhanced blood circulation, preferable tumor accumulation, as well as superior cell uptake as compared to free Bodipy. In particular, the vesicles mainly generate abundant intracellular singlet oxygen for PDT treatment under 660 nm irradiation, while they primarily produce a potent hyperthermia for PTT with tumor ablation through singlet oxygen‐synergized photothermal necrosis under 785 nm irradiation. This approach provides a facile and general strategy to tune photoconversion characteristics of fluorophore dyes for wavelength‐dependent photoinduced cancer therapy. 相似文献
18.
19.